4X5AA

Anthranilate phosphoribosyltransferase variant r193a from mycobacterium tuberculosis remains ligand-free when co-crystallised with prpp and mg
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
348
structure length
345
Chain Sequence
SVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVAREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 119
structure length 345
sequence length 348
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2014-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x5aA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x5aA02
5BNEA 2BPQA 4ZOFA 4GKMA 1KHDA 4GTNA 1AZYA 2TPTA 1BRWA 4GIUA 4EAFA 4ZOKA 4GA5A 4YI7A 4EADA 4GA6A 3QS8A 4X59A 5BO3A 3TWPA 4N93A 4XR5A 4X5EA 4N5VA 3H5QA 5C2LA 4IJ1A 3QQSA 4YEKA 4OWOA 3QSAA 4OWVA 4N8QA 3QR9A 4ZTVA 1GXBA 3GBRA 1ZYKA 1KGZA 2J0FA 3R6CA 4X5AA 1O17A 2ELCA 4X46A 3UU1A 1ZXYA 4OWNA 4X5DA 4M0RA 4X5CA 4GA4A 5C7SA 5BO2A 4HKMA 4YYYA 1OTPA 2WK6A 4OWMA 4LHMA 3R88A 4OWQA 2DSJA 4X5BA 2GVQA 5EY3A 1UOUA 4X58A 4OWSA 4OWUA 5BYTA 4MUOA 1V8GA 5C1RA 1ZVWA 5EP8A 1VQUA 2WK5A 4ZOJA
chains in the Genus database with same CATH superfamily
5BNEA 2BPQA 4ZOFA 4GKMA 1KHDA 4GTNA 1AZYA 2TPTA 1BRWA 4GIUA 4EAFA 4ZOKA 4GA5A 4YI7A 4EADA 4GA6A 3QS8A 4X59A 5BO3A 3TWPA 4N93A 4XR5A 4X5EA 4N5VA 3H5QA 5C2LA 4IJ1A 3QQSA 4YEKA 4OWOA 3QSAA 4F3FC 4OWVA 4N8QA 3QR9A 4ZTVA 1GXBA 3GBRA 1ZYKA 1KGZA 1RRZA 2J0FA 3R6CA 4X5AA 1O17A 2ELCA 4X46A 3UU1A 1ZXYA 4OWNA 4X5DA 4M0RA 4X5CA 4GA4A 5C7SA 5BO2A 4HKMA 4YYYA 1OTPA 2WK6A 4OWMA 4LHMA 3R88A 4OWQA 2DSJA 4X5BA 2GVQA 5EY3A 1UOUA 4X58A 4OWSA 1RF8B 4OWUA 5BYTA 4MUOA 1V8GA 5C1RA 1ZVWA 5EP8A 1VQUA 2WK5A 4ZOJA
chains in the Genus database with same CATH topology
5BNEA 2BPQA 4ZOFA 4GKMA 1KHDA 4GTNA 1AZYA 2TPTA 1BRWA 4GIUA 4EAFA 4ZOKA 4GA5A 4YI7A 4EADA 4GA6A 3QS8A 4X59A 5BO3A 3TWPA 4N93A 4XR5A 4X5EA 4N5VA 3H5QA 5C2LA 4IJ1A 3QQSA 4YEKA 4OWOA 3QSAA 4OWVA 4N8QA 3QR9A 4ZTVA 1GXBA 3GBRA 1ZYKA 1KGZA 2J0FA 3R6CA 4X5AA 1O17A 2ELCA 4X46A 3UU1A 1ZXYA 4OWNA 4X5DA 4M0RA 4X5CA 4GA4A 5C7SA 5BO2A 4HKMA 4YYYA 1OTPA 2WK6A 4OWMA 4LHMA 3R88A 4OWQA 2DSJA 4X5BA 2GVQA 5EY3A 1UOUA 4X58A 4OWSA 4OWUA 5BYTA 4MUOA 1V8GA 5C1RA 1ZVWA 5EP8A 1VQUA 2WK5A 4ZOJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5BNE A;  2BPQ A;  4ZOF A;  4GKM A;  1KHD A;  4GTN A;  1AZY A;  2TPT A;  1BRW A;  4GIU A;  4EAF A;  4ZOK A;  4GA5 A;  4YI7 A;  4EAD A;  4GA6 A;  3QS8 A;  4X59 A;  5BO3 A;  3TWP A;  4N93 A;  4XR5 A;  4X5E A;  4N5V A;  3H5Q A;  5C2L A;  4IJ1 A;  3QQS A;  4YEK A;  4OWO A;  3QSA A;  4OWV A;  4N8Q A;  3QR9 A;  4ZTV A;  1GXB A;  3GBR A;  1ZYK A;  1KGZ A;  2J0F A;  3R6C A;  4X5A A;  1O17 A;  2ELC A;  4X46 A;  3UU1 A;  1ZXY A;  4OWN A;  4X5D A;  4M0R A;  4X5C A;  4GA4 A;  5C7S A;  5BO2 A;  4HKM A;  4YYY A;  1OTP A;  2WK6 A;  4OWM A;  4LHM A;  3R88 A;  4OWQ A;  2DSJ A;  4X5B A;  2GVQ A;  5EY3 A;  1UOU A;  4X58 A;  4OWS A;  4OWU A;  5BYT A;  4MUO A;  1V8G A;  5C1R A;  1ZVW A;  5EP8 A;  1VQU A;  2WK5 A;  4ZOJ A; 
#chains in the Genus database with same CATH topology
 5BNE A;  2BPQ A;  4ZOF A;  4GKM A;  1KHD A;  4GTN A;  1AZY A;  2TPT A;  1BRW A;  4GIU A;  4EAF A;  4ZOK A;  4GA5 A;  4YI7 A;  4EAD A;  4GA6 A;  3QS8 A;  4X59 A;  5BO3 A;  3TWP A;  4N93 A;  4XR5 A;  4X5E A;  4N5V A;  3H5Q A;  5C2L A;  4IJ1 A;  3QQS A;  4YEK A;  4OWO A;  3QSA A;  4F3F C;  4OWV A;  4N8Q A;  3QR9 A;  4ZTV A;  1GXB A;  3GBR A;  1ZYK A;  1KGZ A;  1RRZ A;  2J0F A;  3R6C A;  4X5A A;  1O17 A;  2ELC A;  4X46 A;  3UU1 A;  1ZXY A;  4OWN A;  4X5D A;  4M0R A;  4X5C A;  4GA4 A;  5C7S A;  5BO2 A;  4HKM A;  4YYY A;  1OTP A;  2WK6 A;  4OWM A;  4LHM A;  3R88 A;  4OWQ A;  2DSJ A;  4X5B A;  2GVQ A;  5EY3 A;  1UOU A;  4X58 A;  4OWS A;  1RF8 B;  4OWU A;  5BYT A;  4MUO A;  1V8G A;  5C1R A;  1ZVW A;  5EP8 A;  1VQU A;  2WK5 A;  4ZOJ A; 
#chains in the Genus database with same CATH homology
 5BNE A;  2BPQ A;  4ZOF A;  4GKM A;  1KHD A;  4GTN A;  1AZY A;  2TPT A;  1BRW A;  4GIU A;  4EAF A;  4ZOK A;  4GA5 A;  4YI7 A;  4EAD A;  4GA6 A;  3QS8 A;  4X59 A;  5BO3 A;  3TWP A;  4N93 A;  4XR5 A;  4X5E A;  4N5V A;  3H5Q A;  5C2L A;  4IJ1 A;  3QQS A;  4YEK A;  4OWO A;  3QSA A;  4OWV A;  4N8Q A;  3QR9 A;  4ZTV A;  1GXB A;  3GBR A;  1ZYK A;  1KGZ A;  2J0F A;  3R6C A;  4X5A A;  1O17 A;  2ELC A;  4X46 A;  3UU1 A;  1ZXY A;  4OWN A;  4X5D A;  4M0R A;  4X5C A;  4GA4 A;  5C7S A;  5BO2 A;  4HKM A;  4YYY A;  1OTP A;  2WK6 A;  4OWM A;  4LHM A;  3R88 A;  4OWQ A;  2DSJ A;  4X5B A;  2GVQ A;  5EY3 A;  1UOU A;  4X58 A;  4OWS A;  4OWU A;  5BYT A;  4MUO A;  1V8G A;  5C1R A;  1ZVW A;  5EP8 A;  1VQU A;  2WK5 A;  4ZOJ A; 
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