4IJ1A

Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (anprt; trpd) in absence of substrates.
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
346
structure length
334
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGTVNLSTMAAIVVAAAGVPVVKHGNRAADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 117
structure length 334
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2012-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4ij1A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4ij1A02
4OWQA 4GA5A 4M0RA 4N8QA 4YI7A 1KGZA 1KHDA 4GA6A 4X46A 4HKMA 4LHMA 5C7SA 2DSJA 4X58A 3QSAA 1BRWA 4ZOKA 4GKMA 5C2LA 5BNEA 4ZOJA 2BPQA 4OWUA 1OTPA 4ZTVA 5BO2A 4X5BA 3R88A 1GXBA 4YEKA 1V8GA 5BO3A 4XR5A 4N93A 1AZYA 3R6CA 5EY3A 4YYYA 4ZOFA 1VQUA 4X5EA 4OWVA 3QR9A 2TPTA 3TWPA 2J0FA 5C1RA 1ZXYA 2ELCA 1O17A 2GVQA 4X59A 4X5AA 4OWMA 4GA4A 4X5CA 1ZVWA 2WK6A 2WK5A 1ZYKA 4N5VA 4X5DA 4OWOA 3GBRA 3H5QA 3UU1A 5EP8A 4OWSA 4OWNA 1UOUA 4GIUA 4EADA 4IJ1A 3QS8A 4EAFA 4GTNA 4MUOA 5BYTA 3QQSA
chains in the Genus database with same CATH superfamily
4GA5A 4OWQA 4M0RA 4N8QA 4YI7A 1KGZA 1KHDA 4GA6A 4X46A 4HKMA 4LHMA 5C7SA 2DSJA 4X58A 3QSAA 1BRWA 4ZOKA 4GKMA 5C2LA 5BNEA 4ZOJA 2BPQA 4OWUA 1OTPA 4ZTVA 5BO2A 4X5BA 3R88A 1GXBA 4YEKA 1V8GA 1RF8B 5BO3A 4XR5A 4N93A 1AZYA 3R6CA 5EY3A 4YYYA 4ZOFA 1VQUA 4X5EA 4OWVA 3QR9A 4F3FC 2TPTA 3TWPA 2J0FA 5C1RA 1ZXYA 2ELCA 1O17A 2GVQA 4X59A 4X5AA 4OWMA 4GA4A 4X5CA 1ZVWA 2WK6A 2WK5A 1RRZA 1ZYKA 4N5VA 4X5DA 4OWOA 3GBRA 3H5QA 3UU1A 5EP8A 4OWSA 4OWNA 1UOUA 4GIUA 4EADA 4IJ1A 3QS8A 4EAFA 4GTNA 4MUOA 5BYTA 3QQSA
chains in the Genus database with same CATH topology
4OWQA 4GA5A 4M0RA 4N8QA 4YI7A 1KGZA 1KHDA 4GA6A 4X46A 4HKMA 4LHMA 5C7SA 2DSJA 4X58A 3QSAA 1BRWA 4ZOKA 4GKMA 5C2LA 5BNEA 4ZOJA 2BPQA 4OWUA 1OTPA 4ZTVA 5BO2A 4X5BA 3R88A 1GXBA 4YEKA 1V8GA 5BO3A 4XR5A 4N93A 1AZYA 3R6CA 5EY3A 4YYYA 4ZOFA 1VQUA 4X5EA 4OWVA 3QR9A 2TPTA 3TWPA 2J0FA 5C1RA 1ZXYA 2ELCA 1O17A 2GVQA 4X59A 4X5AA 4OWMA 4GA4A 4X5CA 1ZVWA 2WK6A 2WK5A 1ZYKA 4N5VA 4X5DA 4OWOA 3GBRA 3H5QA 3UU1A 5EP8A 4OWSA 4OWNA 1UOUA 4GIUA 4EADA 4IJ1A 3QS8A 4EAFA 4GTNA 4MUOA 5BYTA 3QQSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OWQ A;  4GA5 A;  4M0R A;  4N8Q A;  4YI7 A;  1KGZ A;  1KHD A;  4GA6 A;  4X46 A;  4HKM A;  4LHM A;  5C7S A;  2DSJ A;  4X58 A;  3QSA A;  1BRW A;  4ZOK A;  4GKM A;  5C2L A;  5BNE A;  4ZOJ A;  2BPQ A;  4OWU A;  1OTP A;  4ZTV A;  5BO2 A;  4X5B A;  3R88 A;  1GXB A;  4YEK A;  1V8G A;  5BO3 A;  4XR5 A;  4N93 A;  1AZY A;  3R6C A;  5EY3 A;  4YYY A;  4ZOF A;  1VQU A;  4X5E A;  4OWV A;  3QR9 A;  2TPT A;  3TWP A;  2J0F A;  5C1R A;  1ZXY A;  2ELC A;  1O17 A;  2GVQ A;  4X59 A;  4X5A A;  4OWM A;  4GA4 A;  4X5C A;  1ZVW A;  2WK6 A;  2WK5 A;  1ZYK A;  4N5V A;  4X5D A;  4OWO A;  3GBR A;  3H5Q A;  3UU1 A;  5EP8 A;  4OWS A;  4OWN A;  1UOU A;  4GIU A;  4EAD A;  4IJ1 A;  3QS8 A;  4EAF A;  4GTN A;  4MUO A;  5BYT A;  3QQS A; 
#chains in the Genus database with same CATH topology
 4GA5 A;  4OWQ A;  4M0R A;  4N8Q A;  4YI7 A;  1KGZ A;  1KHD A;  4GA6 A;  4X46 A;  4HKM A;  4LHM A;  5C7S A;  2DSJ A;  4X58 A;  3QSA A;  1BRW A;  4ZOK A;  4GKM A;  5C2L A;  5BNE A;  4ZOJ A;  2BPQ A;  4OWU A;  1OTP A;  4ZTV A;  5BO2 A;  4X5B A;  3R88 A;  1GXB A;  4YEK A;  1V8G A;  1RF8 B;  5BO3 A;  4XR5 A;  4N93 A;  1AZY A;  3R6C A;  5EY3 A;  4YYY A;  4ZOF A;  1VQU A;  4X5E A;  4OWV A;  3QR9 A;  4F3F C;  2TPT A;  3TWP A;  2J0F A;  5C1R A;  1ZXY A;  2ELC A;  1O17 A;  2GVQ A;  4X59 A;  4X5A A;  4OWM A;  4GA4 A;  4X5C A;  1ZVW A;  2WK6 A;  2WK5 A;  1RRZ A;  1ZYK A;  4N5V A;  4X5D A;  4OWO A;  3GBR A;  3H5Q A;  3UU1 A;  5EP8 A;  4OWS A;  4OWN A;  1UOU A;  4GIU A;  4EAD A;  4IJ1 A;  3QS8 A;  4EAF A;  4GTN A;  4MUO A;  5BYT A;  3QQS A; 
#chains in the Genus database with same CATH homology
 4OWQ A;  4GA5 A;  4M0R A;  4N8Q A;  4YI7 A;  1KGZ A;  1KHD A;  4GA6 A;  4X46 A;  4HKM A;  4LHM A;  5C7S A;  2DSJ A;  4X58 A;  3QSA A;  1BRW A;  4ZOK A;  4GKM A;  5C2L A;  5BNE A;  4ZOJ A;  2BPQ A;  4OWU A;  1OTP A;  4ZTV A;  5BO2 A;  4X5B A;  3R88 A;  1GXB A;  4YEK A;  1V8G A;  5BO3 A;  4XR5 A;  4N93 A;  1AZY A;  3R6C A;  5EY3 A;  4YYY A;  4ZOF A;  1VQU A;  4X5E A;  4OWV A;  3QR9 A;  2TPT A;  3TWP A;  2J0F A;  5C1R A;  1ZXY A;  2ELC A;  1O17 A;  2GVQ A;  4X59 A;  4X5A A;  4OWM A;  4GA4 A;  4X5C A;  1ZVW A;  2WK6 A;  2WK5 A;  1ZYK A;  4N5V A;  4X5D A;  4OWO A;  3GBR A;  3H5Q A;  3UU1 A;  5EP8 A;  4OWS A;  4OWN A;  1UOU A;  4GIU A;  4EAD A;  4IJ1 A;  3QS8 A;  4EAF A;  4GTN A;  4MUO A;  5BYT A;  3QQS A; 
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