1AJAA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
435
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Non specific mono-esterase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 158
structure length 435
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajaA00
2X98A 5LRNA 1AJAA 1EI6A 5EGEA 3T01A 1ANJA 4LREA 4GTZA 5INHA 2W8DA 4LR9A 4LRFA 3IGZB 1ALKA 1ZEBA 1AJBA 5DLWA 5HRTA 3CMRA 3LXQA 2GLQA 1ZEFA 4KAYA 2IUCA 4N7TA 4MIVA 2QZUA 2W5QA 3M7VA 1EW8A 4MY4A 3BDGB 4LRBA 2RH6A 1Y7AA 3A52A 3UN5A 5IJQA 1ELYA 4CXSA 1KH4A 2W5TA 2ZKTA 3M8WA 4UPKA 3WAXA 3Q3QA 1AUKA 1E2SP 4LR7A 3BDFA 1KHNA 3NKNA 2IFYA 4GTYA 1FSUA 4LR8A 4YR1A 1ALIA 4KAVA 1ELZA 1SHNA 1HQAA 4LRDA 3DYCA 3IDDA 4NWJA 3WAVA 5AJ9A 1ZEDA 1N2KA 2W8SA 4ZG7A 3IGYB 5GOVA 3UN3A 1ALJA 5L0KA 4UORA 4B56A 3WBHA 3MK1A 3NKMA 1EW9A 1URBA 3E2DA 3MK2A 2GSOA 2XRGA 5LIAA 3SZYA 3OT9A 5DLVA 2D1GA 2W5XA 1EJJA 4UOPA 2G9YA 4LQYA 4GTWA 3ED4A 3NKPA 3TWZA 1ED9A 3DPCA 1Y6VA 1ANIA 1O99A 3KD8A 2W5RA 5TJ3A 3TG0A 1E3CP 3UNYA 4MHXA 1KH9A 3BDHA 3BDGA 2W5SA 4FDIA 5L0EA 4LRCA 4GTXA 4KJGA 4UPIA 2XR9A 3M8ZA 4QAXA 3SZZA 4FDJA 4TN0A 4CYRA 3NVLA 1SHQA 5IJSA 2W5VA 2GA3A 1P49A 1KH7A 4NWXA 1E33P 4KM4A 4CXUA 3T02A 3WAYA 5K4PA 4LRAA 1N2LA 3MK0A 4UOOA 5LRMA 1B8JA 1ALHA 1KHKA 4CYSA 1AJCA 4ZGAA 3UO0A 1ED8A 2IUCB 1KH5A 3T00A 3B5QA 5GRRA 2VQRA 2GSUA 5L0BA 1KHJA 5LQQA 2W5WA 5KXAA 1HDHA 5EGHA 1ELXA 3TX0A 4UPLA 4ZG9A 1AJDA 3M8YA 1EQJA 4UPHA 2GSNA 1K7HA 4ZG6A 5C66A 3NKRA 5DLTA 4KJDA 4CXKA 3WAWA 1E1ZP 1HJKA 3UN2A 1KHLA 1EW2A 1O98A 2ANHA 3NKOA 4LR2A 1URAA 3NKQA
chains in the Genus database with same CATH superfamily
2X98A 5LRNA 1AJAA 1EI6A 5EGEA 3T01A 1ANJA 4LREA 4GTZA 5INHA 2W8DA 4LR9A 4LRFA 3IGZB 1ALKA 1ZEBA 1AJBA 5DLWA 5HRTA 3CMRA 3LXQA 2GLQA 1ZEFA 4KAYA 2IUCA 4N7TA 4MIVA 2QZUA 2W5QA 3M7VA 1EW8A 4MY4A 3BDGB 4LRBA 2RH6A 1Y7AA 3A52A 3UN5A 5IJQA 1ELYA 4CXSA 1KH4A 2W5TA 2ZKTA 3M8WA 4UPKA 3WAXA 3Q3QA 1AUKA 1E2SP 4LR7A 3BDFA 1KHNA 3NKNA 2IFYA 4GTYA 1FSUA 4LR8A 4YR1A 1ALIA 4KAVA 1ELZA 1SHNA 1HQAA 4LRDA 3DYCA 3IDDA 4NWJA 3WAVA 5AJ9A 1ZEDA 1N2KA 2W8SA 4ZG7A 3IGYB 5GOVA 3UN3A 1ALJA 5L0KA 4UORA 4B56A 3WBHA 3MK1A 3NKMA 1EW9A 1URBA 3E2DA 3MK2A 2GSOA 2XRGA 5LIAA 3SZYA 3OT9A 5DLVA 2D1GA 2W5XA 1EJJA 4UOPA 2G9YA 4LQYA 4GTWA 3ED4A 3NKPA 3TWZA 1ED9A 3DPCA 1Y6VA 1ANIA 1O99A 3KD8A 2W5RA 5TJ3A 3TG0A 1E3CP 3UNYA 4MHXA 1KH9A 3BDHA 3BDGA 2W5SA 4FDIA 5L0EA 4LRCA 4GTXA 4KJGA 4UPIA 2XR9A 3M8ZA 4QAXA 3SZZA 4FDJA 4TN0A 4CYRA 3NVLA 1SHQA 5IJSA 2W5VA 2GA3A 1P49A 1KH7A 4NWXA 1E33P 4KM4A 4CXUA 3T02A 3WAYA 5K4PA 4LRAA 1N2LA 3MK0A 4UOOA 5LRMA 1B8JA 1ALHA 1KHKA 4CYSA 1AJCA 4ZGAA 3UO0A 1ED8A 2IUCB 1KH5A 3T00A 3B5QA 5GRRA 2VQRA 2GSUA 5L0BA 1KHJA 5LQQA 2W5WA 5KXAA 1HDHA 5EGHA 1ELXA 3TX0A 4UPLA 4ZG9A 1AJDA 3M8YA 1EQJA 4UPHA 2GSNA 1K7HA 4ZG6A 5C66A 3NKRA 5DLTA 4KJDA 4CXKA 3WAWA 1E1ZP 1HJKA 3UN2A 1KHLA 1EW2A 1O98A 2ANHA 3NKOA 4LR2A 1URAA 3NKQA
chains in the Genus database with same CATH topology
2X98A 5LRNA 1AJAA 1EI6A 5EGEA 3T01A 1ANJA 4LREA 4GTZA 5INHA 2W8DA 4LR9A 4LRFA 3IGZB 1ALKA 1ZEBA 1AJBA 5DLWA 5HRTA 3CMRA 3LXQA 2GLQA 1ZEFA 4KAYA 2IUCA 4N7TA 4MIVA 2QZUA 2W5QA 3M7VA 1EW8A 4MY4A 3BDGB 4LRBA 2RH6A 1Y7AA 3A52A 3UN5A 5IJQA 1ELYA 4CXSA 1KH4A 2W5TA 2ZKTA 3M8WA 4UPKA 3WAXA 3Q3QA 1AUKA 1E2SP 4LR7A 3BDFA 1KHNA 3NKNA 2IFYA 4GTYA 1FSUA 4LR8A 4YR1A 1ALIA 4KAVA 1ELZA 1SHNA 1HQAA 4LRDA 3DYCA 3IDDA 4NWJA 3WAVA 5AJ9A 1ZEDA 1N2KA 2W8SA 4ZG7A 3IGYB 5GOVA 3UN3A 1ALJA 5L0KA 4UORA 4B56A 3WBHA 3MK1A 3NKMA 1EW9A 1URBA 3E2DA 3MK2A 2GSOA 2XRGA 5LIAA 3SZYA 3OT9A 5DLVA 2D1GA 2W5XA 1EJJA 4UOPA 2G9YA 4LQYA 4GTWA 3ED4A 3NKPA 3TWZA 1ED9A 3DPCA 1Y6VA 1ANIA 1O99A 3KD8A 2W5RA 5TJ3A 3TG0A 1E3CP 3UNYA 4MHXA 1KH9A 3BDHA 3BDGA 2W5SA 4FDIA 5L0EA 4LRCA 4GTXA 4KJGA 4UPIA 2XR9A 3M8ZA 4QAXA 3SZZA 4FDJA 4TN0A 4CYRA 3NVLA 1SHQA 5IJSA 2W5VA 2GA3A 1P49A 1KH7A 4NWXA 1E33P 4KM4A 4CXUA 3T02A 3WAYA 5K4PA 4LRAA 1N2LA 3MK0A 4UOOA 5LRMA 1B8JA 1ALHA 1KHKA 4CYSA 1AJCA 4ZGAA 3UO0A 1ED8A 2IUCB 1KH5A 3T00A 3B5QA 5GRRA 2VQRA 2GSUA 5L0BA 1KHJA 5LQQA 2W5WA 5KXAA 1HDHA 5EGHA 1ELXA 3TX0A 4UPLA 4ZG9A 1AJDA 3M8YA 1EQJA 4UPHA 2GSNA 1K7HA 4ZG6A 5C66A 3NKRA 5DLTA 4KJDA 4CXKA 3WAWA 1E1ZP 1HJKA 3UN2A 1KHLA 1EW2A 1O98A 2ANHA 3NKOA 4LR2A 1URAA 3NKQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X98 A;  5LRN A;  1AJA A;  1EI6 A;  5EGE A;  3T01 A;  1ANJ A;  4LRE A;  4GTZ A;  5INH A;  2W8D A;  4LR9 A;  4LRF A;  3IGZ B;  1ALK A;  1ZEB A;  1AJB A;  5DLW A;  5HRT A;  3CMR A;  3LXQ A;  2GLQ A;  1ZEF A;  4KAY A;  2IUC A;  4N7T A;  4MIV A;  2QZU A;  2W5Q A;  3M7V A;  1EW8 A;  4MY4 A;  3BDG B;  4LRB A;  2RH6 A;  1Y7A A;  3A52 A;  3UN5 A;  5IJQ A;  1ELY A;  4CXS A;  1KH4 A;  2W5T A;  2ZKT A;  3M8W A;  4UPK A;  3WAX A;  3Q3Q A;  1AUK A;  1E2S P;  4LR7 A;  3BDF A;  1KHN A;  3NKN A;  2IFY A;  4GTY A;  1FSU A;  4LR8 A;  4YR1 A;  1ALI A;  4KAV A;  1ELZ A;  1SHN A;  1HQA A;  4LRD A;  3DYC A;  3IDD A;  4NWJ A;  3WAV A;  5AJ9 A;  1ZED A;  1N2K A;  2W8S A;  4ZG7 A;  3IGY B;  5GOV A;  3UN3 A;  1ALJ A;  5L0K A;  4UOR A;  4B56 A;  3WBH A;  3MK1 A;  3NKM A;  1EW9 A;  1URB A;  3E2D A;  3MK2 A;  2GSO A;  2XRG A;  5LIA A;  3SZY A;  3OT9 A;  5DLV A;  2D1G A;  2W5X A;  1EJJ A;  4UOP A;  2G9Y A;  4LQY A;  4GTW A;  3ED4 A;  3NKP A;  3TWZ A;  1ED9 A;  3DPC A;  1Y6V A;  1ANI A;  1O99 A;  3KD8 A;  2W5R A;  5TJ3 A;  3TG0 A;  1E3C P;  3UNY A;  4MHX A;  1KH9 A;  3BDH A;  3BDG A;  2W5S A;  4FDI A;  5L0E A;  4LRC A;  4GTX A;  4KJG A;  4UPI A;  2XR9 A;  3M8Z A;  4QAX A;  3SZZ A;  4FDJ A;  4TN0 A;  4CYR A;  3NVL A;  1SHQ A;  5IJS A;  2W5V A;  2GA3 A;  1P49 A;  1KH7 A;  4NWX A;  1E33 P;  4KM4 A;  4CXU A;  3T02 A;  3WAY A;  5K4P A;  4LRA A;  1N2L A;  3MK0 A;  4UOO A;  5LRM A;  1B8J A;  1ALH A;  1KHK A;  4CYS A;  1AJC A;  4ZGA A;  3UO0 A;  1ED8 A;  2IUC B;  1KH5 A;  3T00 A;  3B5Q A;  5GRR A;  2VQR A;  2GSU A;  5L0B A;  1KHJ A;  5LQQ A;  2W5W A;  5KXA A;  1HDH A;  5EGH A;  1ELX A;  3TX0 A;  4UPL A;  4ZG9 A;  1AJD A;  3M8Y A;  1EQJ A;  4UPH A;  2GSN A;  1K7H A;  4ZG6 A;  5C66 A;  3NKR A;  5DLT A;  4KJD A;  4CXK A;  3WAW A;  1E1Z P;  1HJK A;  3UN2 A;  1KHL A;  1EW2 A;  1O98 A;  2ANH A;  3NKO A;  4LR2 A;  1URA A;  3NKQ A; 
#chains in the Genus database with same CATH topology
 2X98 A;  5LRN A;  1AJA A;  1EI6 A;  5EGE A;  3T01 A;  1ANJ A;  4LRE A;  4GTZ A;  5INH A;  2W8D A;  4LR9 A;  4LRF A;  3IGZ B;  1ALK A;  1ZEB A;  1AJB A;  5DLW A;  5HRT A;  3CMR A;  3LXQ A;  2GLQ A;  1ZEF A;  4KAY A;  2IUC A;  4N7T A;  4MIV A;  2QZU A;  2W5Q A;  3M7V A;  1EW8 A;  4MY4 A;  3BDG B;  4LRB A;  2RH6 A;  1Y7A A;  3A52 A;  3UN5 A;  5IJQ A;  1ELY A;  4CXS A;  1KH4 A;  2W5T A;  2ZKT A;  3M8W A;  4UPK A;  3WAX A;  3Q3Q A;  1AUK A;  1E2S P;  4LR7 A;  3BDF A;  1KHN A;  3NKN A;  2IFY A;  4GTY A;  1FSU A;  4LR8 A;  4YR1 A;  1ALI A;  4KAV A;  1ELZ A;  1SHN A;  1HQA A;  4LRD A;  3DYC A;  3IDD A;  4NWJ A;  3WAV A;  5AJ9 A;  1ZED A;  1N2K A;  2W8S A;  4ZG7 A;  3IGY B;  5GOV A;  3UN3 A;  1ALJ A;  5L0K A;  4UOR A;  4B56 A;  3WBH A;  3MK1 A;  3NKM A;  1EW9 A;  1URB A;  3E2D A;  3MK2 A;  2GSO A;  2XRG A;  5LIA A;  3SZY A;  3OT9 A;  5DLV A;  2D1G A;  2W5X A;  1EJJ A;  4UOP A;  2G9Y A;  4LQY A;  4GTW A;  3ED4 A;  3NKP A;  3TWZ A;  1ED9 A;  3DPC A;  1Y6V A;  1ANI A;  1O99 A;  3KD8 A;  2W5R A;  5TJ3 A;  3TG0 A;  1E3C P;  3UNY A;  4MHX A;  1KH9 A;  3BDH A;  3BDG A;  2W5S A;  4FDI A;  5L0E A;  4LRC A;  4GTX A;  4KJG A;  4UPI A;  2XR9 A;  3M8Z A;  4QAX A;  3SZZ A;  4FDJ A;  4TN0 A;  4CYR A;  3NVL A;  1SHQ A;  5IJS A;  2W5V A;  2GA3 A;  1P49 A;  1KH7 A;  4NWX A;  1E33 P;  4KM4 A;  4CXU A;  3T02 A;  3WAY A;  5K4P A;  4LRA A;  1N2L A;  3MK0 A;  4UOO A;  5LRM A;  1B8J A;  1ALH A;  1KHK A;  4CYS A;  1AJC A;  4ZGA A;  3UO0 A;  1ED8 A;  2IUC B;  1KH5 A;  3T00 A;  3B5Q A;  5GRR A;  2VQR A;  2GSU A;  5L0B A;  1KHJ A;  5LQQ A;  2W5W A;  5KXA A;  1HDH A;  5EGH A;  1ELX A;  3TX0 A;  4UPL A;  4ZG9 A;  1AJD A;  3M8Y A;  1EQJ A;  4UPH A;  2GSN A;  1K7H A;  4ZG6 A;  5C66 A;  3NKR A;  5DLT A;  4KJD A;  4CXK A;  3WAW A;  1E1Z P;  1HJK A;  3UN2 A;  1KHL A;  1EW2 A;  1O98 A;  2ANH A;  3NKO A;  4LR2 A;  1URA A;  3NKQ A; 
#chains in the Genus database with same CATH homology
 2X98 A;  5LRN A;  1AJA A;  1EI6 A;  5EGE A;  3T01 A;  1ANJ A;  4LRE A;  4GTZ A;  5INH A;  2W8D A;  4LR9 A;  4LRF A;  3IGZ B;  1ALK A;  1ZEB A;  1AJB A;  5DLW A;  5HRT A;  3CMR A;  3LXQ A;  2GLQ A;  1ZEF A;  4KAY A;  2IUC A;  4N7T A;  4MIV A;  2QZU A;  2W5Q A;  3M7V A;  1EW8 A;  4MY4 A;  3BDG B;  4LRB A;  2RH6 A;  1Y7A A;  3A52 A;  3UN5 A;  5IJQ A;  1ELY A;  4CXS A;  1KH4 A;  2W5T A;  2ZKT A;  3M8W A;  4UPK A;  3WAX A;  3Q3Q A;  1AUK A;  1E2S P;  4LR7 A;  3BDF A;  1KHN A;  3NKN A;  2IFY A;  4GTY A;  1FSU A;  4LR8 A;  4YR1 A;  1ALI A;  4KAV A;  1ELZ A;  1SHN A;  1HQA A;  4LRD A;  3DYC A;  3IDD A;  4NWJ A;  3WAV A;  5AJ9 A;  1ZED A;  1N2K A;  2W8S A;  4ZG7 A;  3IGY B;  5GOV A;  3UN3 A;  1ALJ A;  5L0K A;  4UOR A;  4B56 A;  3WBH A;  3MK1 A;  3NKM A;  1EW9 A;  1URB A;  3E2D A;  3MK2 A;  2GSO A;  2XRG A;  5LIA A;  3SZY A;  3OT9 A;  5DLV A;  2D1G A;  2W5X A;  1EJJ A;  4UOP A;  2G9Y A;  4LQY A;  4GTW A;  3ED4 A;  3NKP A;  3TWZ A;  1ED9 A;  3DPC A;  1Y6V A;  1ANI A;  1O99 A;  3KD8 A;  2W5R A;  5TJ3 A;  3TG0 A;  1E3C P;  3UNY A;  4MHX A;  1KH9 A;  3BDH A;  3BDG A;  2W5S A;  4FDI A;  5L0E A;  4LRC A;  4GTX A;  4KJG A;  4UPI A;  2XR9 A;  3M8Z A;  4QAX A;  3SZZ A;  4FDJ A;  4TN0 A;  4CYR A;  3NVL A;  1SHQ A;  5IJS A;  2W5V A;  2GA3 A;  1P49 A;  1KH7 A;  4NWX A;  1E33 P;  4KM4 A;  4CXU A;  3T02 A;  3WAY A;  5K4P A;  4LRA A;  1N2L A;  3MK0 A;  4UOO A;  5LRM A;  1B8J A;  1ALH A;  1KHK A;  4CYS A;  1AJC A;  4ZGA A;  3UO0 A;  1ED8 A;  2IUC B;  1KH5 A;  3T00 A;  3B5Q A;  5GRR A;  2VQR A;  2GSU A;  5L0B A;  1KHJ A;  5LQQ A;  2W5W A;  5KXA A;  1HDH A;  5EGH A;  1ELX A;  3TX0 A;  4UPL A;  4ZG9 A;  1AJD A;  3M8Y A;  1EQJ A;  4UPH A;  2GSN A;  1K7H A;  4ZG6 A;  5C66 A;  3NKR A;  5DLT A;  4KJD A;  4CXK A;  3WAW A;  1E1Z P;  1HJK A;  3UN2 A;  1KHL A;  1EW2 A;  1O98 A;  2ANH A;  3NKO A;  4LR2 A;  1URA A;  3NKQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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