5BYTA

Prpp complexed with a single mg in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
346
structure length
343
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding and mimicking of the phosphate-rich substrate, PRPP.
rcsb
molecule tags Transferase/transferase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 124
structure length 343
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2015-06-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 5bytA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 5bytA02
1O17A 1V8GA 4X5EA 4OWUA 3TWPA 4ZOFA 4OWQA 2GVQA 5EP8A 4YYYA 2J0FA 3H5QA 4GIUA 1KHDA 1ZXYA 2WK6A 4X59A 2DSJA 3R6CA 4HKMA 1AZYA 2WK5A 2BPQA 1KGZA 4X5BA 4EAFA 5C2LA 4N8QA 5BO2A 4GA6A 4X5DA 4OWVA 4X5CA 5C1RA 4YEKA 1ZVWA 4X5AA 1UOUA 4OWSA 3UU1A 1BRWA 1GXBA 4GTNA 1ZYKA 4OWNA 4GA4A 4MUOA 1OTPA 4X58A 3R88A 4XR5A 4YI7A 4LHMA 4ZOJA 3QQSA 4ZOKA 4N5VA 4N93A 5BYTA 4OWOA 3GBRA 3QR9A 3QSAA 5C7SA 5EY3A 3QS8A 2TPTA 4OWMA 4ZTVA 5BNEA 2ELCA 5BO3A 4IJ1A 4GA5A 4X46A 4M0RA 1VQUA 4GKMA 4EADA
chains in the Genus database with same CATH superfamily
1O17A 1V8GA 4X5EA 4OWUA 3TWPA 4ZOFA 4OWQA 2GVQA 5EP8A 4YYYA 2J0FA 3H5QA 4GIUA 1KHDA 1ZXYA 1RRZA 2WK6A 4X59A 2DSJA 3R6CA 4HKMA 1AZYA 2WK5A 2BPQA 1KGZA 4X5BA 4F3FC 4EAFA 5C2LA 4N8QA 5BO2A 4GA6A 4X5DA 4OWVA 4X5CA 5C1RA 4YEKA 1ZVWA 4X5AA 1UOUA 4OWSA 3UU1A 1RF8B 1BRWA 1GXBA 4GTNA 1ZYKA 4OWNA 4GA4A 4MUOA 1OTPA 4X58A 3R88A 4XR5A 4YI7A 4LHMA 4ZOJA 3QQSA 4ZOKA 4N5VA 4N93A 5BYTA 4OWOA 3GBRA 3QR9A 3QSAA 5C7SA 5EY3A 3QS8A 2TPTA 4OWMA 4ZTVA 5BNEA 2ELCA 5BO3A 4IJ1A 4GA5A 4X46A 4M0RA 1VQUA 4GKMA 4EADA
chains in the Genus database with same CATH topology
1O17A 1V8GA 4X5EA 4OWUA 3TWPA 4ZOFA 4OWQA 2GVQA 5EP8A 4YYYA 2J0FA 3H5QA 4GIUA 1KHDA 1ZXYA 2WK6A 4X59A 2DSJA 3R6CA 4HKMA 1AZYA 2WK5A 2BPQA 1KGZA 4X5BA 4EAFA 5C2LA 4N8QA 5BO2A 4GA6A 4X5DA 4OWVA 4X5CA 5C1RA 4YEKA 1ZVWA 4X5AA 1UOUA 4OWSA 3UU1A 1BRWA 1GXBA 4GTNA 1ZYKA 4OWNA 4GA4A 4MUOA 1OTPA 4X58A 3R88A 4XR5A 4YI7A 4LHMA 4ZOJA 3QQSA 4ZOKA 4N5VA 4N93A 5BYTA 4OWOA 3GBRA 3QR9A 3QSAA 5C7SA 5EY3A 3QS8A 2TPTA 4OWMA 4ZTVA 5BNEA 2ELCA 5BO3A 4IJ1A 4GA5A 4X46A 4M0RA 1VQUA 4GKMA 4EADA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O17 A;  1V8G A;  4X5E A;  4OWU A;  3TWP A;  4ZOF A;  4OWQ A;  2GVQ A;  5EP8 A;  4YYY A;  2J0F A;  3H5Q A;  4GIU A;  1KHD A;  1ZXY A;  2WK6 A;  4X59 A;  2DSJ A;  3R6C A;  4HKM A;  1AZY A;  2WK5 A;  2BPQ A;  1KGZ A;  4X5B A;  4EAF A;  5C2L A;  4N8Q A;  5BO2 A;  4GA6 A;  4X5D A;  4OWV A;  4X5C A;  5C1R A;  4YEK A;  1ZVW A;  4X5A A;  1UOU A;  4OWS A;  3UU1 A;  1BRW A;  1GXB A;  4GTN A;  1ZYK A;  4OWN A;  4GA4 A;  4MUO A;  1OTP A;  4X58 A;  3R88 A;  4XR5 A;  4YI7 A;  4LHM A;  4ZOJ A;  3QQS A;  4ZOK A;  4N5V A;  4N93 A;  5BYT A;  4OWO A;  3GBR A;  3QR9 A;  3QSA A;  5C7S A;  5EY3 A;  3QS8 A;  2TPT A;  4OWM A;  4ZTV A;  5BNE A;  2ELC A;  5BO3 A;  4IJ1 A;  4GA5 A;  4X46 A;  4M0R A;  1VQU A;  4GKM A;  4EAD A; 
#chains in the Genus database with same CATH topology
 1O17 A;  1V8G A;  4X5E A;  4OWU A;  3TWP A;  4ZOF A;  4OWQ A;  2GVQ A;  5EP8 A;  4YYY A;  2J0F A;  3H5Q A;  4GIU A;  1KHD A;  1ZXY A;  1RRZ A;  2WK6 A;  4X59 A;  2DSJ A;  3R6C A;  4HKM A;  1AZY A;  2WK5 A;  2BPQ A;  1KGZ A;  4X5B A;  4F3F C;  4EAF A;  5C2L A;  4N8Q A;  5BO2 A;  4GA6 A;  4X5D A;  4OWV A;  4X5C A;  5C1R A;  4YEK A;  1ZVW A;  4X5A A;  1UOU A;  4OWS A;  3UU1 A;  1RF8 B;  1BRW A;  1GXB A;  4GTN A;  1ZYK A;  4OWN A;  4GA4 A;  4MUO A;  1OTP A;  4X58 A;  3R88 A;  4XR5 A;  4YI7 A;  4LHM A;  4ZOJ A;  3QQS A;  4ZOK A;  4N5V A;  4N93 A;  5BYT A;  4OWO A;  3GBR A;  3QR9 A;  3QSA A;  5C7S A;  5EY3 A;  3QS8 A;  2TPT A;  4OWM A;  4ZTV A;  5BNE A;  2ELC A;  5BO3 A;  4IJ1 A;  4GA5 A;  4X46 A;  4M0R A;  1VQU A;  4GKM A;  4EAD A; 
#chains in the Genus database with same CATH homology
 1O17 A;  1V8G A;  4X5E A;  4OWU A;  3TWP A;  4ZOF A;  4OWQ A;  2GVQ A;  5EP8 A;  4YYY A;  2J0F A;  3H5Q A;  4GIU A;  1KHD A;  1ZXY A;  2WK6 A;  4X59 A;  2DSJ A;  3R6C A;  4HKM A;  1AZY A;  2WK5 A;  2BPQ A;  1KGZ A;  4X5B A;  4EAF A;  5C2L A;  4N8Q A;  5BO2 A;  4GA6 A;  4X5D A;  4OWV A;  4X5C A;  5C1R A;  4YEK A;  1ZVW A;  4X5A A;  1UOU A;  4OWS A;  3UU1 A;  1BRW A;  1GXB A;  4GTN A;  1ZYK A;  4OWN A;  4GA4 A;  4MUO A;  1OTP A;  4X58 A;  3R88 A;  4XR5 A;  4YI7 A;  4LHM A;  4ZOJ A;  3QQS A;  4ZOK A;  4N5V A;  4N93 A;  5BYT A;  4OWO A;  3GBR A;  3QR9 A;  3QSA A;  5C7S A;  5EY3 A;  3QS8 A;  2TPT A;  4OWM A;  4ZTV A;  5BNE A;  2ELC A;  5BO3 A;  4IJ1 A;  4GA5 A;  4X46 A;  4M0R A;  1VQU A;  4GKM A;  4EAD A; 
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