2WK6A

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
sequence length
446
structure length
446
Chain Sequence
QLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords THYMIDINE PHOSPHORYLASE
publication title Structures of Native Human Thymidine Phosphorylase and in Complex with 5-Iodouracil.
pubmed doi rcsb
source organism Homo sapiens
total genus 155
structure length 446
sequence length 446
chains with identical sequence B
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2009-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 2wk6A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 2wk6A02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 2wk6A03
4OWVA 4HKMA 2WK5A 4YI7A 4YEKA 4N93A 2GVQA 1UOUA 5C1RA 1OTPA 3TWPA 4LHMA 1ZVWA 4X58A 4EAFA 2DSJA 4YYYA 4GIUA 1VQUA 2ELCA 3UU1A 5BO3A 1GXBA 4OWQA 4M0RA 4EADA 2J0FA 4OWUA 5EY3A 4X5DA 4ZOFA 5BO2A 3H5QA 4GA5A 4N5VA 4ZOJA 1ZYKA 4XR5A 4N8QA 4MUOA 4OWNA 3QQSA 4ZTVA 5EP8A 4GTNA 3R6CA 4X5AA 3R88A 3QS8A 1O17A 4ZOKA 2BPQA 3GBRA 1ZXYA 4X59A 4X5BA 4X5EA 5C7SA 1V8GA 4OWMA 4OWSA 4IJ1A 4GA6A 1KGZA 5C2LA 4X5CA 3QSAA 5BYTA 1KHDA 4GA4A 4X46A 2WK6A 3QR9A 1BRWA 2TPTA 4GKMA 5BNEA 1AZYA 4OWOA
chains in the Genus database with same CATH superfamily
4OWVA 1WKIA 2QEXH 1M1KJ 4HKMA 2WK5A 1VLBA 1RRZA 2B7PA 3CMAH 3WO1A 2WP4A 3CCUH 3CF5J 1VQOH 5GAGN 4KWVA 3SR6C 2OTLH 4YI7A 4YEKA 1YTEA 4IO9J 3CCSH 1VQ4H 4N93A 1VQKH 5AN9F 2W3RB 1YIJH 2Q5WE 3BIIE 2GVQA 1QPOA 3WO0A 1UOUA 5C1RA 3PIOJ 3OW2H 1FO4A 1QVGH 2B7QA 1OTPA 1QPQA 2E3TA 1VQ5H 1FMAE 1NVJA 3TWPA 2W54B 4LHMA 1ZVWA 4KWWA 5MPOC 4WFNJ 1NJIJ 1VQ9H 1VQLH 3CD6H 4X58A 4EAFA 1FIQC 5JVHJ 2DSJA 4YYYA 4GIUA 3ETRC 1YTKA 3C2VA 3EUB4 1VQUA 3CC4H 2ELCA 3CCRH 1O4UA 4C80A 3UU1A 1K73J 1QVFH 5BO3A 1N61B 2OMDA 3C2RA 5MLCO 3G71H 1K9MJ 1YJWH 1VQ7H 3GNNA 1YJNH 2JBMA 2ZJQJ 1GXBA 5GAHN 4OWQA 4M0RA 1SB3A 3NS1C 4EADA 3CCEH 1QAPA 2J0FA 4US9A 1Q82J 3CPWH 1YI2H 3NVYC 3B9JC 1N62B 3C2FA 3VMMA 3FAHA 1S72H 1KD1J 4OWUA 1DGJA 5EY3A 4IOAJ 1N8RJ 4F3FC 1M90J 5HUPA 4X5DA 3NVVC 2I14A 3CCLH 4ZOFA 3PAJA 1YITH 5BO2A 3NVWC 3CCVH 4C7ZA 3H5QA 5DM6J 1KQSH 4GA5A 1VQ8H 3CCQH 4N5VA 1X1OA 5AYXA 5JVGJ 2W55B 4ZOJA 1N60B 1VDVA 1ZYKA 1YTDA 5HULA 4XR5A 4AP8A 3I56H 3NRZC 4ZOHA 3WNZA 2QIEA 3CC2H 1Q81J 4N8QA 1QPNA 1ZXIB 1QPRA 4MUOA 2ZJRJ 1Q7YJ 1Q86J 4OWNA 3FC4A 3QQSA 1VQMH 4ZTVA 3PIPJ 5EP8A 3CC7H 1W2BH 4GTNA 5HUOA 2PA2A 3R6CA 3G6EH 1SIJA 3C2EA 4UY8M 3NVZC 4WFAJ 2I1OA 4X5AA 2W3SB 4WF9J 3TQVA 4US8A 3R88A 3QS8A 1O17A 4ZOKA 1JRPB 2BPQA 3CCMH 3GBRA 1N63B 1ZXYA 4X59A 3CMEH 4X5BA 4X5EA 5C7SA 1FM0E 1V8GA 4OWMA 3AMZA 3AM9A 3AN1A 1V97A 4C7YA 1K8AJ 3CXCH 3C2OA 4OWSA 1N5WB 5AYYA 3RPFA 1YHQH 4IJ1A 2QA4H 4GA6A 1FFUB 4U67J 1RF8B 5GADN 3G4SH 1WYGA 1JROB 3CCJH 3J7ZM 5HL7J 1KGZA 5DM7J 4WCEJ 1YJ9H 1Y69K 5C2LA 4X5CA 3QSAA 1NVIE 4USAA 3L4PA 5BYTA 1N5XA 1VQPH 1JJ2H 5H1SO 3I55H 1RM6A 4I9AA 1KHDA 1KC8J 4GA4A 4X46A 2WK6A 2ZJPJ 3L0GA 3QR9A 2OTJH 5GAEN 4IOCJ 1FFVB 1BRWA 2TPTA 4GKMA 5AYZA 5BNEA 1VQ6H 1VQNH 4WFBJ 3DLLJ 1AZYA 2B7NA 4OWOA
chains in the Genus database with same CATH topology
4OWVA 4HKMA 2WK5A 4YI7A 4YEKA 4N93A 2GVQA 1UOUA 5C1RA 1OTPA 3TWPA 4LHMA 1ZVWA 4X58A 4EAFA 2DSJA 4YYYA 4GIUA 1VQUA 2ELCA 3UU1A 5BO3A 1GXBA 4OWQA 4M0RA 4EADA 2J0FA 4OWUA 5EY3A 4X5DA 4ZOFA 5BO2A 3H5QA 4GA5A 4N5VA 4ZOJA 1ZYKA 4XR5A 4N8QA 4MUOA 4OWNA 3QQSA 4ZTVA 5EP8A 4GTNA 3R6CA 4X5AA 3R88A 3QS8A 1O17A 4ZOKA 2BPQA 3GBRA 1ZXYA 4X59A 4X5BA 4X5EA 5C7SA 1V8GA 4OWMA 4OWSA 4IJ1A 4GA6A 1KGZA 5C2LA 4X5CA 3QSAA 5BYTA 1KHDA 4GA4A 4X46A 2WK6A 3QR9A 1BRWA 2TPTA 4GKMA 5BNEA 1AZYA 4OWOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OWV A;  4HKM A;  2WK5 A;  4YI7 A;  4YEK A;  4N93 A;  2GVQ A;  1UOU A;  5C1R A;  1OTP A;  3TWP A;  4LHM A;  1ZVW A;  4X58 A;  4EAF A;  2DSJ A;  4YYY A;  4GIU A;  1VQU A;  2ELC A;  3UU1 A;  5BO3 A;  1GXB A;  4OWQ A;  4M0R A;  4EAD A;  2J0F A;  4OWU A;  5EY3 A;  4X5D A;  4ZOF A;  5BO2 A;  3H5Q A;  4GA5 A;  4N5V A;  4ZOJ A;  1ZYK A;  4XR5 A;  4N8Q A;  4MUO A;  4OWN A;  3QQS A;  4ZTV A;  5EP8 A;  4GTN A;  3R6C A;  4X5A A;  3R88 A;  3QS8 A;  1O17 A;  4ZOK A;  2BPQ A;  3GBR A;  1ZXY A;  4X59 A;  4X5B A;  4X5E A;  5C7S A;  1V8G A;  4OWM A;  4OWS A;  4IJ1 A;  4GA6 A;  1KGZ A;  5C2L A;  4X5C A;  3QSA A;  5BYT A;  1KHD A;  4GA4 A;  4X46 A;  2WK6 A;  3QR9 A;  1BRW A;  2TPT A;  4GKM A;  5BNE A;  1AZY A;  4OWO A; 
#chains in the Genus database with same CATH topology
 4OWV A;  1WKI A;  2QEX H;  1M1K J;  4HKM A;  2WK5 A;  1VLB A;  1RRZ A;  2B7P A;  3CMA H;  3WO1 A;  2WP4 A;  3CCU H;  3CF5 J;  1VQO H;  5GAG N;  4KWV A;  3SR6 C;  2OTL H;  4YI7 A;  4YEK A;  1YTE A;  4IO9 J;  3CCS H;  1VQ4 H;  4N93 A;  1VQK H;  5AN9 F;  2W3R B;  1YIJ H;  2Q5W E;  3BII E;  2GVQ A;  1QPO A;  3WO0 A;  1UOU A;  5C1R A;  3PIO J;  3OW2 H;  1FO4 A;  1QVG H;  2B7Q A;  1OTP A;  1QPQ A;  2E3T A;  1VQ5 H;  1FMA E;  1NVJ A;  3TWP A;  2W54 B;  4LHM A;  1ZVW A;  4KWW A;  5MPO C;  4WFN J;  1NJI J;  1VQ9 H;  1VQL H;  3CD6 H;  4X58 A;  4EAF A;  1FIQ C;  5JVH J;  2DSJ A;  4YYY A;  4GIU A;  3ETR C;  1YTK A;  3C2V A;  3EUB 4;  1VQU A;  3CC4 H;  2ELC A;  3CCR H;  1O4U A;  4C80 A;  3UU1 A;  1K73 J;  1QVF H;  5BO3 A;  1N61 B;  2OMD A;  3C2R A;  5MLC O;  3G71 H;  1K9M J;  1YJW H;  1VQ7 H;  3GNN A;  1YJN H;  2JBM A;  2ZJQ J;  1GXB A;  5GAH N;  4OWQ A;  4M0R A;  1SB3 A;  3NS1 C;  4EAD A;  3CCE H;  1QAP A;  2J0F A;  4US9 A;  1Q82 J;  3CPW H;  1YI2 H;  3NVY C;  3B9J C;  1N62 B;  3C2F A;  3VMM A;  3FAH A;  1S72 H;  1KD1 J;  4OWU A;  1DGJ A;  5EY3 A;  4IOA J;  1N8R J;  4F3F C;  1M90 J;  5HUP A;  4X5D A;  3NVV C;  2I14 A;  3CCL H;  4ZOF A;  3PAJ A;  1YIT H;  5BO2 A;  3NVW C;  3CCV H;  4C7Z A;  3H5Q A;  5DM6 J;  1KQS H;  4GA5 A;  1VQ8 H;  3CCQ H;  4N5V A;  1X1O A;  5AYX A;  5JVG J;  2W55 B;  4ZOJ A;  1N60 B;  1VDV A;  1ZYK A;  1YTD A;  5HUL A;  4XR5 A;  4AP8 A;  3I56 H;  3NRZ C;  4ZOH A;  3WNZ A;  2QIE A;  3CC2 H;  1Q81 J;  4N8Q A;  1QPN A;  1ZXI B;  1QPR A;  4MUO A;  2ZJR J;  1Q7Y J;  1Q86 J;  4OWN A;  3FC4 A;  3QQS A;  1VQM H;  4ZTV A;  3PIP J;  5EP8 A;  3CC7 H;  1W2B H;  4GTN A;  5HUO A;  2PA2 A;  3R6C A;  3G6E H;  1SIJ A;  3C2E A;  4UY8 M;  3NVZ C;  4WFA J;  2I1O A;  4X5A A;  2W3S B;  4WF9 J;  3TQV A;  4US8 A;  3R88 A;  3QS8 A;  1O17 A;  4ZOK A;  1JRP B;  2BPQ A;  3CCM H;  3GBR A;  1N63 B;  1ZXY A;  4X59 A;  3CME H;  4X5B A;  4X5E A;  5C7S A;  1FM0 E;  1V8G A;  4OWM A;  3AMZ A;  3AM9 A;  3AN1 A;  1V97 A;  4C7Y A;  1K8A J;  3CXC H;  3C2O A;  4OWS A;  1N5W B;  5AYY A;  3RPF A;  1YHQ H;  4IJ1 A;  2QA4 H;  4GA6 A;  1FFU B;  4U67 J;  1RF8 B;  5GAD N;  3G4S H;  1WYG A;  1JRO B;  3CCJ H;  3J7Z M;  5HL7 J;  1KGZ A;  5DM7 J;  4WCE J;  1YJ9 H;  1Y69 K;  5C2L A;  4X5C A;  3QSA A;  1NVI E;  4USA A;  3L4P A;  5BYT A;  1N5X A;  1VQP H;  1JJ2 H;  5H1S O;  3I55 H;  1RM6 A;  4I9A A;  1KHD A;  1KC8 J;  4GA4 A;  4X46 A;  2WK6 A;  2ZJP J;  3L0G A;  3QR9 A;  2OTJ H;  5GAE N;  4IOC J;  1FFV B;  1BRW A;  2TPT A;  4GKM A;  5AYZ A;  5BNE A;  1VQ6 H;  1VQN H;  4WFB J;  3DLL J;  1AZY A;  2B7N A;  4OWO A; 
#chains in the Genus database with same CATH homology
 4OWV A;  4HKM A;  2WK5 A;  4YI7 A;  4YEK A;  4N93 A;  2GVQ A;  1UOU A;  5C1R A;  1OTP A;  3TWP A;  4LHM A;  1ZVW A;  4X58 A;  4EAF A;  2DSJ A;  4YYY A;  4GIU A;  1VQU A;  2ELC A;  3UU1 A;  5BO3 A;  1GXB A;  4OWQ A;  4M0R A;  4EAD A;  2J0F A;  4OWU A;  5EY3 A;  4X5D A;  4ZOF A;  5BO2 A;  3H5Q A;  4GA5 A;  4N5V A;  4ZOJ A;  1ZYK A;  4XR5 A;  4N8Q A;  4MUO A;  4OWN A;  3QQS A;  4ZTV A;  5EP8 A;  4GTN A;  3R6C A;  4X5A A;  3R88 A;  3QS8 A;  1O17 A;  4ZOK A;  2BPQ A;  3GBR A;  1ZXY A;  4X59 A;  4X5B A;  4X5E A;  5C7S A;  1V8G A;  4OWM A;  4OWS A;  4IJ1 A;  4GA6 A;  1KGZ A;  5C2L A;  4X5C A;  3QSA A;  5BYT A;  1KHD A;  4GA4 A;  4X46 A;  2WK6 A;  3QR9 A;  1BRW A;  2TPT A;  4GKM A;  5BNE A;  1AZY A;  4OWO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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