5C2LA

Magnesium soaked into the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
349
structure length
349
Chain Sequence
SVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQIL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding and mimicking of the phosphate-rich substrate, PRPP
rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 123
structure length 349
sequence length 349
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2015-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 5c2lA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 5c2lA02
4GA4A 3UU1A 4X5EA 1KGZA 4YEKA 4OWOA 5C7SA 1AZYA 1ZXYA 4N5VA 1ZYKA 3TWPA 3GBRA 4ZOFA 1V8GA 2WK5A 5BO2A 3R88A 4HKMA 4IJ1A 4M0RA 3QR9A 4OWNA 5EY3A 4ZOKA 2BPQA 1GXBA 4MUOA 4X5CA 4N8QA 2GVQA 4OWVA 1BRWA 4OWSA 4GA6A 4ZTVA 5C1RA 2ELCA 4EAFA 4OWUA 1ZVWA 4OWQA 4EADA 2TPTA 1VQUA 1O17A 3R6CA 4X46A 4ZOJA 4X5BA 4LHMA 5BO3A 3QQSA 3QSAA 4GA5A 5C2LA 1UOUA 4N93A 3QS8A 4X59A 4X5AA 4GIUA 2WK6A 4GKMA 1KHDA 4X58A 2J0FA 3H5QA 4GTNA 4OWMA 4XR5A 2DSJA 5BNEA 5EP8A 5BYTA 4YYYA 4X5DA 1OTPA 4YI7A
chains in the Genus database with same CATH superfamily
4GA4A 3UU1A 4X5EA 1KGZA 4YEKA 4OWOA 5C7SA 1AZYA 1ZXYA 4N5VA 1ZYKA 3TWPA 3GBRA 4ZOFA 1V8GA 2WK5A 5BO2A 3R88A 4HKMA 4IJ1A 4M0RA 3QR9A 4OWNA 5EY3A 4ZOKA 2BPQA 1GXBA 4MUOA 4X5CA 4N8QA 2GVQA 4OWVA 1BRWA 4OWSA 4GA6A 4ZTVA 5C1RA 2ELCA 4EAFA 4OWUA 1ZVWA 4OWQA 4EADA 2TPTA 1VQUA 1O17A 3R6CA 4X46A 4ZOJA 4X5BA 4LHMA 5BO3A 3QQSA 3QSAA 4GA5A 5C2LA 4F3FC 1UOUA 4N93A 3QS8A 4X59A 4X5AA 4GIUA 1RF8B 2WK6A 4GKMA 1KHDA 4X58A 2J0FA 3H5QA 1RRZA 4GTNA 4OWMA 4XR5A 2DSJA 5BNEA 5EP8A 5BYTA 4YYYA 4X5DA 1OTPA 4YI7A
chains in the Genus database with same CATH topology
4GA4A 3UU1A 4X5EA 1KGZA 4YEKA 4OWOA 5C7SA 1AZYA 1ZXYA 4N5VA 1ZYKA 3TWPA 3GBRA 4ZOFA 1V8GA 2WK5A 5BO2A 3R88A 4HKMA 4IJ1A 4M0RA 3QR9A 4OWNA 5EY3A 4ZOKA 2BPQA 1GXBA 4MUOA 4X5CA 4N8QA 2GVQA 4OWVA 1BRWA 4OWSA 4GA6A 4ZTVA 5C1RA 2ELCA 4EAFA 4OWUA 1ZVWA 4OWQA 4EADA 2TPTA 1VQUA 1O17A 3R6CA 4X46A 4ZOJA 4X5BA 4LHMA 5BO3A 3QQSA 3QSAA 4GA5A 5C2LA 1UOUA 4N93A 3QS8A 4X59A 4X5AA 4GIUA 2WK6A 4GKMA 1KHDA 4X58A 2J0FA 3H5QA 4GTNA 4OWMA 4XR5A 2DSJA 5BNEA 5EP8A 5BYTA 4YYYA 4X5DA 1OTPA 4YI7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GA4 A;  3UU1 A;  4X5E A;  1KGZ A;  4YEK A;  4OWO A;  5C7S A;  1AZY A;  1ZXY A;  4N5V A;  1ZYK A;  3TWP A;  3GBR A;  4ZOF A;  1V8G A;  2WK5 A;  5BO2 A;  3R88 A;  4HKM A;  4IJ1 A;  4M0R A;  3QR9 A;  4OWN A;  5EY3 A;  4ZOK A;  2BPQ A;  1GXB A;  4MUO A;  4X5C A;  4N8Q A;  2GVQ A;  4OWV A;  1BRW A;  4OWS A;  4GA6 A;  4ZTV A;  5C1R A;  2ELC A;  4EAF A;  4OWU A;  1ZVW A;  4OWQ A;  4EAD A;  2TPT A;  1VQU A;  1O17 A;  3R6C A;  4X46 A;  4ZOJ A;  4X5B A;  4LHM A;  5BO3 A;  3QQS A;  3QSA A;  4GA5 A;  5C2L A;  1UOU A;  4N93 A;  3QS8 A;  4X59 A;  4X5A A;  4GIU A;  2WK6 A;  4GKM A;  1KHD A;  4X58 A;  2J0F A;  3H5Q A;  4GTN A;  4OWM A;  4XR5 A;  2DSJ A;  5BNE A;  5EP8 A;  5BYT A;  4YYY A;  4X5D A;  1OTP A;  4YI7 A; 
#chains in the Genus database with same CATH topology
 4GA4 A;  3UU1 A;  4X5E A;  1KGZ A;  4YEK A;  4OWO A;  5C7S A;  1AZY A;  1ZXY A;  4N5V A;  1ZYK A;  3TWP A;  3GBR A;  4ZOF A;  1V8G A;  2WK5 A;  5BO2 A;  3R88 A;  4HKM A;  4IJ1 A;  4M0R A;  3QR9 A;  4OWN A;  5EY3 A;  4ZOK A;  2BPQ A;  1GXB A;  4MUO A;  4X5C A;  4N8Q A;  2GVQ A;  4OWV A;  1BRW A;  4OWS A;  4GA6 A;  4ZTV A;  5C1R A;  2ELC A;  4EAF A;  4OWU A;  1ZVW A;  4OWQ A;  4EAD A;  2TPT A;  1VQU A;  1O17 A;  3R6C A;  4X46 A;  4ZOJ A;  4X5B A;  4LHM A;  5BO3 A;  3QQS A;  3QSA A;  4GA5 A;  5C2L A;  4F3F C;  1UOU A;  4N93 A;  3QS8 A;  4X59 A;  4X5A A;  4GIU A;  1RF8 B;  2WK6 A;  4GKM A;  1KHD A;  4X58 A;  2J0F A;  3H5Q A;  1RRZ A;  4GTN A;  4OWM A;  4XR5 A;  2DSJ A;  5BNE A;  5EP8 A;  5BYT A;  4YYY A;  4X5D A;  1OTP A;  4YI7 A; 
#chains in the Genus database with same CATH homology
 4GA4 A;  3UU1 A;  4X5E A;  1KGZ A;  4YEK A;  4OWO A;  5C7S A;  1AZY A;  1ZXY A;  4N5V A;  1ZYK A;  3TWP A;  3GBR A;  4ZOF A;  1V8G A;  2WK5 A;  5BO2 A;  3R88 A;  4HKM A;  4IJ1 A;  4M0R A;  3QR9 A;  4OWN A;  5EY3 A;  4ZOK A;  2BPQ A;  1GXB A;  4MUO A;  4X5C A;  4N8Q A;  2GVQ A;  4OWV A;  1BRW A;  4OWS A;  4GA6 A;  4ZTV A;  5C1R A;  2ELC A;  4EAF A;  4OWU A;  1ZVW A;  4OWQ A;  4EAD A;  2TPT A;  1VQU A;  1O17 A;  3R6C A;  4X46 A;  4ZOJ A;  4X5B A;  4LHM A;  5BO3 A;  3QQS A;  3QSA A;  4GA5 A;  5C2L A;  1UOU A;  4N93 A;  3QS8 A;  4X59 A;  4X5A A;  4GIU A;  2WK6 A;  4GKM A;  1KHD A;  4X58 A;  2J0F A;  3H5Q A;  4GTN A;  4OWM A;  4XR5 A;  2DSJ A;  5BNE A;  5EP8 A;  5BYT A;  4YYY A;  4X5D A;  1OTP A;  4YI7 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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