4BHFA

Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 4-(trimethylammonio)pentanoate
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
384
structure length
384
Chain Sequence
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords GAMMA-BUTYROBETAINE DIOXYGENASE
total genus 119
structure length 384
sequence length 384
ec nomenclature ec 1.14.11.1: Gamma-butyrobetaine dioxygenase.
pdb deposition date 2013-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02668 TauD Taurine catabolism dioxygenase TauD, TfdA family
A PF06155 DUF971 Protein of unknown function (DUF971)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.2020.30 Alpha Beta 2-Layer Sandwich NE0471 N-terminal domain-like NE0471 N-terminal domain-like 4bhfA01
3.60.130.10 Alpha Beta 4-Layer Sandwich Double-stranded beta-helix Clavaminate synthase-like 4bhfA02
4M2FA 2WBOA 1OIIA 2OG7A 4BHIA 4BGKA 4BGMA 1DRYA 4NE0A 1OIJB 4CWDA 1GQWA 2OG5A 3EATX 4OJ8A 5KEUA 4M2GA 1GY9A 1DRTA 1DS0A 1JR7A 4YLMX 5J92A 2Q4AA 3V17A 4M26A 4M2EA 3PVJA 5HSXA 4M2IA 4C5WA 3MS5A 1NX4A 1VZ5A 1OIJC 4M25A 4M23A 3LUUA 1OIHA 4C8RA 4BHFA 3O2GA 2R6SA 3R1JA 4J5IA 4CVYA 4M27A 1GVGA 4BHGA 1OIJA 2OG6A 2WBQA 2WBPA 4BG1A 3SWTA 1OTJA 1OIKA 4FFAA 1VZ4A 4M2CA 1NX8A 4Y0EA 3N6WA 1DS1A 3V15A 1Y0ZA 1OS7A
chains in the Genus database with same CATH superfamily
4M2FA 2WBOA 1OIIA 2OG7A 4BHIA 4BGKA 4BGMA 1DRYA 4NE0A 1OIJB 4CWDA 1GQWA 2OG5A 3EATX 4OJ8A 3K8RA 4M2GA 1GY9A 5KEUA 1DRTA 1DS0A 1JR7A 4YLMX 1PG6A 2Q4AA 5J92A 3V17A 4M26A 4M2EA 3PVJA 5HSXA 4M2IA 4C5WA 3MS5A 1NX4A 1VZ5A 1OIJC 4M25A 3V15A 4M23A 3LUUA 1OIHA 4C8RA 4BHFA 3O2GA 2R6SA 3R1JA 4J5IA 4CVYA 4M27A 1GVGA 4BHGA 1OIJA 2OG6A 2WBQA 2WBPA 4BG1A 3SWTA 1OTJA 1OIKA 1YOXA 2X8NA 4FFAA 2AUWA 1VZ4A 1NX8A 4M2CA 3N6WA 1DS1A 4Y0EA 1Y0ZA 1OS7A
chains in the Genus database with same CATH topology
4NE0A 4BGKA 2Y0IA 1JR7A 4M26A 1H2KA 2W0XA 4C5WA 1OIJC 4C8RA 4M27A 1OIJA 4Z2WA 4Z1VA 2WA4A 4BG1A 3SWTA 2X8NA 4NR1A 1VZ4A 4Y0EA 1NX8A 1DS1A 3KCXA 3P3PA 1Y0ZA 1H2MA 4M2FA 2WBOA 1DRYA 3D8CA 4AI8A 4CWDA 1GQWA 2OG5A 3EATX 4M2GA 1GY9A 1DS0A 5J92A 2Q4AA 3PVJA 5HSXA 5JWPA 4M2IA 4M23A 4B7KA 4BHGA 1H2NA 2WBPA 1MZEA 4BIOA 1OTJA 1OIKA 1H2LA 1OS7A 4B7EA 1OIIA 4BGMA 4OJ8A 2YDEA 1NX4A 1IZ3A 1VZ5A 1OIHA 4JAAA 3O2GA 2R6SA 3R1JA 3OD4A 1GVGA 2OG6A 3P3NA 1MZFA 2YC0A 4M2CA 3N6WA 3V15A 2XUMA 2OG7A 4BHIA 2CGOA 1OIJB 5KEUA 3K8RA 1DRTA 2WA3A 4YLMX 3V17A 4M2EA 4M25A 3MS5A 1YCIA 2CGNA 3KCYA 3LUUA 4BHFA 4J5IA 4CVYA 2ILMA 2WBQA 4FFAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4M2F A;  2WBO A;  1OII A;  2OG7 A;  4BHI A;  4BGK A;  4BGM A;  1DRY A;  4NE0 A;  1OIJ B;  4CWD A;  1GQW A;  2OG5 A;  3EAT X;  4OJ8 A;  5KEU A;  4M2G A;  1GY9 A;  1DRT A;  1DS0 A;  1JR7 A;  4YLM X;  5J92 A;  2Q4A A;  3V17 A;  4M26 A;  4M2E A;  3PVJ A;  5HSX A;  4M2I A;  4C5W A;  3MS5 A;  1NX4 A;  1VZ5 A;  1OIJ C;  4M25 A;  4M23 A;  3LUU A;  1OIH A;  4C8R A;  4BHF A;  3O2G A;  2R6S A;  3R1J A;  4J5I A;  4CVY A;  4M27 A;  1GVG A;  4BHG A;  1OIJ A;  2OG6 A;  2WBQ A;  2WBP A;  4BG1 A;  3SWT A;  1OTJ A;  1OIK A;  4FFA A;  1VZ4 A;  4M2C A;  1NX8 A;  4Y0E A;  3N6W A;  1DS1 A;  3V15 A;  1Y0Z A;  1OS7 A; 
#chains in the Genus database with same CATH topology
 4M2F A;  2WBO A;  1OII A;  2OG7 A;  4BHI A;  4BGK A;  4BGM A;  1DRY A;  4NE0 A;  1OIJ B;  4CWD A;  1GQW A;  2OG5 A;  3EAT X;  4OJ8 A;  3K8R A;  4M2G A;  1GY9 A;  5KEU A;  1DRT A;  1DS0 A;  1JR7 A;  4YLM X;  1PG6 A;  2Q4A A;  5J92 A;  3V17 A;  4M26 A;  4M2E A;  3PVJ A;  5HSX A;  4M2I A;  4C5W A;  3MS5 A;  1NX4 A;  1VZ5 A;  1OIJ C;  4M25 A;  3V15 A;  4M23 A;  3LUU A;  1OIH A;  4C8R A;  4BHF A;  3O2G A;  2R6S A;  3R1J A;  4J5I A;  4CVY A;  4M27 A;  1GVG A;  4BHG A;  1OIJ A;  2OG6 A;  2WBQ A;  2WBP A;  4BG1 A;  3SWT A;  1OTJ A;  1OIK A;  1YOX A;  2X8N A;  4FFA A;  2AUW A;  1VZ4 A;  1NX8 A;  4M2C A;  3N6W A;  1DS1 A;  4Y0E A;  1Y0Z A;  1OS7 A; 
#chains in the Genus database with same CATH homology
 4NE0 A;  4BGK A;  2Y0I A;  1JR7 A;  4M26 A;  1H2K A;  2W0X A;  4C5W A;  1OIJ C;  4C8R A;  4M27 A;  1OIJ A;  4Z2W A;  4Z1V A;  2WA4 A;  4BG1 A;  3SWT A;  2X8N A;  4NR1 A;  1VZ4 A;  4Y0E A;  1NX8 A;  1DS1 A;  3KCX A;  3P3P A;  1Y0Z A;  1H2M A;  4M2F A;  2WBO A;  1DRY A;  3D8C A;  4AI8 A;  4CWD A;  1GQW A;  2OG5 A;  3EAT X;  4M2G A;  1GY9 A;  1DS0 A;  5J92 A;  2Q4A A;  3PVJ A;  5HSX A;  5JWP A;  4M2I A;  4M23 A;  4B7K A;  4BHG A;  1H2N A;  2WBP A;  1MZE A;  4BIO A;  1OTJ A;  1OIK A;  1H2L A;  1OS7 A;  4B7E A;  1OII A;  4BGM A;  4OJ8 A;  2YDE A;  1NX4 A;  1IZ3 A;  1VZ5 A;  1OIH A;  4JAA A;  3O2G A;  2R6S A;  3R1J A;  3OD4 A;  1GVG A;  2OG6 A;  3P3N A;  1MZF A;  2YC0 A;  4M2C A;  3N6W A;  3V15 A;  2XUM A;  2OG7 A;  4BHI A;  2CGO A;  1OIJ B;  5KEU A;  3K8R A;  1DRT A;  2WA3 A;  4YLM X;  3V17 A;  4M2E A;  4M25 A;  3MS5 A;  1YCI A;  2CGN A;  3KCY A;  3LUU A;  4BHF A;  4J5I A;  4CVY A;  2ILM A;  2WBQ A;  4FFA A; 
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