4X5CA

Anthranilate phosphoribosyltransferase variant r193l from mycobacterium tuberculosis with pyrophosphate/prpp and mg2+ bound
Total Genus 115

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
347
structure length
347
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVLREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (27-36)AH3 (59-71)AH2 (44-54)S3 (174-178)AH8 (187-196)TI2 (157-160)AH10 (294-306)AH4 (76-89)AH9 (226-237)EMPTYTIV4 (264-267)TII2 (94-97)S7 (268-274)TI1 (99-102)S1 (103-107)AH11 (311-329)TIV2 (181-184)O1 (116-118)AH5 (118-129)S2 (133-137)AH12 (336-353)AH6 (147-154)TIV1 (140-143)AH7 (162-172)3H2 (184-186)3H1 (179-181)3H3 (201-204)S4 (216-220)TI3 (210-213)S5 (240-246)S6 (259-265)TI5 (246-249)TIV3 (254-257)TII3 (331-334)TVIII2 (329-332)3H4 (206-208)TII1 (41-44)TVIII1 (143-146)3H5 (276-279)3H6 (286-289)TI4 (223-226)Updating...
connected with : NaN
publication title Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 115
structure length 347
sequence length 347
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2014-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x5cA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x5cA02
2ELCA 1V8GA 1ZVWA 4M0RA 4N8QA 1ZXYA 4X5EA 4GKMA 4OWSA 2WK6A 3GBRA 4EAFA 4X46A 4GA6A 1O17A 2TPTA 5EP8A 4HKMA 4XR5A 1KHDA 4IJ1A 4N93A 4GA5A 4X5CA 3H5QA 1ZYKA 4LHMA 5C7SA 5BNEA 4OWUA 5BYTA 4YEKA 5EY3A 2GVQA 4OWMA 4OWNA 5C1RA 5BO2A 4X5BA 4YYYA 2DSJA 2WK5A 4ZOFA 4X5DA 5C2LA 4YI7A 4OWVA 4MUOA 1AZYA 3QR9A 4X58A 3R6CA 4OWQA 3QS8A 1BRWA 1KGZA 3QQSA 1OTPA 4N5VA 3TWPA 1VQUA 4X59A 4OWOA 4ZOJA 3QSAA 4GTNA 3R88A 4ZOKA 1UOUA 4GA4A 1GXBA 2J0FA 3UU1A 4GIUA 2BPQA 4EADA 4ZTVA 4X5AA 5BO3A
chains in the Genus database with same CATH superfamily
2ELCA 1V8GA 1ZVWA 4M0RA 4N8QA 1ZXYA 4X5EA 4GKMA 1RRZA 4OWSA 1RF8B 2WK6A 3GBRA 4EAFA 4X46A 4GA6A 1O17A 2TPTA 5EP8A 4HKMA 4XR5A 1KHDA 4IJ1A 4N93A 4GA5A 4X5CA 3H5QA 1ZYKA 4LHMA 5C7SA 5BNEA 4OWUA 5BYTA 4YEKA 5EY3A 2GVQA 4OWMA 4OWNA 5C1RA 5BO2A 4X5BA 4YYYA 2DSJA 2WK5A 4ZOFA 4X5DA 5C2LA 4YI7A 4OWVA 4MUOA 1AZYA 3QR9A 4X58A 3R6CA 4OWQA 3QS8A 1BRWA 1KGZA 3QQSA 1OTPA 4N5VA 3TWPA 1VQUA 4X59A 4OWOA 4ZOJA 3QSAA 4GTNA 3R88A 4ZOKA 1UOUA 4GA4A 1GXBA 2J0FA 3UU1A 4F3FC 4GIUA 2BPQA 4EADA 4ZTVA 4X5AA 5BO3A
chains in the Genus database with same CATH topology
2ELCA 1V8GA 1ZVWA 4M0RA 4N8QA 1ZXYA 4X5EA 4GKMA 4OWSA 2WK6A 3GBRA 4EAFA 4X46A 4GA6A 1O17A 2TPTA 5EP8A 4HKMA 4XR5A 1KHDA 4IJ1A 4N93A 4GA5A 4X5CA 3H5QA 1ZYKA 4LHMA 5C7SA 5BNEA 4OWUA 5BYTA 4YEKA 5EY3A 2GVQA 4OWMA 4OWNA 5C1RA 5BO2A 4X5BA 4YYYA 2DSJA 2WK5A 4ZOFA 4X5DA 5C2LA 4YI7A 4OWVA 4MUOA 1AZYA 3QR9A 4X58A 3R6CA 4OWQA 3QS8A 1BRWA 1KGZA 3QQSA 1OTPA 4N5VA 3TWPA 1VQUA 4X59A 4OWOA 4ZOJA 3QSAA 4GTNA 3R88A 4ZOKA 1UOUA 4GA4A 1GXBA 2J0FA 3UU1A 4GIUA 2BPQA 4EADA 4ZTVA 4X5AA 5BO3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ELC A;  1V8G A;  1ZVW A;  4M0R A;  4N8Q A;  1ZXY A;  4X5E A;  4GKM A;  4OWS A;  2WK6 A;  3GBR A;  4EAF A;  4X46 A;  4GA6 A;  1O17 A;  2TPT A;  5EP8 A;  4HKM A;  4XR5 A;  1KHD A;  4IJ1 A;  4N93 A;  4GA5 A;  4X5C A;  3H5Q A;  1ZYK A;  4LHM A;  5C7S A;  5BNE A;  4OWU A;  5BYT A;  4YEK A;  5EY3 A;  2GVQ A;  4OWM A;  4OWN A;  5C1R A;  5BO2 A;  4X5B A;  4YYY A;  2DSJ A;  2WK5 A;  4ZOF A;  4X5D A;  5C2L A;  4YI7 A;  4OWV A;  4MUO A;  1AZY A;  3QR9 A;  4X58 A;  3R6C A;  4OWQ A;  3QS8 A;  1BRW A;  1KGZ A;  3QQS A;  1OTP A;  4N5V A;  3TWP A;  1VQU A;  4X59 A;  4OWO A;  4ZOJ A;  3QSA A;  4GTN A;  3R88 A;  4ZOK A;  1UOU A;  4GA4 A;  1GXB A;  2J0F A;  3UU1 A;  4GIU A;  2BPQ A;  4EAD A;  4ZTV A;  4X5A A;  5BO3 A; 
#chains in the Genus database with same CATH topology
 2ELC A;  1V8G A;  1ZVW A;  4M0R A;  4N8Q A;  1ZXY A;  4X5E A;  4GKM A;  1RRZ A;  4OWS A;  1RF8 B;  2WK6 A;  3GBR A;  4EAF A;  4X46 A;  4GA6 A;  1O17 A;  2TPT A;  5EP8 A;  4HKM A;  4XR5 A;  1KHD A;  4IJ1 A;  4N93 A;  4GA5 A;  4X5C A;  3H5Q A;  1ZYK A;  4LHM A;  5C7S A;  5BNE A;  4OWU A;  5BYT A;  4YEK A;  5EY3 A;  2GVQ A;  4OWM A;  4OWN A;  5C1R A;  5BO2 A;  4X5B A;  4YYY A;  2DSJ A;  2WK5 A;  4ZOF A;  4X5D A;  5C2L A;  4YI7 A;  4OWV A;  4MUO A;  1AZY A;  3QR9 A;  4X58 A;  3R6C A;  4OWQ A;  3QS8 A;  1BRW A;  1KGZ A;  3QQS A;  1OTP A;  4N5V A;  3TWP A;  1VQU A;  4X59 A;  4OWO A;  4ZOJ A;  3QSA A;  4GTN A;  3R88 A;  4ZOK A;  1UOU A;  4GA4 A;  1GXB A;  2J0F A;  3UU1 A;  4F3F C;  4GIU A;  2BPQ A;  4EAD A;  4ZTV A;  4X5A A;  5BO3 A; 
#chains in the Genus database with same CATH homology
 2ELC A;  1V8G A;  1ZVW A;  4M0R A;  4N8Q A;  1ZXY A;  4X5E A;  4GKM A;  4OWS A;  2WK6 A;  3GBR A;  4EAF A;  4X46 A;  4GA6 A;  1O17 A;  2TPT A;  5EP8 A;  4HKM A;  4XR5 A;  1KHD A;  4IJ1 A;  4N93 A;  4GA5 A;  4X5C A;  3H5Q A;  1ZYK A;  4LHM A;  5C7S A;  5BNE A;  4OWU A;  5BYT A;  4YEK A;  5EY3 A;  2GVQ A;  4OWM A;  4OWN A;  5C1R A;  5BO2 A;  4X5B A;  4YYY A;  2DSJ A;  2WK5 A;  4ZOF A;  4X5D A;  5C2L A;  4YI7 A;  4OWV A;  4MUO A;  1AZY A;  3QR9 A;  4X58 A;  3R6C A;  4OWQ A;  3QS8 A;  1BRW A;  1KGZ A;  3QQS A;  1OTP A;  4N5V A;  3TWP A;  1VQU A;  4X59 A;  4OWO A;  4ZOJ A;  3QSA A;  4GTN A;  3R88 A;  4ZOK A;  1UOU A;  4GA4 A;  1GXB A;  2J0F A;  3UU1 A;  4GIU A;  2BPQ A;  4EAD A;  4ZTV A;  4X5A A;  5BO3 A; 
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