4GIUA

Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (anprt; trpd).
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
346
structure length
346
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 123
structure length 346
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2012-08-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4giuA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4giuA02
4ZOJA 4YEKA 3GBRA 1AZYA 4X46A 4GTNA 1UOUA 2BPQA 4X5AA 3H5QA 4X5CA 3UU1A 2GVQA 2J0FA 4X5EA 4N8QA 1GXBA 4OWQA 4YYYA 5EP8A 3TWPA 4M0RA 5BO3A 1OTPA 5BO2A 2WK5A 4XR5A 4ZOKA 1VQUA 3QS8A 4HKMA 4ZTVA 2WK6A 5BNEA 5BYTA 3QQSA 4X58A 4MUOA 4GA6A 4GA4A 5C7SA 4EADA 4GKMA 4GA5A 4N5VA 1V8GA 4OWVA 1KGZA 4OWMA 1O17A 3R6CA 1ZYKA 1BRWA 3QSAA 4YI7A 4X5BA 3QR9A 4X5DA 4OWNA 4X59A 5C1RA 4N93A 4ZOFA 4OWUA 4LHMA 1KHDA 2ELCA 3R88A 4IJ1A 5EY3A 4OWOA 1ZXYA 1ZVWA 4GIUA 2TPTA 4OWSA 2DSJA 5C2LA 4EAFA
chains in the Genus database with same CATH superfamily
4ZOJA 4YEKA 3GBRA 1AZYA 4X46A 4GTNA 1UOUA 2BPQA 4X5AA 3H5QA 4X5CA 3UU1A 2GVQA 2J0FA 4X5EA 4N8QA 1GXBA 4OWQA 4YYYA 5EP8A 3TWPA 4M0RA 5BO3A 1OTPA 5BO2A 2WK5A 4XR5A 4ZOKA 1VQUA 3QS8A 4HKMA 4ZTVA 2WK6A 5BNEA 3QQSA 5BYTA 4X58A 4MUOA 4GA6A 4GA4A 5C7SA 4EADA 4GA5A 4GKMA 4N5VA 1V8GA 4OWVA 1KGZA 4OWMA 1O17A 3R6CA 1ZYKA 1BRWA 3QSAA 4YI7A 4X5BA 3QR9A 4X5DA 4OWNA 4X59A 5C1RA 4N93A 4ZOFA 4OWUA 4LHMA 1KHDA 2ELCA 3R88A 4F3FC 4IJ1A 5EY3A 4OWOA 1RF8B 1ZXYA 1ZVWA 4GIUA 2TPTA 1RRZA 4OWSA 2DSJA 5C2LA 4EAFA
chains in the Genus database with same CATH topology
4ZOJA 4YEKA 3GBRA 1AZYA 4X46A 4GTNA 1UOUA 2BPQA 4X5AA 3H5QA 4X5CA 3UU1A 2GVQA 2J0FA 4X5EA 4N8QA 1GXBA 4OWQA 4YYYA 5EP8A 3TWPA 4M0RA 5BO3A 1OTPA 5BO2A 2WK5A 4XR5A 4ZOKA 1VQUA 3QS8A 4HKMA 4ZTVA 2WK6A 5BNEA 5BYTA 3QQSA 4X58A 4MUOA 4GA6A 4GA4A 5C7SA 4EADA 4GKMA 4GA5A 4N5VA 1V8GA 4OWVA 1KGZA 4OWMA 1O17A 3R6CA 1ZYKA 1BRWA 3QSAA 4YI7A 4X5BA 3QR9A 4X5DA 4OWNA 4X59A 5C1RA 4N93A 4ZOFA 4OWUA 4LHMA 1KHDA 2ELCA 3R88A 4IJ1A 5EY3A 4OWOA 1ZXYA 1ZVWA 4GIUA 2TPTA 4OWSA 2DSJA 5C2LA 4EAFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZOJ A;  4YEK A;  3GBR A;  1AZY A;  4X46 A;  4GTN A;  1UOU A;  2BPQ A;  4X5A A;  3H5Q A;  4X5C A;  3UU1 A;  2GVQ A;  2J0F A;  4X5E A;  4N8Q A;  1GXB A;  4OWQ A;  4YYY A;  5EP8 A;  3TWP A;  4M0R A;  5BO3 A;  1OTP A;  5BO2 A;  2WK5 A;  4XR5 A;  4ZOK A;  1VQU A;  3QS8 A;  4HKM A;  4ZTV A;  2WK6 A;  5BNE A;  5BYT A;  3QQS A;  4X58 A;  4MUO A;  4GA6 A;  4GA4 A;  5C7S A;  4EAD A;  4GKM A;  4GA5 A;  4N5V A;  1V8G A;  4OWV A;  1KGZ A;  4OWM A;  1O17 A;  3R6C A;  1ZYK A;  1BRW A;  3QSA A;  4YI7 A;  4X5B A;  3QR9 A;  4X5D A;  4OWN A;  4X59 A;  5C1R A;  4N93 A;  4ZOF A;  4OWU A;  4LHM A;  1KHD A;  2ELC A;  3R88 A;  4IJ1 A;  5EY3 A;  4OWO A;  1ZXY A;  1ZVW A;  4GIU A;  2TPT A;  4OWS A;  2DSJ A;  5C2L A;  4EAF A; 
#chains in the Genus database with same CATH topology
 4ZOJ A;  4YEK A;  3GBR A;  1AZY A;  4X46 A;  4GTN A;  1UOU A;  2BPQ A;  4X5A A;  3H5Q A;  4X5C A;  3UU1 A;  2GVQ A;  2J0F A;  4X5E A;  4N8Q A;  1GXB A;  4OWQ A;  4YYY A;  5EP8 A;  3TWP A;  4M0R A;  5BO3 A;  1OTP A;  5BO2 A;  2WK5 A;  4XR5 A;  4ZOK A;  1VQU A;  3QS8 A;  4HKM A;  4ZTV A;  2WK6 A;  5BNE A;  3QQS A;  5BYT A;  4X58 A;  4MUO A;  4GA6 A;  4GA4 A;  5C7S A;  4EAD A;  4GA5 A;  4GKM A;  4N5V A;  1V8G A;  4OWV A;  1KGZ A;  4OWM A;  1O17 A;  3R6C A;  1ZYK A;  1BRW A;  3QSA A;  4YI7 A;  4X5B A;  3QR9 A;  4X5D A;  4OWN A;  4X59 A;  5C1R A;  4N93 A;  4ZOF A;  4OWU A;  4LHM A;  1KHD A;  2ELC A;  3R88 A;  4F3F C;  4IJ1 A;  5EY3 A;  4OWO A;  1RF8 B;  1ZXY A;  1ZVW A;  4GIU A;  2TPT A;  1RRZ A;  4OWS A;  2DSJ A;  5C2L A;  4EAF A; 
#chains in the Genus database with same CATH homology
 4ZOJ A;  4YEK A;  3GBR A;  1AZY A;  4X46 A;  4GTN A;  1UOU A;  2BPQ A;  4X5A A;  3H5Q A;  4X5C A;  3UU1 A;  2GVQ A;  2J0F A;  4X5E A;  4N8Q A;  1GXB A;  4OWQ A;  4YYY A;  5EP8 A;  3TWP A;  4M0R A;  5BO3 A;  1OTP A;  5BO2 A;  2WK5 A;  4XR5 A;  4ZOK A;  1VQU A;  3QS8 A;  4HKM A;  4ZTV A;  2WK6 A;  5BNE A;  5BYT A;  3QQS A;  4X58 A;  4MUO A;  4GA6 A;  4GA4 A;  5C7S A;  4EAD A;  4GKM A;  4GA5 A;  4N5V A;  1V8G A;  4OWV A;  1KGZ A;  4OWM A;  1O17 A;  3R6C A;  1ZYK A;  1BRW A;  3QSA A;  4YI7 A;  4X5B A;  3QR9 A;  4X5D A;  4OWN A;  4X59 A;  5C1R A;  4N93 A;  4ZOF A;  4OWU A;  4LHM A;  1KHD A;  2ELC A;  3R88 A;  4IJ1 A;  5EY3 A;  4OWO A;  1ZXY A;  1ZVW A;  4GIU A;  2TPT A;  4OWS A;  2DSJ A;  5C2L A;  4EAF A; 
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