9PAIA

Cleaved substrate variant of plasminogen activator inhibitor-1
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
346
structure length
346
Chain Sequence
VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVPSSSTAVIVSAR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Homo sapiens
molecule keywords PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364
total genus 91
structure length 346
sequence length 346
ec nomenclature
pdb deposition date 1999-03-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 9paiA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 9paiA01
4ZK0A 1E03I 2HIJI 3F5NA 3NDAA 1ATUA 2XN5A 3EVJI 5C98A 1BR8I 2B5TI 2VDXA 1SR5A 1OYHI 1TB6I 9APIA 1NQ9I 1OO8A 2D26A 5INWA 2VDYA 2XN3A 4DTEA 3F02A 4DY0A 4P0OA 1EZXA 1D5SA 1M93B 2WXZA 1SNGA 3CVMA 3Q02A 5HGCA 3H5CA 3R4LA 2BEHI 4ZK3A 3ZHAA 1QLPA 1IZ2A 1E05I 2H4RA 2H4QA 3DRUA 3PB1I 1OVAA 1DZGL 1R1LI 1LJ5A 4ROBA 5CE0A 3NDDA 2ARQA 1K9OI 4ROAA 1DVMA 3KCGI 4KDSA 2WXZC 2WY1A 2ZNHA 2ZV6A 1QMBA 1OVAC 1DVNA 1LK6I 3DRMA 4EB1L 2QUGA 4IC0A 2WXYC 5BRRI 1SEKA 2WXWA 4X30A 2ACHA 4G8RA 3DLWA 1UHGA 1DZHL 1XQJA 4AU3A 2GD4C 3CWLA 4BB2A 2B4XL 4GA7A 4Y40A 1DZGI 2HIJL 4G8OA 1XQGA 9PAIA 5IO1A 1DB2A 1JVQI 4PYWA 4C41A 1F0CA 4RSQA 1ANTI 1OPHA 1OYHL 1T1FA 1C5GA 3STOA 2PEEA 2OAYA 3VVJA 2XN6A 4RO9A 1AS4A 4CAAA 8APIA 1HP7A 1AZXI 3Q03A 2BEHL 3F1SA 4IF8A 1YXAA 1IMVA 4AJTA 1B3KA 1BY7A 1KCTA 1DZHI 1ATTA 1OVAB 1XU8A 1QMNA 3LE2A 5CDZA 5EI0A 1C8OA 4AFXA 1HLEA 2RIVA 1A7CA 1JMJA 2XN7A 3OZQA 7APIA 1PSIA 2DUTA 4Y3KA 3NE4A 1OC0A 1WZ9A 2VH4A 1JRRA 2ANTI 1LQ8A 3T1PA 4P0FA 3EOXA 2V95A 3FGQA 2CEOA 4EB1I 3UT3A 2H4PA 2PEFA 3DY0A 4AU3B 5CDXA 4AJUA 1JMOA 3PZFA 4AU4A 2WY0C 3CWMA 4AQHA 3CAAA 4YIAA 4AU2A 2WXXA 3LW2A 2OL2A 2RIWA 2R9YA 2ARRA 4C49A 1ATHA 4DY7C 1JTIA 3NDFA 2HI9A 3B9FI 1JJOC 4R9IA 2B4XI 1E04I 1MTPA
chains in the Genus database with same CATH superfamily
4ZK0A 1E03I 2HIJI 3F5NA 3NDAA 1ATUA 2XN5A 3EVJI 5C98A 1BR8I 2B5TI 2VDXA 1SR5A 1OYHI 1TB6I 9APIA 1NQ9I 1OO8A 2D26A 5INWA 2VDYA 2XN3A 4DTEA 3F02A 4DY0A 4P0OA 1EZXA 1D5SA 1M93B 2WXZA 1SNGA 3CVMA 3Q02A 5HGCA 3H5CA 3R4LA 2BEHI 4ZK3A 3ZHAA 1QLPA 1IZ2A 1E05I 2H4RA 2H4QA 3DRUA 3PB1I 1OVAA 1DZGL 1R1LI 1LJ5A 4ROBA 5CE0A 3NDDA 2ARQA 1K9OI 4ROAA 1DVMA 3KCGI 4KDSA 2WXZC 2WY1A 2ZNHA 2ZV6A 1QMBA 1OVAC 1DVNA 1LK6I 3DRMA 4EB1L 2QUGA 4IC0A 2WXYC 5BRRI 1SEKA 2WXWA 4X30A 2ACHA 4G8RA 3DLWA 1UHGA 1DZHL 1XQJA 4AU3A 2GD4C 3CWLA 4BB2A 2B4XL 4GA7A 4Y40A 1DZGI 2HIJL 4G8OA 1XQGA 9PAIA 5IO1A 1DB2A 1JVQI 4PYWA 4C41A 1F0CA 4RSQA 1ANTI 1OPHA 1OYHL 1T1FA 1C5GA 3STOA 2PEEA 2OAYA 3VVJA 2XN6A 4RO9A 1AS4A 4CAAA 8APIA 1HP7A 1AZXI 3Q03A 2BEHL 3F1SA 4IF8A 1YXAA 1IMVA 4AJTA 1B3KA 1BY7A 1KCTA 1DZHI 1ATTA 1OVAB 1XU8A 1QMNA 3LE2A 5CDZA 5EI0A 1C8OA 4AFXA 1HLEA 2RIVA 1A7CA 1JMJA 2XN7A 3OZQA 7APIA 1PSIA 2DUTA 4Y3KA 3NE4A 1OC0A 1WZ9A 2VH4A 1JRRA 2ANTI 1LQ8A 3T1PA 4P0FA 3EOXA 2V95A 3FGQA 2CEOA 4EB1I 3UT3A 2H4PA 2PEFA 3DY0A 4AU3B 5CDXA 4AJUA 1JMOA 3PZFA 4AU4A 2WY0C 3CWMA 4AQHA 3CAAA 4YIAA 4AU2A 2WXXA 3LW2A 2OL2A 2RIWA 2R9YA 2ARRA 4C49A 1ATHA 4DY7C 1JTIA 3NDFA 2HI9A 3B9FI 1JJOC 4R9IA 2B4XI 1E04I 1MTPA
chains in the Genus database with same CATH topology
4ZK0A 1E03I 2HIJI 3F5NA 3NDAA 1ATUA 2XN5A 3EVJI 5C98A 1BR8I 2B5TI 2VDXA 1SR5A 1OYHI 1TB6I 9APIA 1NQ9I 1OO8A 2D26A 5INWA 2VDYA 2XN3A 4DTEA 3F02A 4DY0A 4P0OA 1EZXA 1D5SA 1M93B 2WXZA 1SNGA 3CVMA 3Q02A 5HGCA 3H5CA 3R4LA 2BEHI 4ZK3A 3ZHAA 1QLPA 1IZ2A 1E05I 2H4RA 2H4QA 3DRUA 3PB1I 1OVAA 1DZGL 1R1LI 1LJ5A 4ROBA 5CE0A 3NDDA 2ARQA 1K9OI 4ROAA 1DVMA 3KCGI 4KDSA 2WXZC 2WY1A 2ZNHA 2ZV6A 1QMBA 1OVAC 1DVNA 1LK6I 3DRMA 4EB1L 2QUGA 4IC0A 2WXYC 5BRRI 1SEKA 2WXWA 4X30A 2ACHA 4G8RA 3DLWA 1UHGA 1DZHL 1XQJA 4AU3A 2GD4C 3CWLA 4BB2A 2B4XL 4GA7A 4Y40A 1DZGI 2HIJL 4G8OA 1XQGA 9PAIA 5IO1A 1DB2A 1JVQI 4PYWA 4C41A 1F0CA 4RSQA 1ANTI 1OPHA 1OYHL 1T1FA 1C5GA 3STOA 2PEEA 2OAYA 3VVJA 2XN6A 4RO9A 1AS4A 4CAAA 8APIA 1HP7A 1AZXI 3Q03A 2BEHL 3F1SA 4IF8A 1YXAA 1IMVA 4AJTA 1B3KA 1BY7A 1KCTA 1DZHI 1ATTA 1OVAB 1XU8A 1QMNA 3LE2A 5CDZA 5EI0A 1C8OA 4AFXA 1HLEA 2RIVA 1A7CA 1JMJA 2XN7A 3OZQA 7APIA 1PSIA 2DUTA 4Y3KA 3NE4A 1OC0A 1WZ9A 2VH4A 1JRRA 2ANTI 1LQ8A 3T1PA 4P0FA 3EOXA 2V95A 3FGQA 2CEOA 4EB1I 3UT3A 2H4PA 2PEFA 3DY0A 4AU3B 5CDXA 4AJUA 1JMOA 3PZFA 4AU4A 2WY0C 3CWMA 4AQHA 3CAAA 4YIAA 4AU2A 2WXXA 3LW2A 2OL2A 2RIWA 2R9YA 2ARRA 4C49A 1ATHA 4DY7C 1JTIA 3NDFA 2HI9A 3B9FI 1JJOC 4R9IA 2B4XI 1E04I 1MTPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZK0 A;  1E03 I;  2HIJ I;  3F5N A;  3NDA A;  1ATU A;  2XN5 A;  3EVJ I;  5C98 A;  1BR8 I;  2B5T I;  2VDX A;  1SR5 A;  1OYH I;  1TB6 I;  9API A;  1NQ9 I;  1OO8 A;  2D26 A;  5INW A;  2VDY A;  2XN3 A;  4DTE A;  3F02 A;  4DY0 A;  4P0O A;  1EZX A;  1D5S A;  1M93 B;  2WXZ A;  1SNG A;  3CVM A;  3Q02 A;  5HGC A;  3H5C A;  3R4L A;  2BEH I;  4ZK3 A;  3ZHA A;  1QLP A;  1IZ2 A;  1E05 I;  2H4R A;  2H4Q A;  3DRU A;  3PB1 I;  1OVA A;  1DZG L;  1R1L I;  1LJ5 A;  4ROB A;  5CE0 A;  3NDD A;  2ARQ A;  1K9O I;  4ROA A;  1DVM A;  3KCG I;  4KDS A;  2WXZ C;  2WY1 A;  2ZNH A;  2ZV6 A;  1QMB A;  1OVA C;  1DVN A;  1LK6 I;  3DRM A;  4EB1 L;  2QUG A;  4IC0 A;  2WXY C;  5BRR I;  1SEK A;  2WXW A;  4X30 A;  2ACH A;  4G8R A;  3DLW A;  1UHG A;  1DZH L;  1XQJ A;  4AU3 A;  2GD4 C;  3CWL A;  4BB2 A;  2B4X L;  4GA7 A;  4Y40 A;  1DZG I;  2HIJ L;  4G8O A;  1XQG A;  9PAI A;  5IO1 A;  1DB2 A;  1JVQ I;  4PYW A;  4C41 A;  1F0C A;  4RSQ A;  1ANT I;  1OPH A;  1OYH L;  1T1F A;  1C5G A;  3STO A;  2PEE A;  2OAY A;  3VVJ A;  2XN6 A;  4RO9 A;  1AS4 A;  4CAA A;  8API A;  1HP7 A;  1AZX I;  3Q03 A;  2BEH L;  3F1S A;  4IF8 A;  1YXA A;  1IMV A;  4AJT A;  1B3K A;  1BY7 A;  1KCT A;  1DZH I;  1ATT A;  1OVA B;  1XU8 A;  1QMN A;  3LE2 A;  5CDZ A;  5EI0 A;  1C8O A;  4AFX A;  1HLE A;  2RIV A;  1A7C A;  1JMJ A;  2XN7 A;  3OZQ A;  7API A;  1PSI A;  2DUT A;  4Y3K A;  3NE4 A;  1OC0 A;  1WZ9 A;  2VH4 A;  1JRR A;  2ANT I;  1LQ8 A;  3T1P A;  4P0F A;  3EOX A;  2V95 A;  3FGQ A;  2CEO A;  4EB1 I;  3UT3 A;  2H4P A;  2PEF A;  3DY0 A;  4AU3 B;  5CDX A;  4AJU A;  1JMO A;  3PZF A;  4AU4 A;  2WY0 C;  3CWM A;  4AQH A;  3CAA A;  4YIA A;  4AU2 A;  2WXX A;  3LW2 A;  2OL2 A;  2RIW A;  2R9Y A;  2ARR A;  4C49 A;  1ATH A;  4DY7 C;  1JTI A;  3NDF A;  2HI9 A;  3B9F I;  1JJO C;  4R9I A;  2B4X I;  1E04 I;  1MTP A; 
#chains in the Genus database with same CATH topology
 4ZK0 A;  1E03 I;  2HIJ I;  3F5N A;  3NDA A;  1ATU A;  2XN5 A;  3EVJ I;  5C98 A;  1BR8 I;  2B5T I;  2VDX A;  1SR5 A;  1OYH I;  1TB6 I;  9API A;  1NQ9 I;  1OO8 A;  2D26 A;  5INW A;  2VDY A;  2XN3 A;  4DTE A;  3F02 A;  4DY0 A;  4P0O A;  1EZX A;  1D5S A;  1M93 B;  2WXZ A;  1SNG A;  3CVM A;  3Q02 A;  5HGC A;  3H5C A;  3R4L A;  2BEH I;  4ZK3 A;  3ZHA A;  1QLP A;  1IZ2 A;  1E05 I;  2H4R A;  2H4Q A;  3DRU A;  3PB1 I;  1OVA A;  1DZG L;  1R1L I;  1LJ5 A;  4ROB A;  5CE0 A;  3NDD A;  2ARQ A;  1K9O I;  4ROA A;  1DVM A;  3KCG I;  4KDS A;  2WXZ C;  2WY1 A;  2ZNH A;  2ZV6 A;  1QMB A;  1OVA C;  1DVN A;  1LK6 I;  3DRM A;  4EB1 L;  2QUG A;  4IC0 A;  2WXY C;  5BRR I;  1SEK A;  2WXW A;  4X30 A;  2ACH A;  4G8R A;  3DLW A;  1UHG A;  1DZH L;  1XQJ A;  4AU3 A;  2GD4 C;  3CWL A;  4BB2 A;  2B4X L;  4GA7 A;  4Y40 A;  1DZG I;  2HIJ L;  4G8O A;  1XQG A;  9PAI A;  5IO1 A;  1DB2 A;  1JVQ I;  4PYW A;  4C41 A;  1F0C A;  4RSQ A;  1ANT I;  1OPH A;  1OYH L;  1T1F A;  1C5G A;  3STO A;  2PEE A;  2OAY A;  3VVJ A;  2XN6 A;  4RO9 A;  1AS4 A;  4CAA A;  8API A;  1HP7 A;  1AZX I;  3Q03 A;  2BEH L;  3F1S A;  4IF8 A;  1YXA A;  1IMV A;  4AJT A;  1B3K A;  1BY7 A;  1KCT A;  1DZH I;  1ATT A;  1OVA B;  1XU8 A;  1QMN A;  3LE2 A;  5CDZ A;  5EI0 A;  1C8O A;  4AFX A;  1HLE A;  2RIV A;  1A7C A;  1JMJ A;  2XN7 A;  3OZQ A;  7API A;  1PSI A;  2DUT A;  4Y3K A;  3NE4 A;  1OC0 A;  1WZ9 A;  2VH4 A;  1JRR A;  2ANT I;  1LQ8 A;  3T1P A;  4P0F A;  3EOX A;  2V95 A;  3FGQ A;  2CEO A;  4EB1 I;  3UT3 A;  2H4P A;  2PEF A;  3DY0 A;  4AU3 B;  5CDX A;  4AJU A;  1JMO A;  3PZF A;  4AU4 A;  2WY0 C;  3CWM A;  4AQH A;  3CAA A;  4YIA A;  4AU2 A;  2WXX A;  3LW2 A;  2OL2 A;  2RIW A;  2R9Y A;  2ARR A;  4C49 A;  1ATH A;  4DY7 C;  1JTI A;  3NDF A;  2HI9 A;  3B9F I;  1JJO C;  4R9I A;  2B4X I;  1E04 I;  1MTP A; 
#chains in the Genus database with same CATH homology
 4ZK0 A;  1E03 I;  2HIJ I;  3F5N A;  3NDA A;  1ATU A;  2XN5 A;  3EVJ I;  5C98 A;  1BR8 I;  2B5T I;  2VDX A;  1SR5 A;  1OYH I;  1TB6 I;  9API A;  1NQ9 I;  1OO8 A;  2D26 A;  5INW A;  2VDY A;  2XN3 A;  4DTE A;  3F02 A;  4DY0 A;  4P0O A;  1EZX A;  1D5S A;  1M93 B;  2WXZ A;  1SNG A;  3CVM A;  3Q02 A;  5HGC A;  3H5C A;  3R4L A;  2BEH I;  4ZK3 A;  3ZHA A;  1QLP A;  1IZ2 A;  1E05 I;  2H4R A;  2H4Q A;  3DRU A;  3PB1 I;  1OVA A;  1DZG L;  1R1L I;  1LJ5 A;  4ROB A;  5CE0 A;  3NDD A;  2ARQ A;  1K9O I;  4ROA A;  1DVM A;  3KCG I;  4KDS A;  2WXZ C;  2WY1 A;  2ZNH A;  2ZV6 A;  1QMB A;  1OVA C;  1DVN A;  1LK6 I;  3DRM A;  4EB1 L;  2QUG A;  4IC0 A;  2WXY C;  5BRR I;  1SEK A;  2WXW A;  4X30 A;  2ACH A;  4G8R A;  3DLW A;  1UHG A;  1DZH L;  1XQJ A;  4AU3 A;  2GD4 C;  3CWL A;  4BB2 A;  2B4X L;  4GA7 A;  4Y40 A;  1DZG I;  2HIJ L;  4G8O A;  1XQG A;  9PAI A;  5IO1 A;  1DB2 A;  1JVQ I;  4PYW A;  4C41 A;  1F0C A;  4RSQ A;  1ANT I;  1OPH A;  1OYH L;  1T1F A;  1C5G A;  3STO A;  2PEE A;  2OAY A;  3VVJ A;  2XN6 A;  4RO9 A;  1AS4 A;  4CAA A;  8API A;  1HP7 A;  1AZX I;  3Q03 A;  2BEH L;  3F1S A;  4IF8 A;  1YXA A;  1IMV A;  4AJT A;  1B3K A;  1BY7 A;  1KCT A;  1DZH I;  1ATT A;  1OVA B;  1XU8 A;  1QMN A;  3LE2 A;  5CDZ A;  5EI0 A;  1C8O A;  4AFX A;  1HLE A;  2RIV A;  1A7C A;  1JMJ A;  2XN7 A;  3OZQ A;  7API A;  1PSI A;  2DUT A;  4Y3K A;  3NE4 A;  1OC0 A;  1WZ9 A;  2VH4 A;  1JRR A;  2ANT I;  1LQ8 A;  3T1P A;  4P0F A;  3EOX A;  2V95 A;  3FGQ A;  2CEO A;  4EB1 I;  3UT3 A;  2H4P A;  2PEF A;  3DY0 A;  4AU3 B;  5CDX A;  4AJU A;  1JMO A;  3PZF A;  4AU4 A;  2WY0 C;  3CWM A;  4AQH A;  3CAA A;  4YIA A;  4AU2 A;  2WXX A;  3LW2 A;  2OL2 A;  2RIW A;  2R9Y A;  2ARR A;  4C49 A;  1ATH A;  4DY7 C;  1JTI A;  3NDF A;  2HI9 A;  3B9F I;  1JJO C;  4R9I A;  2B4X I;  1E04 I;  1MTP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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