2B9SB

Crystal structure of heterodimeric l. donovani topoisomerase i-vanadate-dna complex
Total Genus 9
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
52
structure length
52
Chain Sequence
KAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKKFPWAMNAENFDF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA.
pubmed doi rcsb
molecule tags Isomerase/dna
source organism Leishmania donovani
molecule keywords 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'
total genus 9
structure length 52
sequence length 52
ec nomenclature ec 5.99.1.2: Transferred entry: 5.6.2.2.
pdb deposition date 2005-10-12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.10 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 2b9sB00
1RR8C 1T8IA 1RRJA 1R49A 1K4TA 1EJ9A 1A36A 1NH3A 1A31A 1K4SA 1A35A 1LPQA 1SC7A 2B9SB 1TL8A 1SEUA
chains in the Genus database with same CATH superfamily
4OYDB 1TWGA 1R5ZA 1EJ9A 1A31A 4IP9A 3H0GA 2WB1A 3GTLA 4AN8A 4FXDA 2O5JD 1TWFA 5JSBB 5JSNB 1LPQA 3K5NA 1Y1WA 3DU6A 4KC6A 3CQZA 1I6VD 1Y698 2VUMA 3K5MA 1I50A 1WQGA 1NH3A 4O26A 1SFOA 4JLRC 1TWAA 4KAWX 2R7ZA 3GTPA 2B63A 3GTQA 2E2HA 1EK8A 3LHPS 4AYBA 1TWHA 1I3QA 2NVYA 4EJ3A 2R93A 4IP8A 5MLC9 2A69D 2A6ED 5C9HA 4NOLA 4FGUA 3GTKA 1RRJA 4D3ZA 2NVXA 1SC7A 2JA5A 2Y0SA 4Q5VA 4KDDA 1RR8C 1WQHA 1R49A 2A6HD 2JA7A 1ISEA 1YNJD 1EH1A 1WCMA 2F4QA 3MAQA 1Q8IA 2A68D 1HQMD 1K4TA 1IW7D 2R92A 1A35A 1K83A 3K59A 1V9MA 1R9TA 2E2IA 4FYDA 3IAYA 1Y1VA 3K5LA 3HKZA 4F3EA 1K4SA 2PMZA 4Q5GA 2JA6A 3GTGA 1T8IA 4NOKA 2R4GA 4KB2A 3K57A 1WQFA 3SJRA 3GTJA 2CW0D 5CQGA 2WAQA 1MIUA 1TL8A 3M4AA 1TWCA 4LMOA 1ZYRD 1IS1A 4GFQA 4C2MA 4H3TA 2B9SB 1TGOA 1DD5A 3DU5A 4AHCA 1GE9A 3LF9A 1A36A 4NOMA 3K5OA 3WVOA 1YNND 4D3YA 3FKIA 3K58A 1SEUA 3GTMA 4L8IA 4KB4A 3GTOA 1SMYD 4QCLA 2YU9A 2BE5D 3P9AA 3KYLA 4QIWA
chains in the Genus database with same CATH topology
4OYDB 1TWGA 1R5ZA 1EJ9A 1A31A 4IP9A 3H0GA 2WB1A 3GTLA 4AN8A 4FXDA 2O5JD 1TWFA 5JSBB 5JSNB 1LPQA 3K5NA 1Y1WA 3DU6A 4KC6A 3CQZA 1I6VD 1Y698 2VUMA 3K5MA 1I50A 1WQGA 1NH3A 4O26A 1SFOA 4JLRC 1TWAA 4KAWX 2R7ZA 3GTPA 2B63A 3GTQA 2E2HA 1EK8A 3LHPS 4AYBA 1TWHA 1I3QA 2NVYA 4EJ3A 2R93A 4IP8A 5MLC9 2A69D 2A6ED 5C9HA 4NOLA 4FGUA 3GTKA 1RRJA 4D3ZA 2NVXA 1SC7A 2JA5A 2Y0SA 4Q5VA 4KDDA 1RR8C 1WQHA 1R49A 2A6HD 2JA7A 1ISEA 1YNJD 1EH1A 1WCMA 2F4QA 3MAQA 1Q8IA 2A68D 1HQMD 1K4TA 1IW7D 2R92A 1A35A 1K83A 3K59A 1V9MA 1R9TA 2E2IA 4FYDA 3IAYA 1Y1VA 3K5LA 3HKZA 4F3EA 1K4SA 2PMZA 4Q5GA 2JA6A 3GTGA 1T8IA 4NOKA 2R4GA 4KB2A 3K57A 1WQFA 3SJRA 3GTJA 2CW0D 5CQGA 2WAQA 1MIUA 1TL8A 3M4AA 1TWCA 4LMOA 1ZYRD 1IS1A 4GFQA 4C2MA 4H3TA 2B9SB 1TGOA 1DD5A 3DU5A 4AHCA 1GE9A 3LF9A 1A36A 4NOMA 3K5OA 3WVOA 1YNND 4D3YA 3FKIA 3K58A 1SEUA 3GTMA 4L8IA 4KB4A 3GTOA 1SMYD 4QCLA 2YU9A 2BE5D 3P9AA 3KYLA 4QIWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RR8 C;  1T8I A;  1RRJ A;  1R49 A;  1K4T A;  1EJ9 A;  1A36 A;  1NH3 A;  1A31 A;  1K4S A;  1A35 A;  1LPQ A;  1SC7 A;  2B9S B;  1TL8 A;  1SEU A; 
#chains in the Genus database with same CATH topology
 4OYD B;  1TWG A;  1R5Z A;  1EJ9 A;  1A31 A;  4IP9 A;  3H0G A;  2WB1 A;  3GTL A;  4AN8 A;  4FXD A;  2O5J D;  1TWF A;  5JSB B;  5JSN B;  1LPQ A;  3K5N A;  1Y1W A;  3DU6 A;  4KC6 A;  3CQZ A;  1I6V D;  1Y69 8;  2VUM A;  3K5M A;  1I50 A;  1WQG A;  1NH3 A;  4O26 A;  1SFO A;  4JLR C;  1TWA A;  4KAW X;  2R7Z A;  3GTP A;  2B63 A;  3GTQ A;  2E2H A;  1EK8 A;  3LHP S;  4AYB A;  1TWH A;  1I3Q A;  2NVY A;  4EJ3 A;  2R93 A;  4IP8 A;  5MLC 9;  2A69 D;  2A6E D;  5C9H A;  4NOL A;  4FGU A;  3GTK A;  1RRJ A;  4D3Z A;  2NVX A;  1SC7 A;  2JA5 A;  2Y0S A;  4Q5V A;  4KDD A;  1RR8 C;  1WQH A;  1R49 A;  2A6H D;  2JA7 A;  1ISE A;  1YNJ D;  1EH1 A;  1WCM A;  2F4Q A;  3MAQ A;  1Q8I A;  2A68 D;  1HQM D;  1K4T A;  1IW7 D;  2R92 A;  1A35 A;  1K83 A;  3K59 A;  1V9M A;  1R9T A;  2E2I A;  4FYD A;  3IAY A;  1Y1V A;  3K5L A;  3HKZ A;  4F3E A;  1K4S A;  2PMZ A;  4Q5G A;  2JA6 A;  3GTG A;  1T8I A;  4NOK A;  2R4G A;  4KB2 A;  3K57 A;  1WQF A;  3SJR A;  3GTJ A;  2CW0 D;  5CQG A;  2WAQ A;  1MIU A;  1TL8 A;  3M4A A;  1TWC A;  4LMO A;  1ZYR D;  1IS1 A;  4GFQ A;  4C2M A;  4H3T A;  2B9S B;  1TGO A;  1DD5 A;  3DU5 A;  4AHC A;  1GE9 A;  3LF9 A;  1A36 A;  4NOM A;  3K5O A;  3WVO A;  1YNN D;  4D3Y A;  3FKI A;  3K58 A;  1SEU A;  3GTM A;  4L8I A;  4KB4 A;  3GTO A;  1SMY D;  4QCL A;  2YU9 A;  2BE5 D;  3P9A A;  3KYL A;  4QIW A; 
#chains in the Genus database with same CATH homology
 4OYD B;  1TWG A;  1R5Z A;  1EJ9 A;  1A31 A;  4IP9 A;  3H0G A;  2WB1 A;  3GTL A;  4AN8 A;  4FXD A;  2O5J D;  1TWF A;  5JSB B;  5JSN B;  1LPQ A;  3K5N A;  1Y1W A;  3DU6 A;  4KC6 A;  3CQZ A;  1I6V D;  1Y69 8;  2VUM A;  3K5M A;  1I50 A;  1WQG A;  1NH3 A;  4O26 A;  1SFO A;  4JLR C;  1TWA A;  4KAW X;  2R7Z A;  3GTP A;  2B63 A;  3GTQ A;  2E2H A;  1EK8 A;  3LHP S;  4AYB A;  1TWH A;  1I3Q A;  2NVY A;  4EJ3 A;  2R93 A;  4IP8 A;  5MLC 9;  2A69 D;  2A6E D;  5C9H A;  4NOL A;  4FGU A;  3GTK A;  1RRJ A;  4D3Z A;  2NVX A;  1SC7 A;  2JA5 A;  2Y0S A;  4Q5V A;  4KDD A;  1RR8 C;  1WQH A;  1R49 A;  2A6H D;  2JA7 A;  1ISE A;  1YNJ D;  1EH1 A;  1WCM A;  2F4Q A;  3MAQ A;  1Q8I A;  2A68 D;  1HQM D;  1K4T A;  1IW7 D;  2R92 A;  1A35 A;  1K83 A;  3K59 A;  1V9M A;  1R9T A;  2E2I A;  4FYD A;  3IAY A;  1Y1V A;  3K5L A;  3HKZ A;  4F3E A;  1K4S A;  2PMZ A;  4Q5G A;  2JA6 A;  3GTG A;  1T8I A;  4NOK A;  2R4G A;  4KB2 A;  3K57 A;  1WQF A;  3SJR A;  3GTJ A;  2CW0 D;  5CQG A;  2WAQ A;  1MIU A;  1TL8 A;  3M4A A;  1TWC A;  4LMO A;  1ZYR D;  1IS1 A;  4GFQ A;  4C2M A;  4H3T A;  2B9S B;  1TGO A;  1DD5 A;  3DU5 A;  4AHC A;  1GE9 A;  3LF9 A;  1A36 A;  4NOM A;  3K5O A;  3WVO A;  1YNN D;  4D3Y A;  3FKI A;  3K58 A;  1SEU A;  3GTM A;  4L8I A;  4KB4 A;  3GTO A;  1SMY D;  4QCL A;  2YU9 A;  2BE5 D;  3P9A A;  3KYL A;  4QIW A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...