4C5WA

Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 4-(ethyldimethylammonio)butanoate
Total Genus 120
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
384
structure length
384
Chain Sequence
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords GAMMA-BUTYROBETAINE DIOXYGENASE
total genus 120
structure length 384
sequence length 384
ec nomenclature ec 1.14.11.1: Gamma-butyrobetaine dioxygenase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02668 TauD Taurine catabolism dioxygenase TauD, TfdA family
A PF06155 DUF971 Protein of unknown function (DUF971)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.2020.30 Alpha Beta 2-Layer Sandwich NE0471 N-terminal domain-like NE0471 N-terminal domain-like 4c5wA01
3.60.130.10 Alpha Beta 4-Layer Sandwich Double-stranded beta-helix Clavaminate synthase-like 4c5wA02
4BG1A 1OIKA 1VZ4A 4M2FA 4BHFA 4BGKA 3R1JA 1OIIA 4M2EA 4C8RA 1OIJC 4M2IA 1OTJA 4M2GA 1NX4A 1DS1A 2WBOA 1GY9A 1OIHA 1OS7A 2WBQA 4M26A 2OG6A 4M2CA 2OG5A 1OIJB 3SWTA 1Y0ZA 1GQWA 4FFAA 4BHGA 5KEUA 3EATX 1DRYA 4BGMA 4M25A 5HSXA 3O2GA 1GVGA 1OIJA 2Q4AA 2WBPA 4NE0A 5J92A 4Y0EA 3LUUA 1JR7A 4YLMX 4OJ8A 3V15A 4BHIA 3MS5A 2OG7A 4J5IA 2R6SA 1NX8A 4CVYA 3N6WA 3PVJA 4M27A 1DRTA 1VZ5A 3V17A 1DS0A 4C5WA 4CWDA 4M23A
chains in the Genus database with same CATH superfamily
4BG1A 1OIKA 1VZ4A 4M2FA 4BHFA 4BGKA 3R1JA 1OIIA 4M2EA 4C8RA 1OIJC 4M2IA 1OTJA 4M2GA 1NX4A 1DS1A 2WBOA 1GY9A 1OIHA 1OS7A 2WBQA 4M26A 2AUWA 2OG6A 4M2CA 2OG5A 1OIJB 3SWTA 1Y0ZA 1GQWA 4FFAA 4BHGA 5KEUA 3EATX 1DRYA 4BGMA 1PG6A 4M25A 5HSXA 3O2GA 1GVGA 1OIJA 2Q4AA 2WBPA 4NE0A 5J92A 4Y0EA 3LUUA 3K8RA 1JR7A 4OJ8A 4YLMX 3V15A 4BHIA 3MS5A 2OG7A 4J5IA 2R6SA 1NX8A 4CVYA 3N6WA 3PVJA 4M27A 1DRTA 1VZ5A 1YOXA 3V17A 1DS0A 4C5WA 4CWDA 2X8NA 4M23A
chains in the Genus database with same CATH topology
4BG1A 1OIKA 1H2NA 4BGKA 4C8RA 1NX4A 2WBOA 2WBQA 2W0XA 2OG6A 3P3NA 5JWPA 1H2MA 4BGMA 4M25A 5HSXA 2WBPA 4NE0A 3K8RA 4YLMX 3V15A 4BHIA 2R6SA 2XUMA 3N6WA 3OD4A 4B7EA 2X8NA 4BHFA 2CGNA 1OIHA 3KCYA 1Y0ZA 4BHGA 1OIJA 2Q4AA 3LUUA 1JR7A 2OG7A 3KCXA 3PVJA 4M27A 1DRTA 1VZ5A 3V17A 4Z2WA 1DS0A 4C5WA 4CWDA 3P3PA 4M2FA 3R1JA 1OIIA 4M2EA 4M2IA 1OTJA 1OS7A 4M26A 4BIOA 2ILMA 3D8CA 4M2CA 1OIJB 4B7KA 1YCIA 1GQWA 3EATX 1DRYA 2WA4A 2Y0IA 4NR1A 5J92A 4OJ8A 1MZEA 4J5IA 4CVYA 1NX8A 4M23A 1VZ4A 1H2LA 4M2GA 1OIJC 1IZ3A 2YDEA 1DS1A 2YC0A 1GY9A 4AI8A 2OG5A 3SWTA 4FFAA 5KEUA 3O2GA 1GVGA 4Z1VA 4Y0EA 2WA3A 1H2KA 1MZFA 3MS5A 4JAAA 2CGOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BG1 A;  1OIK A;  1VZ4 A;  4M2F A;  4BHF A;  4BGK A;  3R1J A;  1OII A;  4M2E A;  4C8R A;  1OIJ C;  4M2I A;  1OTJ A;  4M2G A;  1NX4 A;  1DS1 A;  2WBO A;  1GY9 A;  1OIH A;  1OS7 A;  2WBQ A;  4M26 A;  2OG6 A;  4M2C A;  2OG5 A;  1OIJ B;  3SWT A;  1Y0Z A;  1GQW A;  4FFA A;  4BHG A;  5KEU A;  3EAT X;  1DRY A;  4BGM A;  4M25 A;  5HSX A;  3O2G A;  1GVG A;  1OIJ A;  2Q4A A;  2WBP A;  4NE0 A;  5J92 A;  4Y0E A;  3LUU A;  1JR7 A;  4YLM X;  4OJ8 A;  3V15 A;  4BHI A;  3MS5 A;  2OG7 A;  4J5I A;  2R6S A;  1NX8 A;  4CVY A;  3N6W A;  3PVJ A;  4M27 A;  1DRT A;  1VZ5 A;  3V17 A;  1DS0 A;  4C5W A;  4CWD A;  4M23 A; 
#chains in the Genus database with same CATH topology
 4BG1 A;  1OIK A;  1VZ4 A;  4M2F A;  4BHF A;  4BGK A;  3R1J A;  1OII A;  4M2E A;  4C8R A;  1OIJ C;  4M2I A;  1OTJ A;  4M2G A;  1NX4 A;  1DS1 A;  2WBO A;  1GY9 A;  1OIH A;  1OS7 A;  2WBQ A;  4M26 A;  2AUW A;  2OG6 A;  4M2C A;  2OG5 A;  1OIJ B;  3SWT A;  1Y0Z A;  1GQW A;  4FFA A;  4BHG A;  5KEU A;  3EAT X;  1DRY A;  4BGM A;  1PG6 A;  4M25 A;  5HSX A;  3O2G A;  1GVG A;  1OIJ A;  2Q4A A;  2WBP A;  4NE0 A;  5J92 A;  4Y0E A;  3LUU A;  3K8R A;  1JR7 A;  4OJ8 A;  4YLM X;  3V15 A;  4BHI A;  3MS5 A;  2OG7 A;  4J5I A;  2R6S A;  1NX8 A;  4CVY A;  3N6W A;  3PVJ A;  4M27 A;  1DRT A;  1VZ5 A;  1YOX A;  3V17 A;  1DS0 A;  4C5W A;  4CWD A;  2X8N A;  4M23 A; 
#chains in the Genus database with same CATH homology
 4BG1 A;  1OIK A;  1H2N A;  4BGK A;  4C8R A;  1NX4 A;  2WBO A;  2WBQ A;  2W0X A;  2OG6 A;  3P3N A;  5JWP A;  1H2M A;  4BGM A;  4M25 A;  5HSX A;  2WBP A;  4NE0 A;  3K8R A;  4YLM X;  3V15 A;  4BHI A;  2R6S A;  2XUM A;  3N6W A;  3OD4 A;  4B7E A;  2X8N A;  4BHF A;  2CGN A;  1OIH A;  3KCY A;  1Y0Z A;  4BHG A;  1OIJ A;  2Q4A A;  3LUU A;  1JR7 A;  2OG7 A;  3KCX A;  3PVJ A;  4M27 A;  1DRT A;  1VZ5 A;  3V17 A;  4Z2W A;  1DS0 A;  4C5W A;  4CWD A;  3P3P A;  4M2F A;  3R1J A;  1OII A;  4M2E A;  4M2I A;  1OTJ A;  1OS7 A;  4M26 A;  4BIO A;  2ILM A;  3D8C A;  4M2C A;  1OIJ B;  4B7K A;  1YCI A;  1GQW A;  3EAT X;  1DRY A;  2WA4 A;  2Y0I A;  4NR1 A;  5J92 A;  4OJ8 A;  1MZE A;  4J5I A;  4CVY A;  1NX8 A;  4M23 A;  1VZ4 A;  1H2L A;  4M2G A;  1OIJ C;  1IZ3 A;  2YDE A;  1DS1 A;  2YC0 A;  1GY9 A;  4AI8 A;  2OG5 A;  3SWT A;  4FFA A;  5KEU A;  3O2G A;  1GVG A;  4Z1V A;  4Y0E A;  2WA3 A;  1H2K A;  1MZF A;  3MS5 A;  4JAA A;  2CGO A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...