4GIUA

Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (anprt; trpd).
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
346
structure length
346
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 123
structure length 346
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2012-08-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4giuA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4giuA02
2BPQA 3R6CA 5BNEA 1V8GA 1ZXYA 5BO2A 1ZYKA 1UOUA 1KGZA 4GTNA 4YYYA 1BRWA 4N8QA 4ZOKA 4GA6A 4ZOFA 1OTPA 4GKMA 4HKMA 4X5BA 4EADA 5BYTA 3R88A 4OWNA 4YEKA 4X58A 4OWOA 1O17A 4OWMA 5EY3A 4MUOA 5EP8A 4EAFA 4XR5A 1AZYA 2DSJA 4X5DA 3GBRA 2TPTA 4OWUA 2ELCA 4GIUA 3QR9A 2WK6A 4X5AA 4LHMA 4OWQA 5C7SA 4X59A 4ZTVA 4OWSA 4M0RA 3QS8A 4N5VA 4X5CA 4ZOJA 3QSAA 4GA5A 2J0FA 4X46A 1GXBA 4OWVA 3UU1A 4IJ1A 2WK5A 5BO3A 4N93A 4GA4A 5C2LA 4YI7A 3QQSA 5C1RA 1VQUA 1KHDA 4X5EA 3H5QA 3TWPA 2GVQA 1ZVWA
chains in the Genus database with same CATH superfamily
2BPQA 3R6CA 5BNEA 1V8GA 4F3FC 1ZXYA 5BO2A 1ZYKA 1UOUA 1KGZA 4GTNA 4YYYA 1BRWA 4N8QA 4ZOKA 4GA6A 4ZOFA 1OTPA 4GKMA 4HKMA 4X5BA 4EADA 5BYTA 3R88A 4OWNA 4YEKA 4X58A 4OWOA 1O17A 4OWMA 5EY3A 4MUOA 5EP8A 4EAFA 4XR5A 1AZYA 2DSJA 4X5DA 3GBRA 2TPTA 4OWUA 2ELCA 4GIUA 3QR9A 2WK6A 4X5AA 4LHMA 4OWQA 1RF8B 5C7SA 4X59A 4ZTVA 4OWSA 4M0RA 3QS8A 4N5VA 4X5CA 4ZOJA 3QSAA 4GA5A 2J0FA 4X46A 1GXBA 4OWVA 3UU1A 4IJ1A 2WK5A 5BO3A 4N93A 4GA4A 1RRZA 5C2LA 4YI7A 3QQSA 5C1RA 1VQUA 1KHDA 4X5EA 3H5QA 3TWPA 2GVQA 1ZVWA
chains in the Genus database with same CATH topology
2BPQA 3R6CA 5BNEA 1V8GA 1ZXYA 5BO2A 1ZYKA 1UOUA 1KGZA 4GTNA 4YYYA 1BRWA 4N8QA 4ZOKA 4GA6A 4ZOFA 1OTPA 4GKMA 4HKMA 4X5BA 4EADA 5BYTA 3R88A 4OWNA 4YEKA 4X58A 4OWOA 1O17A 4OWMA 5EY3A 4MUOA 5EP8A 4EAFA 4XR5A 1AZYA 2DSJA 4X5DA 3GBRA 2TPTA 4OWUA 2ELCA 4GIUA 3QR9A 2WK6A 4X5AA 4LHMA 4OWQA 5C7SA 4X59A 4ZTVA 4OWSA 4M0RA 3QS8A 4N5VA 4X5CA 4ZOJA 3QSAA 4GA5A 2J0FA 4X46A 1GXBA 4OWVA 3UU1A 4IJ1A 2WK5A 5BO3A 4N93A 4GA4A 5C2LA 4YI7A 3QQSA 5C1RA 1VQUA 1KHDA 4X5EA 3H5QA 3TWPA 2GVQA 1ZVWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BPQ A;  3R6C A;  5BNE A;  1V8G A;  1ZXY A;  5BO2 A;  1ZYK A;  1UOU A;  1KGZ A;  4GTN A;  4YYY A;  1BRW A;  4N8Q A;  4ZOK A;  4GA6 A;  4ZOF A;  1OTP A;  4GKM A;  4HKM A;  4X5B A;  4EAD A;  5BYT A;  3R88 A;  4OWN A;  4YEK A;  4X58 A;  4OWO A;  1O17 A;  4OWM A;  5EY3 A;  4MUO A;  5EP8 A;  4EAF A;  4XR5 A;  1AZY A;  2DSJ A;  4X5D A;  3GBR A;  2TPT A;  4OWU A;  2ELC A;  4GIU A;  3QR9 A;  2WK6 A;  4X5A A;  4LHM A;  4OWQ A;  5C7S A;  4X59 A;  4ZTV A;  4OWS A;  4M0R A;  3QS8 A;  4N5V A;  4X5C A;  4ZOJ A;  3QSA A;  4GA5 A;  2J0F A;  4X46 A;  1GXB A;  4OWV A;  3UU1 A;  4IJ1 A;  2WK5 A;  5BO3 A;  4N93 A;  4GA4 A;  5C2L A;  4YI7 A;  3QQS A;  5C1R A;  1VQU A;  1KHD A;  4X5E A;  3H5Q A;  3TWP A;  2GVQ A;  1ZVW A; 
#chains in the Genus database with same CATH topology
 2BPQ A;  3R6C A;  5BNE A;  1V8G A;  4F3F C;  1ZXY A;  5BO2 A;  1ZYK A;  1UOU A;  1KGZ A;  4GTN A;  4YYY A;  1BRW A;  4N8Q A;  4ZOK A;  4GA6 A;  4ZOF A;  1OTP A;  4GKM A;  4HKM A;  4X5B A;  4EAD A;  5BYT A;  3R88 A;  4OWN A;  4YEK A;  4X58 A;  4OWO A;  1O17 A;  4OWM A;  5EY3 A;  4MUO A;  5EP8 A;  4EAF A;  4XR5 A;  1AZY A;  2DSJ A;  4X5D A;  3GBR A;  2TPT A;  4OWU A;  2ELC A;  4GIU A;  3QR9 A;  2WK6 A;  4X5A A;  4LHM A;  4OWQ A;  1RF8 B;  5C7S A;  4X59 A;  4ZTV A;  4OWS A;  4M0R A;  3QS8 A;  4N5V A;  4X5C A;  4ZOJ A;  3QSA A;  4GA5 A;  2J0F A;  4X46 A;  1GXB A;  4OWV A;  3UU1 A;  4IJ1 A;  2WK5 A;  5BO3 A;  4N93 A;  4GA4 A;  1RRZ A;  5C2L A;  4YI7 A;  3QQS A;  5C1R A;  1VQU A;  1KHD A;  4X5E A;  3H5Q A;  3TWP A;  2GVQ A;  1ZVW A; 
#chains in the Genus database with same CATH homology
 2BPQ A;  3R6C A;  5BNE A;  1V8G A;  1ZXY A;  5BO2 A;  1ZYK A;  1UOU A;  1KGZ A;  4GTN A;  4YYY A;  1BRW A;  4N8Q A;  4ZOK A;  4GA6 A;  4ZOF A;  1OTP A;  4GKM A;  4HKM A;  4X5B A;  4EAD A;  5BYT A;  3R88 A;  4OWN A;  4YEK A;  4X58 A;  4OWO A;  1O17 A;  4OWM A;  5EY3 A;  4MUO A;  5EP8 A;  4EAF A;  4XR5 A;  1AZY A;  2DSJ A;  4X5D A;  3GBR A;  2TPT A;  4OWU A;  2ELC A;  4GIU A;  3QR9 A;  2WK6 A;  4X5A A;  4LHM A;  4OWQ A;  5C7S A;  4X59 A;  4ZTV A;  4OWS A;  4M0R A;  3QS8 A;  4N5V A;  4X5C A;  4ZOJ A;  3QSA A;  4GA5 A;  2J0F A;  4X46 A;  1GXB A;  4OWV A;  3UU1 A;  4IJ1 A;  2WK5 A;  5BO3 A;  4N93 A;  4GA4 A;  5C2L A;  4YI7 A;  3QQS A;  5C1R A;  1VQU A;  1KHD A;  4X5E A;  3H5Q A;  3TWP A;  2GVQ A;  1ZVW A; 
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