4OWQA

Anthranilate phosphoribosyl transferase from mycobacterium tuberculosis in complex with 3-methylanthranilate, prpp and magnesium
Total Genus 121
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
347
structure length
347
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 121
structure length 347
sequence length 347
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2014-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4owqA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4owqA02
2DSJA 1O17A 4YYYA 5C1RA 1KHDA 1V8GA 2WK5A 4ZTVA 2J0FA 1OTPA 4GKMA 1UOUA 4OWNA 3QS8A 5BO2A 4X59A 4M0RA 4GA4A 3R88A 2TPTA 3QSAA 1ZXYA 2WK6A 5BO3A 3QR9A 4X5CA 1KGZA 2BPQA 4X46A 4ZOKA 3QQSA 5BNEA 5BYTA 2GVQA 3TWPA 5C2LA 4HKMA 5C7SA 4GIUA 4N8QA 4GA5A 1GXBA 3UU1A 4X5AA 1ZVWA 5EP8A 4XR5A 4MUOA 3H5QA 4N5VA 3R6CA 1BRWA 1VQUA 4OWVA 4OWOA 4EADA 4X5EA 4GA6A 4OWUA 4X5BA 4YI7A 3GBRA 5EY3A 4LHMA 4ZOFA 4ZOJA 4YEKA 4OWSA 1AZYA 4OWMA 4X5DA 4N93A 4OWQA 4EAFA 2ELCA 1ZYKA 4IJ1A 4X58A 4GTNA
chains in the Genus database with same CATH superfamily
2DSJA 1O17A 4YYYA 5C1RA 1KHDA 1V8GA 2WK5A 4ZTVA 2J0FA 1OTPA 1RRZA 4GKMA 1UOUA 4OWNA 3QS8A 5BO2A 4X59A 4M0RA 4GA4A 3R88A 2TPTA 3QSAA 1ZXYA 2WK6A 5BO3A 3QR9A 4X5CA 1KGZA 2BPQA 4X46A 4F3FC 4ZOKA 3QQSA 5BNEA 5BYTA 2GVQA 3TWPA 5C2LA 4HKMA 5C7SA 4GIUA 4N8QA 4GA5A 1GXBA 3UU1A 4X5AA 1ZVWA 5EP8A 4XR5A 4MUOA 3H5QA 4N5VA 3R6CA 1RF8B 1BRWA 1VQUA 4OWVA 4OWOA 4EADA 4X5EA 4GA6A 4OWUA 4X5BA 4YI7A 3GBRA 5EY3A 4LHMA 4ZOFA 4ZOJA 4YEKA 4OWSA 1AZYA 4OWMA 4X5DA 4N93A 4OWQA 4EAFA 2ELCA 1ZYKA 4IJ1A 4X58A 4GTNA
chains in the Genus database with same CATH topology
2DSJA 1O17A 4YYYA 5C1RA 1KHDA 1V8GA 2WK5A 4ZTVA 2J0FA 1OTPA 4GKMA 1UOUA 4OWNA 3QS8A 5BO2A 4X59A 4M0RA 4GA4A 3R88A 2TPTA 3QSAA 1ZXYA 2WK6A 5BO3A 3QR9A 4X5CA 1KGZA 2BPQA 4X46A 4ZOKA 3QQSA 5BNEA 5BYTA 2GVQA 3TWPA 5C2LA 4HKMA 5C7SA 4GIUA 4N8QA 4GA5A 1GXBA 3UU1A 4X5AA 1ZVWA 5EP8A 4XR5A 4MUOA 3H5QA 4N5VA 3R6CA 1BRWA 1VQUA 4OWVA 4OWOA 4EADA 4X5EA 4GA6A 4OWUA 4X5BA 4YI7A 3GBRA 5EY3A 4LHMA 4ZOFA 4ZOJA 4YEKA 4OWSA 1AZYA 4OWMA 4X5DA 4N93A 4OWQA 4EAFA 2ELCA 1ZYKA 4IJ1A 4X58A 4GTNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DSJ A;  1O17 A;  4YYY A;  5C1R A;  1KHD A;  1V8G A;  2WK5 A;  4ZTV A;  2J0F A;  1OTP A;  4GKM A;  1UOU A;  4OWN A;  3QS8 A;  5BO2 A;  4X59 A;  4M0R A;  4GA4 A;  3R88 A;  2TPT A;  3QSA A;  1ZXY A;  2WK6 A;  5BO3 A;  3QR9 A;  4X5C A;  1KGZ A;  2BPQ A;  4X46 A;  4ZOK A;  3QQS A;  5BNE A;  5BYT A;  2GVQ A;  3TWP A;  5C2L A;  4HKM A;  5C7S A;  4GIU A;  4N8Q A;  4GA5 A;  1GXB A;  3UU1 A;  4X5A A;  1ZVW A;  5EP8 A;  4XR5 A;  4MUO A;  3H5Q A;  4N5V A;  3R6C A;  1BRW A;  1VQU A;  4OWV A;  4OWO A;  4EAD A;  4X5E A;  4GA6 A;  4OWU A;  4X5B A;  4YI7 A;  3GBR A;  5EY3 A;  4LHM A;  4ZOF A;  4ZOJ A;  4YEK A;  4OWS A;  1AZY A;  4OWM A;  4X5D A;  4N93 A;  4OWQ A;  4EAF A;  2ELC A;  1ZYK A;  4IJ1 A;  4X58 A;  4GTN A; 
#chains in the Genus database with same CATH topology
 2DSJ A;  1O17 A;  4YYY A;  5C1R A;  1KHD A;  1V8G A;  2WK5 A;  4ZTV A;  2J0F A;  1OTP A;  1RRZ A;  4GKM A;  1UOU A;  4OWN A;  3QS8 A;  5BO2 A;  4X59 A;  4M0R A;  4GA4 A;  3R88 A;  2TPT A;  3QSA A;  1ZXY A;  2WK6 A;  5BO3 A;  3QR9 A;  4X5C A;  1KGZ A;  2BPQ A;  4X46 A;  4F3F C;  4ZOK A;  3QQS A;  5BNE A;  5BYT A;  2GVQ A;  3TWP A;  5C2L A;  4HKM A;  5C7S A;  4GIU A;  4N8Q A;  4GA5 A;  1GXB A;  3UU1 A;  4X5A A;  1ZVW A;  5EP8 A;  4XR5 A;  4MUO A;  3H5Q A;  4N5V A;  3R6C A;  1RF8 B;  1BRW A;  1VQU A;  4OWV A;  4OWO A;  4EAD A;  4X5E A;  4GA6 A;  4OWU A;  4X5B A;  4YI7 A;  3GBR A;  5EY3 A;  4LHM A;  4ZOF A;  4ZOJ A;  4YEK A;  4OWS A;  1AZY A;  4OWM A;  4X5D A;  4N93 A;  4OWQ A;  4EAF A;  2ELC A;  1ZYK A;  4IJ1 A;  4X58 A;  4GTN A; 
#chains in the Genus database with same CATH homology
 2DSJ A;  1O17 A;  4YYY A;  5C1R A;  1KHD A;  1V8G A;  2WK5 A;  4ZTV A;  2J0F A;  1OTP A;  4GKM A;  1UOU A;  4OWN A;  3QS8 A;  5BO2 A;  4X59 A;  4M0R A;  4GA4 A;  3R88 A;  2TPT A;  3QSA A;  1ZXY A;  2WK6 A;  5BO3 A;  3QR9 A;  4X5C A;  1KGZ A;  2BPQ A;  4X46 A;  4ZOK A;  3QQS A;  5BNE A;  5BYT A;  2GVQ A;  3TWP A;  5C2L A;  4HKM A;  5C7S A;  4GIU A;  4N8Q A;  4GA5 A;  1GXB A;  3UU1 A;  4X5A A;  1ZVW A;  5EP8 A;  4XR5 A;  4MUO A;  3H5Q A;  4N5V A;  3R6C A;  1BRW A;  1VQU A;  4OWV A;  4OWO A;  4EAD A;  4X5E A;  4GA6 A;  4OWU A;  4X5B A;  4YI7 A;  3GBR A;  5EY3 A;  4LHM A;  4ZOF A;  4ZOJ A;  4YEK A;  4OWS A;  1AZY A;  4OWM A;  4X5D A;  4N93 A;  4OWQ A;  4EAF A;  2ELC A;  1ZYK A;  4IJ1 A;  4X58 A;  4GTN A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...