3TWP | Genus

Total Genus 120

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	120
sequence length	346
structure length	346
Chain Sequence	PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. pubmed doi rcsb
molecule keywords	Anthranilate phosphoribosyltransferase
molecule tags	Transferase/transferase inhibitor
source organism	Mycobacterium tuberculosis
total genus	120
structure length	346
sequence length	346
chains with identical sequence	B, C, D
ec nomenclature	ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date	2011-09-22

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00591	Glycos_transf_3	Glycosyl transferase family, a/b domain
A	PF02885	Glycos_trans_3N	Glycosyl transferase family, helical bundle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.970.10	Mainly Alpha	Up-down Bundle	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C	3twpA01
3.40.1030.10	Alpha Beta	3-Layer(aba) Sandwich	Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	3twpA02

4OWNA 4N5VA 2WK6A 5BNEA 4YYYA 1OTPA 4OWOA 4OWVA 3TWPA 4IJ1A 4X5DA 5BO2A 4ZOFA 4OWSA 4GA4A 1VQUA 3R6CA 5BYTA 1KGZA 4GA5A 1ZXYA 1UOUA 1AZYA 4X5EA 4ZTVA 2J0FA 1ZVWA 1KHDA 4X58A 2WK5A 3H5QA 4ZOKA 2DSJA 2ELCA 4X46A 5C1RA 5EY3A 4YI7A 4X5BA 4GKMA 4X59A 4EAFA 5BO3A 1ZYKA 4OWUA 4OWQA 4N93A 4LHMA 3QQSA 4M0RA 1BRWA 3GBRA 3UU1A 4OWMA 2GVQA 1GXBA 1O17A 4MUOA 2TPTA 5EP8A 2BPQA 3QSAA 5C7SA 4HKMA 4N8QA 4X5AA 5C2LA 4XR5A 3QS8A 4EADA 1V8GA 4X5CA 4YEKA 4GTNA 3R88A 3QR9A 4GA6A 4ZOJA 4GIUA
chains in the Genus database with same CATH superfamily

4OWNA 4N5VA 2WK6A 5BNEA 4F3FC 4YYYA 1OTPA 4OWOA 4OWVA 3TWPA 4IJ1A 1RRZA 4X5DA 5BO2A 4ZOFA 4OWSA 4GA4A 1VQUA 3R6CA 5BYTA 1KGZA 4GA5A 1ZXYA 1UOUA 1AZYA 4X5EA 4ZTVA 2J0FA 1ZVWA 1KHDA 4X58A 2WK5A 3H5QA 4ZOKA 2DSJA 2ELCA 4X46A 5C1RA 5EY3A 4YI7A 4X5BA 4GKMA 4X59A 4EAFA 5BO3A 1ZYKA 4OWUA 4OWQA 4N93A 4LHMA 3QQSA 4M0RA 1BRWA 3GBRA 3UU1A 4OWMA 2GVQA 1GXBA 1O17A 4MUOA 2TPTA 5EP8A 1RF8B 2BPQA 3QSAA 5C7SA 4HKMA 4N8QA 4X5AA 5C2LA 4XR5A 3QS8A 4EADA 1V8GA 4X5CA 4YEKA 4GTNA 3R88A 3QR9A 4GA6A 4ZOJA 4GIUA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4OWN A;  4N5V A;  2WK6 A;  5BNE A;  4YYY A;  1OTP A;  4OWO A;  4OWV A;  3TWP A;  4IJ1 A;  4X5D A;  5BO2 A;  4ZOF A;  4OWS A;  4GA4 A;  1VQU A;  3R6C A;  5BYT A;  1KGZ A;  4GA5 A;  1ZXY A;  1UOU A;  1AZY A;  4X5E A;  4ZTV A;  2J0F A;  1ZVW A;  1KHD A;  4X58 A;  2WK5 A;  3H5Q A;  4ZOK A;  2DSJ A;  2ELC A;  4X46 A;  5C1R A;  5EY3 A;  4YI7 A;  4X5B A;  4GKM A;  4X59 A;  4EAF A;  5BO3 A;  1ZYK A;  4OWU A;  4OWQ A;  4N93 A;  4LHM A;  3QQS A;  4M0R A;  1BRW A;  3GBR A;  3UU1 A;  4OWM A;  2GVQ A;  1GXB A;  1O17 A;  4MUO A;  2TPT A;  5EP8 A;  2BPQ A;  3QSA A;  5C7S A;  4HKM A;  4N8Q A;  4X5A A;  5C2L A;  4XR5 A;  3QS8 A;  4EAD A;  1V8G A;  4X5C A;  4YEK A;  4GTN A;  3R88 A;  3QR9 A;  4GA6 A;  4ZOJ A;  4GIU A; 
#chains in the Genus database with same CATH topology
 4OWN A;  4N5V A;  2WK6 A;  5BNE A;  4F3F C;  4YYY A;  1OTP A;  4OWO A;  4OWV A;  3TWP A;  4IJ1 A;  1RRZ A;  4X5D A;  5BO2 A;  4ZOF A;  4OWS A;  4GA4 A;  1VQU A;  3R6C A;  5BYT A;  1KGZ A;  4GA5 A;  1ZXY A;  1UOU A;  1AZY A;  4X5E A;  4ZTV A;  2J0F A;  1ZVW A;  1KHD A;  4X58 A;  2WK5 A;  3H5Q A;  4ZOK A;  2DSJ A;  2ELC A;  4X46 A;  5C1R A;  5EY3 A;  4YI7 A;  4X5B A;  4GKM A;  4X59 A;  4EAF A;  5BO3 A;  1ZYK A;  4OWU A;  4OWQ A;  4N93 A;  4LHM A;  3QQS A;  4M0R A;  1BRW A;  3GBR A;  3UU1 A;  4OWM A;  2GVQ A;  1GXB A;  1O17 A;  4MUO A;  2TPT A;  5EP8 A;  1RF8 B;  2BPQ A;  3QSA A;  5C7S A;  4HKM A;  4N8Q A;  4X5A A;  5C2L A;  4XR5 A;  3QS8 A;  4EAD A;  1V8G A;  4X5C A;  4YEK A;  4GTN A;  3R88 A;  3QR9 A;  4GA6 A;  4ZOJ A;  4GIU A; 
#chains in the Genus database with same CATH homology
 4OWN A;  4N5V A;  2WK6 A;  5BNE A;  4YYY A;  1OTP A;  4OWO A;  4OWV A;  3TWP A;  4IJ1 A;  4X5D A;  5BO2 A;  4ZOF A;  4OWS A;  4GA4 A;  1VQU A;  3R6C A;  5BYT A;  1KGZ A;  4GA5 A;  1ZXY A;  1UOU A;  1AZY A;  4X5E A;  4ZTV A;  2J0F A;  1ZVW A;  1KHD A;  4X58 A;  2WK5 A;  3H5Q A;  4ZOK A;  2DSJ A;  2ELC A;  4X46 A;  5C1R A;  5EY3 A;  4YI7 A;  4X5B A;  4GKM A;  4X59 A;  4EAF A;  5BO3 A;  1ZYK A;  4OWU A;  4OWQ A;  4N93 A;  4LHM A;  3QQS A;  4M0R A;  1BRW A;  3GBR A;  3UU1 A;  4OWM A;  2GVQ A;  1GXB A;  1O17 A;  4MUO A;  2TPT A;  5EP8 A;  2BPQ A;  3QSA A;  5C7S A;  4HKM A;  4N8Q A;  4X5A A;  5C2L A;  4XR5 A;  3QS8 A;  4EAD A;  1V8G A;  4X5C A;  4YEK A;  4GTN A;  3R88 A;  3QR9 A;  4GA6 A;  4ZOJ A;  4GIU A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3TWPA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations