2B9SB

Crystal structure of heterodimeric l. donovani topoisomerase i-vanadate-dna complex
Total Genus 9

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
52
structure length
52
Chain Sequence
KAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKKFPWAMNAENFDF

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Isomerase/dna
source organism Leishmania donovani
publication title The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA.
pubmed doi rcsb
molecule keywords 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'
total genus 9
structure length 52
sequence length 52
ec nomenclature ec 5.99.1.2: Transferred entry: 5.6.2.2.
pdb deposition date 2005-10-12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.10 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 2b9sB00
1A36A 1SC7A 2B9SB 1K4SA 1NH3A 1LPQA 1A35A 1EJ9A 1T8IA 1A31A 1TL8A 1SEUA 1RR8C 1RRJA 1K4TA 1R49A
chains in the Genus database with same CATH superfamily
2F4QA 3K57A 1GE9A 4KB4A 3K59A 3CQZA 1K83A 4D3YA 1WCMA 1DD5A 1I6VD 3FKIA 4FGUA 1SEUA 1RR8C 2R93A 5C9HA 4KAWX 4LMOA 3LF9A 1NH3A 3M4AA 2NVXA 1EH1A 1EJ9A 1WQGA 2B63A 1TWFA 4AHCA 2A6HD 4KDDA 1A35A 5MLC9 1TGOA 1TWCA 4L8IA 2A6ED 4D3ZA 2WB1A 4IP8A 3GTQA 1YNJD 4IP9A 5JSNB 3DU5A 1YNND 1IW7D 1MIUA 1SMYD 3SJRA 3DU6A 2B9SB 1I50A 4OYDB 2R4GA 4JLRC 2JA7A 3GTJA 1TWGA 4AYBA 3GTLA 2CW0D 1HQMD 4AN8A 2A69D 3K5MA 3K5LA 1A31A 4NOMA 1RRJA 1I3QA 4H3TA 1A36A 3GTGA 4C2MA 1Q8IA 3LHPS 3GTPA 2JA5A 1Y1WA 4Q5VA 1LPQA 2R92A 1R9TA 1WQFA 1TL8A 1K4TA 3KYLA 3WVOA 4FXDA 2O5JD 1SC7A 2E2HA 3HKZA 3GTMA 3MAQA 1WQHA 2YU9A 2A68D 4QCLA 1R5ZA 4KC6A 4Q5GA 5JSBB 1TWAA 5CQGA 4F3EA 4QIWA 2VUMA 3P9AA 2PMZA 3K5NA 3IAYA 4NOLA 4FYDA 4NOKA 3GTOA 1K4SA 1TWHA 1Y1VA 4EJ3A 1ZYRD 3K5OA 1V9MA 3H0GA 2E2IA 1SFOA 2JA6A 4KB2A 2BE5D 1Y698 2R7ZA 3GTKA 1R49A 2NVYA 3K58A 1EK8A 4GFQA 1ISEA 1IS1A 1T8IA 4O26A 2Y0SA 2WAQA
chains in the Genus database with same CATH topology
2F4QA 3K57A 1GE9A 4KB4A 3K59A 3CQZA 1K83A 4D3YA 1WCMA 1DD5A 1I6VD 3FKIA 4FGUA 1SEUA 1RR8C 2R93A 5C9HA 4KAWX 4LMOA 3LF9A 1NH3A 3M4AA 2NVXA 1EH1A 1EJ9A 1WQGA 2B63A 1TWFA 4AHCA 2A6HD 4KDDA 1A35A 5MLC9 1TGOA 1TWCA 4L8IA 2A6ED 4D3ZA 2WB1A 4IP8A 3GTQA 1YNJD 4IP9A 5JSNB 3DU5A 1YNND 1IW7D 1MIUA 1SMYD 3SJRA 3DU6A 2B9SB 1I50A 4OYDB 2R4GA 4JLRC 2JA7A 3GTJA 1TWGA 4AYBA 3GTLA 2CW0D 1HQMD 4AN8A 2A69D 3K5MA 3K5LA 1A31A 4NOMA 1RRJA 1I3QA 4H3TA 1A36A 3GTGA 4C2MA 1Q8IA 3LHPS 3GTPA 2JA5A 1Y1WA 4Q5VA 1LPQA 2R92A 1R9TA 1WQFA 1TL8A 1K4TA 3KYLA 3WVOA 4FXDA 2O5JD 1SC7A 2E2HA 3HKZA 3GTMA 3MAQA 1WQHA 2YU9A 2A68D 4QCLA 1R5ZA 4KC6A 4Q5GA 5JSBB 1TWAA 5CQGA 4F3EA 4QIWA 2VUMA 3P9AA 2PMZA 3K5NA 3IAYA 4NOLA 4FYDA 4NOKA 3GTOA 1K4SA 1TWHA 1Y1VA 4EJ3A 1ZYRD 3K5OA 1V9MA 3H0GA 2E2IA 1SFOA 2JA6A 4KB2A 2BE5D 1Y698 2R7ZA 3GTKA 1R49A 2NVYA 3K58A 1EK8A 4GFQA 1ISEA 1IS1A 1T8IA 4O26A 2Y0SA 2WAQA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1A36 A;  1SC7 A;  2B9S B;  1K4S A;  1NH3 A;  1LPQ A;  1A35 A;  1EJ9 A;  1T8I A;  1A31 A;  1TL8 A;  1SEU A;  1RR8 C;  1RRJ A;  1K4T A;  1R49 A; 
#chains in the Genus database with same CATH topology
 2F4Q A;  3K57 A;  1GE9 A;  4KB4 A;  3K59 A;  3CQZ A;  1K83 A;  4D3Y A;  1WCM A;  1DD5 A;  1I6V D;  3FKI A;  4FGU A;  1SEU A;  1RR8 C;  2R93 A;  5C9H A;  4KAW X;  4LMO A;  3LF9 A;  1NH3 A;  3M4A A;  2NVX A;  1EH1 A;  1EJ9 A;  1WQG A;  2B63 A;  1TWF A;  4AHC A;  2A6H D;  4KDD A;  1A35 A;  5MLC 9;  1TGO A;  1TWC A;  4L8I A;  2A6E D;  4D3Z A;  2WB1 A;  4IP8 A;  3GTQ A;  1YNJ D;  4IP9 A;  5JSN B;  3DU5 A;  1YNN D;  1IW7 D;  1MIU A;  1SMY D;  3SJR A;  3DU6 A;  2B9S B;  1I50 A;  4OYD B;  2R4G A;  4JLR C;  2JA7 A;  3GTJ A;  1TWG A;  4AYB A;  3GTL A;  2CW0 D;  1HQM D;  4AN8 A;  2A69 D;  3K5M A;  3K5L A;  1A31 A;  4NOM A;  1RRJ A;  1I3Q A;  4H3T A;  1A36 A;  3GTG A;  4C2M A;  1Q8I A;  3LHP S;  3GTP A;  2JA5 A;  1Y1W A;  4Q5V A;  1LPQ A;  2R92 A;  1R9T A;  1WQF A;  1TL8 A;  1K4T A;  3KYL A;  3WVO A;  4FXD A;  2O5J D;  1SC7 A;  2E2H A;  3HKZ A;  3GTM A;  3MAQ A;  1WQH A;  2YU9 A;  2A68 D;  4QCL A;  1R5Z A;  4KC6 A;  4Q5G A;  5JSB B;  1TWA A;  5CQG A;  4F3E A;  4QIW A;  2VUM A;  3P9A A;  2PMZ A;  3K5N A;  3IAY A;  4NOL A;  4FYD A;  4NOK A;  3GTO A;  1K4S A;  1TWH A;  1Y1V A;  4EJ3 A;  1ZYR D;  3K5O A;  1V9M A;  3H0G A;  2E2I A;  1SFO A;  2JA6 A;  4KB2 A;  2BE5 D;  1Y69 8;  2R7Z A;  3GTK A;  1R49 A;  2NVY A;  3K58 A;  1EK8 A;  4GFQ A;  1ISE A;  1IS1 A;  1T8I A;  4O26 A;  2Y0S A;  2WAQ A; 
#chains in the Genus database with same CATH homology
 2F4Q A;  3K57 A;  1GE9 A;  4KB4 A;  3K59 A;  3CQZ A;  1K83 A;  4D3Y A;  1WCM A;  1DD5 A;  1I6V D;  3FKI A;  4FGU A;  1SEU A;  1RR8 C;  2R93 A;  5C9H A;  4KAW X;  4LMO A;  3LF9 A;  1NH3 A;  3M4A A;  2NVX A;  1EH1 A;  1EJ9 A;  1WQG A;  2B63 A;  1TWF A;  4AHC A;  2A6H D;  4KDD A;  1A35 A;  5MLC 9;  1TGO A;  1TWC A;  4L8I A;  2A6E D;  4D3Z A;  2WB1 A;  4IP8 A;  3GTQ A;  1YNJ D;  4IP9 A;  5JSN B;  3DU5 A;  1YNN D;  1IW7 D;  1MIU A;  1SMY D;  3SJR A;  3DU6 A;  2B9S B;  1I50 A;  4OYD B;  2R4G A;  4JLR C;  2JA7 A;  3GTJ A;  1TWG A;  4AYB A;  3GTL A;  2CW0 D;  1HQM D;  4AN8 A;  2A69 D;  3K5M A;  3K5L A;  1A31 A;  4NOM A;  1RRJ A;  1I3Q A;  4H3T A;  1A36 A;  3GTG A;  4C2M A;  1Q8I A;  3LHP S;  3GTP A;  2JA5 A;  1Y1W A;  4Q5V A;  1LPQ A;  2R92 A;  1R9T A;  1WQF A;  1TL8 A;  1K4T A;  3KYL A;  3WVO A;  4FXD A;  2O5J D;  1SC7 A;  2E2H A;  3HKZ A;  3GTM A;  3MAQ A;  1WQH A;  2YU9 A;  2A68 D;  4QCL A;  1R5Z A;  4KC6 A;  4Q5G A;  5JSB B;  1TWA A;  5CQG A;  4F3E A;  4QIW A;  2VUM A;  3P9A A;  2PMZ A;  3K5N A;  3IAY A;  4NOL A;  4FYD A;  4NOK A;  3GTO A;  1K4S A;  1TWH A;  1Y1V A;  4EJ3 A;  1ZYR D;  3K5O A;  1V9M A;  3H0G A;  2E2I A;  1SFO A;  2JA6 A;  4KB2 A;  2BE5 D;  1Y69 8;  2R7Z A;  3GTK A;  1R49 A;  2NVY A;  3K58 A;  1EK8 A;  4GFQ A;  1ISE A;  1IS1 A;  1T8I A;  4O26 A;  2Y0S A;  2WAQ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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