4X58A

Anthranilate phosphoribosyl transferase variant n138a from mycobacterium tuberculosis in complex with prpp and mg
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
347
structure length
347
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGARAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 124
structure length 347
sequence length 347
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2014-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x58A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x58A02
4YI7A 5C7SA 4IJ1A 5BO2A 3GBRA 4GA5A 5BO3A 4YEKA 4X5DA 4X46A 4N93A 4HKMA 2WK5A 2GVQA 1KHDA 1KGZA 2BPQA 5C1RA 4XR5A 1ZVWA 3QSAA 3TWPA 4N8QA 1UOUA 5BYTA 4YYYA 5BNEA 4GA4A 4GKMA 4OWQA 3UU1A 3QQSA 2ELCA 1GXBA 4ZTVA 4EAFA 1ZYKA 4M0RA 2TPTA 4OWUA 4GA6A 4OWMA 1OTPA 4EADA 4N5VA 3H5QA 1V8GA 4ZOFA 3R88A 4OWSA 4X5EA 4GTNA 3QR9A 5EP8A 1VQUA 4X5BA 1BRWA 2J0FA 4X58A 4X5AA 5EY3A 3R6CA 1AZYA 4OWNA 5C2LA 3QS8A 4OWOA 4X59A 1ZXYA 4LHMA 4X5CA 2WK6A 2DSJA 4ZOKA 1O17A 4OWVA 4GIUA 4ZOJA 4MUOA
chains in the Genus database with same CATH superfamily
4YI7A 5C7SA 4IJ1A 5BO2A 3GBRA 4GA5A 5BO3A 4YEKA 4X5DA 4X46A 4N93A 4HKMA 2WK5A 2GVQA 1KHDA 1KGZA 2BPQA 5C1RA 4XR5A 1ZVWA 3QSAA 3TWPA 4N8QA 1UOUA 5BYTA 4YYYA 1RF8B 5BNEA 4GA4A 4GKMA 1RRZA 4OWQA 3UU1A 3QQSA 4F3FC 2ELCA 1GXBA 4ZTVA 4EAFA 1ZYKA 4M0RA 2TPTA 4GA6A 4OWUA 4OWMA 1OTPA 4EADA 4N5VA 3H5QA 1V8GA 4ZOFA 3R88A 4OWSA 4X5EA 4GTNA 3QR9A 5EP8A 1VQUA 4X5BA 1BRWA 2J0FA 4X58A 4X5AA 5EY3A 3R6CA 1AZYA 4OWNA 5C2LA 3QS8A 4OWOA 4X59A 1ZXYA 4LHMA 4X5CA 2WK6A 2DSJA 4ZOKA 1O17A 4OWVA 4GIUA 4ZOJA 4MUOA
chains in the Genus database with same CATH topology
4YI7A 5C7SA 4IJ1A 5BO2A 3GBRA 4GA5A 5BO3A 4YEKA 4X5DA 4X46A 4N93A 4HKMA 2WK5A 2GVQA 1KHDA 1KGZA 2BPQA 5C1RA 4XR5A 1ZVWA 3QSAA 3TWPA 4N8QA 1UOUA 5BYTA 4YYYA 5BNEA 4GA4A 4GKMA 4OWQA 3UU1A 3QQSA 2ELCA 1GXBA 4ZTVA 4EAFA 1ZYKA 4M0RA 2TPTA 4OWUA 4GA6A 4OWMA 1OTPA 4EADA 4N5VA 3H5QA 1V8GA 4ZOFA 3R88A 4OWSA 4X5EA 4GTNA 3QR9A 5EP8A 1VQUA 4X5BA 1BRWA 2J0FA 4X58A 4X5AA 5EY3A 3R6CA 1AZYA 4OWNA 5C2LA 3QS8A 4OWOA 4X59A 1ZXYA 4LHMA 4X5CA 2WK6A 2DSJA 4ZOKA 1O17A 4OWVA 4GIUA 4ZOJA 4MUOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YI7 A;  5C7S A;  4IJ1 A;  5BO2 A;  3GBR A;  4GA5 A;  5BO3 A;  4YEK A;  4X5D A;  4X46 A;  4N93 A;  4HKM A;  2WK5 A;  2GVQ A;  1KHD A;  1KGZ A;  2BPQ A;  5C1R A;  4XR5 A;  1ZVW A;  3QSA A;  3TWP A;  4N8Q A;  1UOU A;  5BYT A;  4YYY A;  5BNE A;  4GA4 A;  4GKM A;  4OWQ A;  3UU1 A;  3QQS A;  2ELC A;  1GXB A;  4ZTV A;  4EAF A;  1ZYK A;  4M0R A;  2TPT A;  4OWU A;  4GA6 A;  4OWM A;  1OTP A;  4EAD A;  4N5V A;  3H5Q A;  1V8G A;  4ZOF A;  3R88 A;  4OWS A;  4X5E A;  4GTN A;  3QR9 A;  5EP8 A;  1VQU A;  4X5B A;  1BRW A;  2J0F A;  4X58 A;  4X5A A;  5EY3 A;  3R6C A;  1AZY A;  4OWN A;  5C2L A;  3QS8 A;  4OWO A;  4X59 A;  1ZXY A;  4LHM A;  4X5C A;  2WK6 A;  2DSJ A;  4ZOK A;  1O17 A;  4OWV A;  4GIU A;  4ZOJ A;  4MUO A; 
#chains in the Genus database with same CATH topology
 4YI7 A;  5C7S A;  4IJ1 A;  5BO2 A;  3GBR A;  4GA5 A;  5BO3 A;  4YEK A;  4X5D A;  4X46 A;  4N93 A;  4HKM A;  2WK5 A;  2GVQ A;  1KHD A;  1KGZ A;  2BPQ A;  5C1R A;  4XR5 A;  1ZVW A;  3QSA A;  3TWP A;  4N8Q A;  1UOU A;  5BYT A;  4YYY A;  1RF8 B;  5BNE A;  4GA4 A;  4GKM A;  1RRZ A;  4OWQ A;  3UU1 A;  3QQS A;  4F3F C;  2ELC A;  1GXB A;  4ZTV A;  4EAF A;  1ZYK A;  4M0R A;  2TPT A;  4GA6 A;  4OWU A;  4OWM A;  1OTP A;  4EAD A;  4N5V A;  3H5Q A;  1V8G A;  4ZOF A;  3R88 A;  4OWS A;  4X5E A;  4GTN A;  3QR9 A;  5EP8 A;  1VQU A;  4X5B A;  1BRW A;  2J0F A;  4X58 A;  4X5A A;  5EY3 A;  3R6C A;  1AZY A;  4OWN A;  5C2L A;  3QS8 A;  4OWO A;  4X59 A;  1ZXY A;  4LHM A;  4X5C A;  2WK6 A;  2DSJ A;  4ZOK A;  1O17 A;  4OWV A;  4GIU A;  4ZOJ A;  4MUO A; 
#chains in the Genus database with same CATH homology
 4YI7 A;  5C7S A;  4IJ1 A;  5BO2 A;  3GBR A;  4GA5 A;  5BO3 A;  4YEK A;  4X5D A;  4X46 A;  4N93 A;  4HKM A;  2WK5 A;  2GVQ A;  1KHD A;  1KGZ A;  2BPQ A;  5C1R A;  4XR5 A;  1ZVW A;  3QSA A;  3TWP A;  4N8Q A;  1UOU A;  5BYT A;  4YYY A;  5BNE A;  4GA4 A;  4GKM A;  4OWQ A;  3UU1 A;  3QQS A;  2ELC A;  1GXB A;  4ZTV A;  4EAF A;  1ZYK A;  4M0R A;  2TPT A;  4OWU A;  4GA6 A;  4OWM A;  1OTP A;  4EAD A;  4N5V A;  3H5Q A;  1V8G A;  4ZOF A;  3R88 A;  4OWS A;  4X5E A;  4GTN A;  3QR9 A;  5EP8 A;  1VQU A;  4X5B A;  1BRW A;  2J0F A;  4X58 A;  4X5A A;  5EY3 A;  3R6C A;  1AZY A;  4OWN A;  5C2L A;  3QS8 A;  4OWO A;  4X59 A;  1ZXY A;  4LHM A;  4X5C A;  2WK6 A;  2DSJ A;  4ZOK A;  1O17 A;  4OWV A;  4GIU A;  4ZOJ A;  4MUO A; 
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