4OYDB

Crystal structure of a computationally designed inhibitor of an epstein-barr viral bcl-2 protein
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
117
structure length
117
Chain Sequence
ADPKKVLDKAKDQAENRVRELKQKLEELYKEARKLDLTQEMRRKLELRYIAAMLMAIGDIYNAIRQAKQEADKLKKAGLVNSQQLDELKRRLEELKEEASRKARDYGREFQLKLEYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells.
pubmed doi rcsb
molecule tags Viral protein/inhibitor
source organism Epstein-barr virus
molecule keywords Apoptosis regulator BHRF1
total genus 53
structure length 117
sequence length 117
chains with identical sequence D
ec nomenclature
pdb deposition date 2014-02-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.20 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 4oydB00
1WQHA 5MLC9 4KAWX 1EK8A 4OYDB 1Y698 3LHPS 5JSNB 1WQGA 4KDDA 4KB4A 1DD5A 4KC6A 1ISEA 4GFQA 1WQFA 1IS1A 4KB2A 4L8IA 1GE9A 4JLRC 1EH1A 3LF9A 5JSBB
chains in the Genus database with same CATH superfamily
4H3TA 4KAWX 2R92A 3WVOA 4D3YA 1EK8A 4O26A 2VUMA 1I50A 1EJ9A 3GTMA 1Y1VA 2B63A 3IAYA 5JSNB 1WQGA 1LPQA 2JA6A 2WB1A 3GTLA 2F4QA 2A6ED 1ISEA 3K5NA 1K4TA 1WQFA 4D3ZA 1TGOA 4L8IA 1RR8C 2B9SB 4FYDA 2BE5D 3FKIA 1WQHA 2NVXA 3CQZA 1T8IA 2A68D 2YU9A 1K83A 4Q5VA 1TL8A 4QIWA 3KYLA 1A31A 3GTGA 3GTKA 2R7ZA 1WCMA 1NH3A 5C9HA 1Y1WA 1I6VD 3GTPA 3DU5A 4GFQA 2NVYA 1IS1A 1SEUA 4KB2A 1MIUA 4NOKA 4F3EA 4NOLA 2E2IA 5CQGA 2A6HD 1IW7D 3SJRA 1V9MA 1TWHA 2JA5A 4LMOA 1TWGA 4OYDB 1SMYD 3MAQA 1HQMD 2E2HA 2Y0SA 1SC7A 4KB4A 1A35A 4FGUA 4KC6A 3M4AA 1R5ZA 1ZYRD 3DU6A 4AYBA 1GE9A 4AHCA 3K58A 1TWAA 2CW0D 1K4SA 4IP9A 3LF9A 3P9AA 2R4GA 1RRJA 1A36A 1TWCA 5MLC9 1Q8IA 3K5OA 4QCLA 3GTQA 2JA7A 2PMZA 3K5LA 2O5JD 1R49A 2WAQA 1Y698 3LHPS 3H0GA 4KDDA 1DD5A 1I3QA 1TWFA 2R93A 4IP8A 4AN8A 3K5MA 4EJ3A 2A69D 4C2MA 3K59A 3K57A 4JLRC 1EH1A 4Q5GA 3GTJA 4FXDA 4NOMA 1YNND 1YNJD 3GTOA 3HKZA 5JSBB 1SFOA 1R9TA
chains in the Genus database with same CATH topology
4H3TA 4KAWX 2R92A 3WVOA 4D3YA 1EK8A 4O26A 2VUMA 1I50A 1EJ9A 3GTMA 1Y1VA 2B63A 3IAYA 5JSNB 1WQGA 1LPQA 2JA6A 2WB1A 3GTLA 2F4QA 2A6ED 1ISEA 3K5NA 1K4TA 1WQFA 4D3ZA 1TGOA 4L8IA 1RR8C 2B9SB 4FYDA 2BE5D 3FKIA 1WQHA 2NVXA 3CQZA 1T8IA 2A68D 2YU9A 1K83A 4Q5VA 1TL8A 4QIWA 3KYLA 1A31A 3GTGA 3GTKA 2R7ZA 1WCMA 1NH3A 5C9HA 1Y1WA 1I6VD 3GTPA 3DU5A 4GFQA 2NVYA 1IS1A 1SEUA 4KB2A 1MIUA 4NOKA 4F3EA 4NOLA 2E2IA 5CQGA 2A6HD 1IW7D 3SJRA 1V9MA 1TWHA 2JA5A 4LMOA 1TWGA 4OYDB 1SMYD 3MAQA 1HQMD 2E2HA 2Y0SA 1SC7A 4KB4A 1A35A 4FGUA 4KC6A 3M4AA 1R5ZA 1ZYRD 3DU6A 4AYBA 1GE9A 4AHCA 3K58A 1TWAA 2CW0D 1K4SA 4IP9A 3LF9A 3P9AA 2R4GA 1RRJA 1A36A 1TWCA 5MLC9 1Q8IA 3K5OA 4QCLA 3GTQA 2JA7A 2PMZA 3K5LA 2O5JD 1R49A 2WAQA 1Y698 3LHPS 3H0GA 4KDDA 1DD5A 1I3QA 1TWFA 2R93A 4IP8A 4AN8A 3K5MA 4EJ3A 2A69D 4C2MA 3K59A 3K57A 4JLRC 1EH1A 4Q5GA 3GTJA 4FXDA 4NOMA 1YNND 1YNJD 3GTOA 3HKZA 5JSBB 1SFOA 1R9TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WQH A;  5MLC 9;  4KAW X;  1EK8 A;  4OYD B;  1Y69 8;  3LHP S;  5JSN B;  1WQG A;  4KDD A;  4KB4 A;  1DD5 A;  4KC6 A;  1ISE A;  4GFQ A;  1WQF A;  1IS1 A;  4KB2 A;  4L8I A;  1GE9 A;  4JLR C;  1EH1 A;  3LF9 A;  5JSB B; 
#chains in the Genus database with same CATH topology
 4H3T A;  4KAW X;  2R92 A;  3WVO A;  4D3Y A;  1EK8 A;  4O26 A;  2VUM A;  1I50 A;  1EJ9 A;  3GTM A;  1Y1V A;  2B63 A;  3IAY A;  5JSN B;  1WQG A;  1LPQ A;  2JA6 A;  2WB1 A;  3GTL A;  2F4Q A;  2A6E D;  1ISE A;  3K5N A;  1K4T A;  1WQF A;  4D3Z A;  1TGO A;  4L8I A;  1RR8 C;  2B9S B;  4FYD A;  2BE5 D;  3FKI A;  1WQH A;  2NVX A;  3CQZ A;  1T8I A;  2A68 D;  2YU9 A;  1K83 A;  4Q5V A;  1TL8 A;  4QIW A;  3KYL A;  1A31 A;  3GTG A;  3GTK A;  2R7Z A;  1WCM A;  1NH3 A;  5C9H A;  1Y1W A;  1I6V D;  3GTP A;  3DU5 A;  4GFQ A;  2NVY A;  1IS1 A;  1SEU A;  4KB2 A;  1MIU A;  4NOK A;  4F3E A;  4NOL A;  2E2I A;  5CQG A;  2A6H D;  1IW7 D;  3SJR A;  1V9M A;  1TWH A;  2JA5 A;  4LMO A;  1TWG A;  4OYD B;  1SMY D;  3MAQ A;  1HQM D;  2E2H A;  2Y0S A;  1SC7 A;  4KB4 A;  1A35 A;  4FGU A;  4KC6 A;  3M4A A;  1R5Z A;  1ZYR D;  3DU6 A;  4AYB A;  1GE9 A;  4AHC A;  3K58 A;  1TWA A;  2CW0 D;  1K4S A;  4IP9 A;  3LF9 A;  3P9A A;  2R4G A;  1RRJ A;  1A36 A;  1TWC A;  5MLC 9;  1Q8I A;  3K5O A;  4QCL A;  3GTQ A;  2JA7 A;  2PMZ A;  3K5L A;  2O5J D;  1R49 A;  2WAQ A;  1Y69 8;  3LHP S;  3H0G A;  4KDD A;  1DD5 A;  1I3Q A;  1TWF A;  2R93 A;  4IP8 A;  4AN8 A;  3K5M A;  4EJ3 A;  2A69 D;  4C2M A;  3K59 A;  3K57 A;  4JLR C;  1EH1 A;  4Q5G A;  3GTJ A;  4FXD A;  4NOM A;  1YNN D;  1YNJ D;  3GTO A;  3HKZ A;  5JSB B;  1SFO A;  1R9T A; 
#chains in the Genus database with same CATH homology
 4H3T A;  4KAW X;  2R92 A;  3WVO A;  4D3Y A;  1EK8 A;  4O26 A;  2VUM A;  1I50 A;  1EJ9 A;  3GTM A;  1Y1V A;  2B63 A;  3IAY A;  5JSN B;  1WQG A;  1LPQ A;  2JA6 A;  2WB1 A;  3GTL A;  2F4Q A;  2A6E D;  1ISE A;  3K5N A;  1K4T A;  1WQF A;  4D3Z A;  1TGO A;  4L8I A;  1RR8 C;  2B9S B;  4FYD A;  2BE5 D;  3FKI A;  1WQH A;  2NVX A;  3CQZ A;  1T8I A;  2A68 D;  2YU9 A;  1K83 A;  4Q5V A;  1TL8 A;  4QIW A;  3KYL A;  1A31 A;  3GTG A;  3GTK A;  2R7Z A;  1WCM A;  1NH3 A;  5C9H A;  1Y1W A;  1I6V D;  3GTP A;  3DU5 A;  4GFQ A;  2NVY A;  1IS1 A;  1SEU A;  4KB2 A;  1MIU A;  4NOK A;  4F3E A;  4NOL A;  2E2I A;  5CQG A;  2A6H D;  1IW7 D;  3SJR A;  1V9M A;  1TWH A;  2JA5 A;  4LMO A;  1TWG A;  4OYD B;  1SMY D;  3MAQ A;  1HQM D;  2E2H A;  2Y0S A;  1SC7 A;  4KB4 A;  1A35 A;  4FGU A;  4KC6 A;  3M4A A;  1R5Z A;  1ZYR D;  3DU6 A;  4AYB A;  1GE9 A;  4AHC A;  3K58 A;  1TWA A;  2CW0 D;  1K4S A;  4IP9 A;  3LF9 A;  3P9A A;  2R4G A;  1RRJ A;  1A36 A;  1TWC A;  5MLC 9;  1Q8I A;  3K5O A;  4QCL A;  3GTQ A;  2JA7 A;  2PMZ A;  3K5L A;  2O5J D;  1R49 A;  2WAQ A;  1Y69 8;  3LHP S;  3H0G A;  4KDD A;  1DD5 A;  1I3Q A;  1TWF A;  2R93 A;  4IP8 A;  4AN8 A;  3K5M A;  4EJ3 A;  2A69 D;  4C2M A;  3K59 A;  3K57 A;  4JLR C;  1EH1 A;  4Q5G A;  3GTJ A;  4FXD A;  4NOM A;  1YNN D;  1YNJ D;  3GTO A;  3HKZ A;  5JSB B;  1SFO A;  1R9T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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