3UU1 | Genus

Total Genus 117

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	117
sequence length	346
structure length	338
Chain Sequence	PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 338 atoms

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338 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. pubmed doi rcsb
molecule keywords	Anthranilate phosphoribosyltransferase
molecule tags	Transferase/transferase inhibitor
source organism	Mycobacterium tuberculosis
total genus	117
structure length	338
sequence length	346
chains with identical sequence	B, C, D
ec nomenclature	ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date	2011-11-27

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00591	Glycos_transf_3	Glycosyl transferase family, a/b domain
A	PF02885	Glycos_trans_3N	Glycosyl transferase family, helical bundle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.970.10	Mainly Alpha	Up-down Bundle	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C	3uu1A01
3.40.1030.10	Alpha Beta	3-Layer(aba) Sandwich	Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	3uu1A02

4GIUA 3QQSA 2TPTA 1ZYKA 1BRWA 4ZOKA 2ELCA 1GXBA 2BPQA 4YYYA 1AZYA 1ZVWA 3R88A 4OWUA 4X5EA 5C1RA 3QS8A 4X46A 4GTNA 5C2LA 4X5CA 5EY3A 4OWSA 4MUOA 4YEKA 4EAFA 5BO3A 4X58A 3UU1A 4GA6A 1OTPA 3QSAA 3R6CA 3TWPA 4ZTVA 3QR9A 4OWOA 1O17A 1VQUA 2WK5A 4ZOJA 4OWMA 5BO2A 4HKMA 3H5QA 4ZOFA 2GVQA 4X59A 4X5DA 5C7SA 2DSJA 4N5VA 4M0RA 4OWQA 4GKMA 1KHDA 4GA4A 4OWNA 5BYTA 4X5BA 4YI7A 1KGZA 5EP8A 3GBRA 2J0FA 4N8QA 4XR5A 4N93A 4OWVA 4EADA 4X5AA 1V8GA 4GA5A 4IJ1A 1ZXYA 4LHMA 5BNEA 2WK6A 1UOUA
chains in the Genus database with same CATH superfamily

4GIUA 3QQSA 2TPTA 1ZYKA 1BRWA 4ZOKA 2ELCA 1GXBA 2BPQA 4YYYA 1AZYA 1ZVWA 3R88A 4OWUA 4X5EA 5C1RA 3QS8A 4X46A 4GTNA 5C2LA 4X5CA 5EY3A 4OWSA 4MUOA 4YEKA 4EAFA 5BO3A 4X58A 3UU1A 4GA6A 1OTPA 3QSAA 3R6CA 3TWPA 4ZTVA 3QR9A 4OWOA 1O17A 1VQUA 2WK5A 4ZOJA 4OWMA 5BO2A 4HKMA 3H5QA 4ZOFA 2GVQA 4X59A 4X5DA 5C7SA 2DSJA 4N5VA 4M0RA 4OWQA 4F3FC 1RF8B 4GKMA 1KHDA 4GA4A 4OWNA 5BYTA 4X5BA 4YI7A 1KGZA 1RRZA 5EP8A 3GBRA 2J0FA 4N8QA 4XR5A 4N93A 4OWVA 4EADA 4X5AA 1V8GA 4GA5A 4IJ1A 1ZXYA 4LHMA 5BNEA 2WK6A 1UOUA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4GIU A;  3QQS A;  2TPT A;  1ZYK A;  1BRW A;  4ZOK A;  2ELC A;  1GXB A;  2BPQ A;  4YYY A;  1AZY A;  1ZVW A;  3R88 A;  4OWU A;  4X5E A;  5C1R A;  3QS8 A;  4X46 A;  4GTN A;  5C2L A;  4X5C A;  5EY3 A;  4OWS A;  4MUO A;  4YEK A;  4EAF A;  5BO3 A;  4X58 A;  3UU1 A;  4GA6 A;  1OTP A;  3QSA A;  3R6C A;  3TWP A;  4ZTV A;  3QR9 A;  4OWO A;  1O17 A;  1VQU A;  2WK5 A;  4ZOJ A;  4OWM A;  5BO2 A;  4HKM A;  3H5Q A;  4ZOF A;  2GVQ A;  4X59 A;  4X5D A;  5C7S A;  2DSJ A;  4N5V A;  4M0R A;  4OWQ A;  4GKM A;  1KHD A;  4GA4 A;  4OWN A;  5BYT A;  4X5B A;  4YI7 A;  1KGZ A;  5EP8 A;  3GBR A;  2J0F A;  4N8Q A;  4XR5 A;  4N93 A;  4OWV A;  4EAD A;  4X5A A;  1V8G A;  4GA5 A;  4IJ1 A;  1ZXY A;  4LHM A;  5BNE A;  2WK6 A;  1UOU A; 
#chains in the Genus database with same CATH topology
 4GIU A;  3QQS A;  2TPT A;  1ZYK A;  1BRW A;  4ZOK A;  2ELC A;  1GXB A;  2BPQ A;  4YYY A;  1AZY A;  1ZVW A;  3R88 A;  4OWU A;  4X5E A;  5C1R A;  3QS8 A;  4X46 A;  4GTN A;  5C2L A;  4X5C A;  5EY3 A;  4OWS A;  4MUO A;  4YEK A;  4EAF A;  5BO3 A;  4X58 A;  3UU1 A;  4GA6 A;  1OTP A;  3QSA A;  3R6C A;  3TWP A;  4ZTV A;  3QR9 A;  4OWO A;  1O17 A;  1VQU A;  2WK5 A;  4ZOJ A;  4OWM A;  5BO2 A;  4HKM A;  3H5Q A;  4ZOF A;  2GVQ A;  4X59 A;  4X5D A;  5C7S A;  2DSJ A;  4N5V A;  4M0R A;  4OWQ A;  4F3F C;  1RF8 B;  4GKM A;  1KHD A;  4GA4 A;  4OWN A;  5BYT A;  4X5B A;  4YI7 A;  1KGZ A;  1RRZ A;  5EP8 A;  3GBR A;  2J0F A;  4N8Q A;  4XR5 A;  4N93 A;  4OWV A;  4EAD A;  4X5A A;  1V8G A;  4GA5 A;  4IJ1 A;  1ZXY A;  4LHM A;  5BNE A;  2WK6 A;  1UOU A; 
#chains in the Genus database with same CATH homology
 4GIU A;  3QQS A;  2TPT A;  1ZYK A;  1BRW A;  4ZOK A;  2ELC A;  1GXB A;  2BPQ A;  4YYY A;  1AZY A;  1ZVW A;  3R88 A;  4OWU A;  4X5E A;  5C1R A;  3QS8 A;  4X46 A;  4GTN A;  5C2L A;  4X5C A;  5EY3 A;  4OWS A;  4MUO A;  4YEK A;  4EAF A;  5BO3 A;  4X58 A;  3UU1 A;  4GA6 A;  1OTP A;  3QSA A;  3R6C A;  3TWP A;  4ZTV A;  3QR9 A;  4OWO A;  1O17 A;  1VQU A;  2WK5 A;  4ZOJ A;  4OWM A;  5BO2 A;  4HKM A;  3H5Q A;  4ZOF A;  2GVQ A;  4X59 A;  4X5D A;  5C7S A;  2DSJ A;  4N5V A;  4M0R A;  4OWQ A;  4GKM A;  1KHD A;  4GA4 A;  4OWN A;  5BYT A;  4X5B A;  4YI7 A;  1KGZ A;  5EP8 A;  3GBR A;  2J0F A;  4N8Q A;  4XR5 A;  4N93 A;  4OWV A;  4EAD A;  4X5A A;  1V8G A;  4GA5 A;  4IJ1 A;  1ZXY A;  4LHM A;  5BNE A;  2WK6 A;  1UOU A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3UU1A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations