5C7SA

Prpp complexed with two mn2+ in the active site of mycobacterium tuberculosis anthranilate phosphoribosyltransferase (anprt; trpd)
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
346
structure length
344
Chain Sequence
VPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding and mimicking of the phosphate-rich substrate, PRPP
rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Anthranilate phosphoribosyltransferase
total genus 122
structure length 344
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2015-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 5c7sA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 5c7sA02
3H5QA 5BO3A 4M0RA 1O17A 4X59A 3QR9A 1KGZA 4GKMA 4YYYA 4YI7A 1AZYA 4LHMA 1VQUA 4X46A 4X5BA 2WK6A 3QQSA 2GVQA 4N5VA 2TPTA 3R88A 1V8GA 1ZXYA 5C7SA 4HKMA 5BNEA 4YEKA 4X5CA 2ELCA 5EP8A 4OWSA 3GBRA 4OWOA 4GA6A 4GA4A 1ZYKA 5BYTA 4OWMA 4EAFA 4X5DA 4N93A 4ZOKA 4N8QA 1ZVWA 5C2LA 2BPQA 4X5EA 4X5AA 3UU1A 1KHDA 3QSAA 1GXBA 4OWNA 4OWQA 4EADA 5EY3A 4XR5A 4GTNA 4IJ1A 4ZTVA 4OWVA 4ZOJA 3TWPA 2J0FA 4OWUA 5C1RA 4ZOFA 4GIUA 1OTPA 4MUOA 3QS8A 3R6CA 2WK5A 4X58A 1UOUA 2DSJA 5BO2A 4GA5A 1BRWA
chains in the Genus database with same CATH superfamily
4F3FC 3H5QA 5BO3A 4M0RA 1O17A 4X59A 3QR9A 1KGZA 4GKMA 4YYYA 4YI7A 1AZYA 4LHMA 1VQUA 4X46A 4X5BA 2WK6A 3QQSA 2GVQA 4N5VA 2TPTA 3R88A 1V8GA 1ZXYA 5C7SA 4HKMA 5BNEA 4YEKA 4X5CA 2ELCA 5EP8A 4OWSA 3GBRA 4OWOA 4GA6A 4GA4A 1ZYKA 5BYTA 4OWMA 4EAFA 4X5DA 4N93A 4ZOKA 1RF8B 4N8QA 1ZVWA 5C2LA 2BPQA 4X5EA 4X5AA 3UU1A 1KHDA 3QSAA 1GXBA 4OWNA 1RRZA 4OWQA 4EADA 5EY3A 4XR5A 4GTNA 4IJ1A 4ZTVA 4OWVA 4ZOJA 3TWPA 2J0FA 4OWUA 5C1RA 4ZOFA 4GIUA 1OTPA 4MUOA 3QS8A 3R6CA 2WK5A 4X58A 1UOUA 2DSJA 5BO2A 4GA5A 1BRWA
chains in the Genus database with same CATH topology
3H5QA 5BO3A 4M0RA 1O17A 4X59A 3QR9A 1KGZA 4GKMA 4YYYA 4YI7A 1AZYA 4LHMA 1VQUA 4X46A 4X5BA 2WK6A 3QQSA 2GVQA 4N5VA 2TPTA 3R88A 1V8GA 1ZXYA 5C7SA 4HKMA 5BNEA 4YEKA 4X5CA 2ELCA 5EP8A 4OWSA 3GBRA 4OWOA 4GA6A 4GA4A 1ZYKA 5BYTA 4OWMA 4EAFA 4X5DA 4N93A 4ZOKA 4N8QA 1ZVWA 5C2LA 2BPQA 4X5EA 4X5AA 3UU1A 1KHDA 3QSAA 1GXBA 4OWNA 4OWQA 4EADA 5EY3A 4XR5A 4GTNA 4IJ1A 4ZTVA 4OWVA 4ZOJA 3TWPA 2J0FA 4OWUA 5C1RA 4ZOFA 4GIUA 1OTPA 4MUOA 3QS8A 3R6CA 2WK5A 4X58A 1UOUA 2DSJA 5BO2A 4GA5A 1BRWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H5Q A;  5BO3 A;  4M0R A;  1O17 A;  4X59 A;  3QR9 A;  1KGZ A;  4GKM A;  4YYY A;  4YI7 A;  1AZY A;  4LHM A;  1VQU A;  4X46 A;  4X5B A;  2WK6 A;  3QQS A;  2GVQ A;  4N5V A;  2TPT A;  3R88 A;  1V8G A;  1ZXY A;  5C7S A;  4HKM A;  5BNE A;  4YEK A;  4X5C A;  2ELC A;  5EP8 A;  4OWS A;  3GBR A;  4OWO A;  4GA6 A;  4GA4 A;  1ZYK A;  5BYT A;  4OWM A;  4EAF A;  4X5D A;  4N93 A;  4ZOK A;  4N8Q A;  1ZVW A;  5C2L A;  2BPQ A;  4X5E A;  4X5A A;  3UU1 A;  1KHD A;  3QSA A;  1GXB A;  4OWN A;  4OWQ A;  4EAD A;  5EY3 A;  4XR5 A;  4GTN A;  4IJ1 A;  4ZTV A;  4OWV A;  4ZOJ A;  3TWP A;  2J0F A;  4OWU A;  5C1R A;  4ZOF A;  4GIU A;  1OTP A;  4MUO A;  3QS8 A;  3R6C A;  2WK5 A;  4X58 A;  1UOU A;  2DSJ A;  5BO2 A;  4GA5 A;  1BRW A; 
#chains in the Genus database with same CATH topology
 4F3F C;  3H5Q A;  5BO3 A;  4M0R A;  1O17 A;  4X59 A;  3QR9 A;  1KGZ A;  4GKM A;  4YYY A;  4YI7 A;  1AZY A;  4LHM A;  1VQU A;  4X46 A;  4X5B A;  2WK6 A;  3QQS A;  2GVQ A;  4N5V A;  2TPT A;  3R88 A;  1V8G A;  1ZXY A;  5C7S A;  4HKM A;  5BNE A;  4YEK A;  4X5C A;  2ELC A;  5EP8 A;  4OWS A;  3GBR A;  4OWO A;  4GA6 A;  4GA4 A;  1ZYK A;  5BYT A;  4OWM A;  4EAF A;  4X5D A;  4N93 A;  4ZOK A;  1RF8 B;  4N8Q A;  1ZVW A;  5C2L A;  2BPQ A;  4X5E A;  4X5A A;  3UU1 A;  1KHD A;  3QSA A;  1GXB A;  4OWN A;  1RRZ A;  4OWQ A;  4EAD A;  5EY3 A;  4XR5 A;  4GTN A;  4IJ1 A;  4ZTV A;  4OWV A;  4ZOJ A;  3TWP A;  2J0F A;  4OWU A;  5C1R A;  4ZOF A;  4GIU A;  1OTP A;  4MUO A;  3QS8 A;  3R6C A;  2WK5 A;  4X58 A;  1UOU A;  2DSJ A;  5BO2 A;  4GA5 A;  1BRW A; 
#chains in the Genus database with same CATH homology
 3H5Q A;  5BO3 A;  4M0R A;  1O17 A;  4X59 A;  3QR9 A;  1KGZ A;  4GKM A;  4YYY A;  4YI7 A;  1AZY A;  4LHM A;  1VQU A;  4X46 A;  4X5B A;  2WK6 A;  3QQS A;  2GVQ A;  4N5V A;  2TPT A;  3R88 A;  1V8G A;  1ZXY A;  5C7S A;  4HKM A;  5BNE A;  4YEK A;  4X5C A;  2ELC A;  5EP8 A;  4OWS A;  3GBR A;  4OWO A;  4GA6 A;  4GA4 A;  1ZYK A;  5BYT A;  4OWM A;  4EAF A;  4X5D A;  4N93 A;  4ZOK A;  4N8Q A;  1ZVW A;  5C2L A;  2BPQ A;  4X5E A;  4X5A A;  3UU1 A;  1KHD A;  3QSA A;  1GXB A;  4OWN A;  4OWQ A;  4EAD A;  5EY3 A;  4XR5 A;  4GTN A;  4IJ1 A;  4ZTV A;  4OWV A;  4ZOJ A;  3TWP A;  2J0F A;  4OWU A;  5C1R A;  4ZOF A;  4GIU A;  1OTP A;  4MUO A;  3QS8 A;  3R6C A;  2WK5 A;  4X58 A;  1UOU A;  2DSJ A;  5BO2 A;  4GA5 A;  1BRW A; 
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