4JLRC

Crystal structure of a designed respiratory syncytial virus immunogen in complex with motavizumab
Total Genus 29
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
103
structure length
100
Chain Sequence
KDAERRFDKFVEAAKNKFDKFKAALDIKEERRKDMKKLARKEAEQARRAVRNRLSELLSKINDMPITNDQKKLMSNDVLKFAAEAEKKIEALAADAEDKF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Proof of principle for epitope-focused vaccine design.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Motavizumab Fab heavy chain
total genus 29
structure length 100
sequence length 103
chains with identical sequence S
ec nomenclature
pdb deposition date 2013-03-12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.20 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 4jlrC00
1GE9A 1DD5A 5JSNB 4KC6A 5JSBB 3LF9A 1EH1A 1IS1A 4JLRC 4GFQA 4KB2A 4KAWX 1Y698 4KDDA 4KB4A 1WQFA 4OYDB 3LHPS 5MLC9 1ISEA 1WQHA 1WQGA 4L8IA 1EK8A
chains in the Genus database with same CATH superfamily
2NVYA 2R92A 1DD5A 1Y1VA 3K5NA 4H3TA 4NOLA 1TL8A 1IS1A 2BE5D 2Y0SA 3K5OA 2E2IA 3IAYA 1NH3A 2YU9A 2E2HA 4GFQA 4LMOA 4KAWX 1Q8IA 4D3YA 2JA5A 3LHPS 1I6VD 1HQMD 1SC7A 1ISEA 4O26A 4QIWA 1SFOA 1WCMA 1GE9A 2A6HD 3K5LA 4KC6A 2F4QA 3K5MA 5JSBB 3H0GA 3LF9A 3P9AA 1EH1A 2PMZA 3GTLA 4FXDA 1YNND 2NVXA 1I50A 4AHCA 4F3EA 3KYLA 3GTOA 5C9HA 1Y1WA 4JLRC 2WAQA 1TGOA 1RRJA 3K57A 1LPQA 1TWGA 3SJRA 3WVOA 1A36A 4KDDA 4AYBA 3K59A 4IP8A 1MIUA 2B63A 4Q5GA 4Q5VA 3DU5A 4L8IA 3GTJA 3K58A 3GTMA 5JSNB 3DU6A 1R5ZA 4NOMA 4FYDA 2O5JD 1SMYD 1TWAA 1YNJD 3GTKA 3FKIA 4AN8A 1I3QA 4KB2A 2R4GA 2A69D 1A35A 1A31A 1RR8C 1T8IA 1WQFA 4D3ZA 5MLC9 4FGUA 2R7ZA 2CW0D 3HKZA 1IW7D 3GTQA 1TWCA 1SEUA 2R93A 4IP9A 2A6ED 4QCLA 2VUMA 1K4TA 4NOKA 4C2MA 1TWHA 3M4AA 2A68D 1EJ9A 3MAQA 1ZYRD 2WB1A 3GTPA 4EJ3A 5CQGA 2JA7A 1Y698 1R9TA 1K83A 4KB4A 3CQZA 4OYDB 2JA6A 1V9MA 2B9SB 3GTGA 1K4SA 1TWFA 1WQHA 1WQGA 1R49A 1EK8A
chains in the Genus database with same CATH topology
2NVYA 2R92A 1DD5A 1Y1VA 3K5NA 4H3TA 4NOLA 1TL8A 1IS1A 2BE5D 2Y0SA 3K5OA 2E2IA 3IAYA 1NH3A 2YU9A 2E2HA 4GFQA 4LMOA 4KAWX 1Q8IA 4D3YA 2JA5A 3LHPS 1I6VD 1HQMD 1SC7A 1ISEA 4O26A 4QIWA 1SFOA 1WCMA 1GE9A 2A6HD 3K5LA 4KC6A 2F4QA 3K5MA 5JSBB 3H0GA 3LF9A 3P9AA 1EH1A 2PMZA 3GTLA 4FXDA 1YNND 2NVXA 1I50A 4AHCA 4F3EA 3KYLA 3GTOA 5C9HA 1Y1WA 4JLRC 2WAQA 1TGOA 1RRJA 3K57A 1LPQA 1TWGA 3SJRA 3WVOA 1A36A 4KDDA 4AYBA 3K59A 4IP8A 1MIUA 2B63A 4Q5GA 4Q5VA 3DU5A 4L8IA 3GTJA 3K58A 3GTMA 5JSNB 3DU6A 1R5ZA 4NOMA 4FYDA 2O5JD 1SMYD 1TWAA 1YNJD 3GTKA 3FKIA 4AN8A 1I3QA 4KB2A 2R4GA 2A69D 1A35A 1A31A 1RR8C 1T8IA 1WQFA 4D3ZA 5MLC9 4FGUA 2R7ZA 2CW0D 3HKZA 1IW7D 3GTQA 1TWCA 1SEUA 2R93A 4IP9A 2A6ED 4QCLA 2VUMA 1K4TA 4NOKA 4C2MA 1TWHA 3M4AA 2A68D 1EJ9A 3MAQA 1ZYRD 2WB1A 3GTPA 4EJ3A 5CQGA 2JA7A 1Y698 1R9TA 1K83A 4KB4A 3CQZA 4OYDB 2JA6A 1V9MA 2B9SB 3GTGA 1K4SA 1TWFA 1WQHA 1WQGA 1R49A 1EK8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GE9 A;  1DD5 A;  5JSN B;  4KC6 A;  5JSB B;  3LF9 A;  1EH1 A;  1IS1 A;  4JLR C;  4GFQ A;  4KB2 A;  4KAW X;  1Y69 8;  4KDD A;  4KB4 A;  1WQF A;  4OYD B;  3LHP S;  5MLC 9;  1ISE A;  1WQH A;  1WQG A;  4L8I A;  1EK8 A; 
#chains in the Genus database with same CATH topology
 2NVY A;  2R92 A;  1DD5 A;  1Y1V A;  3K5N A;  4H3T A;  4NOL A;  1TL8 A;  1IS1 A;  2BE5 D;  2Y0S A;  3K5O A;  2E2I A;  3IAY A;  1NH3 A;  2YU9 A;  2E2H A;  4GFQ A;  4LMO A;  4KAW X;  1Q8I A;  4D3Y A;  2JA5 A;  3LHP S;  1I6V D;  1HQM D;  1SC7 A;  1ISE A;  4O26 A;  4QIW A;  1SFO A;  1WCM A;  1GE9 A;  2A6H D;  3K5L A;  4KC6 A;  2F4Q A;  3K5M A;  5JSB B;  3H0G A;  3LF9 A;  3P9A A;  1EH1 A;  2PMZ A;  3GTL A;  4FXD A;  1YNN D;  2NVX A;  1I50 A;  4AHC A;  4F3E A;  3KYL A;  3GTO A;  5C9H A;  1Y1W A;  4JLR C;  2WAQ A;  1TGO A;  1RRJ A;  3K57 A;  1LPQ A;  1TWG A;  3SJR A;  3WVO A;  1A36 A;  4KDD A;  4AYB A;  3K59 A;  4IP8 A;  1MIU A;  2B63 A;  4Q5G A;  4Q5V A;  3DU5 A;  4L8I A;  3GTJ A;  3K58 A;  3GTM A;  5JSN B;  3DU6 A;  1R5Z A;  4NOM A;  4FYD A;  2O5J D;  1SMY D;  1TWA A;  1YNJ D;  3GTK A;  3FKI A;  4AN8 A;  1I3Q A;  4KB2 A;  2R4G A;  2A69 D;  1A35 A;  1A31 A;  1RR8 C;  1T8I A;  1WQF A;  4D3Z A;  5MLC 9;  4FGU A;  2R7Z A;  2CW0 D;  3HKZ A;  1IW7 D;  3GTQ A;  1TWC A;  1SEU A;  2R93 A;  4IP9 A;  2A6E D;  4QCL A;  2VUM A;  1K4T A;  4NOK A;  4C2M A;  1TWH A;  3M4A A;  2A68 D;  1EJ9 A;  3MAQ A;  1ZYR D;  2WB1 A;  3GTP A;  4EJ3 A;  5CQG A;  2JA7 A;  1Y69 8;  1R9T A;  1K83 A;  4KB4 A;  3CQZ A;  4OYD B;  2JA6 A;  1V9M A;  2B9S B;  3GTG A;  1K4S A;  1TWF A;  1WQH A;  1WQG A;  1R49 A;  1EK8 A; 
#chains in the Genus database with same CATH homology
 2NVY A;  2R92 A;  1DD5 A;  1Y1V A;  3K5N A;  4H3T A;  4NOL A;  1TL8 A;  1IS1 A;  2BE5 D;  2Y0S A;  3K5O A;  2E2I A;  3IAY A;  1NH3 A;  2YU9 A;  2E2H A;  4GFQ A;  4LMO A;  4KAW X;  1Q8I A;  4D3Y A;  2JA5 A;  3LHP S;  1I6V D;  1HQM D;  1SC7 A;  1ISE A;  4O26 A;  4QIW A;  1SFO A;  1WCM A;  1GE9 A;  2A6H D;  3K5L A;  4KC6 A;  2F4Q A;  3K5M A;  5JSB B;  3H0G A;  3LF9 A;  3P9A A;  1EH1 A;  2PMZ A;  3GTL A;  4FXD A;  1YNN D;  2NVX A;  1I50 A;  4AHC A;  4F3E A;  3KYL A;  3GTO A;  5C9H A;  1Y1W A;  4JLR C;  2WAQ A;  1TGO A;  1RRJ A;  3K57 A;  1LPQ A;  1TWG A;  3SJR A;  3WVO A;  1A36 A;  4KDD A;  4AYB A;  3K59 A;  4IP8 A;  1MIU A;  2B63 A;  4Q5G A;  4Q5V A;  3DU5 A;  4L8I A;  3GTJ A;  3K58 A;  3GTM A;  5JSN B;  3DU6 A;  1R5Z A;  4NOM A;  4FYD A;  2O5J D;  1SMY D;  1TWA A;  1YNJ D;  3GTK A;  3FKI A;  4AN8 A;  1I3Q A;  4KB2 A;  2R4G A;  2A69 D;  1A35 A;  1A31 A;  1RR8 C;  1T8I A;  1WQF A;  4D3Z A;  5MLC 9;  4FGU A;  2R7Z A;  2CW0 D;  3HKZ A;  1IW7 D;  3GTQ A;  1TWC A;  1SEU A;  2R93 A;  4IP9 A;  2A6E D;  4QCL A;  2VUM A;  1K4T A;  4NOK A;  4C2M A;  1TWH A;  3M4A A;  2A68 D;  1EJ9 A;  3MAQ A;  1ZYR D;  2WB1 A;  3GTP A;  4EJ3 A;  5CQG A;  2JA7 A;  1Y69 8;  1R9T A;  1K83 A;  4KB4 A;  3CQZ A;  4OYD B;  2JA6 A;  1V9M A;  2B9S B;  3GTG A;  1K4S A;  1TWF A;  1WQH A;  1WQG A;  1R49 A;  1EK8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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