4C5WA

Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 4-(ethyldimethylammonio)butanoate
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
384
structure length
384
Chain Sequence
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords GAMMA-BUTYROBETAINE DIOXYGENASE
total genus 120
structure length 384
sequence length 384
ec nomenclature ec 1.14.11.1: Gamma-butyrobetaine dioxygenase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02668 TauD Taurine catabolism dioxygenase TauD, TfdA family
A PF06155 DUF971 Protein of unknown function (DUF971)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.2020.30 Alpha Beta 2-Layer Sandwich NE0471 N-terminal domain-like NE0471 N-terminal domain-like 4c5wA01
3.60.130.10 Alpha Beta 4-Layer Sandwich Double-stranded beta-helix Clavaminate synthase-like 4c5wA02
3PVJA 2WBOA 1DRTA 1VZ5A 2OG7A 1DRYA 4BGMA 1JR7A 1GY9A 1NX8A 2OG6A 4OJ8A 4CWDA 4FFAA 1GQWA 3LUUA 1OIJB 3V15A 4CVYA 5J92A 1OTJA 1Y0ZA 1DS0A 3MS5A 2R6SA 2WBQA 3R1JA 3V17A 1VZ4A 4J5IA 3N6WA 2OG5A 1OIHA 4M23A 4M27A 4BHGA 1NX4A 4C8RA 4BG1A 1OIKA 4C5WA 2WBPA 4M26A 4M2GA 4BHFA 1OS7A 5KEUA 2Q4AA 4YLMX 4M25A 4M2CA 5HSXA 1DS1A 4M2EA 4BHIA 1OIJA 1OIJC 4M2IA 3EATX 4BGKA 3O2GA 4NE0A 4Y0EA 4M2FA 1OIIA 3SWTA 1GVGA
chains in the Genus database with same CATH superfamily
3PVJA 2AUWA 2WBOA 1DRTA 1VZ5A 2OG7A 1DRYA 4BGMA 1JR7A 1GY9A 1NX8A 2OG6A 4OJ8A 4CWDA 1YOXA 4FFAA 1GQWA 3LUUA 1OIJB 3V15A 4CVYA 5J92A 1OTJA 1Y0ZA 1DS0A 3MS5A 2R6SA 2WBQA 3R1JA 3V17A 1VZ4A 4J5IA 3N6WA 2OG5A 1OIHA 4M23A 4M27A 4BHGA 1NX4A 4C8RA 4BG1A 1OIKA 4C5WA 2WBPA 4M26A 4M2GA 4BHFA 1OS7A 3K8RA 1PG6A 2Q4AA 5KEUA 4YLMX 2X8NA 4M25A 4M2CA 5HSXA 1DS1A 4M2EA 4BHIA 1OIJA 1OIJC 4M2IA 3EATX 4BGKA 3O2GA 4NE0A 4Y0EA 4M2FA 1OIIA 3SWTA 1GVGA
chains in the Genus database with same CATH topology
3PVJA 2YC0A 4BGMA 4OJ8A 4CWDA 4FFAA 2CGNA 1MZEA 4CVYA 1OTJA 1Y0ZA 3P3PA 1DS0A 3V17A 4BHGA 1NX4A 3D8CA 4M26A 1OS7A 3K8RA 4YLMX 2W0XA 2X8NA 5HSXA 1DS1A 1OIJC 3KCXA 4JAAA 3EATX 4Y0EA 4BIOA 1GVGA 1IZ3A 1NX8A 3V15A 1H2MA 2CGOA 3MS5A 4M27A 2Q4AA 4BGKA 4NE0A 3SWTA 1DRTA 1VZ5A 1YCIA 2OG7A 1DRYA 2ILMA 1H2NA 1GQWA 3LUUA 1OIJB 5J92A 1H2KA 4NR1A 2R6SA 3P3NA 4J5IA 3N6WA 4Z1VA 2WBPA 4M2GA 4BHFA 5JWPA 4M25A 4M2IA 4B7KA 4M2CA 2WBOA 3KCYA 4Z2WA 1JR7A 1GY9A 2OG6A 2XUMA 2YDEA 3OD4A 4AI8A 2WBQA 3R1JA 4B7EA 1VZ4A 2OG5A 1OIHA 4M23A 2WA4A 4C8RA 4BG1A 1OIKA 4C5WA 2WA3A 2Y0IA 1H2LA 5KEUA 4M2EA 4BHIA 1OIJA 3O2GA 4M2FA 1OIIA 1MZFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PVJ A;  2WBO A;  1DRT A;  1VZ5 A;  2OG7 A;  1DRY A;  4BGM A;  1JR7 A;  1GY9 A;  1NX8 A;  2OG6 A;  4OJ8 A;  4CWD A;  4FFA A;  1GQW A;  3LUU A;  1OIJ B;  3V15 A;  4CVY A;  5J92 A;  1OTJ A;  1Y0Z A;  1DS0 A;  3MS5 A;  2R6S A;  2WBQ A;  3R1J A;  3V17 A;  1VZ4 A;  4J5I A;  3N6W A;  2OG5 A;  1OIH A;  4M23 A;  4M27 A;  4BHG A;  1NX4 A;  4C8R A;  4BG1 A;  1OIK A;  4C5W A;  2WBP A;  4M26 A;  4M2G A;  4BHF A;  1OS7 A;  5KEU A;  2Q4A A;  4YLM X;  4M25 A;  4M2C A;  5HSX A;  1DS1 A;  4M2E A;  4BHI A;  1OIJ A;  1OIJ C;  4M2I A;  3EAT X;  4BGK A;  3O2G A;  4NE0 A;  4Y0E A;  4M2F A;  1OII A;  3SWT A;  1GVG A; 
#chains in the Genus database with same CATH topology
 3PVJ A;  2AUW A;  2WBO A;  1DRT A;  1VZ5 A;  2OG7 A;  1DRY A;  4BGM A;  1JR7 A;  1GY9 A;  1NX8 A;  2OG6 A;  4OJ8 A;  4CWD A;  1YOX A;  4FFA A;  1GQW A;  3LUU A;  1OIJ B;  3V15 A;  4CVY A;  5J92 A;  1OTJ A;  1Y0Z A;  1DS0 A;  3MS5 A;  2R6S A;  2WBQ A;  3R1J A;  3V17 A;  1VZ4 A;  4J5I A;  3N6W A;  2OG5 A;  1OIH A;  4M23 A;  4M27 A;  4BHG A;  1NX4 A;  4C8R A;  4BG1 A;  1OIK A;  4C5W A;  2WBP A;  4M26 A;  4M2G A;  4BHF A;  1OS7 A;  3K8R A;  1PG6 A;  2Q4A A;  5KEU A;  4YLM X;  2X8N A;  4M25 A;  4M2C A;  5HSX A;  1DS1 A;  4M2E A;  4BHI A;  1OIJ A;  1OIJ C;  4M2I A;  3EAT X;  4BGK A;  3O2G A;  4NE0 A;  4Y0E A;  4M2F A;  1OII A;  3SWT A;  1GVG A; 
#chains in the Genus database with same CATH homology
 3PVJ A;  2YC0 A;  4BGM A;  4OJ8 A;  4CWD A;  4FFA A;  2CGN A;  1MZE A;  4CVY A;  1OTJ A;  1Y0Z A;  3P3P A;  1DS0 A;  3V17 A;  4BHG A;  1NX4 A;  3D8C A;  4M26 A;  1OS7 A;  3K8R A;  4YLM X;  2W0X A;  2X8N A;  5HSX A;  1DS1 A;  1OIJ C;  3KCX A;  4JAA A;  3EAT X;  4Y0E A;  4BIO A;  1GVG A;  1IZ3 A;  1NX8 A;  3V15 A;  1H2M A;  2CGO A;  3MS5 A;  4M27 A;  2Q4A A;  4BGK A;  4NE0 A;  3SWT A;  1DRT A;  1VZ5 A;  1YCI A;  2OG7 A;  1DRY A;  2ILM A;  1H2N A;  1GQW A;  3LUU A;  1OIJ B;  5J92 A;  1H2K A;  4NR1 A;  2R6S A;  3P3N A;  4J5I A;  3N6W A;  4Z1V A;  2WBP A;  4M2G A;  4BHF A;  5JWP A;  4M25 A;  4M2I A;  4B7K A;  4M2C A;  2WBO A;  3KCY A;  4Z2W A;  1JR7 A;  1GY9 A;  2OG6 A;  2XUM A;  2YDE A;  3OD4 A;  4AI8 A;  2WBQ A;  3R1J A;  4B7E A;  1VZ4 A;  2OG5 A;  1OIH A;  4M23 A;  2WA4 A;  4C8R A;  4BG1 A;  1OIK A;  4C5W A;  2WA3 A;  2Y0I A;  1H2L A;  5KEU A;  4M2E A;  4BHI A;  1OIJ A;  3O2G A;  4M2F A;  1OII A;  1MZF A; 
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