8APIA

The s variant of human alpha1-antitrypsin, structure and implications for function and metabolism
Total Genus 95
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
340
structure length
340
Chain Sequence
DHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Proteinase inhibitor
molecule keywords ALPHA-1 ANTITRYPSIN (CHAIN A)
publication title The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
pubmed doi rcsb
total genus 95
structure length 340
sequence length 340
ec nomenclature
pdb deposition date 1988-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 8apiA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 8apiA02
2B5TI 1B3KA 4PYWA 1DVMA 4DY7C 2ANTI 1F0CA 1QLPA 2OL2A 3DY0A 1DZHI 3OZQA 1DB2A 1C8OA 4R9IA 2CEOA 2ZV6A 3Q03A 4ZK0A 2WXYC 4AU3B 1WZ9A 1JJOC 2ACHA 4C49A 1A7CA 1K9OI 1D5SA 2HIJI 2OAYA 2WY1A 4CAAA 5EI0A 1ATUA 2B4XL 3LE2A 9PAIA 3CAAA 1QMNA 1YXAA 4AFXA 1MTPA 4Y40A 2V95A 3F1SA 1LK6I 1DZGI 2XN3A 1R1LI 4GA7A 4P0FA 4ROBA 4AU4A 2WXZC 1XU8A 2RIWA 3Q02A 4G8RA 2HI9A 2XN7A 3H5CA 1AZXI 1HLEA 1OPHA 2D26A 5BRRI 3NDAA 2WXXA 3FGQA 1JMOA 4EB1L 1JMJA 1SNGA 3LW2A 4RSQA 9APIA 4IF8A 2QUGA 4AU2A 5C98A 1QMBA 1JRRA 1UHGA 3VVJA 1IMVA 3NDDA 1OVAB 3EVJI 2ARQA 5INWA 2WXZA 4ROAA 1JTIA 1ATHA 3UT3A 2WXWA 2XN6A 4ZK3A 5CDXA 1LJ5A 5HGCA 1E05I 3STOA 3B9FI 4AJTA 4BB2A 4IC0A 1KCTA 3DRMA 5CDZA 1DZHL 3T1PA 2BEHL 1SEKA 1DVNA 3NE4A 1M93B 1NQ9I 4RO9A 2VH4A 1OC0A 2H4QA 3CVMA 2RIVA 2VDXA 1LQ8A 2HIJL 1JVQI 3ZHAA 1E03I 1OYHL 2DUTA 1OVAC 4YIAA 3NDFA 4DTEA 5IO1A 2WY0C 3DRUA 1E04I 4G8OA 2VDYA 2B4XI 1DZGL 7APIA 4P0OA 5CE0A 1ATTA 3DLWA 2ZNHA 3F02A 1SR5A 1BR8I 4C41A 2PEEA 4AU3A 2BEHI 3CWMA 2R9YA 3PZFA 2H4PA 4AJUA 1OVAA 4EB1I 1OO8A 1AS4A 3EOXA 1ANTI 3KCGI 1IZ2A 4AQHA 1EZXA 3F5NA 1PSIA 3R4LA 1BY7A 2XN5A 1OYHI 2ARRA 1HP7A 4X30A 1TB6I 1T1FA 4Y3KA 1XQJA 3CWLA 1C5GA 2GD4C 2H4RA 4KDSA 1XQGA 8APIA 2PEFA 4DY0A 3PB1I
chains in the Genus database with same CATH superfamily
2B5TI 1B3KA 4PYWA 1DVMA 4DY7C 2ANTI 1F0CA 1QLPA 2OL2A 3DY0A 1DZHI 3OZQA 1DB2A 1C8OA 4R9IA 2CEOA 2ZV6A 3Q03A 4ZK0A 2WXYC 4AU3B 1WZ9A 1JJOC 2ACHA 4C49A 1A7CA 1K9OI 1D5SA 2HIJI 2OAYA 2WY1A 4CAAA 5EI0A 1ATUA 2B4XL 3LE2A 9PAIA 3CAAA 1QMNA 1YXAA 4AFXA 1MTPA 4Y40A 2V95A 3F1SA 1LK6I 1DZGI 2XN3A 1R1LI 4GA7A 4P0FA 4ROBA 4AU4A 2WXZC 1XU8A 2RIWA 3Q02A 4G8RA 2HI9A 2XN7A 3H5CA 1AZXI 1HLEA 1OPHA 2D26A 5BRRI 3NDAA 2WXXA 3FGQA 1JMOA 4EB1L 1JMJA 1SNGA 3LW2A 4RSQA 9APIA 4IF8A 2QUGA 4AU2A 5C98A 1QMBA 1JRRA 1UHGA 3VVJA 1IMVA 3NDDA 1OVAB 3EVJI 2ARQA 5INWA 2WXZA 4ROAA 1JTIA 1ATHA 3UT3A 2WXWA 2XN6A 4ZK3A 5CDXA 1LJ5A 5HGCA 1E05I 3STOA 3B9FI 4AJTA 4BB2A 4IC0A 1KCTA 3DRMA 5CDZA 1DZHL 3T1PA 2BEHL 1SEKA 1DVNA 3NE4A 1M93B 1NQ9I 4RO9A 2VH4A 1OC0A 2H4QA 3CVMA 2RIVA 2VDXA 1LQ8A 2HIJL 1JVQI 3ZHAA 1E03I 1OYHL 2DUTA 1OVAC 4YIAA 3NDFA 4DTEA 5IO1A 2WY0C 3DRUA 1E04I 4G8OA 2VDYA 2B4XI 1DZGL 7APIA 4P0OA 5CE0A 1ATTA 3DLWA 2ZNHA 3F02A 1SR5A 1BR8I 4C41A 2PEEA 4AU3A 2BEHI 3CWMA 2R9YA 3PZFA 2H4PA 4AJUA 1OVAA 4EB1I 1OO8A 1AS4A 3EOXA 1ANTI 3KCGI 1IZ2A 4AQHA 1EZXA 3F5NA 1PSIA 3R4LA 1BY7A 2XN5A 1OYHI 2ARRA 1HP7A 4X30A 1TB6I 1T1FA 4Y3KA 1XQJA 3CWLA 1C5GA 2GD4C 2H4RA 4KDSA 1XQGA 8APIA 2PEFA 4DY0A 3PB1I
chains in the Genus database with same CATH topology
2B5TI 1B3KA 4PYWA 1DVMA 4DY7C 2ANTI 1F0CA 1QLPA 2OL2A 3DY0A 1DZHI 3OZQA 1DB2A 1C8OA 4R9IA 2CEOA 2ZV6A 3Q03A 4ZK0A 2WXYC 4AU3B 1WZ9A 1JJOC 2ACHA 4C49A 1A7CA 1K9OI 1D5SA 2HIJI 2OAYA 2WY1A 4CAAA 5EI0A 1ATUA 2B4XL 3LE2A 9PAIA 3CAAA 1QMNA 1YXAA 4AFXA 1MTPA 4Y40A 2V95A 3F1SA 1LK6I 1DZGI 2XN3A 1R1LI 4GA7A 4P0FA 4ROBA 4AU4A 2WXZC 1XU8A 2RIWA 3Q02A 4G8RA 2HI9A 2XN7A 3H5CA 1AZXI 1HLEA 1OPHA 2D26A 5BRRI 3NDAA 2WXXA 3FGQA 1JMOA 4EB1L 1JMJA 1SNGA 3LW2A 4RSQA 9APIA 4IF8A 2QUGA 4AU2A 5C98A 1QMBA 1JRRA 1UHGA 3VVJA 1IMVA 3NDDA 1OVAB 3EVJI 2ARQA 5INWA 2WXZA 4ROAA 1JTIA 1ATHA 3UT3A 2WXWA 2XN6A 4ZK3A 5CDXA 1LJ5A 5HGCA 1E05I 3STOA 3B9FI 4AJTA 4BB2A 4IC0A 1KCTA 3DRMA 5CDZA 1DZHL 3T1PA 2BEHL 1SEKA 1DVNA 3NE4A 1M93B 1NQ9I 4RO9A 2VH4A 1OC0A 2H4QA 3CVMA 2RIVA 2VDXA 1LQ8A 2HIJL 1JVQI 3ZHAA 1E03I 1OYHL 2DUTA 1OVAC 4YIAA 3NDFA 4DTEA 5IO1A 2WY0C 3DRUA 1E04I 4G8OA 2VDYA 2B4XI 1DZGL 7APIA 4P0OA 5CE0A 1ATTA 3DLWA 2ZNHA 3F02A 1SR5A 1BR8I 4C41A 2PEEA 4AU3A 2BEHI 3CWMA 2R9YA 3PZFA 2H4PA 4AJUA 1OVAA 4EB1I 1OO8A 1AS4A 3EOXA 1ANTI 3KCGI 1IZ2A 4AQHA 1EZXA 3F5NA 1PSIA 3R4LA 1BY7A 2XN5A 1OYHI 2ARRA 1HP7A 4X30A 1TB6I 1T1FA 4Y3KA 1XQJA 3CWLA 1C5GA 2GD4C 2H4RA 4KDSA 1XQGA 8APIA 2PEFA 4DY0A 3PB1I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B5T I;  1B3K A;  4PYW A;  1DVM A;  4DY7 C;  2ANT I;  1F0C A;  1QLP A;  2OL2 A;  3DY0 A;  1DZH I;  3OZQ A;  1DB2 A;  1C8O A;  4R9I A;  2CEO A;  2ZV6 A;  3Q03 A;  4ZK0 A;  2WXY C;  4AU3 B;  1WZ9 A;  1JJO C;  2ACH A;  4C49 A;  1A7C A;  1K9O I;  1D5S A;  2HIJ I;  2OAY A;  2WY1 A;  4CAA A;  5EI0 A;  1ATU A;  2B4X L;  3LE2 A;  9PAI A;  3CAA A;  1QMN A;  1YXA A;  4AFX A;  1MTP A;  4Y40 A;  2V95 A;  3F1S A;  1LK6 I;  1DZG I;  2XN3 A;  1R1L I;  4GA7 A;  4P0F A;  4ROB A;  4AU4 A;  2WXZ C;  1XU8 A;  2RIW A;  3Q02 A;  4G8R A;  2HI9 A;  2XN7 A;  3H5C A;  1AZX I;  1HLE A;  1OPH A;  2D26 A;  5BRR I;  3NDA A;  2WXX A;  3FGQ A;  1JMO A;  4EB1 L;  1JMJ A;  1SNG A;  3LW2 A;  4RSQ A;  9API A;  4IF8 A;  2QUG A;  4AU2 A;  5C98 A;  1QMB A;  1JRR A;  1UHG A;  3VVJ A;  1IMV A;  3NDD A;  1OVA B;  3EVJ I;  2ARQ A;  5INW A;  2WXZ A;  4ROA A;  1JTI A;  1ATH A;  3UT3 A;  2WXW A;  2XN6 A;  4ZK3 A;  5CDX A;  1LJ5 A;  5HGC A;  1E05 I;  3STO A;  3B9F I;  4AJT A;  4BB2 A;  4IC0 A;  1KCT A;  3DRM A;  5CDZ A;  1DZH L;  3T1P A;  2BEH L;  1SEK A;  1DVN A;  3NE4 A;  1M93 B;  1NQ9 I;  4RO9 A;  2VH4 A;  1OC0 A;  2H4Q A;  3CVM A;  2RIV A;  2VDX A;  1LQ8 A;  2HIJ L;  1JVQ I;  3ZHA A;  1E03 I;  1OYH L;  2DUT A;  1OVA C;  4YIA A;  3NDF A;  4DTE A;  5IO1 A;  2WY0 C;  3DRU A;  1E04 I;  4G8O A;  2VDY A;  2B4X I;  1DZG L;  7API A;  4P0O A;  5CE0 A;  1ATT A;  3DLW A;  2ZNH A;  3F02 A;  1SR5 A;  1BR8 I;  4C41 A;  2PEE A;  4AU3 A;  2BEH I;  3CWM A;  2R9Y A;  3PZF A;  2H4P A;  4AJU A;  1OVA A;  4EB1 I;  1OO8 A;  1AS4 A;  3EOX A;  1ANT I;  3KCG I;  1IZ2 A;  4AQH A;  1EZX A;  3F5N A;  1PSI A;  3R4L A;  1BY7 A;  2XN5 A;  1OYH I;  2ARR A;  1HP7 A;  4X30 A;  1TB6 I;  1T1F A;  4Y3K A;  1XQJ A;  3CWL A;  1C5G A;  2GD4 C;  2H4R A;  4KDS A;  1XQG A;  8API A;  2PEF A;  4DY0 A;  3PB1 I; 
#chains in the Genus database with same CATH topology
 2B5T I;  1B3K A;  4PYW A;  1DVM A;  4DY7 C;  2ANT I;  1F0C A;  1QLP A;  2OL2 A;  3DY0 A;  1DZH I;  3OZQ A;  1DB2 A;  1C8O A;  4R9I A;  2CEO A;  2ZV6 A;  3Q03 A;  4ZK0 A;  2WXY C;  4AU3 B;  1WZ9 A;  1JJO C;  2ACH A;  4C49 A;  1A7C A;  1K9O I;  1D5S A;  2HIJ I;  2OAY A;  2WY1 A;  4CAA A;  5EI0 A;  1ATU A;  2B4X L;  3LE2 A;  9PAI A;  3CAA A;  1QMN A;  1YXA A;  4AFX A;  1MTP A;  4Y40 A;  2V95 A;  3F1S A;  1LK6 I;  1DZG I;  2XN3 A;  1R1L I;  4GA7 A;  4P0F A;  4ROB A;  4AU4 A;  2WXZ C;  1XU8 A;  2RIW A;  3Q02 A;  4G8R A;  2HI9 A;  2XN7 A;  3H5C A;  1AZX I;  1HLE A;  1OPH A;  2D26 A;  5BRR I;  3NDA A;  2WXX A;  3FGQ A;  1JMO A;  4EB1 L;  1JMJ A;  1SNG A;  3LW2 A;  4RSQ A;  9API A;  4IF8 A;  2QUG A;  4AU2 A;  5C98 A;  1QMB A;  1JRR A;  1UHG A;  3VVJ A;  1IMV A;  3NDD A;  1OVA B;  3EVJ I;  2ARQ A;  5INW A;  2WXZ A;  4ROA A;  1JTI A;  1ATH A;  3UT3 A;  2WXW A;  2XN6 A;  4ZK3 A;  5CDX A;  1LJ5 A;  5HGC A;  1E05 I;  3STO A;  3B9F I;  4AJT A;  4BB2 A;  4IC0 A;  1KCT A;  3DRM A;  5CDZ A;  1DZH L;  3T1P A;  2BEH L;  1SEK A;  1DVN A;  3NE4 A;  1M93 B;  1NQ9 I;  4RO9 A;  2VH4 A;  1OC0 A;  2H4Q A;  3CVM A;  2RIV A;  2VDX A;  1LQ8 A;  2HIJ L;  1JVQ I;  3ZHA A;  1E03 I;  1OYH L;  2DUT A;  1OVA C;  4YIA A;  3NDF A;  4DTE A;  5IO1 A;  2WY0 C;  3DRU A;  1E04 I;  4G8O A;  2VDY A;  2B4X I;  1DZG L;  7API A;  4P0O A;  5CE0 A;  1ATT A;  3DLW A;  2ZNH A;  3F02 A;  1SR5 A;  1BR8 I;  4C41 A;  2PEE A;  4AU3 A;  2BEH I;  3CWM A;  2R9Y A;  3PZF A;  2H4P A;  4AJU A;  1OVA A;  4EB1 I;  1OO8 A;  1AS4 A;  3EOX A;  1ANT I;  3KCG I;  1IZ2 A;  4AQH A;  1EZX A;  3F5N A;  1PSI A;  3R4L A;  1BY7 A;  2XN5 A;  1OYH I;  2ARR A;  1HP7 A;  4X30 A;  1TB6 I;  1T1F A;  4Y3K A;  1XQJ A;  3CWL A;  1C5G A;  2GD4 C;  2H4R A;  4KDS A;  1XQG A;  8API A;  2PEF A;  4DY0 A;  3PB1 I; 
#chains in the Genus database with same CATH homology
 2B5T I;  1B3K A;  4PYW A;  1DVM A;  4DY7 C;  2ANT I;  1F0C A;  1QLP A;  2OL2 A;  3DY0 A;  1DZH I;  3OZQ A;  1DB2 A;  1C8O A;  4R9I A;  2CEO A;  2ZV6 A;  3Q03 A;  4ZK0 A;  2WXY C;  4AU3 B;  1WZ9 A;  1JJO C;  2ACH A;  4C49 A;  1A7C A;  1K9O I;  1D5S A;  2HIJ I;  2OAY A;  2WY1 A;  4CAA A;  5EI0 A;  1ATU A;  2B4X L;  3LE2 A;  9PAI A;  3CAA A;  1QMN A;  1YXA A;  4AFX A;  1MTP A;  4Y40 A;  2V95 A;  3F1S A;  1LK6 I;  1DZG I;  2XN3 A;  1R1L I;  4GA7 A;  4P0F A;  4ROB A;  4AU4 A;  2WXZ C;  1XU8 A;  2RIW A;  3Q02 A;  4G8R A;  2HI9 A;  2XN7 A;  3H5C A;  1AZX I;  1HLE A;  1OPH A;  2D26 A;  5BRR I;  3NDA A;  2WXX A;  3FGQ A;  1JMO A;  4EB1 L;  1JMJ A;  1SNG A;  3LW2 A;  4RSQ A;  9API A;  4IF8 A;  2QUG A;  4AU2 A;  5C98 A;  1QMB A;  1JRR A;  1UHG A;  3VVJ A;  1IMV A;  3NDD A;  1OVA B;  3EVJ I;  2ARQ A;  5INW A;  2WXZ A;  4ROA A;  1JTI A;  1ATH A;  3UT3 A;  2WXW A;  2XN6 A;  4ZK3 A;  5CDX A;  1LJ5 A;  5HGC A;  1E05 I;  3STO A;  3B9F I;  4AJT A;  4BB2 A;  4IC0 A;  1KCT A;  3DRM A;  5CDZ A;  1DZH L;  3T1P A;  2BEH L;  1SEK A;  1DVN A;  3NE4 A;  1M93 B;  1NQ9 I;  4RO9 A;  2VH4 A;  1OC0 A;  2H4Q A;  3CVM A;  2RIV A;  2VDX A;  1LQ8 A;  2HIJ L;  1JVQ I;  3ZHA A;  1E03 I;  1OYH L;  2DUT A;  1OVA C;  4YIA A;  3NDF A;  4DTE A;  5IO1 A;  2WY0 C;  3DRU A;  1E04 I;  4G8O A;  2VDY A;  2B4X I;  1DZG L;  7API A;  4P0O A;  5CE0 A;  1ATT A;  3DLW A;  2ZNH A;  3F02 A;  1SR5 A;  1BR8 I;  4C41 A;  2PEE A;  4AU3 A;  2BEH I;  3CWM A;  2R9Y A;  3PZF A;  2H4P A;  4AJU A;  1OVA A;  4EB1 I;  1OO8 A;  1AS4 A;  3EOX A;  1ANT I;  3KCG I;  1IZ2 A;  4AQH A;  1EZX A;  3F5N A;  1PSI A;  3R4L A;  1BY7 A;  2XN5 A;  1OYH I;  2ARR A;  1HP7 A;  4X30 A;  1TB6 I;  1T1F A;  4Y3K A;  1XQJ A;  3CWL A;  1C5G A;  2GD4 C;  2H4R A;  4KDS A;  1XQG A;  8API A;  2PEF A;  4DY0 A;  3PB1 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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