4IJ1A

Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (anprt; trpd) in absence of substrates.
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
346
structure length
334
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGTVNLSTMAAIVVAAAGVPVVKHGNRAADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 117
structure length 334
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2012-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4ij1A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4ij1A02
1AZYA 3UU1A 4X5EA 1KGZA 4X5DA 4ZOJA 5C1RA 4OWNA 1BRWA 4EADA 5BO2A 2WK6A 4N5VA 3QSAA 2GVQA 4X59A 4OWQA 4EAFA 4OWOA 4OWUA 1OTPA 3R88A 4GKMA 4M0RA 4X58A 4HKMA 4ZOKA 4OWSA 4LHMA 1O17A 1ZVWA 4GA4A 1ZXYA 4OWVA 4GIUA 4X5BA 4YEKA 4X46A 4MUOA 5BO3A 4XR5A 3H5QA 4N8QA 5BYTA 2ELCA 2J0FA 5C2LA 3GBRA 4GA5A 4OWMA 3QS8A 4GA6A 3QQSA 1KHDA 1UOUA 5C7SA 5EP8A 4ZTVA 1GXBA 2WK5A 5EY3A 1V8GA 2DSJA 3QR9A 4YYYA 4X5CA 1ZYKA 4N93A 4IJ1A 4X5AA 4GTNA 4ZOFA 5BNEA 4YI7A 2BPQA 3TWPA 3R6CA 1VQUA 2TPTA
chains in the Genus database with same CATH superfamily
1AZYA 3UU1A 4X5EA 1KGZA 4X5DA 4ZOJA 5C1RA 4OWNA 1BRWA 4EADA 5BO2A 2WK6A 4N5VA 3QSAA 2GVQA 4X59A 4OWQA 4EAFA 4OWOA 4OWUA 1OTPA 3R88A 4GKMA 1RF8B 4M0RA 4X58A 4HKMA 4ZOKA 4OWSA 4LHMA 1O17A 1ZVWA 4GA4A 1ZXYA 4OWVA 4GIUA 4X5BA 4YEKA 4X46A 4MUOA 5BO3A 4XR5A 3H5QA 4N8QA 5BYTA 2ELCA 2J0FA 5C2LA 4F3FC 3GBRA 4GA5A 4OWMA 3QS8A 4GA6A 3QQSA 1KHDA 1UOUA 5C7SA 5EP8A 4ZTVA 1RRZA 1GXBA 2WK5A 5EY3A 1V8GA 2DSJA 3QR9A 4YYYA 4X5CA 1ZYKA 4N93A 4IJ1A 4X5AA 4GTNA 4ZOFA 5BNEA 4YI7A 2BPQA 3TWPA 3R6CA 1VQUA 2TPTA
chains in the Genus database with same CATH topology
1AZYA 3UU1A 4X5EA 1KGZA 4X5DA 4ZOJA 5C1RA 4OWNA 1BRWA 4EADA 5BO2A 2WK6A 4N5VA 3QSAA 2GVQA 4X59A 4OWQA 4EAFA 4OWOA 4OWUA 1OTPA 3R88A 4GKMA 4M0RA 4X58A 4HKMA 4ZOKA 4OWSA 4LHMA 1O17A 1ZVWA 4GA4A 1ZXYA 4OWVA 4GIUA 4X5BA 4YEKA 4X46A 4MUOA 5BO3A 4XR5A 3H5QA 4N8QA 5BYTA 2ELCA 2J0FA 5C2LA 3GBRA 4GA5A 4OWMA 3QS8A 4GA6A 3QQSA 1KHDA 1UOUA 5C7SA 5EP8A 4ZTVA 1GXBA 2WK5A 5EY3A 1V8GA 2DSJA 3QR9A 4YYYA 4X5CA 1ZYKA 4N93A 4IJ1A 4X5AA 4GTNA 4ZOFA 5BNEA 4YI7A 2BPQA 3TWPA 3R6CA 1VQUA 2TPTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AZY A;  3UU1 A;  4X5E A;  1KGZ A;  4X5D A;  4ZOJ A;  5C1R A;  4OWN A;  1BRW A;  4EAD A;  5BO2 A;  2WK6 A;  4N5V A;  3QSA A;  2GVQ A;  4X59 A;  4OWQ A;  4EAF A;  4OWO A;  4OWU A;  1OTP A;  3R88 A;  4GKM A;  4M0R A;  4X58 A;  4HKM A;  4ZOK A;  4OWS A;  4LHM A;  1O17 A;  1ZVW A;  4GA4 A;  1ZXY A;  4OWV A;  4GIU A;  4X5B A;  4YEK A;  4X46 A;  4MUO A;  5BO3 A;  4XR5 A;  3H5Q A;  4N8Q A;  5BYT A;  2ELC A;  2J0F A;  5C2L A;  3GBR A;  4GA5 A;  4OWM A;  3QS8 A;  4GA6 A;  3QQS A;  1KHD A;  1UOU A;  5C7S A;  5EP8 A;  4ZTV A;  1GXB A;  2WK5 A;  5EY3 A;  1V8G A;  2DSJ A;  3QR9 A;  4YYY A;  4X5C A;  1ZYK A;  4N93 A;  4IJ1 A;  4X5A A;  4GTN A;  4ZOF A;  5BNE A;  4YI7 A;  2BPQ A;  3TWP A;  3R6C A;  1VQU A;  2TPT A; 
#chains in the Genus database with same CATH topology
 1AZY A;  3UU1 A;  4X5E A;  1KGZ A;  4X5D A;  4ZOJ A;  5C1R A;  4OWN A;  1BRW A;  4EAD A;  5BO2 A;  2WK6 A;  4N5V A;  3QSA A;  2GVQ A;  4X59 A;  4OWQ A;  4EAF A;  4OWO A;  4OWU A;  1OTP A;  3R88 A;  4GKM A;  1RF8 B;  4M0R A;  4X58 A;  4HKM A;  4ZOK A;  4OWS A;  4LHM A;  1O17 A;  1ZVW A;  4GA4 A;  1ZXY A;  4OWV A;  4GIU A;  4X5B A;  4YEK A;  4X46 A;  4MUO A;  5BO3 A;  4XR5 A;  3H5Q A;  4N8Q A;  5BYT A;  2ELC A;  2J0F A;  5C2L A;  4F3F C;  3GBR A;  4GA5 A;  4OWM A;  3QS8 A;  4GA6 A;  3QQS A;  1KHD A;  1UOU A;  5C7S A;  5EP8 A;  4ZTV A;  1RRZ A;  1GXB A;  2WK5 A;  5EY3 A;  1V8G A;  2DSJ A;  3QR9 A;  4YYY A;  4X5C A;  1ZYK A;  4N93 A;  4IJ1 A;  4X5A A;  4GTN A;  4ZOF A;  5BNE A;  4YI7 A;  2BPQ A;  3TWP A;  3R6C A;  1VQU A;  2TPT A; 
#chains in the Genus database with same CATH homology
 1AZY A;  3UU1 A;  4X5E A;  1KGZ A;  4X5D A;  4ZOJ A;  5C1R A;  4OWN A;  1BRW A;  4EAD A;  5BO2 A;  2WK6 A;  4N5V A;  3QSA A;  2GVQ A;  4X59 A;  4OWQ A;  4EAF A;  4OWO A;  4OWU A;  1OTP A;  3R88 A;  4GKM A;  4M0R A;  4X58 A;  4HKM A;  4ZOK A;  4OWS A;  4LHM A;  1O17 A;  1ZVW A;  4GA4 A;  1ZXY A;  4OWV A;  4GIU A;  4X5B A;  4YEK A;  4X46 A;  4MUO A;  5BO3 A;  4XR5 A;  3H5Q A;  4N8Q A;  5BYT A;  2ELC A;  2J0F A;  5C2L A;  3GBR A;  4GA5 A;  4OWM A;  3QS8 A;  4GA6 A;  3QQS A;  1KHD A;  1UOU A;  5C7S A;  5EP8 A;  4ZTV A;  1GXB A;  2WK5 A;  5EY3 A;  1V8G A;  2DSJ A;  3QR9 A;  4YYY A;  4X5C A;  1ZYK A;  4N93 A;  4IJ1 A;  4X5A A;  4GTN A;  4ZOF A;  5BNE A;  4YI7 A;  2BPQ A;  3TWP A;  3R6C A;  1VQU A;  2TPT A; 
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