5EI0A

Structure of rcl-cleaved vaspin (serpina12)
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
Knots found
sequence length
373
structure length
372
Chain Sequence
KQRMAAKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNITAIFILPDEGKLKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPETPLVVKIDKPYLLLIYSEKIPSVLFLGKIVNPI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of cleaved vaspin (serpinA12).
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Homo sapiens
molecule keywords Serpin A12
total genus 92
structure length 372
sequence length 373
chains with identical sequence E
other databases KnotProt 2.0: Artifct S -31 -31 -
ec nomenclature
pdb deposition date 2015-10-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 5ei0A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 5ei0A01
1YXAA 1NQ9I 5CDXA 3NDDA 4PYWA 2ARQA 3DRMA 4AJTA 1UHGA 2H4QA 3NE4A 3DRUA 2ANTI 4P0OA 1ANTI 1LJ5A 2XN6A 3Q02A 4KDSA 2V95A 4RO9A 3VVJA 1IMVA 2ZNHA 3LE2A 4ZK0A 1OVAB 4AQHA 1JRRA 3EVJI 5CDZA 2ARRA 1K9OI 2WXZC 3CWMA 4CAAA 4GA7A 2B5TI 1OO8A 1ATHA 2QUGA 2WY1A 4AU3A 3F02A 7APIA 2HIJI 9PAIA 1DVNA 3OZQA 4C49A 2BEHI 1BY7A 3Q03A 4AU2A 1XQGA 3UT3A 1MTPA 2RIVA 1PSIA 3CWLA 1ATTA 2XN3A 1M93B 1D5SA 4DTEA 4BB2A 1HP7A 1XU8A 3FGQA 1QMBA 4RSQA 3STOA 1OYHI 1E03I 2HIJL 3B9FI 2VH4A 4ZK3A 1XQJA 1E04I 3F5NA 2BEHL 1C8OA 1OC0A 1AZXI 3NDAA 4G8OA 1EZXA 1BR8I 1R1LI 1A7CA 3H5CA 3LW2A 2H4PA 4ROAA 2OL2A 1DB2A 1OPHA 1DVMA 3CVMA 1WZ9A 4P0FA 8APIA 1JVQI 3PZFA 2WXWA 1OVAC 4EB1L 9APIA 1SR5A 3R4LA 2H4RA 4DY7C 2B4XL 1ATUA 2DUTA 1OYHL 2WXYC 3CAAA 5CE0A 4AU4A 1JJOC 4EB1I 1SNGA 2ZV6A 1DZGL 2D26A 1T1FA 2GD4C 1OVAA 2B4XI 4ROBA 3T1PA 2VDXA 1JTIA 2ACHA 2XN7A 1E05I 1TB6I 3DY0A 4Y40A 1DZGI 3F1SA 1AS4A 1DZHI 3KCGI 4R9IA 2CEOA 2RIWA 4C41A 4G8RA 1B3KA 2WY0C 5IO1A 2VDYA 1HLEA 5EI0A 4Y3KA 2XN5A 3PB1I 1JMOA 3DLWA 4AFXA 5HGCA 2PEFA 1IZ2A 1C5GA 2HI9A 3EOXA 4X30A 3ZHAA 2OAYA 1QLPA 1F0CA 1QMNA 1JMJA 1KCTA 2R9YA 4DY0A 4YIAA 4AU3B 5INWA 1LQ8A 1SEKA 1DZHL 4AJUA 2PEEA 2WXXA 3NDFA 1LK6I 5C98A 4IF8A 4IC0A 2WXZA 5BRRI
chains in the Genus database with same CATH superfamily
1YXAA 1NQ9I 5CDXA 3NDDA 4PYWA 2ARQA 3DRMA 4AJTA 1UHGA 2H4QA 3NE4A 3DRUA 2ANTI 4P0OA 1ANTI 1LJ5A 2XN6A 3Q02A 4KDSA 2V95A 4RO9A 3VVJA 1IMVA 2ZNHA 3LE2A 4ZK0A 1OVAB 4AQHA 1JRRA 3EVJI 5CDZA 2ARRA 1K9OI 2WXZC 3CWMA 4CAAA 4GA7A 2B5TI 1OO8A 1ATHA 2QUGA 2WY1A 4AU3A 3F02A 7APIA 2HIJI 9PAIA 1DVNA 3OZQA 4C49A 2BEHI 1BY7A 3Q03A 4AU2A 1XQGA 3UT3A 1MTPA 2RIVA 1PSIA 3CWLA 1ATTA 2XN3A 1M93B 1D5SA 4DTEA 4BB2A 1HP7A 1XU8A 3FGQA 1QMBA 4RSQA 3STOA 1OYHI 1E03I 2HIJL 3B9FI 2VH4A 4ZK3A 1XQJA 1E04I 3F5NA 2BEHL 1C8OA 1OC0A 1AZXI 3NDAA 4G8OA 1EZXA 1BR8I 1R1LI 1A7CA 3H5CA 3LW2A 2H4PA 4ROAA 2OL2A 1DB2A 1OPHA 1DVMA 3CVMA 1WZ9A 4P0FA 8APIA 1JVQI 3PZFA 2WXWA 1OVAC 4EB1L 9APIA 1SR5A 3R4LA 2H4RA 4DY7C 2B4XL 1ATUA 2DUTA 1OYHL 2WXYC 3CAAA 5CE0A 4AU4A 1JJOC 4EB1I 1SNGA 2ZV6A 1DZGL 2D26A 1T1FA 2GD4C 1OVAA 2B4XI 4ROBA 3T1PA 2VDXA 1JTIA 2ACHA 2XN7A 1E05I 1TB6I 3DY0A 4Y40A 1DZGI 3F1SA 1AS4A 1DZHI 3KCGI 4R9IA 2CEOA 2RIWA 4C41A 4G8RA 1B3KA 2WY0C 5IO1A 2VDYA 1HLEA 5EI0A 4Y3KA 2XN5A 3PB1I 1JMOA 3DLWA 4AFXA 5HGCA 2PEFA 1IZ2A 1C5GA 2HI9A 3EOXA 4X30A 3ZHAA 2OAYA 1QLPA 1F0CA 1QMNA 1JMJA 1KCTA 2R9YA 4DY0A 4YIAA 4AU3B 5INWA 1LQ8A 1SEKA 1DZHL 4AJUA 2PEEA 2WXXA 3NDFA 1LK6I 5C98A 4IF8A 4IC0A 2WXZA 5BRRI
chains in the Genus database with same CATH topology
1YXAA 1NQ9I 5CDXA 3NDDA 4PYWA 2ARQA 3DRMA 4AJTA 1UHGA 2H4QA 3NE4A 3DRUA 2ANTI 4P0OA 1ANTI 1LJ5A 2XN6A 3Q02A 4KDSA 2V95A 4RO9A 3VVJA 1IMVA 2ZNHA 3LE2A 4ZK0A 1OVAB 4AQHA 1JRRA 3EVJI 5CDZA 2ARRA 1K9OI 2WXZC 3CWMA 4CAAA 4GA7A 2B5TI 1OO8A 1ATHA 2QUGA 2WY1A 4AU3A 3F02A 7APIA 2HIJI 9PAIA 1DVNA 3OZQA 4C49A 2BEHI 1BY7A 3Q03A 4AU2A 1XQGA 3UT3A 1MTPA 2RIVA 1PSIA 3CWLA 1ATTA 2XN3A 1M93B 1D5SA 4DTEA 4BB2A 1HP7A 1XU8A 3FGQA 1QMBA 4RSQA 3STOA 1OYHI 1E03I 2HIJL 3B9FI 2VH4A 4ZK3A 1XQJA 1E04I 3F5NA 2BEHL 1C8OA 1OC0A 1AZXI 3NDAA 4G8OA 1EZXA 1BR8I 1R1LI 1A7CA 3H5CA 3LW2A 2H4PA 4ROAA 2OL2A 1DB2A 1OPHA 1DVMA 3CVMA 1WZ9A 4P0FA 8APIA 1JVQI 3PZFA 2WXWA 1OVAC 4EB1L 9APIA 1SR5A 3R4LA 2H4RA 4DY7C 2B4XL 1ATUA 2DUTA 1OYHL 2WXYC 3CAAA 5CE0A 4AU4A 1JJOC 4EB1I 1SNGA 2ZV6A 1DZGL 2D26A 1T1FA 2GD4C 1OVAA 2B4XI 4ROBA 3T1PA 2VDXA 1JTIA 2ACHA 2XN7A 1E05I 1TB6I 3DY0A 4Y40A 1DZGI 3F1SA 1AS4A 1DZHI 3KCGI 4R9IA 2CEOA 2RIWA 4C41A 4G8RA 1B3KA 2WY0C 5IO1A 2VDYA 1HLEA 5EI0A 4Y3KA 2XN5A 3PB1I 1JMOA 3DLWA 4AFXA 5HGCA 2PEFA 1IZ2A 1C5GA 2HI9A 3EOXA 4X30A 3ZHAA 2OAYA 1QLPA 1F0CA 1QMNA 1JMJA 1KCTA 2R9YA 4DY0A 4YIAA 4AU3B 5INWA 1LQ8A 1SEKA 1DZHL 4AJUA 2PEEA 2WXXA 3NDFA 1LK6I 5C98A 4IF8A 4IC0A 2WXZA 5BRRI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YXA A;  1NQ9 I;  5CDX A;  3NDD A;  4PYW A;  2ARQ A;  3DRM A;  4AJT A;  1UHG A;  2H4Q A;  3NE4 A;  3DRU A;  2ANT I;  4P0O A;  1ANT I;  1LJ5 A;  2XN6 A;  3Q02 A;  4KDS A;  2V95 A;  4RO9 A;  3VVJ A;  1IMV A;  2ZNH A;  3LE2 A;  4ZK0 A;  1OVA B;  4AQH A;  1JRR A;  3EVJ I;  5CDZ A;  2ARR A;  1K9O I;  2WXZ C;  3CWM A;  4CAA A;  4GA7 A;  2B5T I;  1OO8 A;  1ATH A;  2QUG A;  2WY1 A;  4AU3 A;  3F02 A;  7API A;  2HIJ I;  9PAI A;  1DVN A;  3OZQ A;  4C49 A;  2BEH I;  1BY7 A;  3Q03 A;  4AU2 A;  1XQG A;  3UT3 A;  1MTP A;  2RIV A;  1PSI A;  3CWL A;  1ATT A;  2XN3 A;  1M93 B;  1D5S A;  4DTE A;  4BB2 A;  1HP7 A;  1XU8 A;  3FGQ A;  1QMB A;  4RSQ A;  3STO A;  1OYH I;  1E03 I;  2HIJ L;  3B9F I;  2VH4 A;  4ZK3 A;  1XQJ A;  1E04 I;  3F5N A;  2BEH L;  1C8O A;  1OC0 A;  1AZX I;  3NDA A;  4G8O A;  1EZX A;  1BR8 I;  1R1L I;  1A7C A;  3H5C A;  3LW2 A;  2H4P A;  4ROA A;  2OL2 A;  1DB2 A;  1OPH A;  1DVM A;  3CVM A;  1WZ9 A;  4P0F A;  8API A;  1JVQ I;  3PZF A;  2WXW A;  1OVA C;  4EB1 L;  9API A;  1SR5 A;  3R4L A;  2H4R A;  4DY7 C;  2B4X L;  1ATU A;  2DUT A;  1OYH L;  2WXY C;  3CAA A;  5CE0 A;  4AU4 A;  1JJO C;  4EB1 I;  1SNG A;  2ZV6 A;  1DZG L;  2D26 A;  1T1F A;  2GD4 C;  1OVA A;  2B4X I;  4ROB A;  3T1P A;  2VDX A;  1JTI A;  2ACH A;  2XN7 A;  1E05 I;  1TB6 I;  3DY0 A;  4Y40 A;  1DZG I;  3F1S A;  1AS4 A;  1DZH I;  3KCG I;  4R9I A;  2CEO A;  2RIW A;  4C41 A;  4G8R A;  1B3K A;  2WY0 C;  5IO1 A;  2VDY A;  1HLE A;  5EI0 A;  4Y3K A;  2XN5 A;  3PB1 I;  1JMO A;  3DLW A;  4AFX A;  5HGC A;  2PEF A;  1IZ2 A;  1C5G A;  2HI9 A;  3EOX A;  4X30 A;  3ZHA A;  2OAY A;  1QLP A;  1F0C A;  1QMN A;  1JMJ A;  1KCT A;  2R9Y A;  4DY0 A;  4YIA A;  4AU3 B;  5INW A;  1LQ8 A;  1SEK A;  1DZH L;  4AJU A;  2PEE A;  2WXX A;  3NDF A;  1LK6 I;  5C98 A;  4IF8 A;  4IC0 A;  2WXZ A;  5BRR I; 
#chains in the Genus database with same CATH topology
 1YXA A;  1NQ9 I;  5CDX A;  3NDD A;  4PYW A;  2ARQ A;  3DRM A;  4AJT A;  1UHG A;  2H4Q A;  3NE4 A;  3DRU A;  2ANT I;  4P0O A;  1ANT I;  1LJ5 A;  2XN6 A;  3Q02 A;  4KDS A;  2V95 A;  4RO9 A;  3VVJ A;  1IMV A;  2ZNH A;  3LE2 A;  4ZK0 A;  1OVA B;  4AQH A;  1JRR A;  3EVJ I;  5CDZ A;  2ARR A;  1K9O I;  2WXZ C;  3CWM A;  4CAA A;  4GA7 A;  2B5T I;  1OO8 A;  1ATH A;  2QUG A;  2WY1 A;  4AU3 A;  3F02 A;  7API A;  2HIJ I;  9PAI A;  1DVN A;  3OZQ A;  4C49 A;  2BEH I;  1BY7 A;  3Q03 A;  4AU2 A;  1XQG A;  3UT3 A;  1MTP A;  2RIV A;  1PSI A;  3CWL A;  1ATT A;  2XN3 A;  1M93 B;  1D5S A;  4DTE A;  4BB2 A;  1HP7 A;  1XU8 A;  3FGQ A;  1QMB A;  4RSQ A;  3STO A;  1OYH I;  1E03 I;  2HIJ L;  3B9F I;  2VH4 A;  4ZK3 A;  1XQJ A;  1E04 I;  3F5N A;  2BEH L;  1C8O A;  1OC0 A;  1AZX I;  3NDA A;  4G8O A;  1EZX A;  1BR8 I;  1R1L I;  1A7C A;  3H5C A;  3LW2 A;  2H4P A;  4ROA A;  2OL2 A;  1DB2 A;  1OPH A;  1DVM A;  3CVM A;  1WZ9 A;  4P0F A;  8API A;  1JVQ I;  3PZF A;  2WXW A;  1OVA C;  4EB1 L;  9API A;  1SR5 A;  3R4L A;  2H4R A;  4DY7 C;  2B4X L;  1ATU A;  2DUT A;  1OYH L;  2WXY C;  3CAA A;  5CE0 A;  4AU4 A;  1JJO C;  4EB1 I;  1SNG A;  2ZV6 A;  1DZG L;  2D26 A;  1T1F A;  2GD4 C;  1OVA A;  2B4X I;  4ROB A;  3T1P A;  2VDX A;  1JTI A;  2ACH A;  2XN7 A;  1E05 I;  1TB6 I;  3DY0 A;  4Y40 A;  1DZG I;  3F1S A;  1AS4 A;  1DZH I;  3KCG I;  4R9I A;  2CEO A;  2RIW A;  4C41 A;  4G8R A;  1B3K A;  2WY0 C;  5IO1 A;  2VDY A;  1HLE A;  5EI0 A;  4Y3K A;  2XN5 A;  3PB1 I;  1JMO A;  3DLW A;  4AFX A;  5HGC A;  2PEF A;  1IZ2 A;  1C5G A;  2HI9 A;  3EOX A;  4X30 A;  3ZHA A;  2OAY A;  1QLP A;  1F0C A;  1QMN A;  1JMJ A;  1KCT A;  2R9Y A;  4DY0 A;  4YIA A;  4AU3 B;  5INW A;  1LQ8 A;  1SEK A;  1DZH L;  4AJU A;  2PEE A;  2WXX A;  3NDF A;  1LK6 I;  5C98 A;  4IF8 A;  4IC0 A;  2WXZ A;  5BRR I; 
#chains in the Genus database with same CATH homology
 1YXA A;  1NQ9 I;  5CDX A;  3NDD A;  4PYW A;  2ARQ A;  3DRM A;  4AJT A;  1UHG A;  2H4Q A;  3NE4 A;  3DRU A;  2ANT I;  4P0O A;  1ANT I;  1LJ5 A;  2XN6 A;  3Q02 A;  4KDS A;  2V95 A;  4RO9 A;  3VVJ A;  1IMV A;  2ZNH A;  3LE2 A;  4ZK0 A;  1OVA B;  4AQH A;  1JRR A;  3EVJ I;  5CDZ A;  2ARR A;  1K9O I;  2WXZ C;  3CWM A;  4CAA A;  4GA7 A;  2B5T I;  1OO8 A;  1ATH A;  2QUG A;  2WY1 A;  4AU3 A;  3F02 A;  7API A;  2HIJ I;  9PAI A;  1DVN A;  3OZQ A;  4C49 A;  2BEH I;  1BY7 A;  3Q03 A;  4AU2 A;  1XQG A;  3UT3 A;  1MTP A;  2RIV A;  1PSI A;  3CWL A;  1ATT A;  2XN3 A;  1M93 B;  1D5S A;  4DTE A;  4BB2 A;  1HP7 A;  1XU8 A;  3FGQ A;  1QMB A;  4RSQ A;  3STO A;  1OYH I;  1E03 I;  2HIJ L;  3B9F I;  2VH4 A;  4ZK3 A;  1XQJ A;  1E04 I;  3F5N A;  2BEH L;  1C8O A;  1OC0 A;  1AZX I;  3NDA A;  4G8O A;  1EZX A;  1BR8 I;  1R1L I;  1A7C A;  3H5C A;  3LW2 A;  2H4P A;  4ROA A;  2OL2 A;  1DB2 A;  1OPH A;  1DVM A;  3CVM A;  1WZ9 A;  4P0F A;  8API A;  1JVQ I;  3PZF A;  2WXW A;  1OVA C;  4EB1 L;  9API A;  1SR5 A;  3R4L A;  2H4R A;  4DY7 C;  2B4X L;  1ATU A;  2DUT A;  1OYH L;  2WXY C;  3CAA A;  5CE0 A;  4AU4 A;  1JJO C;  4EB1 I;  1SNG A;  2ZV6 A;  1DZG L;  2D26 A;  1T1F A;  2GD4 C;  1OVA A;  2B4X I;  4ROB A;  3T1P A;  2VDX A;  1JTI A;  2ACH A;  2XN7 A;  1E05 I;  1TB6 I;  3DY0 A;  4Y40 A;  1DZG I;  3F1S A;  1AS4 A;  1DZH I;  3KCG I;  4R9I A;  2CEO A;  2RIW A;  4C41 A;  4G8R A;  1B3K A;  2WY0 C;  5IO1 A;  2VDY A;  1HLE A;  5EI0 A;  4Y3K A;  2XN5 A;  3PB1 I;  1JMO A;  3DLW A;  4AFX A;  5HGC A;  2PEF A;  1IZ2 A;  1C5G A;  2HI9 A;  3EOX A;  4X30 A;  3ZHA A;  2OAY A;  1QLP A;  1F0C A;  1QMN A;  1JMJ A;  1KCT A;  2R9Y A;  4DY0 A;  4YIA A;  4AU3 B;  5INW A;  1LQ8 A;  1SEK A;  1DZH L;  4AJU A;  2PEE A;  2WXX A;  3NDF A;  1LK6 I;  5C98 A;  4IF8 A;  4IC0 A;  2WXZ A;  5BRR I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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