7APIA

The s variant of human alpha1-antitrypsin, structure and implications for function and metabolism
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
339
structure length
339
Chain Sequence
HPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Proteinase inhibitor
molecule keywords ALPHA 1-ANTITRYPSIN
publication title The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
pubmed doi rcsb
source organism Homo sapiens
total genus 89
structure length 339
sequence length 339
ec nomenclature
pdb deposition date 1988-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 7apiA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 7apiA02
1E04I 4AU2A 4RO9A 9APIA 1MTPA 2WXXA 4C49A 1BY7A 4EB1L 2RIVA 1SNGA 3CVMA 3ZHAA 1QLPA 4AJUA 3R4LA 2D26A 4ZK0A 2XN7A 4ZK3A 4GA7A 1QMBA 1PSIA 1ATHA 4EB1I 3PB1I 4DY7C 1DVNA 4DY0A 1LQ8A 5BRRI 2V95A 4DTEA 4C41A 4PYWA 1JRRA 3FGQA 4G8RA 2GD4C 3NDDA 4ROAA 2VDXA 3T1PA 1LJ5A 5HGCA 4BB2A 1ATUA 1HP7A 3CWLA 3LE2A 1IMVA 4AU4A 1T1FA 5CE0A 1JTIA 3CWMA 5IO1A 3B9FI 2R9YA 3DRUA 1OVAC 2WXZA 1UHGA 1JJOC 1BR8I 1D5SA 2HIJL 3OZQA 1OPHA 3VVJA 1JMOA 1NQ9I 1AS4A 2VH4A 5C98A 1E05I 3STOA 1M93B 3DRMA 2B5TI 3DY0A 3KCGI 4G8OA 2DUTA 2ZV6A 3EVJI 2ARQA 1OVAB 1C5GA 4X30A 2ACHA 1B3KA 1XU8A 2ANTI 2OL2A 4Y3KA 5CDZA 4AU3B 1WZ9A 8APIA 4Y40A 1DZGL 1AZXI 1XQJA 1K9OI 2BEHL 3LW2A 2RIWA 1A7CA 2B4XL 2XN3A 1E03I 4KDSA 2CEOA 1C8OA 3F5NA 3UT3A 2OAYA 3F02A 1F0CA 4R9IA 4P0OA 1ANTI 3NDFA 1IZ2A 1JMJA 4P0FA 3DLWA 2B4XI 3H5CA 4ROBA 2ARRA 1YXAA 9PAIA 1KCTA 3F1SA 1DVMA 2H4PA 2HIJI 2PEEA 2WY0C 2WXWA 4CAAA 2HI9A 2WXYC 1LK6I 1OC0A 1XQGA 1OYHL 4RSQA 1DB2A 1QMNA 2XN5A 1JVQI 2VDYA 3EOXA 1DZHL 1TB6I 4IF8A 1OO8A 1SEKA 2H4RA 1EZXA 1HLEA 3NE4A 4IC0A 1OVAA 2WXZC 2WY1A 1OYHI 4AJTA 3Q02A 2QUGA 1DZGI 4AFXA 1DZHI 4AQHA 4AU3A 2H4QA 2BEHI 2XN6A 1SR5A 3CAAA 1R1LI 2ZNHA 4YIAA 3PZFA 5EI0A 5CDXA 7APIA 1ATTA 3Q03A 3NDAA 5INWA 2PEFA
chains in the Genus database with same CATH superfamily
1E04I 4AU2A 4RO9A 9APIA 1MTPA 2WXXA 4C49A 1BY7A 4EB1L 2RIVA 1SNGA 3CVMA 3ZHAA 1QLPA 4AJUA 3R4LA 2D26A 4ZK0A 2XN7A 4ZK3A 4GA7A 1QMBA 1PSIA 1ATHA 4EB1I 3PB1I 4DY7C 1DVNA 4DY0A 1LQ8A 5BRRI 2V95A 4DTEA 4C41A 4PYWA 1JRRA 3FGQA 4G8RA 2GD4C 3NDDA 4ROAA 2VDXA 3T1PA 1LJ5A 5HGCA 4BB2A 1ATUA 1HP7A 3CWLA 3LE2A 1IMVA 4AU4A 1T1FA 5CE0A 1JTIA 3CWMA 5IO1A 3B9FI 2R9YA 3DRUA 1OVAC 2WXZA 1UHGA 1JJOC 1BR8I 1D5SA 2HIJL 3OZQA 1OPHA 3VVJA 1JMOA 1NQ9I 1AS4A 2VH4A 5C98A 1E05I 3STOA 1M93B 3DRMA 2B5TI 3DY0A 3KCGI 4G8OA 2DUTA 2ZV6A 3EVJI 2ARQA 1OVAB 1C5GA 4X30A 2ACHA 1B3KA 1XU8A 2ANTI 2OL2A 4Y3KA 5CDZA 4AU3B 1WZ9A 8APIA 4Y40A 1DZGL 1AZXI 1XQJA 1K9OI 2BEHL 3LW2A 2RIWA 1A7CA 2B4XL 2XN3A 1E03I 4KDSA 2CEOA 1C8OA 3F5NA 3UT3A 2OAYA 3F02A 1F0CA 4R9IA 4P0OA 1ANTI 3NDFA 1IZ2A 1JMJA 4P0FA 3DLWA 2B4XI 3H5CA 4ROBA 2ARRA 1YXAA 9PAIA 1KCTA 3F1SA 1DVMA 2H4PA 2HIJI 2PEEA 2WY0C 2WXWA 4CAAA 2HI9A 2WXYC 1LK6I 1OC0A 1XQGA 1OYHL 4RSQA 1DB2A 1QMNA 2XN5A 1JVQI 2VDYA 3EOXA 1DZHL 1TB6I 4IF8A 1OO8A 1SEKA 2H4RA 1EZXA 1HLEA 3NE4A 4IC0A 1OVAA 2WXZC 2WY1A 1OYHI 4AJTA 3Q02A 2QUGA 1DZGI 4AFXA 1DZHI 4AQHA 4AU3A 2H4QA 2BEHI 2XN6A 1SR5A 3CAAA 1R1LI 2ZNHA 4YIAA 3PZFA 5EI0A 5CDXA 7APIA 1ATTA 3Q03A 3NDAA 5INWA 2PEFA
chains in the Genus database with same CATH topology
1E04I 4AU2A 4RO9A 9APIA 1MTPA 2WXXA 4C49A 1BY7A 4EB1L 2RIVA 1SNGA 3CVMA 3ZHAA 1QLPA 4AJUA 3R4LA 2D26A 4ZK0A 2XN7A 4ZK3A 4GA7A 1QMBA 1PSIA 1ATHA 4EB1I 3PB1I 4DY7C 1DVNA 4DY0A 1LQ8A 5BRRI 2V95A 4DTEA 4C41A 4PYWA 1JRRA 3FGQA 4G8RA 2GD4C 3NDDA 4ROAA 2VDXA 3T1PA 1LJ5A 5HGCA 4BB2A 1ATUA 1HP7A 3CWLA 3LE2A 1IMVA 4AU4A 1T1FA 5CE0A 1JTIA 3CWMA 5IO1A 3B9FI 2R9YA 3DRUA 1OVAC 2WXZA 1UHGA 1JJOC 1BR8I 1D5SA 2HIJL 3OZQA 1OPHA 3VVJA 1JMOA 1NQ9I 1AS4A 2VH4A 5C98A 1E05I 3STOA 1M93B 3DRMA 2B5TI 3DY0A 3KCGI 4G8OA 2DUTA 2ZV6A 3EVJI 2ARQA 1OVAB 1C5GA 4X30A 2ACHA 1B3KA 1XU8A 2ANTI 2OL2A 4Y3KA 5CDZA 4AU3B 1WZ9A 8APIA 4Y40A 1DZGL 1AZXI 1XQJA 1K9OI 2BEHL 3LW2A 2RIWA 1A7CA 2B4XL 2XN3A 1E03I 4KDSA 2CEOA 1C8OA 3F5NA 3UT3A 2OAYA 3F02A 1F0CA 4R9IA 4P0OA 1ANTI 3NDFA 1IZ2A 1JMJA 4P0FA 3DLWA 2B4XI 3H5CA 4ROBA 2ARRA 1YXAA 9PAIA 1KCTA 3F1SA 1DVMA 2H4PA 2HIJI 2PEEA 2WY0C 2WXWA 4CAAA 2HI9A 2WXYC 1LK6I 1OC0A 1XQGA 1OYHL 4RSQA 1DB2A 1QMNA 2XN5A 1JVQI 2VDYA 3EOXA 1DZHL 1TB6I 4IF8A 1OO8A 1SEKA 2H4RA 1EZXA 1HLEA 3NE4A 4IC0A 1OVAA 2WXZC 2WY1A 1OYHI 4AJTA 3Q02A 2QUGA 1DZGI 4AFXA 1DZHI 4AQHA 4AU3A 2H4QA 2BEHI 2XN6A 1SR5A 3CAAA 1R1LI 2ZNHA 4YIAA 3PZFA 5EI0A 5CDXA 7APIA 1ATTA 3Q03A 3NDAA 5INWA 2PEFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1E04 I;  4AU2 A;  4RO9 A;  9API A;  1MTP A;  2WXX A;  4C49 A;  1BY7 A;  4EB1 L;  2RIV A;  1SNG A;  3CVM A;  3ZHA A;  1QLP A;  4AJU A;  3R4L A;  2D26 A;  4ZK0 A;  2XN7 A;  4ZK3 A;  4GA7 A;  1QMB A;  1PSI A;  1ATH A;  4EB1 I;  3PB1 I;  4DY7 C;  1DVN A;  4DY0 A;  1LQ8 A;  5BRR I;  2V95 A;  4DTE A;  4C41 A;  4PYW A;  1JRR A;  3FGQ A;  4G8R A;  2GD4 C;  3NDD A;  4ROA A;  2VDX A;  3T1P A;  1LJ5 A;  5HGC A;  4BB2 A;  1ATU A;  1HP7 A;  3CWL A;  3LE2 A;  1IMV A;  4AU4 A;  1T1F A;  5CE0 A;  1JTI A;  3CWM A;  5IO1 A;  3B9F I;  2R9Y A;  3DRU A;  1OVA C;  2WXZ A;  1UHG A;  1JJO C;  1BR8 I;  1D5S A;  2HIJ L;  3OZQ A;  1OPH A;  3VVJ A;  1JMO A;  1NQ9 I;  1AS4 A;  2VH4 A;  5C98 A;  1E05 I;  3STO A;  1M93 B;  3DRM A;  2B5T I;  3DY0 A;  3KCG I;  4G8O A;  2DUT A;  2ZV6 A;  3EVJ I;  2ARQ A;  1OVA B;  1C5G A;  4X30 A;  2ACH A;  1B3K A;  1XU8 A;  2ANT I;  2OL2 A;  4Y3K A;  5CDZ A;  4AU3 B;  1WZ9 A;  8API A;  4Y40 A;  1DZG L;  1AZX I;  1XQJ A;  1K9O I;  2BEH L;  3LW2 A;  2RIW A;  1A7C A;  2B4X L;  2XN3 A;  1E03 I;  4KDS A;  2CEO A;  1C8O A;  3F5N A;  3UT3 A;  2OAY A;  3F02 A;  1F0C A;  4R9I A;  4P0O A;  1ANT I;  3NDF A;  1IZ2 A;  1JMJ A;  4P0F A;  3DLW A;  2B4X I;  3H5C A;  4ROB A;  2ARR A;  1YXA A;  9PAI A;  1KCT A;  3F1S A;  1DVM A;  2H4P A;  2HIJ I;  2PEE A;  2WY0 C;  2WXW A;  4CAA A;  2HI9 A;  2WXY C;  1LK6 I;  1OC0 A;  1XQG A;  1OYH L;  4RSQ A;  1DB2 A;  1QMN A;  2XN5 A;  1JVQ I;  2VDY A;  3EOX A;  1DZH L;  1TB6 I;  4IF8 A;  1OO8 A;  1SEK A;  2H4R A;  1EZX A;  1HLE A;  3NE4 A;  4IC0 A;  1OVA A;  2WXZ C;  2WY1 A;  1OYH I;  4AJT A;  3Q02 A;  2QUG A;  1DZG I;  4AFX A;  1DZH I;  4AQH A;  4AU3 A;  2H4Q A;  2BEH I;  2XN6 A;  1SR5 A;  3CAA A;  1R1L I;  2ZNH A;  4YIA A;  3PZF A;  5EI0 A;  5CDX A;  7API A;  1ATT A;  3Q03 A;  3NDA A;  5INW A;  2PEF A; 
#chains in the Genus database with same CATH topology
 1E04 I;  4AU2 A;  4RO9 A;  9API A;  1MTP A;  2WXX A;  4C49 A;  1BY7 A;  4EB1 L;  2RIV A;  1SNG A;  3CVM A;  3ZHA A;  1QLP A;  4AJU A;  3R4L A;  2D26 A;  4ZK0 A;  2XN7 A;  4ZK3 A;  4GA7 A;  1QMB A;  1PSI A;  1ATH A;  4EB1 I;  3PB1 I;  4DY7 C;  1DVN A;  4DY0 A;  1LQ8 A;  5BRR I;  2V95 A;  4DTE A;  4C41 A;  4PYW A;  1JRR A;  3FGQ A;  4G8R A;  2GD4 C;  3NDD A;  4ROA A;  2VDX A;  3T1P A;  1LJ5 A;  5HGC A;  4BB2 A;  1ATU A;  1HP7 A;  3CWL A;  3LE2 A;  1IMV A;  4AU4 A;  1T1F A;  5CE0 A;  1JTI A;  3CWM A;  5IO1 A;  3B9F I;  2R9Y A;  3DRU A;  1OVA C;  2WXZ A;  1UHG A;  1JJO C;  1BR8 I;  1D5S A;  2HIJ L;  3OZQ A;  1OPH A;  3VVJ A;  1JMO A;  1NQ9 I;  1AS4 A;  2VH4 A;  5C98 A;  1E05 I;  3STO A;  1M93 B;  3DRM A;  2B5T I;  3DY0 A;  3KCG I;  4G8O A;  2DUT A;  2ZV6 A;  3EVJ I;  2ARQ A;  1OVA B;  1C5G A;  4X30 A;  2ACH A;  1B3K A;  1XU8 A;  2ANT I;  2OL2 A;  4Y3K A;  5CDZ A;  4AU3 B;  1WZ9 A;  8API A;  4Y40 A;  1DZG L;  1AZX I;  1XQJ A;  1K9O I;  2BEH L;  3LW2 A;  2RIW A;  1A7C A;  2B4X L;  2XN3 A;  1E03 I;  4KDS A;  2CEO A;  1C8O A;  3F5N A;  3UT3 A;  2OAY A;  3F02 A;  1F0C A;  4R9I A;  4P0O A;  1ANT I;  3NDF A;  1IZ2 A;  1JMJ A;  4P0F A;  3DLW A;  2B4X I;  3H5C A;  4ROB A;  2ARR A;  1YXA A;  9PAI A;  1KCT A;  3F1S A;  1DVM A;  2H4P A;  2HIJ I;  2PEE A;  2WY0 C;  2WXW A;  4CAA A;  2HI9 A;  2WXY C;  1LK6 I;  1OC0 A;  1XQG A;  1OYH L;  4RSQ A;  1DB2 A;  1QMN A;  2XN5 A;  1JVQ I;  2VDY A;  3EOX A;  1DZH L;  1TB6 I;  4IF8 A;  1OO8 A;  1SEK A;  2H4R A;  1EZX A;  1HLE A;  3NE4 A;  4IC0 A;  1OVA A;  2WXZ C;  2WY1 A;  1OYH I;  4AJT A;  3Q02 A;  2QUG A;  1DZG I;  4AFX A;  1DZH I;  4AQH A;  4AU3 A;  2H4Q A;  2BEH I;  2XN6 A;  1SR5 A;  3CAA A;  1R1L I;  2ZNH A;  4YIA A;  3PZF A;  5EI0 A;  5CDX A;  7API A;  1ATT A;  3Q03 A;  3NDA A;  5INW A;  2PEF A; 
#chains in the Genus database with same CATH homology
 1E04 I;  4AU2 A;  4RO9 A;  9API A;  1MTP A;  2WXX A;  4C49 A;  1BY7 A;  4EB1 L;  2RIV A;  1SNG A;  3CVM A;  3ZHA A;  1QLP A;  4AJU A;  3R4L A;  2D26 A;  4ZK0 A;  2XN7 A;  4ZK3 A;  4GA7 A;  1QMB A;  1PSI A;  1ATH A;  4EB1 I;  3PB1 I;  4DY7 C;  1DVN A;  4DY0 A;  1LQ8 A;  5BRR I;  2V95 A;  4DTE A;  4C41 A;  4PYW A;  1JRR A;  3FGQ A;  4G8R A;  2GD4 C;  3NDD A;  4ROA A;  2VDX A;  3T1P A;  1LJ5 A;  5HGC A;  4BB2 A;  1ATU A;  1HP7 A;  3CWL A;  3LE2 A;  1IMV A;  4AU4 A;  1T1F A;  5CE0 A;  1JTI A;  3CWM A;  5IO1 A;  3B9F I;  2R9Y A;  3DRU A;  1OVA C;  2WXZ A;  1UHG A;  1JJO C;  1BR8 I;  1D5S A;  2HIJ L;  3OZQ A;  1OPH A;  3VVJ A;  1JMO A;  1NQ9 I;  1AS4 A;  2VH4 A;  5C98 A;  1E05 I;  3STO A;  1M93 B;  3DRM A;  2B5T I;  3DY0 A;  3KCG I;  4G8O A;  2DUT A;  2ZV6 A;  3EVJ I;  2ARQ A;  1OVA B;  1C5G A;  4X30 A;  2ACH A;  1B3K A;  1XU8 A;  2ANT I;  2OL2 A;  4Y3K A;  5CDZ A;  4AU3 B;  1WZ9 A;  8API A;  4Y40 A;  1DZG L;  1AZX I;  1XQJ A;  1K9O I;  2BEH L;  3LW2 A;  2RIW A;  1A7C A;  2B4X L;  2XN3 A;  1E03 I;  4KDS A;  2CEO A;  1C8O A;  3F5N A;  3UT3 A;  2OAY A;  3F02 A;  1F0C A;  4R9I A;  4P0O A;  1ANT I;  3NDF A;  1IZ2 A;  1JMJ A;  4P0F A;  3DLW A;  2B4X I;  3H5C A;  4ROB A;  2ARR A;  1YXA A;  9PAI A;  1KCT A;  3F1S A;  1DVM A;  2H4P A;  2HIJ I;  2PEE A;  2WY0 C;  2WXW A;  4CAA A;  2HI9 A;  2WXY C;  1LK6 I;  1OC0 A;  1XQG A;  1OYH L;  4RSQ A;  1DB2 A;  1QMN A;  2XN5 A;  1JVQ I;  2VDY A;  3EOX A;  1DZH L;  1TB6 I;  4IF8 A;  1OO8 A;  1SEK A;  2H4R A;  1EZX A;  1HLE A;  3NE4 A;  4IC0 A;  1OVA A;  2WXZ C;  2WY1 A;  1OYH I;  4AJT A;  3Q02 A;  2QUG A;  1DZG I;  4AFX A;  1DZH I;  4AQH A;  4AU3 A;  2H4Q A;  2BEH I;  2XN6 A;  1SR5 A;  3CAA A;  1R1L I;  2ZNH A;  4YIA A;  3PZF A;  5EI0 A;  5CDX A;  7API A;  1ATT A;  3Q03 A;  3NDA A;  5INW A;  2PEF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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