4CWDA

Crystal structure of human gamma-butyrobetaine,2-oxoglutarate in complex with 449, a novel substrate
Total Genus 119
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
385
structure length
385
Chain Sequence
SMACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords GAMMA-BUTYROBETAINE DIOXYGENASE
total genus 119
structure length 385
sequence length 385
ec nomenclature ec 1.14.11.1: Gamma-butyrobetaine dioxygenase.
pdb deposition date 2014-04-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02668 TauD Taurine catabolism dioxygenase TauD, TfdA family
A PF06155 DUF971 Protein of unknown function (DUF971)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.2020.30 Alpha Beta 2-Layer Sandwich NE0471 N-terminal domain-like NE0471 N-terminal domain-like 4cwdA01
3.60.130.10 Alpha Beta 4-Layer Sandwich Double-stranded beta-helix Clavaminate synthase-like 4cwdA02
4BGMA 4C8RA 3PVJA 4M27A 1OIIA 3SWTA 4BHIA 1GVGA 1NX4A 4OJ8A 1VZ5A 1DS0A 3O2GA 1NX8A 1OTJA 1Y0ZA 3LUUA 1OIJA 1OIJB 4BGKA 2WBOA 2OG5A 5KEUA 3R1JA 4M25A 4M23A 2OG6A 4Y0EA 1DRYA 4M2FA 3N6WA 3MS5A 5J92A 4FFAA 1OIKA 4C5WA 4CWDA 3V17A 4CVYA 2WBPA 2R6SA 4BHFA 2Q4AA 4YLMX 2OG7A 1GQWA 4M26A 3EATX 4J5IA 1JR7A 4BG1A 1DS1A 1OIJC 3V15A 4M2CA 4M2GA 4BHGA 1GY9A 1OIHA 1OS7A 1VZ4A 1DRTA 4M2IA 4NE0A 5HSXA 2WBQA 4M2EA
chains in the Genus database with same CATH superfamily
4BGMA 4C8RA 1YOXA 3PVJA 4M27A 1OIIA 3SWTA 4BHIA 1GVGA 4NE0A 1NX4A 4OJ8A 1VZ5A 1DS0A 3O2GA 1NX8A 1OTJA 1Y0ZA 3LUUA 1OIJA 1OIJB 4BGKA 2WBOA 2OG5A 5KEUA 3R1JA 4M25A 4M23A 2OG6A 2AUWA 4Y0EA 1DRYA 4M2FA 3N6WA 3MS5A 5J92A 4FFAA 1OIKA 4C5WA 4CWDA 3V17A 4CVYA 2WBPA 2R6SA 4BHFA 1PG6A 2Q4AA 4YLMX 2OG7A 1GQWA 4M26A 3EATX 4J5IA 1JR7A 4BG1A 1DS1A 1OIJC 3V15A 4M2CA 4M2GA 2X8NA 4BHGA 1GY9A 1OIHA 1OS7A 1VZ4A 1DRTA 4M2IA 3K8RA 5HSXA 2WBQA 4M2EA
chains in the Genus database with same CATH topology
1MZEA 4C8RA 4Z1VA 4M27A 1NX4A 1OTJA 2WBOA 3LUUA 1OIJB 3P3PA 1H2LA 4AI8A 4M2FA 3N6WA 3MS5A 1H2MA 4C5WA 4CWDA 3KCXA 2Y0IA 4BHFA 2CGNA 1MZFA 1YCIA 4M2CA 4M2GA 4BIOA 2X8NA 3K8RA 4BGMA 3PVJA 2CGOA 3O2GA 1Y0ZA 1NX8A 1OIJA 3R1JA 1DRYA 5JWPA 3D8CA 4FFAA 3V17A 2Q4AA 2OG7A 2YDEA 1JR7A 1OIJC 1OIHA 1OS7A 3SWTA 4BHIA 4OJ8A 1DS0A 4M23A 4Y0EA 3P3NA 1IZ3A 4YLMX 1GQWA 3V15A 3OD4A 1DS1A 3KCYA 2YC0A 4BHGA 2WBPA 1DRTA 4NE0A 4NR1A 2ILMA 1OIIA 2WA4A 1GVGA 1VZ5A 2WA3A 1H2KA 4BGKA 5KEUA 2OG5A 4M25A 4B7KA 2OG6A 4JAAA 5J92A 1OIKA 4CVYA 2R6SA 2XUMA 4M26A 3EATX 4J5IA 4Z2WA 1H2NA 4BG1A 2W0XA 1GY9A 1VZ4A 4M2IA 4B7EA 5HSXA 2WBQA 4M2EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BGM A;  4C8R A;  3PVJ A;  4M27 A;  1OII A;  3SWT A;  4BHI A;  1GVG A;  1NX4 A;  4OJ8 A;  1VZ5 A;  1DS0 A;  3O2G A;  1NX8 A;  1OTJ A;  1Y0Z A;  3LUU A;  1OIJ A;  1OIJ B;  4BGK A;  2WBO A;  2OG5 A;  5KEU A;  3R1J A;  4M25 A;  4M23 A;  2OG6 A;  4Y0E A;  1DRY A;  4M2F A;  3N6W A;  3MS5 A;  5J92 A;  4FFA A;  1OIK A;  4C5W A;  4CWD A;  3V17 A;  4CVY A;  2WBP A;  2R6S A;  4BHF A;  2Q4A A;  4YLM X;  2OG7 A;  1GQW A;  4M26 A;  3EAT X;  4J5I A;  1JR7 A;  4BG1 A;  1DS1 A;  1OIJ C;  3V15 A;  4M2C A;  4M2G A;  4BHG A;  1GY9 A;  1OIH A;  1OS7 A;  1VZ4 A;  1DRT A;  4M2I A;  4NE0 A;  5HSX A;  2WBQ A;  4M2E A; 
#chains in the Genus database with same CATH topology
 4BGM A;  4C8R A;  1YOX A;  3PVJ A;  4M27 A;  1OII A;  3SWT A;  4BHI A;  1GVG A;  4NE0 A;  1NX4 A;  4OJ8 A;  1VZ5 A;  1DS0 A;  3O2G A;  1NX8 A;  1OTJ A;  1Y0Z A;  3LUU A;  1OIJ A;  1OIJ B;  4BGK A;  2WBO A;  2OG5 A;  5KEU A;  3R1J A;  4M25 A;  4M23 A;  2OG6 A;  2AUW A;  4Y0E A;  1DRY A;  4M2F A;  3N6W A;  3MS5 A;  5J92 A;  4FFA A;  1OIK A;  4C5W A;  4CWD A;  3V17 A;  4CVY A;  2WBP A;  2R6S A;  4BHF A;  1PG6 A;  2Q4A A;  4YLM X;  2OG7 A;  1GQW A;  4M26 A;  3EAT X;  4J5I A;  1JR7 A;  4BG1 A;  1DS1 A;  1OIJ C;  3V15 A;  4M2C A;  4M2G A;  2X8N A;  4BHG A;  1GY9 A;  1OIH A;  1OS7 A;  1VZ4 A;  1DRT A;  4M2I A;  3K8R A;  5HSX A;  2WBQ A;  4M2E A; 
#chains in the Genus database with same CATH homology
 1MZE A;  4C8R A;  4Z1V A;  4M27 A;  1NX4 A;  1OTJ A;  2WBO A;  3LUU A;  1OIJ B;  3P3P A;  1H2L A;  4AI8 A;  4M2F A;  3N6W A;  3MS5 A;  1H2M A;  4C5W A;  4CWD A;  3KCX A;  2Y0I A;  4BHF A;  2CGN A;  1MZF A;  1YCI A;  4M2C A;  4M2G A;  4BIO A;  2X8N A;  3K8R A;  4BGM A;  3PVJ A;  2CGO A;  3O2G A;  1Y0Z A;  1NX8 A;  1OIJ A;  3R1J A;  1DRY A;  5JWP A;  3D8C A;  4FFA A;  3V17 A;  2Q4A A;  2OG7 A;  2YDE A;  1JR7 A;  1OIJ C;  1OIH A;  1OS7 A;  3SWT A;  4BHI A;  4OJ8 A;  1DS0 A;  4M23 A;  4Y0E A;  3P3N A;  1IZ3 A;  4YLM X;  1GQW A;  3V15 A;  3OD4 A;  1DS1 A;  3KCY A;  2YC0 A;  4BHG A;  2WBP A;  1DRT A;  4NE0 A;  4NR1 A;  2ILM A;  1OII A;  2WA4 A;  1GVG A;  1VZ5 A;  2WA3 A;  1H2K A;  4BGK A;  5KEU A;  2OG5 A;  4M25 A;  4B7K A;  2OG6 A;  4JAA A;  5J92 A;  1OIK A;  4CVY A;  2R6S A;  2XUM A;  4M26 A;  3EAT X;  4J5I A;  4Z2W A;  1H2N A;  4BG1 A;  2W0X A;  1GY9 A;  1VZ4 A;  4M2I A;  4B7E A;  5HSX A;  2WBQ A;  4M2E A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...