5IO1A

Crystal structure of recombinant human z alpha-1-antitrypsin
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
371
structure length
365
Chain Sequence
NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDKKGCELEAIPRSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords Alpha-1-antitrypsin
publication title Molecular Mechanism of Z alpha 1-Antitrypsin Deficiency
pubmed doi rcsb
source organism Homo sapiens
total genus 100
structure length 365
sequence length 371
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-03-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 5io1A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 5io1A01
5HGCA 1JVQI 1JMOA 3DRMA 4EB1I 2XN6A 1OYHL 4DY7C 1M93B 1TB6I 1DZHI 2QUGA 4RSQA 9PAIA 1JJOC 4PYWA 1AS4A 4AQHA 2WXWA 1SEKA 1ATTA 5BRRI 4IC0A 4P0OA 3CAAA 1LQ8A 1K9OI 2WXZC 7APIA 1HP7A 1B3KA 2HIJL 3F5NA 3F02A 2ZNHA 8APIA 1C8OA 4C41A 3EVJI 1F0CA 1DVMA 2DUTA 3DRUA 2GD4C 3LW2A 2R9YA 4ZK0A 5CDXA 3NE4A 1ATHA 1OYHI 3DY0A 1DZGL 1OVAC 1PSIA 2OL2A 1DVNA 1WZ9A 3H5CA 4Y3KA 2WXZA 4AU4A 5CDZA 4G8RA 5CE0A 4YIAA 1E03I 2XN5A 1R1LI 2WY1A 2ARQA 2XN7A 3DLWA 3NDFA 3VVJA 2BEHL 1OO8A 4CAAA 2PEFA 1LK6I 4AFXA 2HIJI 4IF8A 1QMBA 1UHGA 2B4XL 2WXYC 1EZXA 1MTPA 4AJUA 4DTEA 1E05I 1JRRA 5IO1A 2OAYA 1DZGI 3FGQA 2H4RA 1KCTA 3Q02A 1HLEA 4G8OA 4AU2A 3OZQA 4BB2A 2ZV6A 4X30A 5INWA 4Y40A 1BY7A 2V95A 2BEHI 3EOXA 3PB1I 2B5TI 2CEOA 1A7CA 3Q03A 3CVMA 1SR5A 3UT3A 4AU3A 2H4PA 1ATUA 2HI9A 2XN3A 4ROBA 1OVAA 1D5SA 1XQGA 1LJ5A 3PZFA 2B4XI 2PEEA 3T1PA 1SNGA 3CWMA 2D26A 4AU3B 2ARRA 1XQJA 1IMVA 1XU8A 1OVAB 2RIVA 2VDXA 4R9IA 3KCGI 4EB1L 1YXAA 1IZ2A 1QLPA 1OC0A 2H4QA 1JTIA 1BR8I 3LE2A 3NDAA 4C49A 1DZHL 1OPHA 3F1SA 1ANTI 5EI0A 1DB2A 1C5GA 3CWLA 1AZXI 1E04I 2WXXA 4DY0A 5C98A 3STOA 1NQ9I 4AJTA 3B9FI 3NDDA 4RO9A 2WY0C 2ANTI 4KDSA 4GA7A 4P0FA 2ACHA 3ZHAA 1T1FA 2RIWA 3R4LA 2VDYA 4ROAA 4ZK3A 9APIA 1QMNA 2VH4A 1JMJA
chains in the Genus database with same CATH superfamily
5HGCA 1JVQI 1JMOA 3DRMA 4EB1I 2XN6A 1OYHL 4DY7C 1M93B 1TB6I 1DZHI 2QUGA 4RSQA 9PAIA 1JJOC 4PYWA 1AS4A 4AQHA 2WXWA 1SEKA 1ATTA 5BRRI 4IC0A 4P0OA 3CAAA 1LQ8A 1K9OI 2WXZC 7APIA 1HP7A 1B3KA 2HIJL 3F5NA 3F02A 2ZNHA 8APIA 1C8OA 4C41A 3EVJI 1F0CA 1DVMA 2DUTA 3DRUA 2GD4C 3LW2A 2R9YA 4ZK0A 5CDXA 3NE4A 1ATHA 1OYHI 3DY0A 1DZGL 1OVAC 1PSIA 2OL2A 1DVNA 1WZ9A 3H5CA 4Y3KA 2WXZA 4AU4A 5CDZA 4G8RA 5CE0A 4YIAA 1E03I 2XN5A 1R1LI 2WY1A 2ARQA 2XN7A 3DLWA 3NDFA 3VVJA 2BEHL 1OO8A 4CAAA 2PEFA 1LK6I 4AFXA 2HIJI 4IF8A 1QMBA 1UHGA 2B4XL 2WXYC 1EZXA 1MTPA 4AJUA 4DTEA 1E05I 1JRRA 5IO1A 2OAYA 1DZGI 3FGQA 2H4RA 1KCTA 3Q02A 1HLEA 4G8OA 4AU2A 3OZQA 4BB2A 2ZV6A 4X30A 5INWA 4Y40A 1BY7A 2V95A 2BEHI 3EOXA 3PB1I 2B5TI 2CEOA 1A7CA 3Q03A 3CVMA 1SR5A 3UT3A 4AU3A 2H4PA 1ATUA 2HI9A 2XN3A 4ROBA 1OVAA 1D5SA 1XQGA 1LJ5A 3PZFA 2B4XI 2PEEA 3T1PA 1SNGA 3CWMA 2D26A 4AU3B 2ARRA 1XQJA 1IMVA 1XU8A 1OVAB 2RIVA 2VDXA 4R9IA 3KCGI 4EB1L 1YXAA 1IZ2A 1QLPA 1OC0A 2H4QA 1JTIA 1BR8I 3LE2A 3NDAA 4C49A 1DZHL 1OPHA 3F1SA 1ANTI 5EI0A 1DB2A 1C5GA 3CWLA 1AZXI 1E04I 2WXXA 4DY0A 5C98A 3STOA 1NQ9I 4AJTA 3B9FI 3NDDA 4RO9A 2WY0C 2ANTI 4KDSA 4GA7A 4P0FA 2ACHA 3ZHAA 1T1FA 2RIWA 3R4LA 2VDYA 4ROAA 4ZK3A 9APIA 1QMNA 2VH4A 1JMJA
chains in the Genus database with same CATH topology
5HGCA 1JVQI 1JMOA 3DRMA 4EB1I 2XN6A 1OYHL 4DY7C 1M93B 1TB6I 1DZHI 2QUGA 4RSQA 9PAIA 1JJOC 4PYWA 1AS4A 4AQHA 2WXWA 1SEKA 1ATTA 5BRRI 4IC0A 4P0OA 3CAAA 1LQ8A 1K9OI 2WXZC 7APIA 1HP7A 1B3KA 2HIJL 3F5NA 3F02A 2ZNHA 8APIA 1C8OA 4C41A 3EVJI 1F0CA 1DVMA 2DUTA 3DRUA 2GD4C 3LW2A 2R9YA 4ZK0A 5CDXA 3NE4A 1ATHA 1OYHI 3DY0A 1DZGL 1OVAC 1PSIA 2OL2A 1DVNA 1WZ9A 3H5CA 4Y3KA 2WXZA 4AU4A 5CDZA 4G8RA 5CE0A 4YIAA 1E03I 2XN5A 1R1LI 2WY1A 2ARQA 2XN7A 3DLWA 3NDFA 3VVJA 2BEHL 1OO8A 4CAAA 2PEFA 1LK6I 4AFXA 2HIJI 4IF8A 1QMBA 1UHGA 2B4XL 2WXYC 1EZXA 1MTPA 4AJUA 4DTEA 1E05I 1JRRA 5IO1A 2OAYA 1DZGI 3FGQA 2H4RA 1KCTA 3Q02A 1HLEA 4G8OA 4AU2A 3OZQA 4BB2A 2ZV6A 4X30A 5INWA 4Y40A 1BY7A 2V95A 2BEHI 3EOXA 3PB1I 2B5TI 2CEOA 1A7CA 3Q03A 3CVMA 1SR5A 3UT3A 4AU3A 2H4PA 1ATUA 2HI9A 2XN3A 4ROBA 1OVAA 1D5SA 1XQGA 1LJ5A 3PZFA 2B4XI 2PEEA 3T1PA 1SNGA 3CWMA 2D26A 4AU3B 2ARRA 1XQJA 1IMVA 1XU8A 1OVAB 2RIVA 2VDXA 4R9IA 3KCGI 4EB1L 1YXAA 1IZ2A 1QLPA 1OC0A 2H4QA 1JTIA 1BR8I 3LE2A 3NDAA 4C49A 1DZHL 1OPHA 3F1SA 1ANTI 5EI0A 1DB2A 1C5GA 3CWLA 1AZXI 1E04I 2WXXA 4DY0A 5C98A 3STOA 1NQ9I 4AJTA 3B9FI 3NDDA 4RO9A 2WY0C 2ANTI 4KDSA 4GA7A 4P0FA 2ACHA 3ZHAA 1T1FA 2RIWA 3R4LA 2VDYA 4ROAA 4ZK3A 9APIA 1QMNA 2VH4A 1JMJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HGC A;  1JVQ I;  1JMO A;  3DRM A;  4EB1 I;  2XN6 A;  1OYH L;  4DY7 C;  1M93 B;  1TB6 I;  1DZH I;  2QUG A;  4RSQ A;  9PAI A;  1JJO C;  4PYW A;  1AS4 A;  4AQH A;  2WXW A;  1SEK A;  1ATT A;  5BRR I;  4IC0 A;  4P0O A;  3CAA A;  1LQ8 A;  1K9O I;  2WXZ C;  7API A;  1HP7 A;  1B3K A;  2HIJ L;  3F5N A;  3F02 A;  2ZNH A;  8API A;  1C8O A;  4C41 A;  3EVJ I;  1F0C A;  1DVM A;  2DUT A;  3DRU A;  2GD4 C;  3LW2 A;  2R9Y A;  4ZK0 A;  5CDX A;  3NE4 A;  1ATH A;  1OYH I;  3DY0 A;  1DZG L;  1OVA C;  1PSI A;  2OL2 A;  1DVN A;  1WZ9 A;  3H5C A;  4Y3K A;  2WXZ A;  4AU4 A;  5CDZ A;  4G8R A;  5CE0 A;  4YIA A;  1E03 I;  2XN5 A;  1R1L I;  2WY1 A;  2ARQ A;  2XN7 A;  3DLW A;  3NDF A;  3VVJ A;  2BEH L;  1OO8 A;  4CAA A;  2PEF A;  1LK6 I;  4AFX A;  2HIJ I;  4IF8 A;  1QMB A;  1UHG A;  2B4X L;  2WXY C;  1EZX A;  1MTP A;  4AJU A;  4DTE A;  1E05 I;  1JRR A;  5IO1 A;  2OAY A;  1DZG I;  3FGQ A;  2H4R A;  1KCT A;  3Q02 A;  1HLE A;  4G8O A;  4AU2 A;  3OZQ A;  4BB2 A;  2ZV6 A;  4X30 A;  5INW A;  4Y40 A;  1BY7 A;  2V95 A;  2BEH I;  3EOX A;  3PB1 I;  2B5T I;  2CEO A;  1A7C A;  3Q03 A;  3CVM A;  1SR5 A;  3UT3 A;  4AU3 A;  2H4P A;  1ATU A;  2HI9 A;  2XN3 A;  4ROB A;  1OVA A;  1D5S A;  1XQG A;  1LJ5 A;  3PZF A;  2B4X I;  2PEE A;  3T1P A;  1SNG A;  3CWM A;  2D26 A;  4AU3 B;  2ARR A;  1XQJ A;  1IMV A;  1XU8 A;  1OVA B;  2RIV A;  2VDX A;  4R9I A;  3KCG I;  4EB1 L;  1YXA A;  1IZ2 A;  1QLP A;  1OC0 A;  2H4Q A;  1JTI A;  1BR8 I;  3LE2 A;  3NDA A;  4C49 A;  1DZH L;  1OPH A;  3F1S A;  1ANT I;  5EI0 A;  1DB2 A;  1C5G A;  3CWL A;  1AZX I;  1E04 I;  2WXX A;  4DY0 A;  5C98 A;  3STO A;  1NQ9 I;  4AJT A;  3B9F I;  3NDD A;  4RO9 A;  2WY0 C;  2ANT I;  4KDS A;  4GA7 A;  4P0F A;  2ACH A;  3ZHA A;  1T1F A;  2RIW A;  3R4L A;  2VDY A;  4ROA A;  4ZK3 A;  9API A;  1QMN A;  2VH4 A;  1JMJ A; 
#chains in the Genus database with same CATH topology
 5HGC A;  1JVQ I;  1JMO A;  3DRM A;  4EB1 I;  2XN6 A;  1OYH L;  4DY7 C;  1M93 B;  1TB6 I;  1DZH I;  2QUG A;  4RSQ A;  9PAI A;  1JJO C;  4PYW A;  1AS4 A;  4AQH A;  2WXW A;  1SEK A;  1ATT A;  5BRR I;  4IC0 A;  4P0O A;  3CAA A;  1LQ8 A;  1K9O I;  2WXZ C;  7API A;  1HP7 A;  1B3K A;  2HIJ L;  3F5N A;  3F02 A;  2ZNH A;  8API A;  1C8O A;  4C41 A;  3EVJ I;  1F0C A;  1DVM A;  2DUT A;  3DRU A;  2GD4 C;  3LW2 A;  2R9Y A;  4ZK0 A;  5CDX A;  3NE4 A;  1ATH A;  1OYH I;  3DY0 A;  1DZG L;  1OVA C;  1PSI A;  2OL2 A;  1DVN A;  1WZ9 A;  3H5C A;  4Y3K A;  2WXZ A;  4AU4 A;  5CDZ A;  4G8R A;  5CE0 A;  4YIA A;  1E03 I;  2XN5 A;  1R1L I;  2WY1 A;  2ARQ A;  2XN7 A;  3DLW A;  3NDF A;  3VVJ A;  2BEH L;  1OO8 A;  4CAA A;  2PEF A;  1LK6 I;  4AFX A;  2HIJ I;  4IF8 A;  1QMB A;  1UHG A;  2B4X L;  2WXY C;  1EZX A;  1MTP A;  4AJU A;  4DTE A;  1E05 I;  1JRR A;  5IO1 A;  2OAY A;  1DZG I;  3FGQ A;  2H4R A;  1KCT A;  3Q02 A;  1HLE A;  4G8O A;  4AU2 A;  3OZQ A;  4BB2 A;  2ZV6 A;  4X30 A;  5INW A;  4Y40 A;  1BY7 A;  2V95 A;  2BEH I;  3EOX A;  3PB1 I;  2B5T I;  2CEO A;  1A7C A;  3Q03 A;  3CVM A;  1SR5 A;  3UT3 A;  4AU3 A;  2H4P A;  1ATU A;  2HI9 A;  2XN3 A;  4ROB A;  1OVA A;  1D5S A;  1XQG A;  1LJ5 A;  3PZF A;  2B4X I;  2PEE A;  3T1P A;  1SNG A;  3CWM A;  2D26 A;  4AU3 B;  2ARR A;  1XQJ A;  1IMV A;  1XU8 A;  1OVA B;  2RIV A;  2VDX A;  4R9I A;  3KCG I;  4EB1 L;  1YXA A;  1IZ2 A;  1QLP A;  1OC0 A;  2H4Q A;  1JTI A;  1BR8 I;  3LE2 A;  3NDA A;  4C49 A;  1DZH L;  1OPH A;  3F1S A;  1ANT I;  5EI0 A;  1DB2 A;  1C5G A;  3CWL A;  1AZX I;  1E04 I;  2WXX A;  4DY0 A;  5C98 A;  3STO A;  1NQ9 I;  4AJT A;  3B9F I;  3NDD A;  4RO9 A;  2WY0 C;  2ANT I;  4KDS A;  4GA7 A;  4P0F A;  2ACH A;  3ZHA A;  1T1F A;  2RIW A;  3R4L A;  2VDY A;  4ROA A;  4ZK3 A;  9API A;  1QMN A;  2VH4 A;  1JMJ A; 
#chains in the Genus database with same CATH homology
 5HGC A;  1JVQ I;  1JMO A;  3DRM A;  4EB1 I;  2XN6 A;  1OYH L;  4DY7 C;  1M93 B;  1TB6 I;  1DZH I;  2QUG A;  4RSQ A;  9PAI A;  1JJO C;  4PYW A;  1AS4 A;  4AQH A;  2WXW A;  1SEK A;  1ATT A;  5BRR I;  4IC0 A;  4P0O A;  3CAA A;  1LQ8 A;  1K9O I;  2WXZ C;  7API A;  1HP7 A;  1B3K A;  2HIJ L;  3F5N A;  3F02 A;  2ZNH A;  8API A;  1C8O A;  4C41 A;  3EVJ I;  1F0C A;  1DVM A;  2DUT A;  3DRU A;  2GD4 C;  3LW2 A;  2R9Y A;  4ZK0 A;  5CDX A;  3NE4 A;  1ATH A;  1OYH I;  3DY0 A;  1DZG L;  1OVA C;  1PSI A;  2OL2 A;  1DVN A;  1WZ9 A;  3H5C A;  4Y3K A;  2WXZ A;  4AU4 A;  5CDZ A;  4G8R A;  5CE0 A;  4YIA A;  1E03 I;  2XN5 A;  1R1L I;  2WY1 A;  2ARQ A;  2XN7 A;  3DLW A;  3NDF A;  3VVJ A;  2BEH L;  1OO8 A;  4CAA A;  2PEF A;  1LK6 I;  4AFX A;  2HIJ I;  4IF8 A;  1QMB A;  1UHG A;  2B4X L;  2WXY C;  1EZX A;  1MTP A;  4AJU A;  4DTE A;  1E05 I;  1JRR A;  5IO1 A;  2OAY A;  1DZG I;  3FGQ A;  2H4R A;  1KCT A;  3Q02 A;  1HLE A;  4G8O A;  4AU2 A;  3OZQ A;  4BB2 A;  2ZV6 A;  4X30 A;  5INW A;  4Y40 A;  1BY7 A;  2V95 A;  2BEH I;  3EOX A;  3PB1 I;  2B5T I;  2CEO A;  1A7C A;  3Q03 A;  3CVM A;  1SR5 A;  3UT3 A;  4AU3 A;  2H4P A;  1ATU A;  2HI9 A;  2XN3 A;  4ROB A;  1OVA A;  1D5S A;  1XQG A;  1LJ5 A;  3PZF A;  2B4X I;  2PEE A;  3T1P A;  1SNG A;  3CWM A;  2D26 A;  4AU3 B;  2ARR A;  1XQJ A;  1IMV A;  1XU8 A;  1OVA B;  2RIV A;  2VDX A;  4R9I A;  3KCG I;  4EB1 L;  1YXA A;  1IZ2 A;  1QLP A;  1OC0 A;  2H4Q A;  1JTI A;  1BR8 I;  3LE2 A;  3NDA A;  4C49 A;  1DZH L;  1OPH A;  3F1S A;  1ANT I;  5EI0 A;  1DB2 A;  1C5G A;  3CWL A;  1AZX I;  1E04 I;  2WXX A;  4DY0 A;  5C98 A;  3STO A;  1NQ9 I;  4AJT A;  3B9F I;  3NDD A;  4RO9 A;  2WY0 C;  2ANT I;  4KDS A;  4GA7 A;  4P0F A;  2ACH A;  3ZHA A;  1T1F A;  2RIW A;  3R4L A;  2VDY A;  4ROA A;  4ZK3 A;  9API A;  1QMN A;  2VH4 A;  1JMJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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