4X5EA

Anthranilate phosphoribosyltransferase variant r194a from mycobacterium tuberculosis with pyrophosphate, mg2+ and anthranilate bound
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
348
structure length
345
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRALSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRAEIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQIL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 119
structure length 345
sequence length 348
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2014-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x5eA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x5eA02
4X5AA 1BRWA 2WK6A 5EY3A 4N8QA 5BO2A 3R6CA 4HKMA 5BNEA 4N93A 4EADA 4GA5A 4GA6A 4YEKA 4X5DA 4GIUA 1GXBA 1KGZA 4ZOJA 4LHMA 3QS8A 1O17A 2DSJA 1KHDA 4M0RA 1ZYKA 5C7SA 5BYTA 2TPTA 4X5BA 3R88A 3TWPA 4X5EA 5C2LA 3GBRA 4IJ1A 3H5QA 1OTPA 2ELCA 2WK5A 4GKMA 4ZOFA 4X5CA 4GA4A 4X59A 4ZTVA 4OWSA 1AZYA 3UU1A 4N5VA 2GVQA 3QSAA 4XR5A 1VQUA 4YYYA 1ZVWA 4GTNA 4OWUA 2J0FA 5BO3A 4MUOA 4OWMA 4ZOKA 3QR9A 2BPQA 4X58A 4EAFA 4OWOA 4YI7A 4X46A 5C1RA 4OWNA 3QQSA 1UOUA 4OWQA 1ZXYA 4OWVA 5EP8A 1V8GA
chains in the Genus database with same CATH superfamily
4X5AA 1BRWA 2WK6A 5EY3A 4N8QA 5BO2A 3R6CA 4HKMA 5BNEA 4N93A 4GA5A 4EADA 4GA6A 4YEKA 4X5DA 4GIUA 1GXBA 1KGZA 4ZOJA 4LHMA 3QS8A 1O17A 2DSJA 1KHDA 4M0RA 1ZYKA 5C7SA 5BYTA 2TPTA 4X5BA 3R88A 3TWPA 4X5EA 5C2LA 3GBRA 4IJ1A 3H5QA 1OTPA 2ELCA 2WK5A 4GKMA 4ZOFA 4X5CA 4GA4A 1RF8B 4X59A 4ZTVA 4OWSA 1AZYA 3UU1A 4N5VA 2GVQA 3QSAA 4XR5A 1VQUA 4YYYA 1ZVWA 4GTNA 4OWUA 2J0FA 5BO3A 4MUOA 4OWMA 4ZOKA 3QR9A 2BPQA 4X58A 4EAFA 4OWOA 4YI7A 4X46A 5C1RA 4OWNA 3QQSA 1UOUA 4OWQA 4F3FC 1ZXYA 1RRZA 4OWVA 5EP8A 1V8GA
chains in the Genus database with same CATH topology
4X5AA 1BRWA 2WK6A 5EY3A 4N8QA 5BO2A 3R6CA 4HKMA 5BNEA 4N93A 4EADA 4GA5A 4GA6A 4YEKA 4X5DA 4GIUA 1GXBA 1KGZA 4ZOJA 4LHMA 3QS8A 1O17A 2DSJA 1KHDA 4M0RA 1ZYKA 5C7SA 5BYTA 2TPTA 4X5BA 3R88A 3TWPA 4X5EA 5C2LA 3GBRA 4IJ1A 3H5QA 1OTPA 2ELCA 2WK5A 4GKMA 4ZOFA 4X5CA 4GA4A 4X59A 4ZTVA 4OWSA 1AZYA 3UU1A 4N5VA 2GVQA 3QSAA 4XR5A 1VQUA 4YYYA 1ZVWA 4GTNA 4OWUA 2J0FA 5BO3A 4MUOA 4OWMA 4ZOKA 3QR9A 2BPQA 4X58A 4EAFA 4OWOA 4YI7A 4X46A 5C1RA 4OWNA 3QQSA 1UOUA 4OWQA 1ZXYA 4OWVA 5EP8A 1V8GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X5A A;  1BRW A;  2WK6 A;  5EY3 A;  4N8Q A;  5BO2 A;  3R6C A;  4HKM A;  5BNE A;  4N93 A;  4EAD A;  4GA5 A;  4GA6 A;  4YEK A;  4X5D A;  4GIU A;  1GXB A;  1KGZ A;  4ZOJ A;  4LHM A;  3QS8 A;  1O17 A;  2DSJ A;  1KHD A;  4M0R A;  1ZYK A;  5C7S A;  5BYT A;  2TPT A;  4X5B A;  3R88 A;  3TWP A;  4X5E A;  5C2L A;  3GBR A;  4IJ1 A;  3H5Q A;  1OTP A;  2ELC A;  2WK5 A;  4GKM A;  4ZOF A;  4X5C A;  4GA4 A;  4X59 A;  4ZTV A;  4OWS A;  1AZY A;  3UU1 A;  4N5V A;  2GVQ A;  3QSA A;  4XR5 A;  1VQU A;  4YYY A;  1ZVW A;  4GTN A;  4OWU A;  2J0F A;  5BO3 A;  4MUO A;  4OWM A;  4ZOK A;  3QR9 A;  2BPQ A;  4X58 A;  4EAF A;  4OWO A;  4YI7 A;  4X46 A;  5C1R A;  4OWN A;  3QQS A;  1UOU A;  4OWQ A;  1ZXY A;  4OWV A;  5EP8 A;  1V8G A; 
#chains in the Genus database with same CATH topology
 4X5A A;  1BRW A;  2WK6 A;  5EY3 A;  4N8Q A;  5BO2 A;  3R6C A;  4HKM A;  5BNE A;  4N93 A;  4GA5 A;  4EAD A;  4GA6 A;  4YEK A;  4X5D A;  4GIU A;  1GXB A;  1KGZ A;  4ZOJ A;  4LHM A;  3QS8 A;  1O17 A;  2DSJ A;  1KHD A;  4M0R A;  1ZYK A;  5C7S A;  5BYT A;  2TPT A;  4X5B A;  3R88 A;  3TWP A;  4X5E A;  5C2L A;  3GBR A;  4IJ1 A;  3H5Q A;  1OTP A;  2ELC A;  2WK5 A;  4GKM A;  4ZOF A;  4X5C A;  4GA4 A;  1RF8 B;  4X59 A;  4ZTV A;  4OWS A;  1AZY A;  3UU1 A;  4N5V A;  2GVQ A;  3QSA A;  4XR5 A;  1VQU A;  4YYY A;  1ZVW A;  4GTN A;  4OWU A;  2J0F A;  5BO3 A;  4MUO A;  4OWM A;  4ZOK A;  3QR9 A;  2BPQ A;  4X58 A;  4EAF A;  4OWO A;  4YI7 A;  4X46 A;  5C1R A;  4OWN A;  3QQS A;  1UOU A;  4OWQ A;  4F3F C;  1ZXY A;  1RRZ A;  4OWV A;  5EP8 A;  1V8G A; 
#chains in the Genus database with same CATH homology
 4X5A A;  1BRW A;  2WK6 A;  5EY3 A;  4N8Q A;  5BO2 A;  3R6C A;  4HKM A;  5BNE A;  4N93 A;  4EAD A;  4GA5 A;  4GA6 A;  4YEK A;  4X5D A;  4GIU A;  1GXB A;  1KGZ A;  4ZOJ A;  4LHM A;  3QS8 A;  1O17 A;  2DSJ A;  1KHD A;  4M0R A;  1ZYK A;  5C7S A;  5BYT A;  2TPT A;  4X5B A;  3R88 A;  3TWP A;  4X5E A;  5C2L A;  3GBR A;  4IJ1 A;  3H5Q A;  1OTP A;  2ELC A;  2WK5 A;  4GKM A;  4ZOF A;  4X5C A;  4GA4 A;  4X59 A;  4ZTV A;  4OWS A;  1AZY A;  3UU1 A;  4N5V A;  2GVQ A;  3QSA A;  4XR5 A;  1VQU A;  4YYY A;  1ZVW A;  4GTN A;  4OWU A;  2J0F A;  5BO3 A;  4MUO A;  4OWM A;  4ZOK A;  3QR9 A;  2BPQ A;  4X58 A;  4EAF A;  4OWO A;  4YI7 A;  4X46 A;  5C1R A;  4OWN A;  3QQS A;  1UOU A;  4OWQ A;  1ZXY A;  4OWV A;  5EP8 A;  1V8G A; 
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