3LHPS

Crystal structure of hiv epitope-scaffold 4e10_d0_1isea_004_n 4e10 fv complex
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
116
structure length
116
Chain Sequence
GSISDIRKDAEVRMDKAVEAFKNKLDKFKAAVRKVFPTEERIKDWLKIVRGEAEQARVAVRNVGRDANDKAAALGKDKEINWFDISQSLWDVQKLTDAAIKKIEAALADMEAWLTQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Fv 4E10 heavy chain
total genus 48
structure length 116
sequence length 116
chains with identical sequence T
ec nomenclature
pdb deposition date 2010-01-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.20 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 3lhpS00
4KAWX 4KC6A 1WQGA 4KDDA 4L8IA 1WQFA 4KB2A 1Y698 4KB4A 1EH1A 4OYDB 1GE9A 1ISEA 1DD5A 4GFQA 1WQHA 1IS1A 5MLC9 5JSNB 3LHPS 5JSBB 4JLRC 3LF9A 1EK8A
chains in the Genus database with same CATH superfamily
4KAWX 1WQGA 1YNJD 4AYBA 2NVYA 1K83A 3DU5A 4D3YA 3K5LA 2A68D 3DU6A 1NH3A 1I50A 1SEUA 2NVXA 2A6ED 4OYDB 4AN8A 1RRJA 3FKIA 3SJRA 4GFQA 2WB1A 3K5NA 3GTJA 4QCLA 4C2MA 2O5JD 2R4GA 4KC6A 3H0GA 3WVOA 3GTGA 4L8IA 3K57A 1WQFA 2CW0D 4D3ZA 2E2HA 3GTQA 3K5OA 1WCMA 1TWGA 3MAQA 1EH1A 1IW7D 2A6HD 1TL8A 1GE9A 4FXDA 1I3QA 4LMOA 2JA6A 2A69D 1SMYD 4IP9A 3GTMA 2JA7A 1WQHA 3GTPA 2PMZA 1ZYRD 5MLC9 5JSNB 1RR8C 1I6VD 1EJ9A 3GTKA 3KYLA 1A36A 1R9TA 3P9AA 4KB2A 1TWFA 3M4AA 2E2IA 4NOKA 1SC7A 4NOMA 5C9HA 1Q8IA 4KB4A 2R92A 2JA5A 4IP8A 1TGOA 4Q5VA 3GTLA 1Y1VA 4AHCA 1TWCA 1DD5A 3K5MA 2BE5D 4H3TA 4Q5GA 1A35A 1V9MA 2WAQA 1TWHA 5CQGA 4JLRC 1T8IA 3LF9A 4EJ3A 1Y1WA 2Y0SA 1K4SA 4KDDA 1HQMD 4FGUA 4NOLA 1YNND 1LPQA 3IAYA 3CQZA 1K4TA 2R7ZA 1Y698 2F4QA 2VUMA 4F3EA 4O26A 3K59A 2R93A 3K58A 2B63A 1R49A 1TWAA 1ISEA 1A31A 3GTOA 1IS1A 1MIUA 3HKZA 2B9SB 4FYDA 4QIWA 3LHPS 5JSBB 2YU9A 1R5ZA 1SFOA 1EK8A
chains in the Genus database with same CATH topology
4KAWX 1WQGA 1YNJD 4AYBA 2NVYA 1K83A 3DU5A 4D3YA 3K5LA 2A68D 3DU6A 1NH3A 1I50A 1SEUA 2NVXA 2A6ED 4OYDB 4AN8A 1RRJA 3FKIA 3SJRA 4GFQA 2WB1A 3K5NA 3GTJA 4QCLA 4C2MA 2O5JD 2R4GA 4KC6A 3H0GA 3WVOA 3GTGA 4L8IA 3K57A 1WQFA 2CW0D 4D3ZA 2E2HA 3GTQA 3K5OA 1WCMA 1TWGA 3MAQA 1EH1A 1IW7D 2A6HD 1TL8A 1GE9A 4FXDA 1I3QA 4LMOA 2JA6A 2A69D 1SMYD 4IP9A 3GTMA 2JA7A 1WQHA 3GTPA 2PMZA 1ZYRD 5MLC9 5JSNB 1RR8C 1I6VD 1EJ9A 3GTKA 3KYLA 1A36A 1R9TA 3P9AA 4KB2A 1TWFA 3M4AA 2E2IA 4NOKA 1SC7A 4NOMA 5C9HA 1Q8IA 4KB4A 2R92A 2JA5A 4IP8A 1TGOA 4Q5VA 3GTLA 1Y1VA 4AHCA 1TWCA 1DD5A 3K5MA 2BE5D 4H3TA 4Q5GA 1A35A 1V9MA 2WAQA 1TWHA 5CQGA 4JLRC 1T8IA 3LF9A 4EJ3A 1Y1WA 2Y0SA 1K4SA 4KDDA 1HQMD 4FGUA 4NOLA 1YNND 1LPQA 3IAYA 3CQZA 1K4TA 2R7ZA 1Y698 2F4QA 2VUMA 4F3EA 4O26A 3K59A 2R93A 3K58A 2B63A 1R49A 1TWAA 1ISEA 1A31A 3GTOA 1IS1A 1MIUA 3HKZA 2B9SB 4FYDA 4QIWA 3LHPS 5JSBB 2YU9A 1R5ZA 1SFOA 1EK8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KAW X;  4KC6 A;  1WQG A;  4KDD A;  4L8I A;  1WQF A;  4KB2 A;  1Y69 8;  4KB4 A;  1EH1 A;  4OYD B;  1GE9 A;  1ISE A;  1DD5 A;  4GFQ A;  1WQH A;  1IS1 A;  5MLC 9;  5JSN B;  3LHP S;  5JSB B;  4JLR C;  3LF9 A;  1EK8 A; 
#chains in the Genus database with same CATH topology
 4KAW X;  1WQG A;  1YNJ D;  4AYB A;  2NVY A;  1K83 A;  3DU5 A;  4D3Y A;  3K5L A;  2A68 D;  3DU6 A;  1NH3 A;  1I50 A;  1SEU A;  2NVX A;  2A6E D;  4OYD B;  4AN8 A;  1RRJ A;  3FKI A;  3SJR A;  4GFQ A;  2WB1 A;  3K5N A;  3GTJ A;  4QCL A;  4C2M A;  2O5J D;  2R4G A;  4KC6 A;  3H0G A;  3WVO A;  3GTG A;  4L8I A;  3K57 A;  1WQF A;  2CW0 D;  4D3Z A;  2E2H A;  3GTQ A;  3K5O A;  1WCM A;  1TWG A;  3MAQ A;  1EH1 A;  1IW7 D;  2A6H D;  1TL8 A;  1GE9 A;  4FXD A;  1I3Q A;  4LMO A;  2JA6 A;  2A69 D;  1SMY D;  4IP9 A;  3GTM A;  2JA7 A;  1WQH A;  3GTP A;  2PMZ A;  1ZYR D;  5MLC 9;  5JSN B;  1RR8 C;  1I6V D;  1EJ9 A;  3GTK A;  3KYL A;  1A36 A;  1R9T A;  3P9A A;  4KB2 A;  1TWF A;  3M4A A;  2E2I A;  4NOK A;  1SC7 A;  4NOM A;  5C9H A;  1Q8I A;  4KB4 A;  2R92 A;  2JA5 A;  4IP8 A;  1TGO A;  4Q5V A;  3GTL A;  1Y1V A;  4AHC A;  1TWC A;  1DD5 A;  3K5M A;  2BE5 D;  4H3T A;  4Q5G A;  1A35 A;  1V9M A;  2WAQ A;  1TWH A;  5CQG A;  4JLR C;  1T8I A;  3LF9 A;  4EJ3 A;  1Y1W A;  2Y0S A;  1K4S A;  4KDD A;  1HQM D;  4FGU A;  4NOL A;  1YNN D;  1LPQ A;  3IAY A;  3CQZ A;  1K4T A;  2R7Z A;  1Y69 8;  2F4Q A;  2VUM A;  4F3E A;  4O26 A;  3K59 A;  2R93 A;  3K58 A;  2B63 A;  1R49 A;  1TWA A;  1ISE A;  1A31 A;  3GTO A;  1IS1 A;  1MIU A;  3HKZ A;  2B9S B;  4FYD A;  4QIW A;  3LHP S;  5JSB B;  2YU9 A;  1R5Z A;  1SFO A;  1EK8 A; 
#chains in the Genus database with same CATH homology
 4KAW X;  1WQG A;  1YNJ D;  4AYB A;  2NVY A;  1K83 A;  3DU5 A;  4D3Y A;  3K5L A;  2A68 D;  3DU6 A;  1NH3 A;  1I50 A;  1SEU A;  2NVX A;  2A6E D;  4OYD B;  4AN8 A;  1RRJ A;  3FKI A;  3SJR A;  4GFQ A;  2WB1 A;  3K5N A;  3GTJ A;  4QCL A;  4C2M A;  2O5J D;  2R4G A;  4KC6 A;  3H0G A;  3WVO A;  3GTG A;  4L8I A;  3K57 A;  1WQF A;  2CW0 D;  4D3Z A;  2E2H A;  3GTQ A;  3K5O A;  1WCM A;  1TWG A;  3MAQ A;  1EH1 A;  1IW7 D;  2A6H D;  1TL8 A;  1GE9 A;  4FXD A;  1I3Q A;  4LMO A;  2JA6 A;  2A69 D;  1SMY D;  4IP9 A;  3GTM A;  2JA7 A;  1WQH A;  3GTP A;  2PMZ A;  1ZYR D;  5MLC 9;  5JSN B;  1RR8 C;  1I6V D;  1EJ9 A;  3GTK A;  3KYL A;  1A36 A;  1R9T A;  3P9A A;  4KB2 A;  1TWF A;  3M4A A;  2E2I A;  4NOK A;  1SC7 A;  4NOM A;  5C9H A;  1Q8I A;  4KB4 A;  2R92 A;  2JA5 A;  4IP8 A;  1TGO A;  4Q5V A;  3GTL A;  1Y1V A;  4AHC A;  1TWC A;  1DD5 A;  3K5M A;  2BE5 D;  4H3T A;  4Q5G A;  1A35 A;  1V9M A;  2WAQ A;  1TWH A;  5CQG A;  4JLR C;  1T8I A;  3LF9 A;  4EJ3 A;  1Y1W A;  2Y0S A;  1K4S A;  4KDD A;  1HQM D;  4FGU A;  4NOL A;  1YNN D;  1LPQ A;  3IAY A;  3CQZ A;  1K4T A;  2R7Z A;  1Y69 8;  2F4Q A;  2VUM A;  4F3E A;  4O26 A;  3K59 A;  2R93 A;  3K58 A;  2B63 A;  1R49 A;  1TWA A;  1ISE A;  1A31 A;  3GTO A;  1IS1 A;  1MIU A;  3HKZ A;  2B9S B;  4FYD A;  4QIW A;  3LHP S;  5JSB B;  2YU9 A;  1R5Z A;  1SFO A;  1EK8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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