4IJ1A

Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (anprt; trpd) in absence of substrates.
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
346
structure length
334
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGTVNLSTMAAIVVAAAGVPVVKHGNRAADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
molecule keywords Anthranilate phosphoribosyltransferase
publication title Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 117
structure length 334
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2012-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4ij1A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4ij1A02
1VQUA 4OWVA 4GA5A 4X59A 2DSJA 4MUOA 4OWQA 4OWMA 4IJ1A 4HKMA 3QQSA 4OWUA 1ZVWA 4OWSA 4X5AA 5BO2A 4EAFA 4GKMA 4N93A 1AZYA 4OWOA 5EY3A 4EADA 1UOUA 2ELCA 2BPQA 1KGZA 4M0RA 4ZOKA 4GA4A 4X58A 4YYYA 4ZOFA 2TPTA 5C2LA 5BYTA 4OWNA 4LHMA 4GA6A 4GTNA 3GBRA 3QS8A 1GXBA 3R88A 4X5DA 3UU1A 1ZXYA 4X5CA 1BRWA 3H5QA 5EP8A 4N5VA 4X46A 1V8GA 1KHDA 2WK5A 1O17A 4XR5A 3TWPA 5C1RA 1ZYKA 3QSAA 3QR9A 2J0FA 5C7SA 3R6CA 4GIUA 4X5EA 4ZTVA 1OTPA 4X5BA 2GVQA 4YI7A 4N8QA 2WK6A 4YEKA 5BO3A 5BNEA 4ZOJA
chains in the Genus database with same CATH superfamily
1VQUA 4OWVA 4GA5A 4X59A 2DSJA 4MUOA 4OWQA 4OWMA 4IJ1A 4HKMA 3QQSA 4OWUA 1ZVWA 4OWSA 4X5AA 1RF8B 5BO2A 4EAFA 4GKMA 4N93A 1AZYA 4OWOA 4F3FC 5EY3A 4EADA 1UOUA 2ELCA 2BPQA 1KGZA 4M0RA 4ZOKA 4GA4A 4X58A 4YYYA 4ZOFA 2TPTA 5C2LA 5BYTA 4OWNA 4GA6A 4LHMA 4GTNA 3GBRA 3QS8A 1GXBA 3R88A 4X5DA 3UU1A 1ZXYA 4X5CA 1BRWA 3H5QA 5EP8A 4N5VA 4X46A 1V8GA 1KHDA 1RRZA 2WK5A 1O17A 4XR5A 3TWPA 5C1RA 1ZYKA 3QSAA 3QR9A 2J0FA 5C7SA 3R6CA 4GIUA 4X5EA 4ZTVA 1OTPA 4X5BA 2GVQA 4YI7A 4N8QA 2WK6A 4YEKA 5BO3A 5BNEA 4ZOJA
chains in the Genus database with same CATH topology
1VQUA 4OWVA 4GA5A 4X59A 2DSJA 4MUOA 4OWQA 4OWMA 4IJ1A 4HKMA 3QQSA 4OWUA 1ZVWA 4OWSA 4X5AA 5BO2A 4EAFA 4GKMA 4N93A 1AZYA 4OWOA 5EY3A 4EADA 1UOUA 2ELCA 2BPQA 1KGZA 4M0RA 4ZOKA 4GA4A 4X58A 4YYYA 4ZOFA 2TPTA 5C2LA 5BYTA 4OWNA 4LHMA 4GA6A 4GTNA 3GBRA 3QS8A 1GXBA 3R88A 4X5DA 3UU1A 1ZXYA 4X5CA 1BRWA 3H5QA 5EP8A 4N5VA 4X46A 1V8GA 1KHDA 2WK5A 1O17A 4XR5A 3TWPA 5C1RA 1ZYKA 3QSAA 3QR9A 2J0FA 5C7SA 3R6CA 4GIUA 4X5EA 4ZTVA 1OTPA 4X5BA 2GVQA 4YI7A 4N8QA 2WK6A 4YEKA 5BO3A 5BNEA 4ZOJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VQU A;  4OWV A;  4GA5 A;  4X59 A;  2DSJ A;  4MUO A;  4OWQ A;  4OWM A;  4IJ1 A;  4HKM A;  3QQS A;  4OWU A;  1ZVW A;  4OWS A;  4X5A A;  5BO2 A;  4EAF A;  4GKM A;  4N93 A;  1AZY A;  4OWO A;  5EY3 A;  4EAD A;  1UOU A;  2ELC A;  2BPQ A;  1KGZ A;  4M0R A;  4ZOK A;  4GA4 A;  4X58 A;  4YYY A;  4ZOF A;  2TPT A;  5C2L A;  5BYT A;  4OWN A;  4LHM A;  4GA6 A;  4GTN A;  3GBR A;  3QS8 A;  1GXB A;  3R88 A;  4X5D A;  3UU1 A;  1ZXY A;  4X5C A;  1BRW A;  3H5Q A;  5EP8 A;  4N5V A;  4X46 A;  1V8G A;  1KHD A;  2WK5 A;  1O17 A;  4XR5 A;  3TWP A;  5C1R A;  1ZYK A;  3QSA A;  3QR9 A;  2J0F A;  5C7S A;  3R6C A;  4GIU A;  4X5E A;  4ZTV A;  1OTP A;  4X5B A;  2GVQ A;  4YI7 A;  4N8Q A;  2WK6 A;  4YEK A;  5BO3 A;  5BNE A;  4ZOJ A; 
#chains in the Genus database with same CATH topology
 1VQU A;  4OWV A;  4GA5 A;  4X59 A;  2DSJ A;  4MUO A;  4OWQ A;  4OWM A;  4IJ1 A;  4HKM A;  3QQS A;  4OWU A;  1ZVW A;  4OWS A;  4X5A A;  1RF8 B;  5BO2 A;  4EAF A;  4GKM A;  4N93 A;  1AZY A;  4OWO A;  4F3F C;  5EY3 A;  4EAD A;  1UOU A;  2ELC A;  2BPQ A;  1KGZ A;  4M0R A;  4ZOK A;  4GA4 A;  4X58 A;  4YYY A;  4ZOF A;  2TPT A;  5C2L A;  5BYT A;  4OWN A;  4GA6 A;  4LHM A;  4GTN A;  3GBR A;  3QS8 A;  1GXB A;  3R88 A;  4X5D A;  3UU1 A;  1ZXY A;  4X5C A;  1BRW A;  3H5Q A;  5EP8 A;  4N5V A;  4X46 A;  1V8G A;  1KHD A;  1RRZ A;  2WK5 A;  1O17 A;  4XR5 A;  3TWP A;  5C1R A;  1ZYK A;  3QSA A;  3QR9 A;  2J0F A;  5C7S A;  3R6C A;  4GIU A;  4X5E A;  4ZTV A;  1OTP A;  4X5B A;  2GVQ A;  4YI7 A;  4N8Q A;  2WK6 A;  4YEK A;  5BO3 A;  5BNE A;  4ZOJ A; 
#chains in the Genus database with same CATH homology
 1VQU A;  4OWV A;  4GA5 A;  4X59 A;  2DSJ A;  4MUO A;  4OWQ A;  4OWM A;  4IJ1 A;  4HKM A;  3QQS A;  4OWU A;  1ZVW A;  4OWS A;  4X5A A;  5BO2 A;  4EAF A;  4GKM A;  4N93 A;  1AZY A;  4OWO A;  5EY3 A;  4EAD A;  1UOU A;  2ELC A;  2BPQ A;  1KGZ A;  4M0R A;  4ZOK A;  4GA4 A;  4X58 A;  4YYY A;  4ZOF A;  2TPT A;  5C2L A;  5BYT A;  4OWN A;  4LHM A;  4GA6 A;  4GTN A;  3GBR A;  3QS8 A;  1GXB A;  3R88 A;  4X5D A;  3UU1 A;  1ZXY A;  4X5C A;  1BRW A;  3H5Q A;  5EP8 A;  4N5V A;  4X46 A;  1V8G A;  1KHD A;  2WK5 A;  1O17 A;  4XR5 A;  3TWP A;  5C1R A;  1ZYK A;  3QSA A;  3QR9 A;  2J0F A;  5C7S A;  3R6C A;  4GIU A;  4X5E A;  4ZTV A;  1OTP A;  4X5B A;  2GVQ A;  4YI7 A;  4N8Q A;  2WK6 A;  4YEK A;  5BO3 A;  5BNE A;  4ZOJ A; 
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