3QS8A

Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs174)
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
346
structure length
346
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 115
structure length 346
sequence length 346
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2011-02-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 3qs8A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 3qs8A02
3QS8A 5EP8A 4X59A 4IJ1A 4X5DA 5BO2A 4YI7A 1O17A 4ZOJA 4N8QA 4OWQA 4GTNA 5C2LA 4OWSA 3QR9A 4OWNA 4GKMA 4HKMA 5BYTA 1UOUA 4GA4A 4X5BA 3UU1A 4EADA 1ZVWA 3R88A 1GXBA 2GVQA 4X58A 1V8GA 1KGZA 1VQUA 2DSJA 1KHDA 5BNEA 1ZYKA 4LHMA 4N93A 2WK5A 2WK6A 4GA5A 4OWMA 4X5CA 4M0RA 4YEKA 2BPQA 5EY3A 3GBRA 2TPTA 4ZOFA 4EAFA 4X46A 4MUOA 3TWPA 2ELCA 4ZOKA 4XR5A 1BRWA 4X5EA 5C1RA 5C7SA 4GIUA 4N5VA 4GA6A 3QSAA 4OWUA 1AZYA 3H5QA 4OWVA 4X5AA 3R6CA 3QQSA 4OWOA 1OTPA 5BO3A 4ZTVA 4YYYA 1ZXYA 2J0FA
chains in the Genus database with same CATH superfamily
3QS8A 5EP8A 4X59A 4IJ1A 4X5DA 5BO2A 4F3FC 4YI7A 1O17A 4ZOJA 4N8QA 4OWQA 4GTNA 5C2LA 4OWSA 3QR9A 4OWNA 4GKMA 4HKMA 5BYTA 1UOUA 4GA4A 4X5BA 3UU1A 4EADA 1ZVWA 3R88A 1GXBA 2GVQA 1RRZA 1RF8B 4X58A 1V8GA 1KGZA 1VQUA 2DSJA 1KHDA 5BNEA 1ZYKA 4LHMA 4N93A 2WK5A 2WK6A 4GA5A 4OWMA 4X5CA 4M0RA 4YEKA 2BPQA 5EY3A 3GBRA 2TPTA 4ZOFA 4EAFA 4X46A 4MUOA 3TWPA 2ELCA 4ZOKA 4XR5A 1BRWA 4X5EA 5C1RA 5C7SA 4GIUA 4N5VA 4GA6A 3QSAA 4OWUA 1AZYA 3H5QA 4OWVA 4X5AA 3R6CA 3QQSA 4OWOA 1OTPA 5BO3A 4ZTVA 4YYYA 1ZXYA 2J0FA
chains in the Genus database with same CATH topology
3QS8A 5EP8A 4X59A 4IJ1A 4X5DA 5BO2A 4YI7A 1O17A 4ZOJA 4N8QA 4OWQA 4GTNA 5C2LA 4OWSA 3QR9A 4OWNA 4GKMA 4HKMA 5BYTA 1UOUA 4GA4A 4X5BA 3UU1A 4EADA 1ZVWA 3R88A 1GXBA 2GVQA 4X58A 1V8GA 1KGZA 1VQUA 2DSJA 1KHDA 5BNEA 1ZYKA 4LHMA 4N93A 2WK5A 2WK6A 4GA5A 4OWMA 4X5CA 4M0RA 4YEKA 2BPQA 5EY3A 3GBRA 2TPTA 4ZOFA 4EAFA 4X46A 4MUOA 3TWPA 2ELCA 4ZOKA 4XR5A 1BRWA 4X5EA 5C1RA 5C7SA 4GIUA 4N5VA 4GA6A 3QSAA 4OWUA 1AZYA 3H5QA 4OWVA 4X5AA 3R6CA 3QQSA 4OWOA 1OTPA 5BO3A 4ZTVA 4YYYA 1ZXYA 2J0FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QS8 A;  5EP8 A;  4X59 A;  4IJ1 A;  4X5D A;  5BO2 A;  4YI7 A;  1O17 A;  4ZOJ A;  4N8Q A;  4OWQ A;  4GTN A;  5C2L A;  4OWS A;  3QR9 A;  4OWN A;  4GKM A;  4HKM A;  5BYT A;  1UOU A;  4GA4 A;  4X5B A;  3UU1 A;  4EAD A;  1ZVW A;  3R88 A;  1GXB A;  2GVQ A;  4X58 A;  1V8G A;  1KGZ A;  1VQU A;  2DSJ A;  1KHD A;  5BNE A;  1ZYK A;  4LHM A;  4N93 A;  2WK5 A;  2WK6 A;  4GA5 A;  4OWM A;  4X5C A;  4M0R A;  4YEK A;  2BPQ A;  5EY3 A;  3GBR A;  2TPT A;  4ZOF A;  4EAF A;  4X46 A;  4MUO A;  3TWP A;  2ELC A;  4ZOK A;  4XR5 A;  1BRW A;  4X5E A;  5C1R A;  5C7S A;  4GIU A;  4N5V A;  4GA6 A;  3QSA A;  4OWU A;  1AZY A;  3H5Q A;  4OWV A;  4X5A A;  3R6C A;  3QQS A;  4OWO A;  1OTP A;  5BO3 A;  4ZTV A;  4YYY A;  1ZXY A;  2J0F A; 
#chains in the Genus database with same CATH topology
 3QS8 A;  5EP8 A;  4X59 A;  4IJ1 A;  4X5D A;  5BO2 A;  4F3F C;  4YI7 A;  1O17 A;  4ZOJ A;  4N8Q A;  4OWQ A;  4GTN A;  5C2L A;  4OWS A;  3QR9 A;  4OWN A;  4GKM A;  4HKM A;  5BYT A;  1UOU A;  4GA4 A;  4X5B A;  3UU1 A;  4EAD A;  1ZVW A;  3R88 A;  1GXB A;  2GVQ A;  1RRZ A;  1RF8 B;  4X58 A;  1V8G A;  1KGZ A;  1VQU A;  2DSJ A;  1KHD A;  5BNE A;  1ZYK A;  4LHM A;  4N93 A;  2WK5 A;  2WK6 A;  4GA5 A;  4OWM A;  4X5C A;  4M0R A;  4YEK A;  2BPQ A;  5EY3 A;  3GBR A;  2TPT A;  4ZOF A;  4EAF A;  4X46 A;  4MUO A;  3TWP A;  2ELC A;  4ZOK A;  4XR5 A;  1BRW A;  4X5E A;  5C1R A;  5C7S A;  4GIU A;  4N5V A;  4GA6 A;  3QSA A;  4OWU A;  1AZY A;  3H5Q A;  4OWV A;  4X5A A;  3R6C A;  3QQS A;  4OWO A;  1OTP A;  5BO3 A;  4ZTV A;  4YYY A;  1ZXY A;  2J0F A; 
#chains in the Genus database with same CATH homology
 3QS8 A;  5EP8 A;  4X59 A;  4IJ1 A;  4X5D A;  5BO2 A;  4YI7 A;  1O17 A;  4ZOJ A;  4N8Q A;  4OWQ A;  4GTN A;  5C2L A;  4OWS A;  3QR9 A;  4OWN A;  4GKM A;  4HKM A;  5BYT A;  1UOU A;  4GA4 A;  4X5B A;  3UU1 A;  4EAD A;  1ZVW A;  3R88 A;  1GXB A;  2GVQ A;  4X58 A;  1V8G A;  1KGZ A;  1VQU A;  2DSJ A;  1KHD A;  5BNE A;  1ZYK A;  4LHM A;  4N93 A;  2WK5 A;  2WK6 A;  4GA5 A;  4OWM A;  4X5C A;  4M0R A;  4YEK A;  2BPQ A;  5EY3 A;  3GBR A;  2TPT A;  4ZOF A;  4EAF A;  4X46 A;  4MUO A;  3TWP A;  2ELC A;  4ZOK A;  4XR5 A;  1BRW A;  4X5E A;  5C1R A;  5C7S A;  4GIU A;  4N5V A;  4GA6 A;  3QSA A;  4OWU A;  1AZY A;  3H5Q A;  4OWV A;  4X5A A;  3R6C A;  3QQS A;  4OWO A;  1OTP A;  5BO3 A;  4ZTV A;  4YYY A;  1ZXY A;  2J0F A; 
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