4X5AA

Anthranilate phosphoribosyltransferase variant r193a from mycobacterium tuberculosis remains ligand-free when co-crystallised with prpp and mg
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
348
structure length
345
Chain Sequence
SVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVAREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
source organism Mycobacterium tuberculosis
publication title Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
pubmed doi rcsb
molecule keywords Anthranilate phosphoribosyltransferase
total genus 119
structure length 345
sequence length 348
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2014-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x5aA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x5aA02
1O17A 1V8GA 2ELCA 4GA4A 4GIUA 4M0RA 2DSJA 4OWOA 4N5VA 4X46A 4MUOA 5BYTA 3R6CA 4YEKA 5C7SA 1KHDA 4X58A 5BO3A 3H5QA 5C2LA 1GXBA 4ZOJA 4YI7A 2GVQA 4GTNA 4ZOKA 4GKMA 4LHMA 1KGZA 5EY3A 4HKMA 1ZXYA 4OWUA 5BNEA 4X5EA 4ZOFA 3QSAA 2WK5A 4OWVA 1AZYA 4GA5A 4EAFA 4GA6A 4X5BA 4XR5A 5BO2A 1UOUA 3GBRA 4OWNA 4EADA 4IJ1A 5EP8A 4OWSA 2TPTA 4ZTVA 1VQUA 3QQSA 3R88A 1BRWA 3QS8A 4YYYA 4N8QA 5C1RA 4X59A 1ZVWA 1OTPA 4X5DA 4N93A 1ZYKA 3UU1A 2BPQA 4X5CA 3TWPA 2WK6A 4OWQA 4OWMA 3QR9A 2J0FA 4X5AA
chains in the Genus database with same CATH superfamily
1O17A 1V8GA 2ELCA 4GA4A 4GIUA 4M0RA 2DSJA 4OWOA 4N5VA 4X46A 4MUOA 5BYTA 3R6CA 1RRZA 4YEKA 5C7SA 1KHDA 4X58A 5BO3A 3H5QA 5C2LA 1GXBA 4ZOJA 4YI7A 2GVQA 4GTNA 4ZOKA 4GKMA 4LHMA 1KGZA 5EY3A 4HKMA 1ZXYA 4OWUA 5BNEA 4X5EA 4ZOFA 3QSAA 2WK5A 4OWVA 1AZYA 4GA5A 4EAFA 4GA6A 4X5BA 4XR5A 5BO2A 1UOUA 3GBRA 4OWNA 4EADA 4IJ1A 5EP8A 4OWSA 2TPTA 4ZTVA 1VQUA 3QQSA 3R88A 1BRWA 3QS8A 4YYYA 4N8QA 4F3FC 5C1RA 4X59A 1ZVWA 1OTPA 4X5DA 4N93A 1ZYKA 3UU1A 2BPQA 4X5CA 3TWPA 2WK6A 4OWQA 4OWMA 1RF8B 3QR9A 2J0FA 4X5AA
chains in the Genus database with same CATH topology
1O17A 1V8GA 2ELCA 4GA4A 4GIUA 4M0RA 2DSJA 4OWOA 4N5VA 4X46A 4MUOA 5BYTA 3R6CA 4YEKA 5C7SA 1KHDA 4X58A 5BO3A 3H5QA 5C2LA 1GXBA 4ZOJA 4YI7A 2GVQA 4GTNA 4ZOKA 4GKMA 4LHMA 1KGZA 5EY3A 4HKMA 1ZXYA 4OWUA 5BNEA 4X5EA 4ZOFA 3QSAA 2WK5A 4OWVA 1AZYA 4GA5A 4EAFA 4GA6A 4X5BA 4XR5A 5BO2A 1UOUA 3GBRA 4OWNA 4EADA 4IJ1A 5EP8A 4OWSA 2TPTA 4ZTVA 1VQUA 3QQSA 3R88A 1BRWA 3QS8A 4YYYA 4N8QA 5C1RA 4X59A 1ZVWA 1OTPA 4X5DA 4N93A 1ZYKA 3UU1A 2BPQA 4X5CA 3TWPA 2WK6A 4OWQA 4OWMA 3QR9A 2J0FA 4X5AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O17 A;  1V8G A;  2ELC A;  4GA4 A;  4GIU A;  4M0R A;  2DSJ A;  4OWO A;  4N5V A;  4X46 A;  4MUO A;  5BYT A;  3R6C A;  4YEK A;  5C7S A;  1KHD A;  4X58 A;  5BO3 A;  3H5Q A;  5C2L A;  1GXB A;  4ZOJ A;  4YI7 A;  2GVQ A;  4GTN A;  4ZOK A;  4GKM A;  4LHM A;  1KGZ A;  5EY3 A;  4HKM A;  1ZXY A;  4OWU A;  5BNE A;  4X5E A;  4ZOF A;  3QSA A;  2WK5 A;  4OWV A;  1AZY A;  4GA5 A;  4EAF A;  4GA6 A;  4X5B A;  4XR5 A;  5BO2 A;  1UOU A;  3GBR A;  4OWN A;  4EAD A;  4IJ1 A;  5EP8 A;  4OWS A;  2TPT A;  4ZTV A;  1VQU A;  3QQS A;  3R88 A;  1BRW A;  3QS8 A;  4YYY A;  4N8Q A;  5C1R A;  4X59 A;  1ZVW A;  1OTP A;  4X5D A;  4N93 A;  1ZYK A;  3UU1 A;  2BPQ A;  4X5C A;  3TWP A;  2WK6 A;  4OWQ A;  4OWM A;  3QR9 A;  2J0F A;  4X5A A; 
#chains in the Genus database with same CATH topology
 1O17 A;  1V8G A;  2ELC A;  4GA4 A;  4GIU A;  4M0R A;  2DSJ A;  4OWO A;  4N5V A;  4X46 A;  4MUO A;  5BYT A;  3R6C A;  1RRZ A;  4YEK A;  5C7S A;  1KHD A;  4X58 A;  5BO3 A;  3H5Q A;  5C2L A;  1GXB A;  4ZOJ A;  4YI7 A;  2GVQ A;  4GTN A;  4ZOK A;  4GKM A;  4LHM A;  1KGZ A;  5EY3 A;  4HKM A;  1ZXY A;  4OWU A;  5BNE A;  4X5E A;  4ZOF A;  3QSA A;  2WK5 A;  4OWV A;  1AZY A;  4GA5 A;  4EAF A;  4GA6 A;  4X5B A;  4XR5 A;  5BO2 A;  1UOU A;  3GBR A;  4OWN A;  4EAD A;  4IJ1 A;  5EP8 A;  4OWS A;  2TPT A;  4ZTV A;  1VQU A;  3QQS A;  3R88 A;  1BRW A;  3QS8 A;  4YYY A;  4N8Q A;  4F3F C;  5C1R A;  4X59 A;  1ZVW A;  1OTP A;  4X5D A;  4N93 A;  1ZYK A;  3UU1 A;  2BPQ A;  4X5C A;  3TWP A;  2WK6 A;  4OWQ A;  4OWM A;  1RF8 B;  3QR9 A;  2J0F A;  4X5A A; 
#chains in the Genus database with same CATH homology
 1O17 A;  1V8G A;  2ELC A;  4GA4 A;  4GIU A;  4M0R A;  2DSJ A;  4OWO A;  4N5V A;  4X46 A;  4MUO A;  5BYT A;  3R6C A;  4YEK A;  5C7S A;  1KHD A;  4X58 A;  5BO3 A;  3H5Q A;  5C2L A;  1GXB A;  4ZOJ A;  4YI7 A;  2GVQ A;  4GTN A;  4ZOK A;  4GKM A;  4LHM A;  1KGZ A;  5EY3 A;  4HKM A;  1ZXY A;  4OWU A;  5BNE A;  4X5E A;  4ZOF A;  3QSA A;  2WK5 A;  4OWV A;  1AZY A;  4GA5 A;  4EAF A;  4GA6 A;  4X5B A;  4XR5 A;  5BO2 A;  1UOU A;  3GBR A;  4OWN A;  4EAD A;  4IJ1 A;  5EP8 A;  4OWS A;  2TPT A;  4ZTV A;  1VQU A;  3QQS A;  3R88 A;  1BRW A;  3QS8 A;  4YYY A;  4N8Q A;  5C1R A;  4X59 A;  1ZVW A;  1OTP A;  4X5D A;  4N93 A;  1ZYK A;  3UU1 A;  2BPQ A;  4X5C A;  3TWP A;  2WK6 A;  4OWQ A;  4OWM A;  3QR9 A;  2J0F A;  4X5A A; 
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similar chains in the Genus database (?% sequence similarity)
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