2F4QA

Crystal structure of deinococcus radiodurans topoisomerase ib
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
336
structure length
309
Chain Sequence
PSRTELLAEEYLRREPQKFRLARIARLAVPPAYQDVYVSPDAENELQAFGRDAAGRLQYRYHPDFVQAGALKKWQRLTRFAGALPTLKVATTADLRASGLPPRKVMALMTRLLHVARFRVTYGLSTLRQRHVVVDGNTVTFRFKGKHGVSQHKATSDRTLAANMQKLLDLPGPWLFQTVDAGGGERRRIHSTELNAYLREVIGPFTAKDFRTWGGTLLAAEYLAQQGTESSERQAKKVLVDCVKFVADDLGNTPAVTRGSYICPVIFDRYLDGKVLDDYEPRTERQEAELEGLTRSEGALKRMLESERT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords type I topoisomerase, putative
publication title Crystal structure of a bacterial type IB DNA topoisomerase reveals a preassembled active site in the absence of DNA.
pubmed doi rcsb
source organism Deinococcus radiodurans
molecule tags Isomerase
total genus 98
structure length 309
sequence length 336
ec nomenclature
pdb deposition date 2005-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01028 Topoisom_I Eukaryotic DNA topoisomerase I, catalytic core
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.120 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 2f4qA02
3.30.66.10 Alpha Beta 2-Layer Sandwich Viral Topoisomerase I DNA topoisomerase I domain 2f4qA01
3.90.15.10 Alpha Beta Alpha-Beta Complex Topoisomerase I; Chain A, domain 3 Topoisomerase I; Chain A, domain 3 2f4qA03
2H7GX 1VCCA 1T8IA 1A35A 1A31A 2H7FX 1NH3A 2F4QA 3IGCA 1K4TA 1SEUA 1RRJA 2B9SA 1RR8C 1LPQA 1EJ9A 3M4AA 1SC7A 1R49A 1A36A 1K4SA 1A41A 1TL8A
chains in the Genus database with same CATH superfamily
2B63A 3IAYA 1VCCA 2R92A 3K59A 4NOLA 3GTPA 2A6ED 4H3TA 2NVYA 4IP9A 1ISEA 1HQMD 1Q8IA 1K4TA 1YNJD 1V9MA 3K5OA 1SEUA 4FXDA 2E2HA 3DU6A 1RRJA 4O26A 3K5MA 1R5ZA 3HKZA 4QCLA 4NOMA 1K4SA 1EK8A 2O5JD 4KDDA 4Q5VA 2H7GX 2A68D 1A35A 5CQGA 2Y0SA 1A31A 4QIWA 5C9HA 1WQFA 2R4GA 4GFQA 2E2IA 2H7FX 4KB2A 4AYBA 4IP8A 1Y1WA 4Q5GA 5MLC9 3GTOA 4LMOA 4F3EA 1MIUA 4D3YA 3GTGA 1WQGA 2B9SA 1TWGA 1LPQA 1SFOA 3K57A 2JA7A 5JSNB 3M4AA 3GTMA 2A69D 1SC7A 5JSBB 1YNND 1TWFA 4FYDA 1I50A 1IW7D 1A41A 3FKIA 1GE9A 1T8IA 4NOKA 1I6VD 4C2MA 1K83A 3H0GA 1NH3A 4KAWX 1Y1VA 4EJ3A 2R7ZA 1TWCA 3IGCA 1ZYRD 3DU5A 1EH1A 2VUMA 1IS1A 2WAQA 1RR8C 1DD5A 4D3ZA 4KC6A 1EJ9A 2JA6A 2A6HD 2BE5D 3K58A 1TWAA 4AN8A 1R49A 1A36A 3KYLA 1I3QA 2WB1A 1TL8A 1SMYD 1R9TA 4OYDB 2YU9A 1WCMA 1WQHA 3P9AA 4AHCA 3K5LA 3MAQA 4KB4A 3GTLA 4JLRC 3CQZA 2CW0D 3GTQA 2F4QA 3LHPS 3SJRA 3K5NA 3GTKA 2B9SB 3GTJA 1Y698 1TWHA 4FGUA 3LF9A 1TGOA 2NVXA 2R93A 2JA5A 3WVOA 4L8IA 2PMZA
chains in the Genus database with same CATH topology
2B63A 3IAYA 1VCCA 2R92A 3K59A 4NOLA 3GTPA 2A6ED 4H3TA 2NVYA 4IP9A 1ISEA 1HQMD 1Q8IA 1K4TA 1YNJD 1V9MA 3K5OA 1SEUA 4FXDA 2E2HA 3DU6A 1RRJA 4O26A 3K5MA 1R5ZA 3HKZA 4QCLA 4NOMA 1K4SA 1EK8A 2O5JD 4KDDA 4Q5VA 2H7GX 2A68D 1A35A 5CQGA 2Y0SA 1A31A 4QIWA 5C9HA 1WQFA 2R4GA 4GFQA 2E2IA 2H7FX 4KB2A 4AYBA 4IP8A 1Y1WA 4Q5GA 5MLC9 3GTOA 4LMOA 4F3EA 1MIUA 4D3YA 3GTGA 1WQGA 2B9SA 1TWGA 1LPQA 1SFOA 3K57A 2JA7A 5JSNB 3M4AA 3GTMA 2A69D 1SC7A 5JSBB 1YNND 1TWFA 4FYDA 1I50A 1IW7D 1A41A 3FKIA 1GE9A 1T8IA 4NOKA 1I6VD 4C2MA 1K83A 3H0GA 1NH3A 4KAWX 1Y1VA 4EJ3A 2R7ZA 1TWCA 3IGCA 1ZYRD 3DU5A 1EH1A 2VUMA 1IS1A 2WAQA 1RR8C 1DD5A 4D3ZA 4KC6A 1EJ9A 2JA6A 2A6HD 2BE5D 3K58A 1TWAA 4AN8A 1R49A 1A36A 3KYLA 1I3QA 2WB1A 1TL8A 1SMYD 1R9TA 4OYDB 2YU9A 1WCMA 1WQHA 3P9AA 4AHCA 3K5LA 3MAQA 4KB4A 3GTLA 4JLRC 3CQZA 2CW0D 3GTQA 2F4QA 3LHPS 3SJRA 3K5NA 3GTKA 2B9SB 3GTJA 1Y698 1TWHA 4FGUA 3LF9A 1TGOA 2NVXA 2R93A 2JA5A 3WVOA 4L8IA 2PMZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H7G X;  1VCC A;  1T8I A;  1A35 A;  1A31 A;  2H7F X;  1NH3 A;  2F4Q A;  3IGC A;  1K4T A;  1SEU A;  1RRJ A;  2B9S A;  1RR8 C;  1LPQ A;  1EJ9 A;  3M4A A;  1SC7 A;  1R49 A;  1A36 A;  1K4S A;  1A41 A;  1TL8 A; 
#chains in the Genus database with same CATH topology
 2B63 A;  3IAY A;  1VCC A;  2R92 A;  3K59 A;  4NOL A;  3GTP A;  2A6E D;  4H3T A;  2NVY A;  4IP9 A;  1ISE A;  1HQM D;  1Q8I A;  1K4T A;  1YNJ D;  1V9M A;  3K5O A;  1SEU A;  4FXD A;  2E2H A;  3DU6 A;  1RRJ A;  4O26 A;  3K5M A;  1R5Z A;  3HKZ A;  4QCL A;  4NOM A;  1K4S A;  1EK8 A;  2O5J D;  4KDD A;  4Q5V A;  2H7G X;  2A68 D;  1A35 A;  5CQG A;  2Y0S A;  1A31 A;  4QIW A;  5C9H A;  1WQF A;  2R4G A;  4GFQ A;  2E2I A;  2H7F X;  4KB2 A;  4AYB A;  4IP8 A;  1Y1W A;  4Q5G A;  5MLC 9;  3GTO A;  4LMO A;  4F3E A;  1MIU A;  4D3Y A;  3GTG A;  1WQG A;  2B9S A;  1TWG A;  1LPQ A;  1SFO A;  3K57 A;  2JA7 A;  5JSN B;  3M4A A;  3GTM A;  2A69 D;  1SC7 A;  5JSB B;  1YNN D;  1TWF A;  4FYD A;  1I50 A;  1IW7 D;  1A41 A;  3FKI A;  1GE9 A;  1T8I A;  4NOK A;  1I6V D;  4C2M A;  1K83 A;  3H0G A;  1NH3 A;  4KAW X;  1Y1V A;  4EJ3 A;  2R7Z A;  1TWC A;  3IGC A;  1ZYR D;  3DU5 A;  1EH1 A;  2VUM A;  1IS1 A;  2WAQ A;  1RR8 C;  1DD5 A;  4D3Z A;  4KC6 A;  1EJ9 A;  2JA6 A;  2A6H D;  2BE5 D;  3K58 A;  1TWA A;  4AN8 A;  1R49 A;  1A36 A;  3KYL A;  1I3Q A;  2WB1 A;  1TL8 A;  1SMY D;  1R9T A;  4OYD B;  2YU9 A;  1WCM A;  1WQH A;  3P9A A;  4AHC A;  3K5L A;  3MAQ A;  4KB4 A;  3GTL A;  4JLR C;  3CQZ A;  2CW0 D;  3GTQ A;  2F4Q A;  3LHP S;  3SJR A;  3K5N A;  3GTK A;  2B9S B;  3GTJ A;  1Y69 8;  1TWH A;  4FGU A;  3LF9 A;  1TGO A;  2NVX A;  2R93 A;  2JA5 A;  3WVO A;  4L8I A;  2PMZ A; 
#chains in the Genus database with same CATH homology
 2B63 A;  3IAY A;  1VCC A;  2R92 A;  3K59 A;  4NOL A;  3GTP A;  2A6E D;  4H3T A;  2NVY A;  4IP9 A;  1ISE A;  1HQM D;  1Q8I A;  1K4T A;  1YNJ D;  1V9M A;  3K5O A;  1SEU A;  4FXD A;  2E2H A;  3DU6 A;  1RRJ A;  4O26 A;  3K5M A;  1R5Z A;  3HKZ A;  4QCL A;  4NOM A;  1K4S A;  1EK8 A;  2O5J D;  4KDD A;  4Q5V A;  2H7G X;  2A68 D;  1A35 A;  5CQG A;  2Y0S A;  1A31 A;  4QIW A;  5C9H A;  1WQF A;  2R4G A;  4GFQ A;  2E2I A;  2H7F X;  4KB2 A;  4AYB A;  4IP8 A;  1Y1W A;  4Q5G A;  5MLC 9;  3GTO A;  4LMO A;  4F3E A;  1MIU A;  4D3Y A;  3GTG A;  1WQG A;  2B9S A;  1TWG A;  1LPQ A;  1SFO A;  3K57 A;  2JA7 A;  5JSN B;  3M4A A;  3GTM A;  2A69 D;  1SC7 A;  5JSB B;  1YNN D;  1TWF A;  4FYD A;  1I50 A;  1IW7 D;  1A41 A;  3FKI A;  1GE9 A;  1T8I A;  4NOK A;  1I6V D;  4C2M A;  1K83 A;  3H0G A;  1NH3 A;  4KAW X;  1Y1V A;  4EJ3 A;  2R7Z A;  1TWC A;  3IGC A;  1ZYR D;  3DU5 A;  1EH1 A;  2VUM A;  1IS1 A;  2WAQ A;  1RR8 C;  1DD5 A;  4D3Z A;  4KC6 A;  1EJ9 A;  2JA6 A;  2A6H D;  2BE5 D;  3K58 A;  1TWA A;  4AN8 A;  1R49 A;  1A36 A;  3KYL A;  1I3Q A;  2WB1 A;  1TL8 A;  1SMY D;  1R9T A;  4OYD B;  2YU9 A;  1WCM A;  1WQH A;  3P9A A;  4AHC A;  3K5L A;  3MAQ A;  4KB4 A;  3GTL A;  4JLR C;  3CQZ A;  2CW0 D;  3GTQ A;  2F4Q A;  3LHP S;  3SJR A;  3K5N A;  3GTK A;  2B9S B;  3GTJ A;  1Y69 8;  1TWH A;  4FGU A;  3LF9 A;  1TGO A;  2NVX A;  2R93 A;  2JA5 A;  3WVO A;  4L8I A;  2PMZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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