4X5AA

Anthranilate phosphoribosyltransferase variant r193a from mycobacterium tuberculosis remains ligand-free when co-crystallised with prpp and mg
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
348
structure length
345
Chain Sequence
SVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVAREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 119
structure length 345
sequence length 348
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2014-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x5aA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x5aA02
4EAFA 4OWSA 1UOUA 1O17A 4GA5A 2TPTA 3QQSA 4OWVA 4OWQA 4HKMA 5BO3A 4EADA 2GVQA 4ZOFA 4YEKA 4X5DA 5C1RA 4OWUA 4LHMA 1GXBA 1ZXYA 1BRWA 4N93A 5BYTA 5C2LA 4YYYA 2ELCA 3QR9A 4IJ1A 4X5CA 1AZYA 5BNEA 3QS8A 4GA4A 3QSAA 4GTNA 1OTPA 4OWNA 4N8QA 4X46A 4OWOA 4GA6A 5EY3A 4ZOJA 4M0RA 1KHDA 5BO2A 3H5QA 2J0FA 4GIUA 5C7SA 4MUOA 4X59A 4X5AA 4X5EA 4ZOKA 3TWPA 2DSJA 4XR5A 1ZVWA 5EP8A 4N5VA 4X58A 3UU1A 2BPQA 1V8GA 1KGZA 1VQUA 3R6CA 4OWMA 2WK5A 3R88A 4YI7A 2WK6A 4GKMA 3GBRA 1ZYKA 4ZTVA 4X5BA
chains in the Genus database with same CATH superfamily
1RF8B 4EAFA 4OWSA 1UOUA 1O17A 4GA5A 2TPTA 3QQSA 4OWVA 4OWQA 4HKMA 5BO3A 4EADA 2GVQA 4ZOFA 4YEKA 4X5DA 5C1RA 4OWUA 4LHMA 1GXBA 1ZXYA 1BRWA 4N93A 5BYTA 5C2LA 4YYYA 2ELCA 3QR9A 4IJ1A 4X5CA 1AZYA 5BNEA 3QS8A 4GA4A 3QSAA 4GTNA 1OTPA 4OWNA 4N8QA 4X46A 4OWOA 4GA6A 5EY3A 4ZOJA 4M0RA 1KHDA 5BO2A 3H5QA 2J0FA 4GIUA 5C7SA 4MUOA 4X59A 4X5AA 4X5EA 4ZOKA 3TWPA 2DSJA 4XR5A 1ZVWA 5EP8A 4N5VA 4X58A 3UU1A 2BPQA 1V8GA 1KGZA 1VQUA 3R6CA 4OWMA 2WK5A 3R88A 4YI7A 2WK6A 4GKMA 3GBRA 1ZYKA 1RRZA 4ZTVA 4F3FC 4X5BA
chains in the Genus database with same CATH topology
4EAFA 4OWSA 1UOUA 1O17A 4GA5A 2TPTA 3QQSA 4OWVA 4OWQA 4HKMA 5BO3A 4EADA 2GVQA 4ZOFA 4YEKA 4X5DA 5C1RA 4OWUA 4LHMA 1GXBA 1ZXYA 1BRWA 4N93A 5BYTA 5C2LA 4YYYA 2ELCA 3QR9A 4IJ1A 4X5CA 1AZYA 5BNEA 3QS8A 4GA4A 3QSAA 4GTNA 1OTPA 4OWNA 4N8QA 4X46A 4OWOA 4GA6A 5EY3A 4ZOJA 4M0RA 1KHDA 5BO2A 3H5QA 2J0FA 4GIUA 5C7SA 4MUOA 4X59A 4X5AA 4X5EA 4ZOKA 3TWPA 2DSJA 4XR5A 1ZVWA 5EP8A 4N5VA 4X58A 3UU1A 2BPQA 1V8GA 1KGZA 1VQUA 3R6CA 4OWMA 2WK5A 3R88A 4YI7A 2WK6A 4GKMA 3GBRA 1ZYKA 4ZTVA 4X5BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EAF A;  4OWS A;  1UOU A;  1O17 A;  4GA5 A;  2TPT A;  3QQS A;  4OWV A;  4OWQ A;  4HKM A;  5BO3 A;  4EAD A;  2GVQ A;  4ZOF A;  4YEK A;  4X5D A;  5C1R A;  4OWU A;  4LHM A;  1GXB A;  1ZXY A;  1BRW A;  4N93 A;  5BYT A;  5C2L A;  4YYY A;  2ELC A;  3QR9 A;  4IJ1 A;  4X5C A;  1AZY A;  5BNE A;  3QS8 A;  4GA4 A;  3QSA A;  4GTN A;  1OTP A;  4OWN A;  4N8Q A;  4X46 A;  4OWO A;  4GA6 A;  5EY3 A;  4ZOJ A;  4M0R A;  1KHD A;  5BO2 A;  3H5Q A;  2J0F A;  4GIU A;  5C7S A;  4MUO A;  4X59 A;  4X5A A;  4X5E A;  4ZOK A;  3TWP A;  2DSJ A;  4XR5 A;  1ZVW A;  5EP8 A;  4N5V A;  4X58 A;  3UU1 A;  2BPQ A;  1V8G A;  1KGZ A;  1VQU A;  3R6C A;  4OWM A;  2WK5 A;  3R88 A;  4YI7 A;  2WK6 A;  4GKM A;  3GBR A;  1ZYK A;  4ZTV A;  4X5B A; 
#chains in the Genus database with same CATH topology
 1RF8 B;  4EAF A;  4OWS A;  1UOU A;  1O17 A;  4GA5 A;  2TPT A;  3QQS A;  4OWV A;  4OWQ A;  4HKM A;  5BO3 A;  4EAD A;  2GVQ A;  4ZOF A;  4YEK A;  4X5D A;  5C1R A;  4OWU A;  4LHM A;  1GXB A;  1ZXY A;  1BRW A;  4N93 A;  5BYT A;  5C2L A;  4YYY A;  2ELC A;  3QR9 A;  4IJ1 A;  4X5C A;  1AZY A;  5BNE A;  3QS8 A;  4GA4 A;  3QSA A;  4GTN A;  1OTP A;  4OWN A;  4N8Q A;  4X46 A;  4OWO A;  4GA6 A;  5EY3 A;  4ZOJ A;  4M0R A;  1KHD A;  5BO2 A;  3H5Q A;  2J0F A;  4GIU A;  5C7S A;  4MUO A;  4X59 A;  4X5A A;  4X5E A;  4ZOK A;  3TWP A;  2DSJ A;  4XR5 A;  1ZVW A;  5EP8 A;  4N5V A;  4X58 A;  3UU1 A;  2BPQ A;  1V8G A;  1KGZ A;  1VQU A;  3R6C A;  4OWM A;  2WK5 A;  3R88 A;  4YI7 A;  2WK6 A;  4GKM A;  3GBR A;  1ZYK A;  1RRZ A;  4ZTV A;  4F3F C;  4X5B A; 
#chains in the Genus database with same CATH homology
 4EAF A;  4OWS A;  1UOU A;  1O17 A;  4GA5 A;  2TPT A;  3QQS A;  4OWV A;  4OWQ A;  4HKM A;  5BO3 A;  4EAD A;  2GVQ A;  4ZOF A;  4YEK A;  4X5D A;  5C1R A;  4OWU A;  4LHM A;  1GXB A;  1ZXY A;  1BRW A;  4N93 A;  5BYT A;  5C2L A;  4YYY A;  2ELC A;  3QR9 A;  4IJ1 A;  4X5C A;  1AZY A;  5BNE A;  3QS8 A;  4GA4 A;  3QSA A;  4GTN A;  1OTP A;  4OWN A;  4N8Q A;  4X46 A;  4OWO A;  4GA6 A;  5EY3 A;  4ZOJ A;  4M0R A;  1KHD A;  5BO2 A;  3H5Q A;  2J0F A;  4GIU A;  5C7S A;  4MUO A;  4X59 A;  4X5A A;  4X5E A;  4ZOK A;  3TWP A;  2DSJ A;  4XR5 A;  1ZVW A;  5EP8 A;  4N5V A;  4X58 A;  3UU1 A;  2BPQ A;  1V8G A;  1KGZ A;  1VQU A;  3R6C A;  4OWM A;  2WK5 A;  3R88 A;  4YI7 A;  2WK6 A;  4GKM A;  3GBR A;  1ZYK A;  4ZTV A;  4X5B A; 
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similar chains in the Genus database (?% sequence similarity)
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