9PAIA

Cleaved substrate variant of plasminogen activator inhibitor-1
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
346
structure length
346
Chain Sequence
VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVPSSSTAVIVSAR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase inhibitor
molecule keywords PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364
publication title Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1.
pubmed doi rcsb
source organism Homo sapiens
total genus 91
structure length 346
sequence length 346
ec nomenclature
pdb deposition date 1999-03-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 9paiA02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 9paiA01
2XN6A 1MTPA 2ACHA 4AU4A 1KCTA 1QMBA 4AJTA 2R9YA 2BEHL 1EZXA 2OL2A 2ZNHA 3CVMA 2QUGA 1JMOA 1K9OI 1JVQI 1PSIA 4R9IA 4CAAA 5CDXA 5CE0A 4EB1I 8APIA 1UHGA 4AU2A 3CAAA 3Q03A 1DZHL 1B3KA 5INWA 4IF8A 3LE2A 1ATHA 1YXAA 2ANTI 1C8OA 4Y40A 1T1FA 3PB1I 1SEKA 2ARQA 2B4XI 3DY0A 1SNGA 1XQJA 3KCGI 4AFXA 2V95A 1TB6I 4DY0A 1OC0A 2WY0C 1JMJA 3EVJI 2HI9A 1ANTI 2DUTA 2VDYA 1DVNA 2WY1A 1M93B 3UT3A 1D5SA 4YIAA 4DTEA 1SR5A 3OZQA 4X30A 1DB2A 3NDAA 5BRRI 1AS4A 4AJUA 2D26A 1BY7A 1DZGL 1HP7A 1NQ9I 1WZ9A 2CEOA 4IC0A 3T1PA 9APIA 1OVAC 2HIJL 2PEEA 2H4RA 2WXWA 4RSQA 4ROBA 2OAYA 3LW2A 3EOXA 2XN3A 2WXXA 3F5NA 1OYHI 5CDZA 2PEFA 2H4PA 3F1SA 3ZHAA 2ARRA 3H5CA 5EI0A 2XN7A 4KDSA 1F0CA 2VH4A 1OVAB 1OPHA 1HLEA 4ROAA 4EB1L 2WXYC 4ZK0A 2ZV6A 4P0OA 1JRRA 2WXZC 1E05I 4C41A 1QLPA 4C49A 5C98A 2BEHI 3DRUA 1IMVA 4Y3KA 3VVJA 1LJ5A 2RIWA 1E03I 2B4XL 4ZK3A 3NE4A 1JJOC 1DZHI 1LK6I 1OVAA 4PYWA 3FGQA 1BR8I 1QMNA 3R4LA 3DRMA 2GD4C 4G8OA 3Q02A 4P0FA 1AZXI 1C5GA 3NDFA 4AU3B 1XQGA 3CWLA 4GA7A 3STOA 4G8RA 2H4QA 1XU8A 1E04I 1JTIA 3DLWA 1OO8A 1ATTA 4AQHA 7APIA 2XN5A 1DVMA 4DY7C 3NDDA 1A7CA 9PAIA 2WXZA 3PZFA 4RO9A 1R1LI 1LQ8A 1OYHL 2B5TI 4BB2A 3F02A 4AU3A 2VDXA 3B9FI 1DZGI 1IZ2A 2HIJI 3CWMA 5IO1A 1ATUA 2RIVA 5HGCA
chains in the Genus database with same CATH superfamily
2XN6A 1MTPA 2ACHA 4AU4A 1KCTA 1QMBA 4AJTA 2R9YA 2BEHL 1EZXA 2OL2A 2ZNHA 3CVMA 2QUGA 1JMOA 1K9OI 1JVQI 1PSIA 4R9IA 4CAAA 5CDXA 5CE0A 4EB1I 8APIA 1UHGA 4AU2A 3CAAA 3Q03A 1DZHL 1B3KA 5INWA 4IF8A 3LE2A 1ATHA 1YXAA 2ANTI 1C8OA 4Y40A 1T1FA 3PB1I 1SEKA 2ARQA 2B4XI 3DY0A 1SNGA 1XQJA 3KCGI 4AFXA 2V95A 1TB6I 4DY0A 1OC0A 2WY0C 1JMJA 3EVJI 2HI9A 1ANTI 2DUTA 2VDYA 1DVNA 2WY1A 1M93B 3UT3A 1D5SA 4YIAA 4DTEA 1SR5A 3OZQA 4X30A 1DB2A 3NDAA 5BRRI 1AS4A 4AJUA 2D26A 1BY7A 1DZGL 1HP7A 1NQ9I 1WZ9A 2CEOA 4IC0A 3T1PA 9APIA 1OVAC 2HIJL 2PEEA 2H4RA 2WXWA 4RSQA 4ROBA 2OAYA 3LW2A 3EOXA 2XN3A 2WXXA 3F5NA 1OYHI 5CDZA 2PEFA 2H4PA 3F1SA 3ZHAA 2ARRA 3H5CA 5EI0A 2XN7A 4KDSA 1F0CA 2VH4A 1OVAB 1OPHA 1HLEA 4ROAA 4EB1L 2WXYC 4ZK0A 2ZV6A 4P0OA 1JRRA 2WXZC 1E05I 4C41A 1QLPA 4C49A 5C98A 2BEHI 3DRUA 1IMVA 4Y3KA 3VVJA 1LJ5A 2RIWA 1E03I 2B4XL 4ZK3A 3NE4A 1JJOC 1DZHI 1LK6I 1OVAA 4PYWA 3FGQA 1BR8I 1QMNA 3R4LA 3DRMA 2GD4C 4G8OA 3Q02A 4P0FA 1AZXI 1C5GA 3NDFA 4AU3B 1XQGA 3CWLA 4GA7A 3STOA 4G8RA 2H4QA 1XU8A 1E04I 1JTIA 3DLWA 1OO8A 1ATTA 4AQHA 7APIA 2XN5A 1DVMA 4DY7C 3NDDA 1A7CA 9PAIA 2WXZA 3PZFA 4RO9A 1R1LI 1LQ8A 1OYHL 2B5TI 4BB2A 3F02A 4AU3A 2VDXA 3B9FI 1DZGI 1IZ2A 2HIJI 3CWMA 5IO1A 1ATUA 2RIVA 5HGCA
chains in the Genus database with same CATH topology
2XN6A 1MTPA 2ACHA 4AU4A 1KCTA 1QMBA 4AJTA 2R9YA 2BEHL 1EZXA 2OL2A 2ZNHA 3CVMA 2QUGA 1JMOA 1K9OI 1JVQI 1PSIA 4R9IA 4CAAA 5CDXA 5CE0A 4EB1I 8APIA 1UHGA 4AU2A 3CAAA 3Q03A 1DZHL 1B3KA 5INWA 4IF8A 3LE2A 1ATHA 1YXAA 2ANTI 1C8OA 4Y40A 1T1FA 3PB1I 1SEKA 2ARQA 2B4XI 3DY0A 1SNGA 1XQJA 3KCGI 4AFXA 2V95A 1TB6I 4DY0A 1OC0A 2WY0C 1JMJA 3EVJI 2HI9A 1ANTI 2DUTA 2VDYA 1DVNA 2WY1A 1M93B 3UT3A 1D5SA 4YIAA 4DTEA 1SR5A 3OZQA 4X30A 1DB2A 3NDAA 5BRRI 1AS4A 4AJUA 2D26A 1BY7A 1DZGL 1HP7A 1NQ9I 1WZ9A 2CEOA 4IC0A 3T1PA 9APIA 1OVAC 2HIJL 2PEEA 2H4RA 2WXWA 4RSQA 4ROBA 2OAYA 3LW2A 3EOXA 2XN3A 2WXXA 3F5NA 1OYHI 5CDZA 2PEFA 2H4PA 3F1SA 3ZHAA 2ARRA 3H5CA 5EI0A 2XN7A 4KDSA 1F0CA 2VH4A 1OVAB 1OPHA 1HLEA 4ROAA 4EB1L 2WXYC 4ZK0A 2ZV6A 4P0OA 1JRRA 2WXZC 1E05I 4C41A 1QLPA 4C49A 5C98A 2BEHI 3DRUA 1IMVA 4Y3KA 3VVJA 1LJ5A 2RIWA 1E03I 2B4XL 4ZK3A 3NE4A 1JJOC 1DZHI 1LK6I 1OVAA 4PYWA 3FGQA 1BR8I 1QMNA 3R4LA 3DRMA 2GD4C 4G8OA 3Q02A 4P0FA 1AZXI 1C5GA 3NDFA 4AU3B 1XQGA 3CWLA 4GA7A 3STOA 4G8RA 2H4QA 1XU8A 1E04I 1JTIA 3DLWA 1OO8A 1ATTA 4AQHA 7APIA 2XN5A 1DVMA 4DY7C 3NDDA 1A7CA 9PAIA 2WXZA 3PZFA 4RO9A 1R1LI 1LQ8A 1OYHL 2B5TI 4BB2A 3F02A 4AU3A 2VDXA 3B9FI 1DZGI 1IZ2A 2HIJI 3CWMA 5IO1A 1ATUA 2RIVA 5HGCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XN6 A;  1MTP A;  2ACH A;  4AU4 A;  1KCT A;  1QMB A;  4AJT A;  2R9Y A;  2BEH L;  1EZX A;  2OL2 A;  2ZNH A;  3CVM A;  2QUG A;  1JMO A;  1K9O I;  1JVQ I;  1PSI A;  4R9I A;  4CAA A;  5CDX A;  5CE0 A;  4EB1 I;  8API A;  1UHG A;  4AU2 A;  3CAA A;  3Q03 A;  1DZH L;  1B3K A;  5INW A;  4IF8 A;  3LE2 A;  1ATH A;  1YXA A;  2ANT I;  1C8O A;  4Y40 A;  1T1F A;  3PB1 I;  1SEK A;  2ARQ A;  2B4X I;  3DY0 A;  1SNG A;  1XQJ A;  3KCG I;  4AFX A;  2V95 A;  1TB6 I;  4DY0 A;  1OC0 A;  2WY0 C;  1JMJ A;  3EVJ I;  2HI9 A;  1ANT I;  2DUT A;  2VDY A;  1DVN A;  2WY1 A;  1M93 B;  3UT3 A;  1D5S A;  4YIA A;  4DTE A;  1SR5 A;  3OZQ A;  4X30 A;  1DB2 A;  3NDA A;  5BRR I;  1AS4 A;  4AJU A;  2D26 A;  1BY7 A;  1DZG L;  1HP7 A;  1NQ9 I;  1WZ9 A;  2CEO A;  4IC0 A;  3T1P A;  9API A;  1OVA C;  2HIJ L;  2PEE A;  2H4R A;  2WXW A;  4RSQ A;  4ROB A;  2OAY A;  3LW2 A;  3EOX A;  2XN3 A;  2WXX A;  3F5N A;  1OYH I;  5CDZ A;  2PEF A;  2H4P A;  3F1S A;  3ZHA A;  2ARR A;  3H5C A;  5EI0 A;  2XN7 A;  4KDS A;  1F0C A;  2VH4 A;  1OVA B;  1OPH A;  1HLE A;  4ROA A;  4EB1 L;  2WXY C;  4ZK0 A;  2ZV6 A;  4P0O A;  1JRR A;  2WXZ C;  1E05 I;  4C41 A;  1QLP A;  4C49 A;  5C98 A;  2BEH I;  3DRU A;  1IMV A;  4Y3K A;  3VVJ A;  1LJ5 A;  2RIW A;  1E03 I;  2B4X L;  4ZK3 A;  3NE4 A;  1JJO C;  1DZH I;  1LK6 I;  1OVA A;  4PYW A;  3FGQ A;  1BR8 I;  1QMN A;  3R4L A;  3DRM A;  2GD4 C;  4G8O A;  3Q02 A;  4P0F A;  1AZX I;  1C5G A;  3NDF A;  4AU3 B;  1XQG A;  3CWL A;  4GA7 A;  3STO A;  4G8R A;  2H4Q A;  1XU8 A;  1E04 I;  1JTI A;  3DLW A;  1OO8 A;  1ATT A;  4AQH A;  7API A;  2XN5 A;  1DVM A;  4DY7 C;  3NDD A;  1A7C A;  9PAI A;  2WXZ A;  3PZF A;  4RO9 A;  1R1L I;  1LQ8 A;  1OYH L;  2B5T I;  4BB2 A;  3F02 A;  4AU3 A;  2VDX A;  3B9F I;  1DZG I;  1IZ2 A;  2HIJ I;  3CWM A;  5IO1 A;  1ATU A;  2RIV A;  5HGC A; 
#chains in the Genus database with same CATH topology
 2XN6 A;  1MTP A;  2ACH A;  4AU4 A;  1KCT A;  1QMB A;  4AJT A;  2R9Y A;  2BEH L;  1EZX A;  2OL2 A;  2ZNH A;  3CVM A;  2QUG A;  1JMO A;  1K9O I;  1JVQ I;  1PSI A;  4R9I A;  4CAA A;  5CDX A;  5CE0 A;  4EB1 I;  8API A;  1UHG A;  4AU2 A;  3CAA A;  3Q03 A;  1DZH L;  1B3K A;  5INW A;  4IF8 A;  3LE2 A;  1ATH A;  1YXA A;  2ANT I;  1C8O A;  4Y40 A;  1T1F A;  3PB1 I;  1SEK A;  2ARQ A;  2B4X I;  3DY0 A;  1SNG A;  1XQJ A;  3KCG I;  4AFX A;  2V95 A;  1TB6 I;  4DY0 A;  1OC0 A;  2WY0 C;  1JMJ A;  3EVJ I;  2HI9 A;  1ANT I;  2DUT A;  2VDY A;  1DVN A;  2WY1 A;  1M93 B;  3UT3 A;  1D5S A;  4YIA A;  4DTE A;  1SR5 A;  3OZQ A;  4X30 A;  1DB2 A;  3NDA A;  5BRR I;  1AS4 A;  4AJU A;  2D26 A;  1BY7 A;  1DZG L;  1HP7 A;  1NQ9 I;  1WZ9 A;  2CEO A;  4IC0 A;  3T1P A;  9API A;  1OVA C;  2HIJ L;  2PEE A;  2H4R A;  2WXW A;  4RSQ A;  4ROB A;  2OAY A;  3LW2 A;  3EOX A;  2XN3 A;  2WXX A;  3F5N A;  1OYH I;  5CDZ A;  2PEF A;  2H4P A;  3F1S A;  3ZHA A;  2ARR A;  3H5C A;  5EI0 A;  2XN7 A;  4KDS A;  1F0C A;  2VH4 A;  1OVA B;  1OPH A;  1HLE A;  4ROA A;  4EB1 L;  2WXY C;  4ZK0 A;  2ZV6 A;  4P0O A;  1JRR A;  2WXZ C;  1E05 I;  4C41 A;  1QLP A;  4C49 A;  5C98 A;  2BEH I;  3DRU A;  1IMV A;  4Y3K A;  3VVJ A;  1LJ5 A;  2RIW A;  1E03 I;  2B4X L;  4ZK3 A;  3NE4 A;  1JJO C;  1DZH I;  1LK6 I;  1OVA A;  4PYW A;  3FGQ A;  1BR8 I;  1QMN A;  3R4L A;  3DRM A;  2GD4 C;  4G8O A;  3Q02 A;  4P0F A;  1AZX I;  1C5G A;  3NDF A;  4AU3 B;  1XQG A;  3CWL A;  4GA7 A;  3STO A;  4G8R A;  2H4Q A;  1XU8 A;  1E04 I;  1JTI A;  3DLW A;  1OO8 A;  1ATT A;  4AQH A;  7API A;  2XN5 A;  1DVM A;  4DY7 C;  3NDD A;  1A7C A;  9PAI A;  2WXZ A;  3PZF A;  4RO9 A;  1R1L I;  1LQ8 A;  1OYH L;  2B5T I;  4BB2 A;  3F02 A;  4AU3 A;  2VDX A;  3B9F I;  1DZG I;  1IZ2 A;  2HIJ I;  3CWM A;  5IO1 A;  1ATU A;  2RIV A;  5HGC A; 
#chains in the Genus database with same CATH homology
 2XN6 A;  1MTP A;  2ACH A;  4AU4 A;  1KCT A;  1QMB A;  4AJT A;  2R9Y A;  2BEH L;  1EZX A;  2OL2 A;  2ZNH A;  3CVM A;  2QUG A;  1JMO A;  1K9O I;  1JVQ I;  1PSI A;  4R9I A;  4CAA A;  5CDX A;  5CE0 A;  4EB1 I;  8API A;  1UHG A;  4AU2 A;  3CAA A;  3Q03 A;  1DZH L;  1B3K A;  5INW A;  4IF8 A;  3LE2 A;  1ATH A;  1YXA A;  2ANT I;  1C8O A;  4Y40 A;  1T1F A;  3PB1 I;  1SEK A;  2ARQ A;  2B4X I;  3DY0 A;  1SNG A;  1XQJ A;  3KCG I;  4AFX A;  2V95 A;  1TB6 I;  4DY0 A;  1OC0 A;  2WY0 C;  1JMJ A;  3EVJ I;  2HI9 A;  1ANT I;  2DUT A;  2VDY A;  1DVN A;  2WY1 A;  1M93 B;  3UT3 A;  1D5S A;  4YIA A;  4DTE A;  1SR5 A;  3OZQ A;  4X30 A;  1DB2 A;  3NDA A;  5BRR I;  1AS4 A;  4AJU A;  2D26 A;  1BY7 A;  1DZG L;  1HP7 A;  1NQ9 I;  1WZ9 A;  2CEO A;  4IC0 A;  3T1P A;  9API A;  1OVA C;  2HIJ L;  2PEE A;  2H4R A;  2WXW A;  4RSQ A;  4ROB A;  2OAY A;  3LW2 A;  3EOX A;  2XN3 A;  2WXX A;  3F5N A;  1OYH I;  5CDZ A;  2PEF A;  2H4P A;  3F1S A;  3ZHA A;  2ARR A;  3H5C A;  5EI0 A;  2XN7 A;  4KDS A;  1F0C A;  2VH4 A;  1OVA B;  1OPH A;  1HLE A;  4ROA A;  4EB1 L;  2WXY C;  4ZK0 A;  2ZV6 A;  4P0O A;  1JRR A;  2WXZ C;  1E05 I;  4C41 A;  1QLP A;  4C49 A;  5C98 A;  2BEH I;  3DRU A;  1IMV A;  4Y3K A;  3VVJ A;  1LJ5 A;  2RIW A;  1E03 I;  2B4X L;  4ZK3 A;  3NE4 A;  1JJO C;  1DZH I;  1LK6 I;  1OVA A;  4PYW A;  3FGQ A;  1BR8 I;  1QMN A;  3R4L A;  3DRM A;  2GD4 C;  4G8O A;  3Q02 A;  4P0F A;  1AZX I;  1C5G A;  3NDF A;  4AU3 B;  1XQG A;  3CWL A;  4GA7 A;  3STO A;  4G8R A;  2H4Q A;  1XU8 A;  1E04 I;  1JTI A;  3DLW A;  1OO8 A;  1ATT A;  4AQH A;  7API A;  2XN5 A;  1DVM A;  4DY7 C;  3NDD A;  1A7C A;  9PAI A;  2WXZ A;  3PZF A;  4RO9 A;  1R1L I;  1LQ8 A;  1OYH L;  2B5T I;  4BB2 A;  3F02 A;  4AU3 A;  2VDX A;  3B9F I;  1DZG I;  1IZ2 A;  2HIJ I;  3CWM A;  5IO1 A;  1ATU A;  2RIV A;  5HGC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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