2WK5A

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
448
structure length
448
Chain Sequence
b'EPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords THYMIDINE PHOSPHORYLASE
publication title Structures of Native Human Thymidine Phosphorylase and in Complex with 5-Iodouracil.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 145
structure length 448
sequence length 448
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2009-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 2wk5A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 2wk5A02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 2wk5A03
1UOUA 1KHDA 4X5DA 4GA5A 4ZOFA 4M0RA 4OWNA 2ELCA 1BRWA 1GXBA 1O17A 3QSAA 4N8QA 5C2LA 5C7SA 1AZYA 4XR5A 3QR9A 1ZXYA 4EAFA 4YI7A 2WK6A 3UU1A 4X5CA 4OWUA 3H5QA 4OWQA 1VQUA 4X59A 4LHMA 3QS8A 2DSJA 4X46A 4EADA 4ZTVA 3GBRA 3QQSA 4OWMA 2GVQA 4YEKA 1KGZA 1ZYKA 2WK5A 4GTNA 4MUOA 4N5VA 3R88A 4IJ1A 5BO3A 4OWOA 1V8GA 4YYYA 4OWVA 4GIUA 2TPTA 1ZVWA 5BO2A 4GA4A 4GKMA 2BPQA 4X5EA 4ZOJA 2J0FA 5BNEA 4GA6A 5EP8A 4OWSA 4X58A 3R6CA 4X5BA 5C1RA 4X5AA 4ZOKA 1OTPA 5BYTA 4HKMA 4N93A 3TWPA 5EY3A
chains in the Genus database with same CATH superfamily
1UOUA 2OTJH 2W3SB 2Q5WE 1N60B 1KHDA 4X5DA 3C2VA 1SIJA 2WP4A 4GA5A 4I9AA 4ZOFA 1FIQC 3CC2H 4M0RA 1QPNA 1YTEA 4OWNA 5MPOC 2ZJQJ 2OMDA 5DM6J 3CC4H 3G4SH 2ZJPJ 1VQ6H 2QIEA 2ELCA 1FFVB 1NVIE 1M90J 1YTDA 1BRWA 3L4PA 1GXBA 1YJNH 1QPOA 2QA4H 4IO9J 5AYXA 5HL7J 3C2FA 1O17A 5HUOA 4US9A 3QSAA 2ZJRJ 3PAJA 3C2RA 1VQ8H 4N8QA 1N5XA 2QEXH 5C2LA 3DLLJ 3CCVH 5AN9F 3C2EA 5C7SA 3CCLH 1AZYA 3PIPJ 1O4UA 4IOAJ 2W3RB 1NVJA 2B7NA 4XR5A 3QR9A 4KWVA 3CCMH 4US8A 1ZXYA 3VMMA 1JRPB 4EAFA 1KD1J 1W2BH 2W55B 3ETRC 3PIOJ 4YI7A 2WK6A 1JROB 1VQ9H 3UU1A 2I14A 1QVGH 4X5CA 5GADN 4OWUA 1N63B 3WNZA 5JVGJ 3AMZA 5MLCO 3AM9A 3H5QA 4OWQA 5HULA 3J7ZM 1VQUA 5HUPA 3CCQH 1VQ4H 1Q81J 4X59A 1KC8J 4LHMA 3TQVA 2OTLH 3QS8A 5AYYA 2DSJA 1VQ7H 4X46A 3CC7H 4USAA 3FC4A 1VQKH 3NVZC 3L0GA 1K9MJ 4EADA 3GNNA 1YITH 1WYGA 1ZXIB 4WFBJ 1YTKA 1YJ9H 1K73J 3BIIE 1SB3A 5AYZA 1Q82J 4WCEJ 4ZTVA 3GBRA 5GAHN 3AN1A 3CXCH 4IOCJ 1VDVA 3QQSA 1Q86J 1VQNH 1FO4A 4C80A 4OWMA 3WO0A 1DGJA 2E3TA 2GVQA 2W54B 4C7YA 1RF8B 5H1SO 4YEKA 4WF9J 3OW2H 1QAPA 2PA2A 3FAHA 1KGZA 3NVVC 1YI2H 1YJWH 1ZYKA 2WK5A 5GAEN 3CMEH 1NJIJ 4GTNA 1VQPH 3G71H 4MUOA 3R88A 4N5VA 1V97A 2I1OA 1RRZA 3NRZC 5GAGN 1K8AJ 1M1KJ 3EUB4 4ZOHA 3I56H 1N62B 3CCRH 1VQMH 1VQLH 1N8RJ 4UY8M 4IJ1A 1QPQA 1VQ5H 1X1OA 3B9JC 3NVYC 5BO3A 1JJ2H 3C2OA 4OWOA 1V8GA 3G6EH 4YYYA 4OWVA 4GIUA 2TPTA 1ZVWA 1N5WB 3RPFA 1YIJH 3NS1C 3I55H 1KQSH 5BO2A 3CPWH 4KWWA 4GA4A 3SR6C 4C7ZA 4GKMA 2BPQA 4F3FC 4X5EA 2B7PA 3CCSH 3CD6H 1FM0E 4AP8A 3CMAH 1QPRA 4ZOJA 5DM7J 1WKIA 4U67J 1VQOH 2J0FA 5BNEA 4GA6A 4WFNJ 5EP8A 4OWSA 3CF5J 4X58A 5JVHJ 1VLBA 2JBMA 3R6CA 4WFAJ 4X5BA 5C1RA 1YHQH 3NVWC 1Y69K 3CCUH 4X5AA 1FFUB 3WO1A 2B7QA 3CCEH 1S72H 1FMAE 4ZOKA 1OTPA 1N61B 1RM6A 5BYTA 4HKMA 1QVFH 4N93A 1Q7YJ 3TWPA 5EY3A 3CCJH
chains in the Genus database with same CATH topology
1UOUA 1KHDA 4X5DA 4GA5A 4ZOFA 4M0RA 4OWNA 2ELCA 1BRWA 1GXBA 1O17A 3QSAA 4N8QA 5C2LA 5C7SA 1AZYA 4XR5A 3QR9A 1ZXYA 4EAFA 4YI7A 2WK6A 3UU1A 4X5CA 4OWUA 3H5QA 4OWQA 1VQUA 4X59A 4LHMA 3QS8A 2DSJA 4X46A 4EADA 4ZTVA 3GBRA 3QQSA 4OWMA 2GVQA 4YEKA 1KGZA 1ZYKA 2WK5A 4GTNA 4MUOA 4N5VA 3R88A 4IJ1A 5BO3A 4OWOA 1V8GA 4YYYA 4OWVA 4GIUA 2TPTA 1ZVWA 5BO2A 4GA4A 4GKMA 2BPQA 4X5EA 4ZOJA 2J0FA 5BNEA 4GA6A 5EP8A 4OWSA 4X58A 3R6CA 4X5BA 5C1RA 4X5AA 4ZOKA 1OTPA 5BYTA 4HKMA 4N93A 3TWPA 5EY3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UOU A;  1KHD A;  4X5D A;  4GA5 A;  4ZOF A;  4M0R A;  4OWN A;  2ELC A;  1BRW A;  1GXB A;  1O17 A;  3QSA A;  4N8Q A;  5C2L A;  5C7S A;  1AZY A;  4XR5 A;  3QR9 A;  1ZXY A;  4EAF A;  4YI7 A;  2WK6 A;  3UU1 A;  4X5C A;  4OWU A;  3H5Q A;  4OWQ A;  1VQU A;  4X59 A;  4LHM A;  3QS8 A;  2DSJ A;  4X46 A;  4EAD A;  4ZTV A;  3GBR A;  3QQS A;  4OWM A;  2GVQ A;  4YEK A;  1KGZ A;  1ZYK A;  2WK5 A;  4GTN A;  4MUO A;  4N5V A;  3R88 A;  4IJ1 A;  5BO3 A;  4OWO A;  1V8G A;  4YYY A;  4OWV A;  4GIU A;  2TPT A;  1ZVW A;  5BO2 A;  4GA4 A;  4GKM A;  2BPQ A;  4X5E A;  4ZOJ A;  2J0F A;  5BNE A;  4GA6 A;  5EP8 A;  4OWS A;  4X58 A;  3R6C A;  4X5B A;  5C1R A;  4X5A A;  4ZOK A;  1OTP A;  5BYT A;  4HKM A;  4N93 A;  3TWP A;  5EY3 A; 
#chains in the Genus database with same CATH topology
 1UOU A;  2OTJ H;  2W3S B;  2Q5W E;  1N60 B;  1KHD A;  4X5D A;  3C2V A;  1SIJ A;  2WP4 A;  4GA5 A;  4I9A A;  4ZOF A;  1FIQ C;  3CC2 H;  4M0R A;  1QPN A;  1YTE A;  4OWN A;  5MPO C;  2ZJQ J;  2OMD A;  5DM6 J;  3CC4 H;  3G4S H;  2ZJP J;  1VQ6 H;  2QIE A;  2ELC A;  1FFV B;  1NVI E;  1M90 J;  1YTD A;  1BRW A;  3L4P A;  1GXB A;  1YJN H;  1QPO A;  2QA4 H;  4IO9 J;  5AYX A;  5HL7 J;  3C2F A;  1O17 A;  5HUO A;  4US9 A;  3QSA A;  2ZJR J;  3PAJ A;  3C2R A;  1VQ8 H;  4N8Q A;  1N5X A;  2QEX H;  5C2L A;  3DLL J;  3CCV H;  5AN9 F;  3C2E A;  5C7S A;  3CCL H;  1AZY A;  3PIP J;  1O4U A;  4IOA J;  2W3R B;  1NVJ A;  2B7N A;  4XR5 A;  3QR9 A;  4KWV A;  3CCM H;  4US8 A;  1ZXY A;  3VMM A;  1JRP B;  4EAF A;  1KD1 J;  1W2B H;  2W55 B;  3ETR C;  3PIO J;  4YI7 A;  2WK6 A;  1JRO B;  1VQ9 H;  3UU1 A;  2I14 A;  1QVG H;  4X5C A;  5GAD N;  4OWU A;  1N63 B;  3WNZ A;  5JVG J;  3AMZ A;  5MLC O;  3AM9 A;  3H5Q A;  4OWQ A;  5HUL A;  3J7Z M;  1VQU A;  5HUP A;  3CCQ H;  1VQ4 H;  1Q81 J;  4X59 A;  1KC8 J;  4LHM A;  3TQV A;  2OTL H;  3QS8 A;  5AYY A;  2DSJ A;  1VQ7 H;  4X46 A;  3CC7 H;  4USA A;  3FC4 A;  1VQK H;  3NVZ C;  3L0G A;  1K9M J;  4EAD A;  3GNN A;  1YIT H;  1WYG A;  1ZXI B;  4WFB J;  1YTK A;  1YJ9 H;  1K73 J;  3BII E;  1SB3 A;  5AYZ A;  1Q82 J;  4WCE J;  4ZTV A;  3GBR A;  5GAH N;  3AN1 A;  3CXC H;  4IOC J;  1VDV A;  3QQS A;  1Q86 J;  1VQN H;  1FO4 A;  4C80 A;  4OWM A;  3WO0 A;  1DGJ A;  2E3T A;  2GVQ A;  2W54 B;  4C7Y A;  1RF8 B;  5H1S O;  4YEK A;  4WF9 J;  3OW2 H;  1QAP A;  2PA2 A;  3FAH A;  1KGZ A;  3NVV C;  1YI2 H;  1YJW H;  1ZYK A;  2WK5 A;  5GAE N;  3CME H;  1NJI J;  4GTN A;  1VQP H;  3G71 H;  4MUO A;  3R88 A;  4N5V A;  1V97 A;  2I1O A;  1RRZ A;  3NRZ C;  5GAG N;  1K8A J;  1M1K J;  3EUB 4;  4ZOH A;  3I56 H;  1N62 B;  3CCR H;  1VQM H;  1VQL H;  1N8R J;  4UY8 M;  4IJ1 A;  1QPQ A;  1VQ5 H;  1X1O A;  3B9J C;  3NVY C;  5BO3 A;  1JJ2 H;  3C2O A;  4OWO A;  1V8G A;  3G6E H;  4YYY A;  4OWV A;  4GIU A;  2TPT A;  1ZVW A;  1N5W B;  3RPF A;  1YIJ H;  3NS1 C;  3I55 H;  1KQS H;  5BO2 A;  3CPW H;  4KWW A;  4GA4 A;  3SR6 C;  4C7Z A;  4GKM A;  2BPQ A;  4F3F C;  4X5E A;  2B7P A;  3CCS H;  3CD6 H;  1FM0 E;  4AP8 A;  3CMA H;  1QPR A;  4ZOJ A;  5DM7 J;  1WKI A;  4U67 J;  1VQO H;  2J0F A;  5BNE A;  4GA6 A;  4WFN J;  5EP8 A;  4OWS A;  3CF5 J;  4X58 A;  5JVH J;  1VLB A;  2JBM A;  3R6C A;  4WFA J;  4X5B A;  5C1R A;  1YHQ H;  3NVW C;  1Y69 K;  3CCU H;  4X5A A;  1FFU B;  3WO1 A;  2B7Q A;  3CCE H;  1S72 H;  1FMA E;  4ZOK A;  1OTP A;  1N61 B;  1RM6 A;  5BYT A;  4HKM A;  1QVF H;  4N93 A;  1Q7Y J;  3TWP A;  5EY3 A;  3CCJ H; 
#chains in the Genus database with same CATH homology
 1UOU A;  1KHD A;  4X5D A;  4GA5 A;  4ZOF A;  4M0R A;  4OWN A;  2ELC A;  1BRW A;  1GXB A;  1O17 A;  3QSA A;  4N8Q A;  5C2L A;  5C7S A;  1AZY A;  4XR5 A;  3QR9 A;  1ZXY A;  4EAF A;  4YI7 A;  2WK6 A;  3UU1 A;  4X5C A;  4OWU A;  3H5Q A;  4OWQ A;  1VQU A;  4X59 A;  4LHM A;  3QS8 A;  2DSJ A;  4X46 A;  4EAD A;  4ZTV A;  3GBR A;  3QQS A;  4OWM A;  2GVQ A;  4YEK A;  1KGZ A;  1ZYK A;  2WK5 A;  4GTN A;  4MUO A;  4N5V A;  3R88 A;  4IJ1 A;  5BO3 A;  4OWO A;  1V8G A;  4YYY A;  4OWV A;  4GIU A;  2TPT A;  1ZVW A;  5BO2 A;  4GA4 A;  4GKM A;  2BPQ A;  4X5E A;  4ZOJ A;  2J0F A;  5BNE A;  4GA6 A;  5EP8 A;  4OWS A;  4X58 A;  3R6C A;  4X5B A;  5C1R A;  4X5A A;  4ZOK A;  1OTP A;  5BYT A;  4HKM A;  4N93 A;  3TWP A;  5EY3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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