4ZTV | Genus

Total Genus 124

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	124
sequence length	347
structure length	339
Chain Sequence	PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQIL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 339 atoms

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339 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis. rcsb
molecule keywords	Anthranilate phosphoribosyltransferase
molecule tags	Transferase/transferase inhibitor
source organism	Mycobacterium tuberculosis
total genus	124
structure length	339
sequence length	347
chains with identical sequence	B
ec nomenclature	ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date	2015-05-15

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00591	Glycos_transf_3	Glycosyl transferase family, a/b domain
A	PF02885	Glycos_trans_3N	Glycosyl transferase family, helical bundle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.970.10	Mainly Alpha	Up-down Bundle	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C	4ztvA01
3.40.1030.10	Alpha Beta	3-Layer(aba) Sandwich	Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain	4ztvA02

1KGZA 3QQSA 4YI7A 4MUOA 3QR9A 4OWQA 4XR5A 4OWOA 1V8GA 3QS8A 5C7SA 3UU1A 4X5BA 2TPTA 4YYYA 2BPQA 4EAFA 3R6CA 4ZOJA 4X58A 4GA5A 4GA4A 4N8QA 4X5DA 4X46A 1VQUA 4OWSA 2WK5A 4IJ1A 4OWUA 4M0RA 4GTNA 2GVQA 2WK6A 4ZOKA 3GBRA 4OWVA 5EY3A 4N5VA 4GIUA 1ZYKA 1UOUA 4OWMA 5BO2A 1GXBA 4X5AA 1ZXYA 2J0FA 4OWNA 1BRWA 4X5CA 4X59A 2DSJA 1KHDA 5C1RA 4YEKA 3H5QA 4N93A 4GKMA 1AZYA 4EADA 4ZTVA 2ELCA 3R88A 1O17A 5BYTA 1OTPA 5BO3A 5C2LA 3QSAA 1ZVWA 4HKMA 5BNEA 4LHMA 3TWPA 4GA6A 5EP8A 4X5EA 4ZOFA
chains in the Genus database with same CATH superfamily

1KGZA 1RF8B 3QQSA 4YI7A 4MUOA 3QR9A 4OWQA 4XR5A 1RRZA 4OWOA 1V8GA 3QS8A 5C7SA 3UU1A 4X5BA 2TPTA 4YYYA 2BPQA 4EAFA 3R6CA 4ZOJA 4X58A 4GA5A 4GA4A 4N8QA 4X5DA 4X46A 1VQUA 4OWSA 2WK5A 4IJ1A 4OWUA 4M0RA 4GTNA 2GVQA 2WK6A 4ZOKA 3GBRA 4OWVA 5EY3A 4N5VA 4GIUA 1ZYKA 1UOUA 4OWMA 5BO2A 1GXBA 4X5AA 1ZXYA 4F3FC 2J0FA 4OWNA 1BRWA 4X5CA 4X59A 2DSJA 1KHDA 5C1RA 4YEKA 3H5QA 4N93A 4GKMA 1AZYA 4EADA 4ZTVA 2ELCA 3R88A 1O17A 5BYTA 1OTPA 5BO3A 5C2LA 3QSAA 1ZVWA 4HKMA 5BNEA 4GA6A 4LHMA 3TWPA 5EP8A 4X5EA 4ZOFA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1KGZ A;  3QQS A;  4YI7 A;  4MUO A;  3QR9 A;  4OWQ A;  4XR5 A;  4OWO A;  1V8G A;  3QS8 A;  5C7S A;  3UU1 A;  4X5B A;  2TPT A;  4YYY A;  2BPQ A;  4EAF A;  3R6C A;  4ZOJ A;  4X58 A;  4GA5 A;  4GA4 A;  4N8Q A;  4X5D A;  4X46 A;  1VQU A;  4OWS A;  2WK5 A;  4IJ1 A;  4OWU A;  4M0R A;  4GTN A;  2GVQ A;  2WK6 A;  4ZOK A;  3GBR A;  4OWV A;  5EY3 A;  4N5V A;  4GIU A;  1ZYK A;  1UOU A;  4OWM A;  5BO2 A;  1GXB A;  4X5A A;  1ZXY A;  2J0F A;  4OWN A;  1BRW A;  4X5C A;  4X59 A;  2DSJ A;  1KHD A;  5C1R A;  4YEK A;  3H5Q A;  4N93 A;  4GKM A;  1AZY A;  4EAD A;  4ZTV A;  2ELC A;  3R88 A;  1O17 A;  5BYT A;  1OTP A;  5BO3 A;  5C2L A;  3QSA A;  1ZVW A;  4HKM A;  5BNE A;  4LHM A;  3TWP A;  4GA6 A;  5EP8 A;  4X5E A;  4ZOF A; 
#chains in the Genus database with same CATH topology
 1KGZ A;  1RF8 B;  3QQS A;  4YI7 A;  4MUO A;  3QR9 A;  4OWQ A;  4XR5 A;  1RRZ A;  4OWO A;  1V8G A;  3QS8 A;  5C7S A;  3UU1 A;  4X5B A;  2TPT A;  4YYY A;  2BPQ A;  4EAF A;  3R6C A;  4ZOJ A;  4X58 A;  4GA5 A;  4GA4 A;  4N8Q A;  4X5D A;  4X46 A;  1VQU A;  4OWS A;  2WK5 A;  4IJ1 A;  4OWU A;  4M0R A;  4GTN A;  2GVQ A;  2WK6 A;  4ZOK A;  3GBR A;  4OWV A;  5EY3 A;  4N5V A;  4GIU A;  1ZYK A;  1UOU A;  4OWM A;  5BO2 A;  1GXB A;  4X5A A;  1ZXY A;  4F3F C;  2J0F A;  4OWN A;  1BRW A;  4X5C A;  4X59 A;  2DSJ A;  1KHD A;  5C1R A;  4YEK A;  3H5Q A;  4N93 A;  4GKM A;  1AZY A;  4EAD A;  4ZTV A;  2ELC A;  3R88 A;  1O17 A;  5BYT A;  1OTP A;  5BO3 A;  5C2L A;  3QSA A;  1ZVW A;  4HKM A;  5BNE A;  4GA6 A;  4LHM A;  3TWP A;  5EP8 A;  4X5E A;  4ZOF A; 
#chains in the Genus database with same CATH homology
 1KGZ A;  3QQS A;  4YI7 A;  4MUO A;  3QR9 A;  4OWQ A;  4XR5 A;  4OWO A;  1V8G A;  3QS8 A;  5C7S A;  3UU1 A;  4X5B A;  2TPT A;  4YYY A;  2BPQ A;  4EAF A;  3R6C A;  4ZOJ A;  4X58 A;  4GA5 A;  4GA4 A;  4N8Q A;  4X5D A;  4X46 A;  1VQU A;  4OWS A;  2WK5 A;  4IJ1 A;  4OWU A;  4M0R A;  4GTN A;  2GVQ A;  2WK6 A;  4ZOK A;  3GBR A;  4OWV A;  5EY3 A;  4N5V A;  4GIU A;  1ZYK A;  1UOU A;  4OWM A;  5BO2 A;  1GXB A;  4X5A A;  1ZXY A;  2J0F A;  4OWN A;  1BRW A;  4X5C A;  4X59 A;  2DSJ A;  1KHD A;  5C1R A;  4YEK A;  3H5Q A;  4N93 A;  4GKM A;  1AZY A;  4EAD A;  4ZTV A;  2ELC A;  3R88 A;  1O17 A;  5BYT A;  1OTP A;  5BO3 A;  5C2L A;  3QSA A;  1ZVW A;  4HKM A;  5BNE A;  4LHM A;  3TWP A;  4GA6 A;  5EP8 A;  4X5E A;  4ZOF A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4ZTVA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations