5BYTA

Prpp complexed with a single mg in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
346
structure length
343
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding and mimicking of the phosphate-rich substrate, PRPP.
rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 124
structure length 343
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2015-06-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 5bytA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 5bytA02
3QQSA 3R6CA 2WK6A 4ZOFA 3TWPA 5C7SA 3QS8A 4X5CA 1AZYA 4OWSA 3H5QA 4OWNA 4YI7A 5C2LA 4M0RA 1KHDA 2DSJA 4X5BA 5BO3A 4YYYA 4OWVA 2WK5A 4ZOKA 1ZYKA 4GKMA 4X5AA 4OWOA 1GXBA 4N5VA 5EY3A 3UU1A 4HKMA 4X5DA 1VQUA 4OWMA 4GA5A 4MUOA 4OWQA 4X46A 4XR5A 1BRWA 1KGZA 4GA6A 4GIUA 1ZXYA 2BPQA 1O17A 2TPTA 4IJ1A 4ZOJA 4ZTVA 2GVQA 1ZVWA 1OTPA 3R88A 4X59A 4N93A 5EP8A 4GTNA 5BNEA 3QSAA 4LHMA 3QR9A 5C1RA 5BYTA 3GBRA 1V8GA 2J0FA 4X58A 5BO2A 4GA4A 4EAFA 4OWUA 4N8QA 2ELCA 1UOUA 4EADA 4YEKA 4X5EA
chains in the Genus database with same CATH superfamily
3QQSA 3R6CA 2WK6A 4ZOFA 3TWPA 5C7SA 4F3FC 3QS8A 4X5CA 1AZYA 4OWSA 3H5QA 4OWNA 4YI7A 5C2LA 4M0RA 1KHDA 2DSJA 4X5BA 5BO3A 1RF8B 4YYYA 4OWVA 2WK5A 4ZOKA 1RRZA 1ZYKA 4GKMA 4X5AA 4OWOA 1GXBA 4N5VA 5EY3A 3UU1A 4HKMA 4X5DA 1VQUA 4OWMA 4GA5A 4MUOA 4OWQA 4X46A 4XR5A 1BRWA 1KGZA 4GA6A 4GIUA 1ZXYA 2BPQA 1O17A 2TPTA 4IJ1A 4ZOJA 4ZTVA 2GVQA 1ZVWA 1OTPA 3R88A 4X59A 4N93A 5EP8A 4GTNA 5BNEA 3QSAA 4LHMA 3QR9A 5C1RA 5BYTA 3GBRA 1V8GA 2J0FA 4X58A 5BO2A 4GA4A 4EAFA 4OWUA 4N8QA 2ELCA 1UOUA 4EADA 4YEKA 4X5EA
chains in the Genus database with same CATH topology
3QQSA 3R6CA 2WK6A 4ZOFA 3TWPA 5C7SA 3QS8A 4X5CA 1AZYA 4OWSA 3H5QA 4OWNA 4YI7A 5C2LA 4M0RA 1KHDA 2DSJA 4X5BA 5BO3A 4YYYA 4OWVA 2WK5A 4ZOKA 1ZYKA 4GKMA 4X5AA 4OWOA 1GXBA 4N5VA 5EY3A 3UU1A 4HKMA 4X5DA 1VQUA 4OWMA 4GA5A 4MUOA 4OWQA 4X46A 4XR5A 1BRWA 1KGZA 4GA6A 4GIUA 1ZXYA 2BPQA 1O17A 2TPTA 4IJ1A 4ZOJA 4ZTVA 2GVQA 1ZVWA 1OTPA 3R88A 4X59A 4N93A 5EP8A 4GTNA 5BNEA 3QSAA 4LHMA 3QR9A 5C1RA 5BYTA 3GBRA 1V8GA 2J0FA 4X58A 5BO2A 4GA4A 4EAFA 4OWUA 4N8QA 2ELCA 1UOUA 4EADA 4YEKA 4X5EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QQS A;  3R6C A;  2WK6 A;  4ZOF A;  3TWP A;  5C7S A;  3QS8 A;  4X5C A;  1AZY A;  4OWS A;  3H5Q A;  4OWN A;  4YI7 A;  5C2L A;  4M0R A;  1KHD A;  2DSJ A;  4X5B A;  5BO3 A;  4YYY A;  4OWV A;  2WK5 A;  4ZOK A;  1ZYK A;  4GKM A;  4X5A A;  4OWO A;  1GXB A;  4N5V A;  5EY3 A;  3UU1 A;  4HKM A;  4X5D A;  1VQU A;  4OWM A;  4GA5 A;  4MUO A;  4OWQ A;  4X46 A;  4XR5 A;  1BRW A;  1KGZ A;  4GA6 A;  4GIU A;  1ZXY A;  2BPQ A;  1O17 A;  2TPT A;  4IJ1 A;  4ZOJ A;  4ZTV A;  2GVQ A;  1ZVW A;  1OTP A;  3R88 A;  4X59 A;  4N93 A;  5EP8 A;  4GTN A;  5BNE A;  3QSA A;  4LHM A;  3QR9 A;  5C1R A;  5BYT A;  3GBR A;  1V8G A;  2J0F A;  4X58 A;  5BO2 A;  4GA4 A;  4EAF A;  4OWU A;  4N8Q A;  2ELC A;  1UOU A;  4EAD A;  4YEK A;  4X5E A; 
#chains in the Genus database with same CATH topology
 3QQS A;  3R6C A;  2WK6 A;  4ZOF A;  3TWP A;  5C7S A;  4F3F C;  3QS8 A;  4X5C A;  1AZY A;  4OWS A;  3H5Q A;  4OWN A;  4YI7 A;  5C2L A;  4M0R A;  1KHD A;  2DSJ A;  4X5B A;  5BO3 A;  1RF8 B;  4YYY A;  4OWV A;  2WK5 A;  4ZOK A;  1RRZ A;  1ZYK A;  4GKM A;  4X5A A;  4OWO A;  1GXB A;  4N5V A;  5EY3 A;  3UU1 A;  4HKM A;  4X5D A;  1VQU A;  4OWM A;  4GA5 A;  4MUO A;  4OWQ A;  4X46 A;  4XR5 A;  1BRW A;  1KGZ A;  4GA6 A;  4GIU A;  1ZXY A;  2BPQ A;  1O17 A;  2TPT A;  4IJ1 A;  4ZOJ A;  4ZTV A;  2GVQ A;  1ZVW A;  1OTP A;  3R88 A;  4X59 A;  4N93 A;  5EP8 A;  4GTN A;  5BNE A;  3QSA A;  4LHM A;  3QR9 A;  5C1R A;  5BYT A;  3GBR A;  1V8G A;  2J0F A;  4X58 A;  5BO2 A;  4GA4 A;  4EAF A;  4OWU A;  4N8Q A;  2ELC A;  1UOU A;  4EAD A;  4YEK A;  4X5E A; 
#chains in the Genus database with same CATH homology
 3QQS A;  3R6C A;  2WK6 A;  4ZOF A;  3TWP A;  5C7S A;  3QS8 A;  4X5C A;  1AZY A;  4OWS A;  3H5Q A;  4OWN A;  4YI7 A;  5C2L A;  4M0R A;  1KHD A;  2DSJ A;  4X5B A;  5BO3 A;  4YYY A;  4OWV A;  2WK5 A;  4ZOK A;  1ZYK A;  4GKM A;  4X5A A;  4OWO A;  1GXB A;  4N5V A;  5EY3 A;  3UU1 A;  4HKM A;  4X5D A;  1VQU A;  4OWM A;  4GA5 A;  4MUO A;  4OWQ A;  4X46 A;  4XR5 A;  1BRW A;  1KGZ A;  4GA6 A;  4GIU A;  1ZXY A;  2BPQ A;  1O17 A;  2TPT A;  4IJ1 A;  4ZOJ A;  4ZTV A;  2GVQ A;  1ZVW A;  1OTP A;  3R88 A;  4X59 A;  4N93 A;  5EP8 A;  4GTN A;  5BNE A;  3QSA A;  4LHM A;  3QR9 A;  5C1R A;  5BYT A;  3GBR A;  1V8G A;  2J0F A;  4X58 A;  5BO2 A;  4GA4 A;  4EAF A;  4OWU A;  4N8Q A;  2ELC A;  1UOU A;  4EAD A;  4YEK A;  4X5E A; 
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