4LHMA

Thymidine phosphorylase from e.coli with 3'-azido-3'-deoxythymidine
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
sequence length
440
structure length
440
Chain Sequence
b'LFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Thymidine phosphorylase
publication title 3'-Azidothymidine in the active site of Escherichia coli thymidine phosphorylase: the peculiarity of the binding on the basis of X-ray study.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Transferase
total genus 161
structure length 440
sequence length 440
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2013-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4lhmA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4lhmA02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 4lhmA03
1O17A 5C2LA 4GA4A 4ZOFA 4YEKA 3GBRA 4XR5A 5BO2A 2J0FA 4GA5A 4YI7A 2DSJA 5C1RA 4OWQA 4OWMA 4OWSA 4N93A 4X5CA 4ZTVA 5BO3A 1V8GA 3UU1A 4GA6A 4M0RA 3H5QA 3QR9A 1ZVWA 1VQUA 4N5VA 1KGZA 3R88A 4N8QA 3QQSA 2WK6A 4YYYA 4X5AA 4X5DA 4X46A 4MUOA 1BRWA 2GVQA 5BNEA 1AZYA 4X58A 3R6CA 4X5BA 4OWUA 2ELCA 4OWOA 5C7SA 3QS8A 5EP8A 1ZXYA 4X5EA 4EAFA 4GKMA 4HKMA 4X59A 4EADA 4OWNA 4ZOJA 1ZYKA 1KHDA 4GIUA 4IJ1A 4ZOKA 5EY3A 2TPTA 1UOUA 4LHMA 2WK5A 3TWPA 1OTPA 4OWVA 5BYTA 2BPQA 4GTNA 3QSAA 1GXBA
chains in the Genus database with same CATH superfamily
1O17A 1N8RJ 1DGJA 5C2LA 2B7PA 4GA4A 4ZOFA 3AN1A 5AYXA 4YEKA 1Q81J 3L4PA 3GBRA 4XR5A 3NVZC 1YI2H 5BO2A 2J0FA 4WF9J 4IO9J 5GADN 1FO4A 1FM0E 1VQOH 2QIEA 5HUOA 4GA5A 5DM6J 4YI7A 3PIPJ 4US8A 2DSJA 5JVGJ 1YJ9H 1WKIA 5H1SO 3PAJA 1VDVA 1JROB 1QPQA 5C1RA 4OWQA 1Q82J 4OWMA 1JRPB 4OWSA 4N93A 2W55B 5MLCO 4X5CA 1JJ2H 1FFUB 1NVIE 1W2BH 1QVFH 1YIJH 3G71H 2QEXH 4ZTVA 3I56H 5BO3A 2PA2A 3EUB4 3PIOJ 2B7NA 4USAA 1YHQH 5GAGN 3CMEH 1V8GA 1N62B 3UU1A 2QA4H 4GA6A 4M0RA 4WCEJ 3H5QA 1YTEA 3QR9A 1ZVWA 5HL7J 2ZJQJ 3C2RA 2OMDA 1VQ5H 1VQLH 4US9A 4WFAJ 1VQUA 4N5VA 1ZXIB 3NVYC 1QAPA 3I55H 3CCUH 3WO0A 3C2VA 3CCMH 1KGZA 3R88A 5HULA 4F3FC 4I9AA 4KWWA 4N8QA 3QQSA 1S72H 2WK6A 4YYYA 2JBMA 1Q86J 1NJIJ 4X5AA 3C2FA 4X5DA 3L0GA 1VQMH 4X46A 1VQPH 3BIIE 1VQ7H 1Y69K 3CCVH 5HUPA 3CC4H 2OTLH 1N63B 4MUOA 1BRWA 3ETRC 2GVQA 1KC8J 2Q5WE 3G4SH 3CC2H 1K9MJ 3NVVC 5BNEA 1AZYA 4X58A 1QPOA 2E3TA 1QPNA 1N5XA 3C2EA 3SR6C 3CCSH 1YTKA 2OTJH 3R6CA 1VQ6H 2W3RB 4X5BA 1YITH 5DM7J 3FAHA 3AMZA 3NVWC 2ZJRJ 4OWUA 1SB3A 2ELCA 4OWOA 5C7SA 1QPRA 3WO1A 5GAEN 4C80A 4WFNJ 3OW2H 3QS8A 5EP8A 4IOAJ 1ZXYA 5MPOC 4UY8M 4X5EA 2I1OA 1M90J 1KQSH 2ZJPJ 4C7ZA 1FFVB 3CC7H 5AYYA 4EAFA 1SIJA 2W3SB 2W54B 4GKMA 5GAHN 3CCQH 3RPFA 4WFBJ 3VMMA 4HKMA 1VQ9H 1YTDA 4X59A 3J7ZM 1X1OA 4ZOHA 3GNNA 4EADA 4OWNA 4ZOJA 2B7QA 2WP4A 3CCLH 1ZYKA 1KHDA 3CCRH 1YJWH 3G6EH 1RM6A 1VQ8H 4GIUA 3CPWH 4IJ1A 3NRZC 1M1KJ 4C7YA 3DLLJ 1WYGA 1QVGH 1VLBA 4U67J 3CCJH 5AN9F 1V97A 3AM9A 1O4UA 1KD1J 4AP8A 1FIQC 1VQ4H 1N5WB 4KWVA 3CMAH 3CXCH 3CD6H 1NVJA 4ZOKA 1RF8B 1N61B 5EY3A 2TPTA 3C2OA 1VQKH 1UOUA 4IOCJ 2I14A 1RRZA 1VQNH 3B9JC 1FMAE 4LHMA 2WK5A 1K73J 1K8AJ 3TWPA 3NS1C 1OTPA 5AYZA 3TQVA 3CCEH 5JVHJ 4OWVA 1Q7YJ 3FC4A 3CF5J 5BYTA 2BPQA 4GTNA 1N60B 3QSAA 3WNZA 1YJNH 1GXBA
chains in the Genus database with same CATH topology
1O17A 5C2LA 4GA4A 4ZOFA 4YEKA 3GBRA 4XR5A 5BO2A 2J0FA 4GA5A 4YI7A 2DSJA 5C1RA 4OWQA 4OWMA 4OWSA 4N93A 4X5CA 4ZTVA 5BO3A 1V8GA 3UU1A 4GA6A 4M0RA 3H5QA 3QR9A 1ZVWA 1VQUA 4N5VA 1KGZA 3R88A 4N8QA 3QQSA 2WK6A 4YYYA 4X5AA 4X5DA 4X46A 4MUOA 1BRWA 2GVQA 5BNEA 1AZYA 4X58A 3R6CA 4X5BA 4OWUA 2ELCA 4OWOA 5C7SA 3QS8A 5EP8A 1ZXYA 4X5EA 4EAFA 4GKMA 4HKMA 4X59A 4EADA 4OWNA 4ZOJA 1ZYKA 1KHDA 4GIUA 4IJ1A 4ZOKA 5EY3A 2TPTA 1UOUA 4LHMA 2WK5A 3TWPA 1OTPA 4OWVA 5BYTA 2BPQA 4GTNA 3QSAA 1GXBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O17 A;  5C2L A;  4GA4 A;  4ZOF A;  4YEK A;  3GBR A;  4XR5 A;  5BO2 A;  2J0F A;  4GA5 A;  4YI7 A;  2DSJ A;  5C1R A;  4OWQ A;  4OWM A;  4OWS A;  4N93 A;  4X5C A;  4ZTV A;  5BO3 A;  1V8G A;  3UU1 A;  4GA6 A;  4M0R A;  3H5Q A;  3QR9 A;  1ZVW A;  1VQU A;  4N5V A;  1KGZ A;  3R88 A;  4N8Q A;  3QQS A;  2WK6 A;  4YYY A;  4X5A A;  4X5D A;  4X46 A;  4MUO A;  1BRW A;  2GVQ A;  5BNE A;  1AZY A;  4X58 A;  3R6C A;  4X5B A;  4OWU A;  2ELC A;  4OWO A;  5C7S A;  3QS8 A;  5EP8 A;  1ZXY A;  4X5E A;  4EAF A;  4GKM A;  4HKM A;  4X59 A;  4EAD A;  4OWN A;  4ZOJ A;  1ZYK A;  1KHD A;  4GIU A;  4IJ1 A;  4ZOK A;  5EY3 A;  2TPT A;  1UOU A;  4LHM A;  2WK5 A;  3TWP A;  1OTP A;  4OWV A;  5BYT A;  2BPQ A;  4GTN A;  3QSA A;  1GXB A; 
#chains in the Genus database with same CATH topology
 1O17 A;  1N8R J;  1DGJ A;  5C2L A;  2B7P A;  4GA4 A;  4ZOF A;  3AN1 A;  5AYX A;  4YEK A;  1Q81 J;  3L4P A;  3GBR A;  4XR5 A;  3NVZ C;  1YI2 H;  5BO2 A;  2J0F A;  4WF9 J;  4IO9 J;  5GAD N;  1FO4 A;  1FM0 E;  1VQO H;  2QIE A;  5HUO A;  4GA5 A;  5DM6 J;  4YI7 A;  3PIP J;  4US8 A;  2DSJ A;  5JVG J;  1YJ9 H;  1WKI A;  5H1S O;  3PAJ A;  1VDV A;  1JRO B;  1QPQ A;  5C1R A;  4OWQ A;  1Q82 J;  4OWM A;  1JRP B;  4OWS A;  4N93 A;  2W55 B;  5MLC O;  4X5C A;  1JJ2 H;  1FFU B;  1NVI E;  1W2B H;  1QVF H;  1YIJ H;  3G71 H;  2QEX H;  4ZTV A;  3I56 H;  5BO3 A;  2PA2 A;  3EUB 4;  3PIO J;  2B7N A;  4USA A;  1YHQ H;  5GAG N;  3CME H;  1V8G A;  1N62 B;  3UU1 A;  2QA4 H;  4GA6 A;  4M0R A;  4WCE J;  3H5Q A;  1YTE A;  3QR9 A;  1ZVW A;  5HL7 J;  2ZJQ J;  3C2R A;  2OMD A;  1VQ5 H;  1VQL H;  4US9 A;  4WFA J;  1VQU A;  4N5V A;  1ZXI B;  3NVY C;  1QAP A;  3I55 H;  3CCU H;  3WO0 A;  3C2V A;  3CCM H;  1KGZ A;  3R88 A;  5HUL A;  4F3F C;  4I9A A;  4KWW A;  4N8Q A;  3QQS A;  1S72 H;  2WK6 A;  4YYY A;  2JBM A;  1Q86 J;  1NJI J;  4X5A A;  3C2F A;  4X5D A;  3L0G A;  1VQM H;  4X46 A;  1VQP H;  3BII E;  1VQ7 H;  1Y69 K;  3CCV H;  5HUP A;  3CC4 H;  2OTL H;  1N63 B;  4MUO A;  1BRW A;  3ETR C;  2GVQ A;  1KC8 J;  2Q5W E;  3G4S H;  3CC2 H;  1K9M J;  3NVV C;  5BNE A;  1AZY A;  4X58 A;  1QPO A;  2E3T A;  1QPN A;  1N5X A;  3C2E A;  3SR6 C;  3CCS H;  1YTK A;  2OTJ H;  3R6C A;  1VQ6 H;  2W3R B;  4X5B A;  1YIT H;  5DM7 J;  3FAH A;  3AMZ A;  3NVW C;  2ZJR J;  4OWU A;  1SB3 A;  2ELC A;  4OWO A;  5C7S A;  1QPR A;  3WO1 A;  5GAE N;  4C80 A;  4WFN J;  3OW2 H;  3QS8 A;  5EP8 A;  4IOA J;  1ZXY A;  5MPO C;  4UY8 M;  4X5E A;  2I1O A;  1M90 J;  1KQS H;  2ZJP J;  4C7Z A;  1FFV B;  3CC7 H;  5AYY A;  4EAF A;  1SIJ A;  2W3S B;  2W54 B;  4GKM A;  5GAH N;  3CCQ H;  3RPF A;  4WFB J;  3VMM A;  4HKM A;  1VQ9 H;  1YTD A;  4X59 A;  3J7Z M;  1X1O A;  4ZOH A;  3GNN A;  4EAD A;  4OWN A;  4ZOJ A;  2B7Q A;  2WP4 A;  3CCL H;  1ZYK A;  1KHD A;  3CCR H;  1YJW H;  3G6E H;  1RM6 A;  1VQ8 H;  4GIU A;  3CPW H;  4IJ1 A;  3NRZ C;  1M1K J;  4C7Y A;  3DLL J;  1WYG A;  1QVG H;  1VLB A;  4U67 J;  3CCJ H;  5AN9 F;  1V97 A;  3AM9 A;  1O4U A;  1KD1 J;  4AP8 A;  1FIQ C;  1VQ4 H;  1N5W B;  4KWV A;  3CMA H;  3CXC H;  3CD6 H;  1NVJ A;  4ZOK A;  1RF8 B;  1N61 B;  5EY3 A;  2TPT A;  3C2O A;  1VQK H;  1UOU A;  4IOC J;  2I14 A;  1RRZ A;  1VQN H;  3B9J C;  1FMA E;  4LHM A;  2WK5 A;  1K73 J;  1K8A J;  3TWP A;  3NS1 C;  1OTP A;  5AYZ A;  3TQV A;  3CCE H;  5JVH J;  4OWV A;  1Q7Y J;  3FC4 A;  3CF5 J;  5BYT A;  2BPQ A;  4GTN A;  1N60 B;  3QSA A;  3WNZ A;  1YJN H;  1GXB A; 
#chains in the Genus database with same CATH homology
 1O17 A;  5C2L A;  4GA4 A;  4ZOF A;  4YEK A;  3GBR A;  4XR5 A;  5BO2 A;  2J0F A;  4GA5 A;  4YI7 A;  2DSJ A;  5C1R A;  4OWQ A;  4OWM A;  4OWS A;  4N93 A;  4X5C A;  4ZTV A;  5BO3 A;  1V8G A;  3UU1 A;  4GA6 A;  4M0R A;  3H5Q A;  3QR9 A;  1ZVW A;  1VQU A;  4N5V A;  1KGZ A;  3R88 A;  4N8Q A;  3QQS A;  2WK6 A;  4YYY A;  4X5A A;  4X5D A;  4X46 A;  4MUO A;  1BRW A;  2GVQ A;  5BNE A;  1AZY A;  4X58 A;  3R6C A;  4X5B A;  4OWU A;  2ELC A;  4OWO A;  5C7S A;  3QS8 A;  5EP8 A;  1ZXY A;  4X5E A;  4EAF A;  4GKM A;  4HKM A;  4X59 A;  4EAD A;  4OWN A;  4ZOJ A;  1ZYK A;  1KHD A;  4GIU A;  4IJ1 A;  4ZOK A;  5EY3 A;  2TPT A;  1UOU A;  4LHM A;  2WK5 A;  3TWP A;  1OTP A;  4OWV A;  5BYT A;  2BPQ A;  4GTN A;  3QSA A;  1GXB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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