2WK5A

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
448
structure length
448
Chain Sequence
EPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords THYMIDINE PHOSPHORYLASE
publication title Structures of Native Human Thymidine Phosphorylase and in Complex with 5-Iodouracil.
pubmed doi rcsb
source organism Homo sapiens
total genus 145
structure length 448
sequence length 448
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2009-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 2wk5A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 2wk5A02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 2wk5A03
4X58A 4XR5A 4YYYA 1KGZA 3QSAA 4HKMA 4X46A 4LHMA 4OWQA 1OTPA 3R6CA 1ZYKA 1VQUA 5BO2A 4EADA 4X5CA 4GIUA 1GXBA 2ELCA 5C7SA 4ZTVA 4ZOKA 2BPQA 3UU1A 1ZVWA 2TPTA 4OWVA 1V8GA 4X59A 2WK5A 4GKMA 4IJ1A 4OWNA 4YI7A 5BYTA 4MUOA 4EAFA 4OWOA 1AZYA 5C1RA 4N5VA 4X5EA 4M0RA 5BNEA 4N8QA 4ZOFA 4X5BA 4YEKA 4GA6A 2DSJA 3H5QA 1KHDA 3GBRA 2GVQA 4GA5A 4ZOJA 5C2LA 4X5DA 4N93A 4GTNA 3R88A 5BO3A 1UOUA 2WK6A 4OWMA 5EP8A 4OWUA 4GA4A 5EY3A 3QR9A 4X5AA 1O17A 3QS8A 3TWPA 1ZXYA 2J0FA 4OWSA 1BRWA 3QQSA
chains in the Genus database with same CATH superfamily
2W3SB 1M1KJ 1W2BH 1KD1J 3I55H 4X58A 3C2VA 4XR5A 3GNNA 4C80A 4YYYA 4USAA 1KGZA 3QSAA 4IOCJ 1VQ9H 1RM6A 1QAPA 4HKMA 4X46A 1DGJA 3PAJA 1YTKA 4LHMA 1SIJA 4OWQA 1YHQH 1Q7YJ 1KQSH 5H1SO 1OTPA 5GAEN 4C7ZA 1Y69K 1ZXIB 1N63B 3R6CA 1ZYKA 1VQUA 5AYXA 1RRZA 1JROB 1VLBA 1KC8J 1VQ7H 5BO2A 3CCLH 4EADA 3PIOJ 3AN1A 3CCMH 1FO4A 4X5CA 4GIUA 1GXBA 2ELCA 5C7SA 1VQLH 4IO9J 1VQKH 5HULA 4ZTVA 3G6EH 3C2RA 4I9AA 1VQPH 1WKIA 4ZOKA 1N60B 3TQVA 3I56H 1K9MJ 5HL7J 2W3RB 3RPFA 1VDVA 5GAHN 4F3FC 2BPQA 3UU1A 4US8A 1ZVWA 1N61B 3VMMA 2TPTA 4OWVA 1V8GA 4X59A 2WK5A 1N62B 4GKMA 1YTEA 4IJ1A 3ETRC 2QA4H 1YJ9H 1VQ6H 1FFVB 4OWNA 2OTJH 4C7YA 3FC4A 3AM9A 1VQ4H 4YI7A 3EUB4 2PA2A 4WCEJ 5JVGJ 3CCQH 1FM0E 1Q81J 1V97A 5BYTA 2QEXH 4MUOA 3NVZC 3G71H 4EAFA 4OWOA 3FAHA 3CC2H 3CCJH 3CCSH 5AYYA 4AP8A 4U67J 1RF8B 5DM7J 1AZYA 5C1RA 4N5VA 4X5EA 4M0RA 2JBMA 3NVYC 4US9A 5BNEA 3C2FA 3C2OA 5MLCO 1K73J 4N8QA 3NRZC 4ZOFA 1QPOA 1QPNA 2B7NA 4X5BA 1VQOH 1S72H 4YEKA 5HUPA 4WF9J 4GA6A 1QPRA 3WO1A 2DSJA 1NJIJ 3SR6C 3H5QA 1Q82J 1N5XA 1QVGH 1YTDA 1KHDA 3GBRA 2GVQA 4GA5A 2W55B 2ZJRJ 3DLLJ 1YIJH 4UY8M 5AN9F 5MPOC 3BIIE 3CMAH 4ZOJA 1VQ5H 2I1OA 3WO0A 1YI2H 2ZJPJ 2W54B 3J7ZM 5C2LA 3CF5J 4X5DA 4N93A 3C2EA 5HUOA 3WNZA 1WYGA 1VQMH 1NVJA 4GTNA 2WP4A 3R88A 5BO3A 1VQNH 3CC4H 4IOAJ 1UOUA 1YJWH 1QVFH 3AMZA 5JVHJ 1VQ8H 2WK6A 3L4PA 1Q86J 1JRPB 4OWMA 5EP8A 1FMAE 1NVIE 1YJNH 3CCEH 3CMEH 2QIEA 4OWUA 4GA4A 3CPWH 1SB3A 4KWVA 2B7PA 5EY3A 5DM6J 2OTLH 5GADN 2Q5WE 4WFNJ 4ZOHA 1O4UA 3QR9A 4X5AA 4WFAJ 1FIQC 3B9JC 1O17A 3QS8A 3OW2H 3TWPA 3G4SH 2E3TA 1JJ2H 3PIPJ 4WFBJ 2OMDA 5GAGN 4KWWA 1ZXYA 3L0GA 3CXCH 1YITH 3CD6H 1M90J 3NVVC 1K8AJ 2J0FA 3NVWC 3CCVH 4OWSA 1FFUB 2I14A 1N5WB 3CCUH 3CC7H 1QPQA 1BRWA 3QQSA 2B7QA 3NS1C 2ZJQJ 1N8RJ 5AYZA 1X1OA 3CCRH
chains in the Genus database with same CATH topology
4X58A 4XR5A 4YYYA 1KGZA 3QSAA 4HKMA 4X46A 4LHMA 4OWQA 1OTPA 3R6CA 1ZYKA 1VQUA 5BO2A 4EADA 4X5CA 4GIUA 1GXBA 2ELCA 5C7SA 4ZTVA 4ZOKA 2BPQA 3UU1A 1ZVWA 2TPTA 4OWVA 1V8GA 4X59A 2WK5A 4GKMA 4IJ1A 4OWNA 4YI7A 5BYTA 4MUOA 4EAFA 4OWOA 1AZYA 5C1RA 4N5VA 4X5EA 4M0RA 5BNEA 4N8QA 4ZOFA 4X5BA 4YEKA 4GA6A 2DSJA 3H5QA 1KHDA 3GBRA 2GVQA 4GA5A 4ZOJA 5C2LA 4X5DA 4N93A 4GTNA 3R88A 5BO3A 1UOUA 2WK6A 4OWMA 5EP8A 4OWUA 4GA4A 5EY3A 3QR9A 4X5AA 1O17A 3QS8A 3TWPA 1ZXYA 2J0FA 4OWSA 1BRWA 3QQSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4X58 A;  4XR5 A;  4YYY A;  1KGZ A;  3QSA A;  4HKM A;  4X46 A;  4LHM A;  4OWQ A;  1OTP A;  3R6C A;  1ZYK A;  1VQU A;  5BO2 A;  4EAD A;  4X5C A;  4GIU A;  1GXB A;  2ELC A;  5C7S A;  4ZTV A;  4ZOK A;  2BPQ A;  3UU1 A;  1ZVW A;  2TPT A;  4OWV A;  1V8G A;  4X59 A;  2WK5 A;  4GKM A;  4IJ1 A;  4OWN A;  4YI7 A;  5BYT A;  4MUO A;  4EAF A;  4OWO A;  1AZY A;  5C1R A;  4N5V A;  4X5E A;  4M0R A;  5BNE A;  4N8Q A;  4ZOF A;  4X5B A;  4YEK A;  4GA6 A;  2DSJ A;  3H5Q A;  1KHD A;  3GBR A;  2GVQ A;  4GA5 A;  4ZOJ A;  5C2L A;  4X5D A;  4N93 A;  4GTN A;  3R88 A;  5BO3 A;  1UOU A;  2WK6 A;  4OWM A;  5EP8 A;  4OWU A;  4GA4 A;  5EY3 A;  3QR9 A;  4X5A A;  1O17 A;  3QS8 A;  3TWP A;  1ZXY A;  2J0F A;  4OWS A;  1BRW A;  3QQS A; 
#chains in the Genus database with same CATH topology
 2W3S B;  1M1K J;  1W2B H;  1KD1 J;  3I55 H;  4X58 A;  3C2V A;  4XR5 A;  3GNN A;  4C80 A;  4YYY A;  4USA A;  1KGZ A;  3QSA A;  4IOC J;  1VQ9 H;  1RM6 A;  1QAP A;  4HKM A;  4X46 A;  1DGJ A;  3PAJ A;  1YTK A;  4LHM A;  1SIJ A;  4OWQ A;  1YHQ H;  1Q7Y J;  1KQS H;  5H1S O;  1OTP A;  5GAE N;  4C7Z A;  1Y69 K;  1ZXI B;  1N63 B;  3R6C A;  1ZYK A;  1VQU A;  5AYX A;  1RRZ A;  1JRO B;  1VLB A;  1KC8 J;  1VQ7 H;  5BO2 A;  3CCL H;  4EAD A;  3PIO J;  3AN1 A;  3CCM H;  1FO4 A;  4X5C A;  4GIU A;  1GXB A;  2ELC A;  5C7S A;  1VQL H;  4IO9 J;  1VQK H;  5HUL A;  4ZTV A;  3G6E H;  3C2R A;  4I9A A;  1VQP H;  1WKI A;  4ZOK A;  1N60 B;  3TQV A;  3I56 H;  1K9M J;  5HL7 J;  2W3R B;  3RPF A;  1VDV A;  5GAH N;  4F3F C;  2BPQ A;  3UU1 A;  4US8 A;  1ZVW A;  1N61 B;  3VMM A;  2TPT A;  4OWV A;  1V8G A;  4X59 A;  2WK5 A;  1N62 B;  4GKM A;  1YTE A;  4IJ1 A;  3ETR C;  2QA4 H;  1YJ9 H;  1VQ6 H;  1FFV B;  4OWN A;  2OTJ H;  4C7Y A;  3FC4 A;  3AM9 A;  1VQ4 H;  4YI7 A;  3EUB 4;  2PA2 A;  4WCE J;  5JVG J;  3CCQ H;  1FM0 E;  1Q81 J;  1V97 A;  5BYT A;  2QEX H;  4MUO A;  3NVZ C;  3G71 H;  4EAF A;  4OWO A;  3FAH A;  3CC2 H;  3CCJ H;  3CCS H;  5AYY A;  4AP8 A;  4U67 J;  1RF8 B;  5DM7 J;  1AZY A;  5C1R A;  4N5V A;  4X5E A;  4M0R A;  2JBM A;  3NVY C;  4US9 A;  5BNE A;  3C2F A;  3C2O A;  5MLC O;  1K73 J;  4N8Q A;  3NRZ C;  4ZOF A;  1QPO A;  1QPN A;  2B7N A;  4X5B A;  1VQO H;  1S72 H;  4YEK A;  5HUP A;  4WF9 J;  4GA6 A;  1QPR A;  3WO1 A;  2DSJ A;  1NJI J;  3SR6 C;  3H5Q A;  1Q82 J;  1N5X A;  1QVG H;  1YTD A;  1KHD A;  3GBR A;  2GVQ A;  4GA5 A;  2W55 B;  2ZJR J;  3DLL J;  1YIJ H;  4UY8 M;  5AN9 F;  5MPO C;  3BII E;  3CMA H;  4ZOJ A;  1VQ5 H;  2I1O A;  3WO0 A;  1YI2 H;  2ZJP J;  2W54 B;  3J7Z M;  5C2L A;  3CF5 J;  4X5D A;  4N93 A;  3C2E A;  5HUO A;  3WNZ A;  1WYG A;  1VQM H;  1NVJ A;  4GTN A;  2WP4 A;  3R88 A;  5BO3 A;  1VQN H;  3CC4 H;  4IOA J;  1UOU A;  1YJW H;  1QVF H;  3AMZ A;  5JVH J;  1VQ8 H;  2WK6 A;  3L4P A;  1Q86 J;  1JRP B;  4OWM A;  5EP8 A;  1FMA E;  1NVI E;  1YJN H;  3CCE H;  3CME H;  2QIE A;  4OWU A;  4GA4 A;  3CPW H;  1SB3 A;  4KWV A;  2B7P A;  5EY3 A;  5DM6 J;  2OTL H;  5GAD N;  2Q5W E;  4WFN J;  4ZOH A;  1O4U A;  3QR9 A;  4X5A A;  4WFA J;  1FIQ C;  3B9J C;  1O17 A;  3QS8 A;  3OW2 H;  3TWP A;  3G4S H;  2E3T A;  1JJ2 H;  3PIP J;  4WFB J;  2OMD A;  5GAG N;  4KWW A;  1ZXY A;  3L0G A;  3CXC H;  1YIT H;  3CD6 H;  1M90 J;  3NVV C;  1K8A J;  2J0F A;  3NVW C;  3CCV H;  4OWS A;  1FFU B;  2I14 A;  1N5W B;  3CCU H;  3CC7 H;  1QPQ A;  1BRW A;  3QQS A;  2B7Q A;  3NS1 C;  2ZJQ J;  1N8R J;  5AYZ A;  1X1O A;  3CCR H; 
#chains in the Genus database with same CATH homology
 4X58 A;  4XR5 A;  4YYY A;  1KGZ A;  3QSA A;  4HKM A;  4X46 A;  4LHM A;  4OWQ A;  1OTP A;  3R6C A;  1ZYK A;  1VQU A;  5BO2 A;  4EAD A;  4X5C A;  4GIU A;  1GXB A;  2ELC A;  5C7S A;  4ZTV A;  4ZOK A;  2BPQ A;  3UU1 A;  1ZVW A;  2TPT A;  4OWV A;  1V8G A;  4X59 A;  2WK5 A;  4GKM A;  4IJ1 A;  4OWN A;  4YI7 A;  5BYT A;  4MUO A;  4EAF A;  4OWO A;  1AZY A;  5C1R A;  4N5V A;  4X5E A;  4M0R A;  5BNE A;  4N8Q A;  4ZOF A;  4X5B A;  4YEK A;  4GA6 A;  2DSJ A;  3H5Q A;  1KHD A;  3GBR A;  2GVQ A;  4GA5 A;  4ZOJ A;  5C2L A;  4X5D A;  4N93 A;  4GTN A;  3R88 A;  5BO3 A;  1UOU A;  2WK6 A;  4OWM A;  5EP8 A;  4OWU A;  4GA4 A;  5EY3 A;  3QR9 A;  4X5A A;  1O17 A;  3QS8 A;  3TWP A;  1ZXY A;  2J0F A;  4OWS A;  1BRW A;  3QQS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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