5C1RA

Stereoisomer of prpp bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyl (anprt; trpd)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
345
structure length
343
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding and mimicking of the phosphate-rich substrate, PRPP.
rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 120
structure length 343
sequence length 345
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2015-06-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 5c1rA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 5c1rA02
4N5VA 4X58A 5C7SA 4X5AA 4GA6A 3GBRA 4ZOJA 4X46A 4IJ1A 4X59A 4GKMA 4OWNA 4N93A 3QR9A 4EAFA 1ZXYA 3QQSA 4YYYA 4ZOKA 5C2LA 4MUOA 4EADA 4GA4A 4GA5A 2J0FA 5BO3A 5BNEA 2DSJA 4ZTVA 3UU1A 4HKMA 3H5QA 4OWMA 3TWPA 2WK5A 2BPQA 4OWOA 5EP8A 4ZOFA 4YI7A 2ELCA 3R6CA 5BYTA 3QS8A 4X5BA 1AZYA 4X5EA 4OWSA 4OWVA 1BRWA 4YEKA 4LHMA 1ZYKA 4X5CA 5EY3A 5BO2A 4X5DA 1ZVWA 4M0RA 1GXBA 1V8GA 4GIUA 4XR5A 4N8QA 4OWQA 1UOUA 1KGZA 1VQUA 1OTPA 2TPTA 4GTNA 2GVQA 4OWUA 3R88A 1O17A 3QSAA 2WK6A 5C1RA 1KHDA
chains in the Genus database with same CATH superfamily
4N5VA 4X58A 5C7SA 4X5AA 4GA6A 3GBRA 4ZOJA 4X46A 4IJ1A 4X59A 4GKMA 4OWNA 4N93A 3QR9A 4EAFA 1ZXYA 3QQSA 4YYYA 4ZOKA 5C2LA 4MUOA 4EADA 4GA4A 4F3FC 4GA5A 2J0FA 5BO3A 5BNEA 2DSJA 1RRZA 4ZTVA 3UU1A 4HKMA 3H5QA 4OWMA 3TWPA 2WK5A 2BPQA 4OWOA 5EP8A 4ZOFA 4YI7A 2ELCA 3R6CA 5BYTA 3QS8A 4X5BA 1AZYA 4X5EA 4OWSA 4OWVA 1BRWA 4YEKA 4LHMA 1ZYKA 4X5CA 5EY3A 5BO2A 4X5DA 1ZVWA 4M0RA 1GXBA 1V8GA 4GIUA 4XR5A 4N8QA 4OWQA 1UOUA 1KGZA 1VQUA 1OTPA 2TPTA 4GTNA 2GVQA 4OWUA 3R88A 1O17A 3QSAA 2WK6A 5C1RA 1KHDA 1RF8B
chains in the Genus database with same CATH topology
4N5VA 4X58A 5C7SA 4X5AA 4GA6A 3GBRA 4ZOJA 4X46A 4IJ1A 4X59A 4GKMA 4OWNA 4N93A 3QR9A 4EAFA 1ZXYA 3QQSA 4YYYA 4ZOKA 5C2LA 4MUOA 4EADA 4GA4A 4GA5A 2J0FA 5BO3A 5BNEA 2DSJA 4ZTVA 3UU1A 4HKMA 3H5QA 4OWMA 3TWPA 2WK5A 2BPQA 4OWOA 5EP8A 4ZOFA 4YI7A 2ELCA 3R6CA 5BYTA 3QS8A 4X5BA 1AZYA 4X5EA 4OWSA 4OWVA 1BRWA 4YEKA 4LHMA 1ZYKA 4X5CA 5EY3A 5BO2A 4X5DA 1ZVWA 4M0RA 1GXBA 1V8GA 4GIUA 4XR5A 4N8QA 4OWQA 1UOUA 1KGZA 1VQUA 1OTPA 2TPTA 4GTNA 2GVQA 4OWUA 3R88A 1O17A 3QSAA 2WK6A 5C1RA 1KHDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N5V A;  4X58 A;  5C7S A;  4X5A A;  4GA6 A;  3GBR A;  4ZOJ A;  4X46 A;  4IJ1 A;  4X59 A;  4GKM A;  4OWN A;  4N93 A;  3QR9 A;  4EAF A;  1ZXY A;  3QQS A;  4YYY A;  4ZOK A;  5C2L A;  4MUO A;  4EAD A;  4GA4 A;  4GA5 A;  2J0F A;  5BO3 A;  5BNE A;  2DSJ A;  4ZTV A;  3UU1 A;  4HKM A;  3H5Q A;  4OWM A;  3TWP A;  2WK5 A;  2BPQ A;  4OWO A;  5EP8 A;  4ZOF A;  4YI7 A;  2ELC A;  3R6C A;  5BYT A;  3QS8 A;  4X5B A;  1AZY A;  4X5E A;  4OWS A;  4OWV A;  1BRW A;  4YEK A;  4LHM A;  1ZYK A;  4X5C A;  5EY3 A;  5BO2 A;  4X5D A;  1ZVW A;  4M0R A;  1GXB A;  1V8G A;  4GIU A;  4XR5 A;  4N8Q A;  4OWQ A;  1UOU A;  1KGZ A;  1VQU A;  1OTP A;  2TPT A;  4GTN A;  2GVQ A;  4OWU A;  3R88 A;  1O17 A;  3QSA A;  2WK6 A;  5C1R A;  1KHD A; 
#chains in the Genus database with same CATH topology
 4N5V A;  4X58 A;  5C7S A;  4X5A A;  4GA6 A;  3GBR A;  4ZOJ A;  4X46 A;  4IJ1 A;  4X59 A;  4GKM A;  4OWN A;  4N93 A;  3QR9 A;  4EAF A;  1ZXY A;  3QQS A;  4YYY A;  4ZOK A;  5C2L A;  4MUO A;  4EAD A;  4GA4 A;  4F3F C;  4GA5 A;  2J0F A;  5BO3 A;  5BNE A;  2DSJ A;  1RRZ A;  4ZTV A;  3UU1 A;  4HKM A;  3H5Q A;  4OWM A;  3TWP A;  2WK5 A;  2BPQ A;  4OWO A;  5EP8 A;  4ZOF A;  4YI7 A;  2ELC A;  3R6C A;  5BYT A;  3QS8 A;  4X5B A;  1AZY A;  4X5E A;  4OWS A;  4OWV A;  1BRW A;  4YEK A;  4LHM A;  1ZYK A;  4X5C A;  5EY3 A;  5BO2 A;  4X5D A;  1ZVW A;  4M0R A;  1GXB A;  1V8G A;  4GIU A;  4XR5 A;  4N8Q A;  4OWQ A;  1UOU A;  1KGZ A;  1VQU A;  1OTP A;  2TPT A;  4GTN A;  2GVQ A;  4OWU A;  3R88 A;  1O17 A;  3QSA A;  2WK6 A;  5C1R A;  1KHD A;  1RF8 B; 
#chains in the Genus database with same CATH homology
 4N5V A;  4X58 A;  5C7S A;  4X5A A;  4GA6 A;  3GBR A;  4ZOJ A;  4X46 A;  4IJ1 A;  4X59 A;  4GKM A;  4OWN A;  4N93 A;  3QR9 A;  4EAF A;  1ZXY A;  3QQS A;  4YYY A;  4ZOK A;  5C2L A;  4MUO A;  4EAD A;  4GA4 A;  4GA5 A;  2J0F A;  5BO3 A;  5BNE A;  2DSJ A;  4ZTV A;  3UU1 A;  4HKM A;  3H5Q A;  4OWM A;  3TWP A;  2WK5 A;  2BPQ A;  4OWO A;  5EP8 A;  4ZOF A;  4YI7 A;  2ELC A;  3R6C A;  5BYT A;  3QS8 A;  4X5B A;  1AZY A;  4X5E A;  4OWS A;  4OWV A;  1BRW A;  4YEK A;  4LHM A;  1ZYK A;  4X5C A;  5EY3 A;  5BO2 A;  4X5D A;  1ZVW A;  4M0R A;  1GXB A;  1V8G A;  4GIU A;  4XR5 A;  4N8Q A;  4OWQ A;  1UOU A;  1KGZ A;  1VQU A;  1OTP A;  2TPT A;  4GTN A;  2GVQ A;  4OWU A;  3R88 A;  1O17 A;  3QSA A;  2WK6 A;  5C1R A;  1KHD A; 
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