2TPTA

Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
440
structure length
440
Chain Sequence
LFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords THYMIDINE PHOSPHORYLASE
publication title Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
pubmed doi rcsb
total genus 145
structure length 440
sequence length 440
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 1997-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 2tptA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 2tptA02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 2tptA03
4GTNA 4X5EA 4GA6A 4ZOKA 2WK5A 4GIUA 5BO3A 4X5AA 4GKMA 4OWMA 4ZTVA 2DSJA 1VQUA 1BRWA 4YI7A 4X46A 5BNEA 4OWOA 4X5BA 4X5DA 1ZXYA 1KGZA 2TPTA 4ZOJA 4N5VA 1V8GA 4X59A 1OTPA 2J0FA 4OWQA 5BYTA 3UU1A 3QSAA 3QQSA 1UOUA 4N8QA 2ELCA 5C1RA 1O17A 4X5CA 4N93A 4YYYA 4XR5A 4X58A 3R88A 2GVQA 5C7SA 1ZYKA 4YEKA 3TWPA 3H5QA 3GBRA 4OWVA 4EADA 3R6CA 4ZOFA 4HKMA 4GA5A 4IJ1A 4MUOA 4OWNA 4LHMA 1GXBA 2BPQA 2WK6A 1ZVWA 4OWUA 4OWSA 5EP8A 5C2LA 3QR9A 4EAFA 1AZYA 5EY3A 3QS8A 4GA4A 1KHDA 5BO2A 4M0RA
chains in the Genus database with same CATH superfamily
2B7PA 5HUPA 3DLLJ 3CMEH 4GTNA 4X5EA 3OW2H 4AP8A 1K73J 1VLBA 1W2BH 3WNZA 3CMAH 3CCVH 1Q82J 1NVJA 1QPOA 3CCJH 2QA4H 1K8AJ 4GA6A 4USAA 2I1OA 4ZOKA 2WK5A 4U67J 4GIUA 3AM9A 5BO3A 3C2RA 4X5AA 1VDVA 3NRZC 1VQ6H 1FO4A 3B9JC 4GKMA 4OWMA 5DM7J 1FMAE 3CXCH 1VQ4H 3NVYC 3L0GA 4ZTVA 2DSJA 1VQUA 1BRWA 5JVGJ 4YI7A 4X46A 1M90J 1Y69K 5BNEA 4OWOA 4X5BA 1VQ9H 4X5DA 4WFBJ 2QEXH 1O4UA 5GAEN 1VQKH 1Q7YJ 3CCQH 3WO0A 1S72H 1ZXYA 1YTKA 5AYYA 2B7QA 1KGZA 2TPTA 1VQMH 1YITH 3PIPJ 3CCRH 3CD6H 1N5XA 5HULA 4WFAJ 5AN9F 3CCUH 1YTDA 1QPNA 4ZOJA 3AN1A 3CCLH 1VQPH 1YHQH 4WF9J 3PAJA 2OTJH 4N5VA 3GNNA 1KD1J 3C2EA 3VMMA 4WCEJ 5HUOA 3CC4H 1N63B 3CPWH 1V8GA 4US8A 5JVHJ 4X59A 1OTPA 4F3FC 3NS1C 1FFVB 3RPFA 2J0FA 2W54B 4OWQA 1VQNH 5BYTA 5H1SO 3UU1A 1YI2H 2Q5WE 3QSAA 2PA2A 4KWVA 2W3RB 3CF5J 3BIIE 1RM6A 4UY8M 3QQSA 1UOUA 3C2FA 4C7ZA 4N8QA 3PIOJ 1YTEA 3I56H 3G71H 1YIJH 2ELCA 3CC7H 2WP4A 5C1RA 1N8RJ 1M1KJ 1KC8J 1QVGH 1K9MJ 1O17A 4X5CA 1N62B 2W3SB 4N93A 4YYYA 4XR5A 4WFNJ 4IOCJ 3CCSH 1VQ7H 4X58A 3R88A 1SIJA 2GVQA 3CC2H 3FAHA 1N5WB 1N60B 2B7NA 5HL7J 5C7SA 3C2OA 4C80A 5MPOC 1ZYKA 1QPQA 4YEKA 3TWPA 3EUB4 2OTLH 1FIQC 4C7YA 3ETRC 2ZJPJ 3H5QA 3G4SH 3GBRA 4IOAJ 1NVIE 4OWVA 1N61B 5GAHN 4EADA 1WKIA 1JROB 3R6CA 4ZOFA 3SR6C 2QIEA 1JJ2H 1ZXIB 1X1OA 4HKMA 1FM0E 2OMDA 4ZOHA 3I55H 2ZJQJ 4IO9J 1VQ8H 4GA5A 4IJ1A 4MUOA 1JRPB 4OWNA 1YJNH 1VQ5H 3G6EH 1NJIJ 4LHMA 2W55B 4I9AA 1VQOH 1QPRA 1GXBA 3NVWC 3NVZC 3AMZA 5AYZA 2JBMA 5MLCO 1WYGA 2BPQA 1YJWH 1Q81J 2WK6A 1Q86J 3CCMH 3TQVA 1ZVWA 4OWUA 2I14A 3WO1A 5GADN 4OWSA 5EP8A 5C2LA 1KQSH 2E3TA 3C2VA 1QAPA 2ZJRJ 1RRZA 4US9A 5AYXA 3FC4A 1SB3A 1YJ9H 1QVFH 4KWWA 3NVVC 3QR9A 4EAFA 1AZYA 3L4PA 5EY3A 1RF8B 3CCEH 3QS8A 5DM6J 1VQLH 5GAGN 1FFUB 1V97A 4GA4A 1DGJA 1KHDA 3J7ZM 5BO2A 4M0RA
chains in the Genus database with same CATH topology
4GTNA 4X5EA 4GA6A 4ZOKA 2WK5A 4GIUA 5BO3A 4X5AA 4GKMA 4OWMA 4ZTVA 2DSJA 1VQUA 1BRWA 4YI7A 4X46A 5BNEA 4OWOA 4X5BA 4X5DA 1ZXYA 1KGZA 2TPTA 4ZOJA 4N5VA 1V8GA 4X59A 1OTPA 2J0FA 4OWQA 5BYTA 3UU1A 3QSAA 3QQSA 1UOUA 4N8QA 2ELCA 5C1RA 1O17A 4X5CA 4N93A 4YYYA 4XR5A 4X58A 3R88A 2GVQA 5C7SA 1ZYKA 4YEKA 3TWPA 3H5QA 3GBRA 4OWVA 4EADA 3R6CA 4ZOFA 4HKMA 4GA5A 4IJ1A 4MUOA 4OWNA 4LHMA 1GXBA 2BPQA 2WK6A 1ZVWA 4OWUA 4OWSA 5EP8A 5C2LA 3QR9A 4EAFA 1AZYA 5EY3A 3QS8A 4GA4A 1KHDA 5BO2A 4M0RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GTN A;  4X5E A;  4GA6 A;  4ZOK A;  2WK5 A;  4GIU A;  5BO3 A;  4X5A A;  4GKM A;  4OWM A;  4ZTV A;  2DSJ A;  1VQU A;  1BRW A;  4YI7 A;  4X46 A;  5BNE A;  4OWO A;  4X5B A;  4X5D A;  1ZXY A;  1KGZ A;  2TPT A;  4ZOJ A;  4N5V A;  1V8G A;  4X59 A;  1OTP A;  2J0F A;  4OWQ A;  5BYT A;  3UU1 A;  3QSA A;  3QQS A;  1UOU A;  4N8Q A;  2ELC A;  5C1R A;  1O17 A;  4X5C A;  4N93 A;  4YYY A;  4XR5 A;  4X58 A;  3R88 A;  2GVQ A;  5C7S A;  1ZYK A;  4YEK A;  3TWP A;  3H5Q A;  3GBR A;  4OWV A;  4EAD A;  3R6C A;  4ZOF A;  4HKM A;  4GA5 A;  4IJ1 A;  4MUO A;  4OWN A;  4LHM A;  1GXB A;  2BPQ A;  2WK6 A;  1ZVW A;  4OWU A;  4OWS A;  5EP8 A;  5C2L A;  3QR9 A;  4EAF A;  1AZY A;  5EY3 A;  3QS8 A;  4GA4 A;  1KHD A;  5BO2 A;  4M0R A; 
#chains in the Genus database with same CATH topology
 2B7P A;  5HUP A;  3DLL J;  3CME H;  4GTN A;  4X5E A;  3OW2 H;  4AP8 A;  1K73 J;  1VLB A;  1W2B H;  3WNZ A;  3CMA H;  3CCV H;  1Q82 J;  1NVJ A;  1QPO A;  3CCJ H;  2QA4 H;  1K8A J;  4GA6 A;  4USA A;  2I1O A;  4ZOK A;  2WK5 A;  4U67 J;  4GIU A;  3AM9 A;  5BO3 A;  3C2R A;  4X5A A;  1VDV A;  3NRZ C;  1VQ6 H;  1FO4 A;  3B9J C;  4GKM A;  4OWM A;  5DM7 J;  1FMA E;  3CXC H;  1VQ4 H;  3NVY C;  3L0G A;  4ZTV A;  2DSJ A;  1VQU A;  1BRW A;  5JVG J;  4YI7 A;  4X46 A;  1M90 J;  1Y69 K;  5BNE A;  4OWO A;  4X5B A;  1VQ9 H;  4X5D A;  4WFB J;  2QEX H;  1O4U A;  5GAE N;  1VQK H;  1Q7Y J;  3CCQ H;  3WO0 A;  1S72 H;  1ZXY A;  1YTK A;  5AYY A;  2B7Q A;  1KGZ A;  2TPT A;  1VQM H;  1YIT H;  3PIP J;  3CCR H;  3CD6 H;  1N5X A;  5HUL A;  4WFA J;  5AN9 F;  3CCU H;  1YTD A;  1QPN A;  4ZOJ A;  3AN1 A;  3CCL H;  1VQP H;  1YHQ H;  4WF9 J;  3PAJ A;  2OTJ H;  4N5V A;  3GNN A;  1KD1 J;  3C2E A;  3VMM A;  4WCE J;  5HUO A;  3CC4 H;  1N63 B;  3CPW H;  1V8G A;  4US8 A;  5JVH J;  4X59 A;  1OTP A;  4F3F C;  3NS1 C;  1FFV B;  3RPF A;  2J0F A;  2W54 B;  4OWQ A;  1VQN H;  5BYT A;  5H1S O;  3UU1 A;  1YI2 H;  2Q5W E;  3QSA A;  2PA2 A;  4KWV A;  2W3R B;  3CF5 J;  3BII E;  1RM6 A;  4UY8 M;  3QQS A;  1UOU A;  3C2F A;  4C7Z A;  4N8Q A;  3PIO J;  1YTE A;  3I56 H;  3G71 H;  1YIJ H;  2ELC A;  3CC7 H;  2WP4 A;  5C1R A;  1N8R J;  1M1K J;  1KC8 J;  1QVG H;  1K9M J;  1O17 A;  4X5C A;  1N62 B;  2W3S B;  4N93 A;  4YYY A;  4XR5 A;  4WFN J;  4IOC J;  3CCS H;  1VQ7 H;  4X58 A;  3R88 A;  1SIJ A;  2GVQ A;  3CC2 H;  3FAH A;  1N5W B;  1N60 B;  2B7N A;  5HL7 J;  5C7S A;  3C2O A;  4C80 A;  5MPO C;  1ZYK A;  1QPQ A;  4YEK A;  3TWP A;  3EUB 4;  2OTL H;  1FIQ C;  4C7Y A;  3ETR C;  2ZJP J;  3H5Q A;  3G4S H;  3GBR A;  4IOA J;  1NVI E;  4OWV A;  1N61 B;  5GAH N;  4EAD A;  1WKI A;  1JRO B;  3R6C A;  4ZOF A;  3SR6 C;  2QIE A;  1JJ2 H;  1ZXI B;  1X1O A;  4HKM A;  1FM0 E;  2OMD A;  4ZOH A;  3I55 H;  2ZJQ J;  4IO9 J;  1VQ8 H;  4GA5 A;  4IJ1 A;  4MUO A;  1JRP B;  4OWN A;  1YJN H;  1VQ5 H;  3G6E H;  1NJI J;  4LHM A;  2W55 B;  4I9A A;  1VQO H;  1QPR A;  1GXB A;  3NVW C;  3NVZ C;  3AMZ A;  5AYZ A;  2JBM A;  5MLC O;  1WYG A;  2BPQ A;  1YJW H;  1Q81 J;  2WK6 A;  1Q86 J;  3CCM H;  3TQV A;  1ZVW A;  4OWU A;  2I14 A;  3WO1 A;  5GAD N;  4OWS A;  5EP8 A;  5C2L A;  1KQS H;  2E3T A;  3C2V A;  1QAP A;  2ZJR J;  1RRZ A;  4US9 A;  5AYX A;  3FC4 A;  1SB3 A;  1YJ9 H;  1QVF H;  4KWW A;  3NVV C;  3QR9 A;  4EAF A;  1AZY A;  3L4P A;  5EY3 A;  1RF8 B;  3CCE H;  3QS8 A;  5DM6 J;  1VQL H;  5GAG N;  1FFU B;  1V97 A;  4GA4 A;  1DGJ A;  1KHD A;  3J7Z M;  5BO2 A;  4M0R A; 
#chains in the Genus database with same CATH homology
 4GTN A;  4X5E A;  4GA6 A;  4ZOK A;  2WK5 A;  4GIU A;  5BO3 A;  4X5A A;  4GKM A;  4OWM A;  4ZTV A;  2DSJ A;  1VQU A;  1BRW A;  4YI7 A;  4X46 A;  5BNE A;  4OWO A;  4X5B A;  4X5D A;  1ZXY A;  1KGZ A;  2TPT A;  4ZOJ A;  4N5V A;  1V8G A;  4X59 A;  1OTP A;  2J0F A;  4OWQ A;  5BYT A;  3UU1 A;  3QSA A;  3QQS A;  1UOU A;  4N8Q A;  2ELC A;  5C1R A;  1O17 A;  4X5C A;  4N93 A;  4YYY A;  4XR5 A;  4X58 A;  3R88 A;  2GVQ A;  5C7S A;  1ZYK A;  4YEK A;  3TWP A;  3H5Q A;  3GBR A;  4OWV A;  4EAD A;  3R6C A;  4ZOF A;  4HKM A;  4GA5 A;  4IJ1 A;  4MUO A;  4OWN A;  4LHM A;  1GXB A;  2BPQ A;  2WK6 A;  1ZVW A;  4OWU A;  4OWS A;  5EP8 A;  5C2L A;  3QR9 A;  4EAF A;  1AZY A;  5EY3 A;  3QS8 A;  4GA4 A;  1KHD A;  5BO2 A;  4M0R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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