4C8RA

Human gamma-butyrobetaine dioxygenase (bbox1) in complex with ni(ii) and n-(3-hydroxypicolinoyl)-s-(pyridin-2-ylmethyl)-l-cysteine (ar692b)
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
384
structure length
384
Chain Sequence
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
source organism Homo sapiens
publication title Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of gamma-butyrobetaine hydroxylase.
pubmed doi rcsb
molecule keywords GAMMA-BUTYROBETAINE DIOXYGENASE
total genus 102
structure length 384
sequence length 384
chains with identical sequence B, C, D, E, F
ec nomenclature ec 1.14.11.1: Gamma-butyrobetaine dioxygenase.
pdb deposition date 2013-10-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02668 TauD Taurine catabolism dioxygenase TauD, TfdA family
A PF06155 DUF971 Protein of unknown function (DUF971)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.2020.30 Alpha Beta 2-Layer Sandwich NE0471 N-terminal domain-like NE0471 N-terminal domain-like 4c8rA01
3.60.130.10 Alpha Beta 4-Layer Sandwich Double-stranded beta-helix Clavaminate synthase-like 4c8rA02
4Y0EA 3O2GA 4FFAA 3R1JA 4J5IA 1GY9A 1OIJA 4BGMA 4C5WA 2WBOA 4M2IA 1OIHA 3PVJA 4BG1A 2WBPA 3MS5A 2OG5A 3V15A 4M27A 5KEUA 1DS1A 1DS0A 4CWDA 4BGKA 4M2EA 1OIJB 3EATX 2WBQA 5J92A 1Y0ZA 1GVGA 4M2GA 1OIKA 4M23A 4BHIA 2R6SA 4M26A 4CVYA 1OIIA 4NE0A 3V17A 1VZ4A 2Q4AA 3N6WA 4BHGA 4C8RA 3LUUA 1DRTA 2OG6A 1VZ5A 1JR7A 3SWTA 1NX4A 1OIJC 4BHFA 4M25A 1NX8A 1OTJA 1GQWA 5HSXA 2OG7A 4YLMX 4OJ8A 4M2CA 1OS7A 1DRYA 4M2FA
chains in the Genus database with same CATH superfamily
4Y0EA 3O2GA 4FFAA 3R1JA 4J5IA 1GY9A 1OIJA 4BGMA 4C5WA 2WBOA 4M2IA 1OIHA 3PVJA 4BG1A 1PG6A 2WBPA 3MS5A 2X8NA 2OG5A 4M27A 3V15A 1DS1A 1DS0A 4CWDA 4BGKA 5KEUA 4M2EA 1OIJB 3K8RA 2WBQA 3EATX 1Y0ZA 1GVGA 4M2GA 1OIKA 5J92A 4M23A 4BHIA 2R6SA 4M26A 4CVYA 1OIIA 4NE0A 3V17A 1VZ4A 2Q4AA 3N6WA 4BHGA 4C8RA 3LUUA 1DRTA 2OG6A 1VZ5A 1JR7A 3SWTA 1NX4A 1OIJC 2AUWA 4BHFA 4M25A 1NX8A 1OTJA 1GQWA 5HSXA 2OG7A 4YLMX 1YOXA 4OJ8A 4M2CA 1OS7A 1DRYA 4M2FA
chains in the Genus database with same CATH topology
3O2GA 3R1JA 1GY9A 1YCIA 4M2IA 2YC0A 2WBPA 5KEUA 4Z2WA 2WBQA 1GVGA 5JWPA 4CVYA 1VZ4A 2Q4AA 1H2KA 1JR7A 1NX4A 4BHFA 4M25A 4OJ8A 4M2CA 2W0XA 4FFAA 1MZFA 2YDEA 1OIHA 3PVJA 3MS5A 1DS1A 3OD4A 4B7KA 4AI8A 4M26A 1OIIA 4BHGA 3LUUA 4NR1A 2ILMA 2XUMA 2OG7A 4YLMX 3KCYA 1IZ3A 4Y0EA 4JAAA 2CGNA 1OIJA 4C5WA 4Z1VA 2X8NA 2OG5A 4M27A 3V15A 4M2EA 1OIJB 3EATX 1H2MA 3P3PA 4M2GA 5J92A 1H2LA 1OIKA 4M23A 4C8RA 3SWTA 1OIJC 5HSXA 3KCXA 2Y0IA 2CGOA 4J5IA 2WA3A 4BGMA 2WBOA 4BG1A 1DS0A 4CWDA 4BGKA 3K8RA 1Y0ZA 4BHIA 2R6SA 4NE0A 3V17A 3P3NA 1MZEA 3N6WA 3D8CA 1DRTA 2OG6A 1VZ5A 1H2NA 4B7EA 1NX8A 1OTJA 1GQWA 2WA4A 4BIOA 1OS7A 1DRYA 4M2FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Y0E A;  3O2G A;  4FFA A;  3R1J A;  4J5I A;  1GY9 A;  1OIJ A;  4BGM A;  4C5W A;  2WBO A;  4M2I A;  1OIH A;  3PVJ A;  4BG1 A;  2WBP A;  3MS5 A;  2OG5 A;  3V15 A;  4M27 A;  5KEU A;  1DS1 A;  1DS0 A;  4CWD A;  4BGK A;  4M2E A;  1OIJ B;  3EAT X;  2WBQ A;  5J92 A;  1Y0Z A;  1GVG A;  4M2G A;  1OIK A;  4M23 A;  4BHI A;  2R6S A;  4M26 A;  4CVY A;  1OII A;  4NE0 A;  3V17 A;  1VZ4 A;  2Q4A A;  3N6W A;  4BHG A;  4C8R A;  3LUU A;  1DRT A;  2OG6 A;  1VZ5 A;  1JR7 A;  3SWT A;  1NX4 A;  1OIJ C;  4BHF A;  4M25 A;  1NX8 A;  1OTJ A;  1GQW A;  5HSX A;  2OG7 A;  4YLM X;  4OJ8 A;  4M2C A;  1OS7 A;  1DRY A;  4M2F A; 
#chains in the Genus database with same CATH topology
 4Y0E A;  3O2G A;  4FFA A;  3R1J A;  4J5I A;  1GY9 A;  1OIJ A;  4BGM A;  4C5W A;  2WBO A;  4M2I A;  1OIH A;  3PVJ A;  4BG1 A;  1PG6 A;  2WBP A;  3MS5 A;  2X8N A;  2OG5 A;  4M27 A;  3V15 A;  1DS1 A;  1DS0 A;  4CWD A;  4BGK A;  5KEU A;  4M2E A;  1OIJ B;  3K8R A;  2WBQ A;  3EAT X;  1Y0Z A;  1GVG A;  4M2G A;  1OIK A;  5J92 A;  4M23 A;  4BHI A;  2R6S A;  4M26 A;  4CVY A;  1OII A;  4NE0 A;  3V17 A;  1VZ4 A;  2Q4A A;  3N6W A;  4BHG A;  4C8R A;  3LUU A;  1DRT A;  2OG6 A;  1VZ5 A;  1JR7 A;  3SWT A;  1NX4 A;  1OIJ C;  2AUW A;  4BHF A;  4M25 A;  1NX8 A;  1OTJ A;  1GQW A;  5HSX A;  2OG7 A;  4YLM X;  1YOX A;  4OJ8 A;  4M2C A;  1OS7 A;  1DRY A;  4M2F A; 
#chains in the Genus database with same CATH homology
 3O2G A;  3R1J A;  1GY9 A;  1YCI A;  4M2I A;  2YC0 A;  2WBP A;  5KEU A;  4Z2W A;  2WBQ A;  1GVG A;  5JWP A;  4CVY A;  1VZ4 A;  2Q4A A;  1H2K A;  1JR7 A;  1NX4 A;  4BHF A;  4M25 A;  4OJ8 A;  4M2C A;  2W0X A;  4FFA A;  1MZF A;  2YDE A;  1OIH A;  3PVJ A;  3MS5 A;  1DS1 A;  3OD4 A;  4B7K A;  4AI8 A;  4M26 A;  1OII A;  4BHG A;  3LUU A;  4NR1 A;  2ILM A;  2XUM A;  2OG7 A;  4YLM X;  3KCY A;  1IZ3 A;  4Y0E A;  4JAA A;  2CGN A;  1OIJ A;  4C5W A;  4Z1V A;  2X8N A;  2OG5 A;  4M27 A;  3V15 A;  4M2E A;  1OIJ B;  3EAT X;  1H2M A;  3P3P A;  4M2G A;  5J92 A;  1H2L A;  1OIK A;  4M23 A;  4C8R A;  3SWT A;  1OIJ C;  5HSX A;  3KCX A;  2Y0I A;  2CGO A;  4J5I A;  2WA3 A;  4BGM A;  2WBO A;  4BG1 A;  1DS0 A;  4CWD A;  4BGK A;  3K8R A;  1Y0Z A;  4BHI A;  2R6S A;  4NE0 A;  3V17 A;  3P3N A;  1MZE A;  3N6W A;  3D8C A;  1DRT A;  2OG6 A;  1VZ5 A;  1H2N A;  4B7E A;  1NX8 A;  1OTJ A;  1GQW A;  2WA4 A;  4BIO A;  1OS7 A;  1DRY A;  4M2F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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