5C1RA

Stereoisomer of prpp bound in the active site of mycobacterium tuberculosis anthranilate phosphoribosyl (anprt; trpd)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
345
structure length
343
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding and mimicking of the phosphate-rich substrate, PRPP.
rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 120
structure length 343
sequence length 345
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2015-06-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 5c1rA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 5c1rA02
2GVQA 4OWNA 4GTNA 3UU1A 4XR5A 4LHMA 5BYTA 3QQSA 5C7SA 1GXBA 4GA6A 1UOUA 4X5BA 1ZXYA 2DSJA 1VQUA 3TWPA 1O17A 4EADA 4OWQA 1KGZA 4X5CA 4HKMA 4YYYA 4IJ1A 4MUOA 5BO3A 4GA5A 5EY3A 4OWVA 2ELCA 4OWUA 1V8GA 4EAFA 4M0RA 5BO2A 5C2LA 1OTPA 4X5AA 5BNEA 4ZOJA 4N8QA 1BRWA 5EP8A 4N5VA 4OWOA 3GBRA 2WK5A 2TPTA 4OWMA 4X5EA 4YI7A 4ZOFA 4OWSA 1ZYKA 4GKMA 4X59A 4GA4A 4YEKA 4X46A 1ZVWA 4X58A 2J0FA 3QR9A 1KHDA 4GIUA 3R88A 3R6CA 2BPQA 4X5DA 3H5QA 3QS8A 4N93A 3QSAA 2WK6A 4ZOKA 5C1RA 1AZYA 4ZTVA
chains in the Genus database with same CATH superfamily
1RF8B 2GVQA 1RRZA 4OWNA 4GTNA 3UU1A 4XR5A 4LHMA 5BYTA 3QQSA 5C7SA 1GXBA 4GA6A 1UOUA 4X5BA 1ZXYA 2DSJA 1VQUA 3TWPA 1O17A 4EADA 4OWQA 1KGZA 4X5CA 5BO3A 4HKMA 4YYYA 4IJ1A 4MUOA 4GA5A 5EY3A 4OWVA 2ELCA 4OWUA 1V8GA 4F3FC 4EAFA 4M0RA 5BO2A 5C2LA 1OTPA 4X5AA 5BNEA 4ZOJA 4N8QA 1BRWA 5EP8A 4N5VA 4OWOA 3GBRA 2WK5A 2TPTA 4OWMA 4X5EA 4YI7A 4ZOFA 4OWSA 1ZYKA 4GKMA 4X59A 4GA4A 4YEKA 4X46A 1ZVWA 4X58A 2J0FA 3QR9A 1KHDA 4GIUA 3R88A 3R6CA 2BPQA 4X5DA 3H5QA 3QS8A 4N93A 3QSAA 2WK6A 4ZOKA 5C1RA 1AZYA 4ZTVA
chains in the Genus database with same CATH topology
2GVQA 4OWNA 4GTNA 3UU1A 4XR5A 4LHMA 5BYTA 3QQSA 5C7SA 1GXBA 4GA6A 1UOUA 4X5BA 1ZXYA 2DSJA 1VQUA 3TWPA 1O17A 4EADA 4OWQA 1KGZA 4X5CA 4HKMA 4YYYA 4IJ1A 4MUOA 5BO3A 4GA5A 5EY3A 4OWVA 2ELCA 4OWUA 1V8GA 4EAFA 4M0RA 5BO2A 5C2LA 1OTPA 4X5AA 5BNEA 4ZOJA 4N8QA 1BRWA 5EP8A 4N5VA 4OWOA 3GBRA 2WK5A 2TPTA 4OWMA 4X5EA 4YI7A 4ZOFA 4OWSA 1ZYKA 4GKMA 4X59A 4GA4A 4YEKA 4X46A 1ZVWA 4X58A 2J0FA 3QR9A 1KHDA 4GIUA 3R88A 3R6CA 2BPQA 4X5DA 3H5QA 3QS8A 4N93A 3QSAA 2WK6A 4ZOKA 5C1RA 1AZYA 4ZTVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GVQ A;  4OWN A;  4GTN A;  3UU1 A;  4XR5 A;  4LHM A;  5BYT A;  3QQS A;  5C7S A;  1GXB A;  4GA6 A;  1UOU A;  4X5B A;  1ZXY A;  2DSJ A;  1VQU A;  3TWP A;  1O17 A;  4EAD A;  4OWQ A;  1KGZ A;  4X5C A;  4HKM A;  4YYY A;  4IJ1 A;  4MUO A;  5BO3 A;  4GA5 A;  5EY3 A;  4OWV A;  2ELC A;  4OWU A;  1V8G A;  4EAF A;  4M0R A;  5BO2 A;  5C2L A;  1OTP A;  4X5A A;  5BNE A;  4ZOJ A;  4N8Q A;  1BRW A;  5EP8 A;  4N5V A;  4OWO A;  3GBR A;  2WK5 A;  2TPT A;  4OWM A;  4X5E A;  4YI7 A;  4ZOF A;  4OWS A;  1ZYK A;  4GKM A;  4X59 A;  4GA4 A;  4YEK A;  4X46 A;  1ZVW A;  4X58 A;  2J0F A;  3QR9 A;  1KHD A;  4GIU A;  3R88 A;  3R6C A;  2BPQ A;  4X5D A;  3H5Q A;  3QS8 A;  4N93 A;  3QSA A;  2WK6 A;  4ZOK A;  5C1R A;  1AZY A;  4ZTV A; 
#chains in the Genus database with same CATH topology
 1RF8 B;  2GVQ A;  1RRZ A;  4OWN A;  4GTN A;  3UU1 A;  4XR5 A;  4LHM A;  5BYT A;  3QQS A;  5C7S A;  1GXB A;  4GA6 A;  1UOU A;  4X5B A;  1ZXY A;  2DSJ A;  1VQU A;  3TWP A;  1O17 A;  4EAD A;  4OWQ A;  1KGZ A;  4X5C A;  5BO3 A;  4HKM A;  4YYY A;  4IJ1 A;  4MUO A;  4GA5 A;  5EY3 A;  4OWV A;  2ELC A;  4OWU A;  1V8G A;  4F3F C;  4EAF A;  4M0R A;  5BO2 A;  5C2L A;  1OTP A;  4X5A A;  5BNE A;  4ZOJ A;  4N8Q A;  1BRW A;  5EP8 A;  4N5V A;  4OWO A;  3GBR A;  2WK5 A;  2TPT A;  4OWM A;  4X5E A;  4YI7 A;  4ZOF A;  4OWS A;  1ZYK A;  4GKM A;  4X59 A;  4GA4 A;  4YEK A;  4X46 A;  1ZVW A;  4X58 A;  2J0F A;  3QR9 A;  1KHD A;  4GIU A;  3R88 A;  3R6C A;  2BPQ A;  4X5D A;  3H5Q A;  3QS8 A;  4N93 A;  3QSA A;  2WK6 A;  4ZOK A;  5C1R A;  1AZY A;  4ZTV A; 
#chains in the Genus database with same CATH homology
 2GVQ A;  4OWN A;  4GTN A;  3UU1 A;  4XR5 A;  4LHM A;  5BYT A;  3QQS A;  5C7S A;  1GXB A;  4GA6 A;  1UOU A;  4X5B A;  1ZXY A;  2DSJ A;  1VQU A;  3TWP A;  1O17 A;  4EAD A;  4OWQ A;  1KGZ A;  4X5C A;  4HKM A;  4YYY A;  4IJ1 A;  4MUO A;  5BO3 A;  4GA5 A;  5EY3 A;  4OWV A;  2ELC A;  4OWU A;  1V8G A;  4EAF A;  4M0R A;  5BO2 A;  5C2L A;  1OTP A;  4X5A A;  5BNE A;  4ZOJ A;  4N8Q A;  1BRW A;  5EP8 A;  4N5V A;  4OWO A;  3GBR A;  2WK5 A;  2TPT A;  4OWM A;  4X5E A;  4YI7 A;  4ZOF A;  4OWS A;  1ZYK A;  4GKM A;  4X59 A;  4GA4 A;  4YEK A;  4X46 A;  1ZVW A;  4X58 A;  2J0F A;  3QR9 A;  1KHD A;  4GIU A;  3R88 A;  3R6C A;  2BPQ A;  4X5D A;  3H5Q A;  3QS8 A;  4N93 A;  3QSA A;  2WK6 A;  4ZOK A;  5C1R A;  1AZY A;  4ZTV A; 
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