3QS8A

Anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis (complex with inhibitor acs174)
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
346
structure length
346
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 115
structure length 346
sequence length 346
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2011-02-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 3qs8A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 3qs8A02
3QS8A 4OWMA 2J0FA 4ZOJA 4X5CA 1KGZA 1V8GA 3R6CA 4IJ1A 4N5VA 4YYYA 1ZXYA 4M0RA 4OWUA 1ZYKA 4ZOKA 3QR9A 5EP8A 4EAFA 3H5QA 4X5AA 1AZYA 2DSJA 3UU1A 3QQSA 3TWPA 1ZVWA 5BYTA 4X58A 4GA6A 4GA4A 1GXBA 5BO3A 4OWQA 5C7SA 4EADA 4LHMA 5C1RA 4ZTVA 4ZOFA 5C2LA 1KHDA 4OWSA 1BRWA 4GTNA 2BPQA 5EY3A 4GA5A 4X46A 4X5EA 4X59A 2WK5A 4OWVA 1VQUA 4OWOA 2GVQA 4N8QA 1UOUA 1O17A 5BO2A 4GKMA 4MUOA 3QSAA 5BNEA 3R88A 4YI7A 2TPTA 4GIUA 4X5BA 1OTPA 4N93A 4OWNA 4YEKA 4X5DA 4XR5A 3GBRA 4HKMA 2ELCA 2WK6A
chains in the Genus database with same CATH superfamily
3QS8A 4OWMA 2J0FA 4ZOJA 4X5CA 1KGZA 1V8GA 3R6CA 4IJ1A 4N5VA 4YYYA 1ZXYA 4M0RA 4OWUA 1ZYKA 4ZOKA 3QR9A 5EP8A 4EAFA 3H5QA 4X5AA 1AZYA 2DSJA 3UU1A 3QQSA 3TWPA 1ZVWA 5BYTA 4GA6A 4X58A 4GA4A 1GXBA 5BO3A 4OWQA 5C7SA 4EADA 4LHMA 5C1RA 4ZTVA 4ZOFA 5C2LA 1KHDA 4OWSA 1BRWA 4GTNA 2BPQA 5EY3A 4GA5A 4X46A 4X5EA 4X59A 2WK5A 4OWVA 1VQUA 4OWOA 2GVQA 4N8QA 1UOUA 1O17A 5BO2A 4GKMA 4MUOA 3QSAA 5BNEA 3R88A 1RRZA 4YI7A 2TPTA 4GIUA 4X5BA 1OTPA 4N93A 4OWNA 4F3FC 4YEKA 4X5DA 4XR5A 1RF8B 3GBRA 4HKMA 2ELCA 2WK6A
chains in the Genus database with same CATH topology
3QS8A 4OWMA 2J0FA 4ZOJA 4X5CA 1KGZA 1V8GA 3R6CA 4IJ1A 4N5VA 4YYYA 1ZXYA 4M0RA 4OWUA 1ZYKA 4ZOKA 3QR9A 5EP8A 4EAFA 3H5QA 4X5AA 1AZYA 2DSJA 3UU1A 3QQSA 3TWPA 1ZVWA 5BYTA 4X58A 4GA6A 4GA4A 1GXBA 5BO3A 4OWQA 5C7SA 4EADA 4LHMA 5C1RA 4ZTVA 4ZOFA 5C2LA 1KHDA 4OWSA 1BRWA 4GTNA 2BPQA 5EY3A 4GA5A 4X46A 4X5EA 4X59A 2WK5A 4OWVA 1VQUA 4OWOA 2GVQA 4N8QA 1UOUA 1O17A 5BO2A 4GKMA 4MUOA 3QSAA 5BNEA 3R88A 4YI7A 2TPTA 4GIUA 4X5BA 1OTPA 4N93A 4OWNA 4YEKA 4X5DA 4XR5A 3GBRA 4HKMA 2ELCA 2WK6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QS8 A;  4OWM A;  2J0F A;  4ZOJ A;  4X5C A;  1KGZ A;  1V8G A;  3R6C A;  4IJ1 A;  4N5V A;  4YYY A;  1ZXY A;  4M0R A;  4OWU A;  1ZYK A;  4ZOK A;  3QR9 A;  5EP8 A;  4EAF A;  3H5Q A;  4X5A A;  1AZY A;  2DSJ A;  3UU1 A;  3QQS A;  3TWP A;  1ZVW A;  5BYT A;  4X58 A;  4GA6 A;  4GA4 A;  1GXB A;  5BO3 A;  4OWQ A;  5C7S A;  4EAD A;  4LHM A;  5C1R A;  4ZTV A;  4ZOF A;  5C2L A;  1KHD A;  4OWS A;  1BRW A;  4GTN A;  2BPQ A;  5EY3 A;  4GA5 A;  4X46 A;  4X5E A;  4X59 A;  2WK5 A;  4OWV A;  1VQU A;  4OWO A;  2GVQ A;  4N8Q A;  1UOU A;  1O17 A;  5BO2 A;  4GKM A;  4MUO A;  3QSA A;  5BNE A;  3R88 A;  4YI7 A;  2TPT A;  4GIU A;  4X5B A;  1OTP A;  4N93 A;  4OWN A;  4YEK A;  4X5D A;  4XR5 A;  3GBR A;  4HKM A;  2ELC A;  2WK6 A; 
#chains in the Genus database with same CATH topology
 3QS8 A;  4OWM A;  2J0F A;  4ZOJ A;  4X5C A;  1KGZ A;  1V8G A;  3R6C A;  4IJ1 A;  4N5V A;  4YYY A;  1ZXY A;  4M0R A;  4OWU A;  1ZYK A;  4ZOK A;  3QR9 A;  5EP8 A;  4EAF A;  3H5Q A;  4X5A A;  1AZY A;  2DSJ A;  3UU1 A;  3QQS A;  3TWP A;  1ZVW A;  5BYT A;  4GA6 A;  4X58 A;  4GA4 A;  1GXB A;  5BO3 A;  4OWQ A;  5C7S A;  4EAD A;  4LHM A;  5C1R A;  4ZTV A;  4ZOF A;  5C2L A;  1KHD A;  4OWS A;  1BRW A;  4GTN A;  2BPQ A;  5EY3 A;  4GA5 A;  4X46 A;  4X5E A;  4X59 A;  2WK5 A;  4OWV A;  1VQU A;  4OWO A;  2GVQ A;  4N8Q A;  1UOU A;  1O17 A;  5BO2 A;  4GKM A;  4MUO A;  3QSA A;  5BNE A;  3R88 A;  1RRZ A;  4YI7 A;  2TPT A;  4GIU A;  4X5B A;  1OTP A;  4N93 A;  4OWN A;  4F3F C;  4YEK A;  4X5D A;  4XR5 A;  1RF8 B;  3GBR A;  4HKM A;  2ELC A;  2WK6 A; 
#chains in the Genus database with same CATH homology
 3QS8 A;  4OWM A;  2J0F A;  4ZOJ A;  4X5C A;  1KGZ A;  1V8G A;  3R6C A;  4IJ1 A;  4N5V A;  4YYY A;  1ZXY A;  4M0R A;  4OWU A;  1ZYK A;  4ZOK A;  3QR9 A;  5EP8 A;  4EAF A;  3H5Q A;  4X5A A;  1AZY A;  2DSJ A;  3UU1 A;  3QQS A;  3TWP A;  1ZVW A;  5BYT A;  4X58 A;  4GA6 A;  4GA4 A;  1GXB A;  5BO3 A;  4OWQ A;  5C7S A;  4EAD A;  4LHM A;  5C1R A;  4ZTV A;  4ZOF A;  5C2L A;  1KHD A;  4OWS A;  1BRW A;  4GTN A;  2BPQ A;  5EY3 A;  4GA5 A;  4X46 A;  4X5E A;  4X59 A;  2WK5 A;  4OWV A;  1VQU A;  4OWO A;  2GVQ A;  4N8Q A;  1UOU A;  1O17 A;  5BO2 A;  4GKM A;  4MUO A;  3QSA A;  5BNE A;  3R88 A;  4YI7 A;  2TPT A;  4GIU A;  4X5B A;  1OTP A;  4N93 A;  4OWN A;  4YEK A;  4X5D A;  4XR5 A;  3GBR A;  4HKM A;  2ELC A;  2WK6 A; 
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