5C2MA

The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
237
structure length
237
Chain Sequence
FNYIFAVSYDGELFKGSPPESAQASWLTSATRIGTKGWANFSHLLFNPDGTLYGVVNDKFYKGPTPHRTSAEEWIAQATLIGDGGWGAFRFLFFDPHGVLYGVTEDKLYKREPPSSDEDHWLGSANLLGAEGWGDFEFLFFDPEGKLYGVVNGKLHKGDPPKDRHDAWLGSSTLFKGELWGNFRHLFFTSNGHLCGAHDSFYKKSPPIGLDWLAHESNMVGHGGWHMFKLLISPLPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
pubmed doi rcsb
molecule tags Structural protein
source organism Nematostella vectensis
molecule keywords Predicted protein
total genus 45
structure length 237
sequence length 237
ec nomenclature
pdb deposition date 2015-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF14517 Tachylectin Tachylectin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.115.10.10 Mainly Beta 5 Propeller Tachylectin-2; Chain A Tachylectin 2 5c2mA00
1TL2A 5C2MA
chains in the Genus database with same CATH superfamily
2XQRA 2X8TA 3WN1A 3KF3A 4EQVA 4NOVA 3WPUA 3D61A 3NQHA 5AYCA 5GLKA 2QQUA 4KMIA 5FMDA 5GLLA 5JOZA 4UDGA 2X8FA 3WN0A 3AKIA 3KF5A 1UV4A 3D5YA 3WAUA 3WPZA 3U75A 1Y9GA 3OM7A 1Y7BA 3QEDA 3AKGA 5FK8A 3UGGA 3LF7A 5GLRA 3ZXKA 1VKDA 3VT2A 1YIFA 5C0PA 5FMBA 1UYPA 4O8OA 1YI7A 2AC1A 5GLOA 5FK7A 4N2RA 4FFHA 3WASA 3VSFA 4FFIA 4N4BA 4COTA 5AYEA 5A8CA 2X8SA 3TAWA 4AK6A 1OYGA 2YFRA 3QC2A 1WL7A 5ANNA 4KCBA 3BYJA 5FLWA 5A7VB 4KC7A 3OM6A 3VSRA 3WPYA 5GLNA 1GYDB 3K1UA 3R4ZA 4PVIA 3WPVA 3WN2A 3P2NA 2EXIA 4KCAA 4ONZA 3KSTA 1W2TA 3C2UA 3UGFA 2ADEA 3BYLA 3ZXLA 1ST8A 3PIGA 3WMYA 5C2MA 5A7VA 2YFSA 3LFIA 3D60A 4D47A 1PT2A 3AKFA 1GYEB 3LIHA 5A8DA 3C7OA 2EXKA 5JOYA 3UGHA 3LDRA 5FIXA 3QZ4A 3BYKA 5FKCA 4U6DA 2AEYA 4AK5A 3VSZA 3WMZA 1Y9MA 3C7GA 4FFFA 1TL2A 3LDKA 5GLMA 3R4YA 4UDKE 2ADDA 2AEZA 2EXJA 3OM2A 4O8PA 3SC7X 2QQWA 4UDIA 1YRZA 5AY9A 4KC8A 2EXHA 3LEMA 3LIGA 3QEFA 1GYHA 5B6TA 4UDJA 3VT1A 4AK7A 5JOXA 2VDTA 2YFTA 3C7HA 4FFGA 2OXBA 5JOWA 3U14A 2B4WA 4O8NA 3LV4A 5GLPA 3PIJA 4N1IA 3WATA 4UDKA 5B6SA 3RWKX 3AKHA 4PVAA 4U6BA 3ZXJA 3VT0A 3OM4A 5AYDA 5GLQA 1Y4WA 3QEEA 2QQVA 1W18A 3C7EA 5FMCA 3VSSA 4N2ZA 3BYNA 5FKBA 4MLGA 3R67A 4QQSA 3CU9A 3D5ZA 3OM5A 3C7FA
chains in the Genus database with same CATH topology
1TL2A 5C2MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TL2 A;  5C2M A; 
#chains in the Genus database with same CATH topology
 2XQR A;  2X8T A;  3WN1 A;  3KF3 A;  4EQV A;  4NOV A;  3WPU A;  3D61 A;  3NQH A;  5AYC A;  5GLK A;  2QQU A;  4KMI A;  5FMD A;  5GLL A;  5JOZ A;  4UDG A;  2X8F A;  3WN0 A;  3AKI A;  3KF5 A;  1UV4 A;  3D5Y A;  3WAU A;  3WPZ A;  3U75 A;  1Y9G A;  3OM7 A;  1Y7B A;  3QED A;  3AKG A;  5FK8 A;  3UGG A;  3LF7 A;  5GLR A;  3ZXK A;  1VKD A;  3VT2 A;  1YIF A;  5C0P A;  5FMB A;  1UYP A;  4O8O A;  1YI7 A;  2AC1 A;  5GLO A;  5FK7 A;  4N2R A;  4FFH A;  3WAS A;  3VSF A;  4FFI A;  4N4B A;  4COT A;  5AYE A;  5A8C A;  2X8S A;  3TAW A;  4AK6 A;  1OYG A;  2YFR A;  3QC2 A;  1WL7 A;  5ANN A;  4KCB A;  3BYJ A;  5FLW A;  5A7V B;  4KC7 A;  3OM6 A;  3VSR A;  3WPY A;  5GLN A;  1GYD B;  3K1U A;  3R4Z A;  4PVI A;  3WPV A;  3WN2 A;  3P2N A;  2EXI A;  4KCA A;  4ONZ A;  3KST A;  1W2T A;  3C2U A;  3UGF A;  2ADE A;  3BYL A;  3ZXL A;  1ST8 A;  3PIG A;  3WMY A;  5C2M A;  5A7V A;  2YFS A;  3LFI A;  3D60 A;  4D47 A;  1PT2 A;  3AKF A;  1GYE B;  3LIH A;  5A8D A;  3C7O A;  2EXK A;  5JOY A;  3UGH A;  3LDR A;  5FIX A;  3QZ4 A;  3BYK A;  5FKC A;  4U6D A;  2AEY A;  4AK5 A;  3VSZ A;  3WMZ A;  1Y9M A;  3C7G A;  4FFF A;  1TL2 A;  3LDK A;  5GLM A;  3R4Y A;  4UDK E;  2ADD A;  2AEZ A;  2EXJ A;  3OM2 A;  4O8P A;  3SC7 X;  2QQW A;  4UDI A;  1YRZ A;  5AY9 A;  4KC8 A;  2EXH A;  3LEM A;  3LIG A;  3QEF A;  1GYH A;  5B6T A;  4UDJ A;  3VT1 A;  4AK7 A;  5JOX A;  2VDT A;  2YFT A;  3C7H A;  4FFG A;  2OXB A;  5JOW A;  3U14 A;  2B4W A;  4O8N A;  3LV4 A;  5GLP A;  3PIJ A;  4N1I A;  3WAT A;  4UDK A;  5B6S A;  3RWK X;  3AKH A;  4PVA A;  4U6B A;  3ZXJ A;  3VT0 A;  3OM4 A;  5AYD A;  5GLQ A;  1Y4W A;  3QEE A;  2QQV A;  1W18 A;  3C7E A;  5FMC A;  3VSS A;  4N2Z A;  3BYN A;  5FKB A;  4MLG A;  3R67 A;  4QQS A;  3CU9 A;  3D5Z A;  3OM5 A;  3C7F A; 
#chains in the Genus database with same CATH homology
 1TL2 A;  5C2M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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