3FN1A

E2-ring expansion of the nedd8 cascade confers specificity to cullin modification.
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
92
structure length
92
Chain Sequence
PQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYMQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords NEDD8-activating enzyme E1 catalytic subunit
total genus 21
structure length 92
sequence length 92
ec nomenclature
pdb deposition date 2008-12-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF08825 E2_bind E2 binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.290.20 Alpha Beta Roll Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3 3fn1A00
1Y8XB 3KYCB 5FQ2B 1Y8RB 2LQ7A 1Y8QB 3ONGA 3ONHA 3FN1A 3KYDB 4W5VB 2NVUB
chains in the Genus database with same CATH superfamily
1Y8XB 4JI3D 3T1HD 1IBMD 3DH3A 4JI0D 2UXDD 4DR7D 2UXBD 1N32D 1N34D 1FJGD 5FQ2B 4LF8D 1I94D 2VQED 4JI6D 4JI5D 4NXND 3OTOD 4OUDA 1HNZD 4LF7D 2ISTA 3KYCB 5IWAD 1N33D 1Y8QB 3J7AF 4X65D 2UU9D 4B3TD 4JYAD 3HP7A 2VQFD 4NXMD 1XMQD 1H3FA 2JANA 4NNJA 4LGTA 3T1YD 1N36D 4K0KD 4JI2D 1HNWD 1J5ED 2HHHD 1Y8RB 4GKKD 5LMND 4X66D 5A2QE 1FKAD 3ONGA 4JI1D 3ONHA 1HR0D 4LFBD 4X62D 5LMUD 4LFCD 1IBLD 3KBGA 1HNXD 5LL6S 4GKJD 4X64D 4LF5D 2ZM6D 1P9KA 4II3A 1H3EA 4II2A 2I1SA 1XNQD 4DR6D 4B3MD 4DV5D 2KTLA 4YY3D 4JV5D 4DR1D 2K6PA 3JAME 3KYDB 5KNLA 4LF9D 1KSKA 5FLXE 5IT9E 1C05A 4YHHD 4DV1D 4DV2D 4OX9D 4DUZD 1JH3A 1XMOD 4DV0D 2UXCD 2UUAD 4DV6D 1C06A 3J80E 1DM9A 4B3RD 4KHPD 5BR8D 3CMMA 4JI8D 4LF4D 1VIOA 2ZTBA 1KSLA 4JI7D 4B3SD 4LFAD 4DR4D 2F4VD 4JI4D 2E5LD 3J81E 2UUCD 1KSVA 2LQ7A 1IBKD 3FN1A 1XNRD 4AQYD 2NVUB 4DV7D 4DV4D 4DUYD 2UUBD 4DR2D 4DR3D 4W5VB 4LF6D 4DV3D 4DR5D
chains in the Genus database with same CATH topology
1Y8XB 3KYCB 5FQ2B 1Y8RB 2LQ7A 1Y8QB 3ONGA 3ONHA 3FN1A 3KYDB 4W5VB 2NVUB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y8X B;  3KYC B;  5FQ2 B;  1Y8R B;  2LQ7 A;  1Y8Q B;  3ONG A;  3ONH A;  3FN1 A;  3KYD B;  4W5V B;  2NVU B; 
#chains in the Genus database with same CATH topology
 1Y8X B;  4JI3 D;  3T1H D;  1IBM D;  3DH3 A;  4JI0 D;  2UXD D;  4DR7 D;  2UXB D;  1N32 D;  1N34 D;  1FJG D;  5FQ2 B;  4LF8 D;  1I94 D;  2VQE D;  4JI6 D;  4JI5 D;  4NXN D;  3OTO D;  4OUD A;  1HNZ D;  4LF7 D;  2IST A;  3KYC B;  5IWA D;  1N33 D;  1Y8Q B;  3J7A F;  4X65 D;  2UU9 D;  4B3T D;  4JYA D;  3HP7 A;  2VQF D;  4NXM D;  1XMQ D;  1H3F A;  2JAN A;  4NNJ A;  4LGT A;  3T1Y D;  1N36 D;  4K0K D;  4JI2 D;  1HNW D;  1J5E D;  2HHH D;  1Y8R B;  4GKK D;  5LMN D;  4X66 D;  5A2Q E;  1FKA D;  3ONG A;  4JI1 D;  3ONH A;  1HR0 D;  4LFB D;  4X62 D;  5LMU D;  4LFC D;  1IBL D;  3KBG A;  1HNX D;  5LL6 S;  4GKJ D;  4X64 D;  4LF5 D;  2ZM6 D;  1P9K A;  4II3 A;  1H3E A;  4II2 A;  2I1S A;  1XNQ D;  4DR6 D;  4B3M D;  4DV5 D;  2KTL A;  4YY3 D;  4JV5 D;  4DR1 D;  2K6P A;  3JAM E;  3KYD B;  5KNL A;  4LF9 D;  1KSK A;  5FLX E;  5IT9 E;  1C05 A;  4YHH D;  4DV1 D;  4DV2 D;  4OX9 D;  4DUZ D;  1JH3 A;  1XMO D;  4DV0 D;  2UXC D;  2UUA D;  4DV6 D;  1C06 A;  3J80 E;  1DM9 A;  4B3R D;  4KHP D;  5BR8 D;  3CMM A;  4JI8 D;  4LF4 D;  1VIO A;  2ZTB A;  1KSL A;  4JI7 D;  4B3S D;  4LFA D;  4DR4 D;  2F4V D;  4JI4 D;  2E5L D;  3J81 E;  2UUC D;  1KSV A;  2LQ7 A;  1IBK D;  3FN1 A;  1XNR D;  4AQY D;  2NVU B;  4DV7 D;  4DV4 D;  4DUY D;  2UUB D;  4DR2 D;  4DR3 D;  4W5V B;  4LF6 D;  4DV3 D;  4DR5 D; 
#chains in the Genus database with same CATH homology
 1Y8X B;  3KYC B;  5FQ2 B;  1Y8R B;  2LQ7 A;  1Y8Q B;  3ONG A;  3ONH A;  3FN1 A;  3KYD B;  4W5V B;  2NVU B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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