1AJAA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
435
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Non specific mono-esterase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 158
structure length 435
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajaA00
5LQQA 4LR7A 4FDIA 5C66A 5DLWA 3T02A 1EJJA 1ANJA 1KH9A 3ED4A 4UPIA 4CYSA 1ELYA 3WBHA 3MK2A 1N2KA 2QZUA 4KM4A 3UO0A 2D1GA 4UORA 4CXUA 4LRDA 1E33P 4UPKA 4ZG9A 5LRMA 5HRTA 4CXKA 2W5RA 1O98A 4LREA 3DYCA 3M7VA 4LR8A 3UNYA 2IFYA 5LIAA 4LR9A 4LR2A 2W8SA 3DPCA 3NKMA 3NKNA 5DLVA 4FDJA 1ZEBA 1KH7A 3UN2A 3BDGB 3T00A 4TN0A 1SHQA 2IUCA 5IJQA 5K4PA 3OT9A 5GOVA 1E2SP 2W5WA 4KAVA 3E2DA 1E3CP 4LRAA 3NVLA 1ZEFA 4GTYA 4NWXA 4B56A 1AUKA 2W5XA 3NKRA 4CYRA 3IDDA 3LXQA 4YR1A 5DLTA 5AJ9A 1URBA 5L0KA 5IJSA 4KJGA 5TJ3A 1EW2A 3WAWA 5GRRA 2X98A 4ZGAA 4UOPA 1AJAA 3CMRA 4GTXA 3IGYB 3BDHA 4MHXA 3BDFA 2W5SA 4LRFA 2RH6A 1KHJA 5KXAA 5EGEA 3Q3QA 5LRNA 1ED8A 4N7TA 4KAYA 1URAA 2ZKTA 3TWZA 3NKQA 3IGZB 3M8YA 3MK1A 1ALKA 1KHLA 1SHNA 1ELXA 3M8WA 4LQYA 5L0EA 1KH5A 1K7HA 3BDGA 4GTZA 1HDHA 1ELZA 4LRBA 3WAYA 1N2LA 5L0BA 3M8ZA 3MK0A 3UN5A 4MIVA 1ALHA 3NKPA 5INHA 1EI6A 2XRGA 2W5QA 1ALIA 4UPHA 1Y7AA 4KJDA 1EW9A 4NWJA 3SZYA 1ALJA 1ZEDA 3NKOA 4GTWA 3TG0A 5EGHA 1B8JA 2GA3A 1P49A 1KHKA 4CXSA 1AJBA 1KHNA 2GSOA 1HJKA 2GLQA 4MY4A 4QAXA 3T01A 1HQAA 3UN3A 2VQRA 2GSNA 1O99A 3SZZA 2W5VA 1EW8A 1ED9A 3KD8A 1AJCA 4ZG6A 4ZG7A 4UOOA 2W8DA 1E1ZP 3WAXA 1Y6VA 2ANHA 2G9YA 3B5QA 2XR9A 2W5TA 1KH4A 4LRCA 1EQJA 1FSUA 1AJDA 2GSUA 4UPLA 3WAVA 3A52A 2IUCB 3TX0A 1ANIA
chains in the Genus database with same CATH superfamily
5LQQA 4LR7A 4FDIA 5C66A 5DLWA 3T02A 1EJJA 1ANJA 1KH9A 3ED4A 4UPIA 4CYSA 1ELYA 3WBHA 3MK2A 1N2KA 2QZUA 4KM4A 3UO0A 2D1GA 4UORA 4CXUA 4LRDA 1E33P 4UPKA 4ZG9A 5LRMA 5HRTA 4CXKA 2W5RA 1O98A 4LREA 3DYCA 3M7VA 4LR8A 3UNYA 2IFYA 5LIAA 4LR9A 4LR2A 2W8SA 3DPCA 3NKMA 3NKNA 5DLVA 4FDJA 1ZEBA 1KH7A 3UN2A 3BDGB 3T00A 4TN0A 1SHQA 2IUCA 5IJQA 5K4PA 3OT9A 5GOVA 1E2SP 2W5WA 4KAVA 3E2DA 1E3CP 4LRAA 3NVLA 1ZEFA 4GTYA 4NWXA 4B56A 1AUKA 2W5XA 3NKRA 4CYRA 3IDDA 3LXQA 4YR1A 5DLTA 5AJ9A 1URBA 5L0KA 5IJSA 4KJGA 5TJ3A 1EW2A 3WAWA 5GRRA 2X98A 4ZGAA 4UOPA 1AJAA 3CMRA 4GTXA 3IGYB 3BDHA 4MHXA 3BDFA 2W5SA 4LRFA 2RH6A 1KHJA 5KXAA 5EGEA 3Q3QA 5LRNA 1ED8A 4N7TA 4KAYA 1URAA 2ZKTA 3TWZA 3NKQA 3IGZB 3M8YA 3MK1A 1ALKA 1KHLA 1SHNA 1ELXA 3M8WA 4LQYA 5L0EA 1KH5A 1K7HA 3BDGA 4GTZA 1HDHA 1ELZA 4LRBA 3WAYA 1N2LA 5L0BA 3M8ZA 3MK0A 3UN5A 4MIVA 1ALHA 3NKPA 5INHA 1EI6A 2XRGA 2W5QA 1ALIA 4UPHA 1Y7AA 4KJDA 1EW9A 4NWJA 3SZYA 1ALJA 1ZEDA 3NKOA 4GTWA 3TG0A 5EGHA 1B8JA 2GA3A 1P49A 1KHKA 4CXSA 1AJBA 1KHNA 2GSOA 1HJKA 2GLQA 4MY4A 4QAXA 3T01A 1HQAA 3UN3A 2VQRA 2GSNA 1O99A 3SZZA 2W5VA 1EW8A 1ED9A 3KD8A 1AJCA 4ZG6A 4ZG7A 4UOOA 2W8DA 1E1ZP 3WAXA 1Y6VA 2ANHA 2G9YA 3B5QA 2XR9A 2W5TA 1KH4A 4LRCA 1EQJA 1FSUA 1AJDA 2GSUA 4UPLA 3WAVA 3A52A 2IUCB 3TX0A 1ANIA
chains in the Genus database with same CATH topology
5LQQA 4LR7A 4FDIA 5C66A 5DLWA 3T02A 1EJJA 1ANJA 1KH9A 3ED4A 4UPIA 4CYSA 1ELYA 3WBHA 3MK2A 1N2KA 2QZUA 4KM4A 3UO0A 2D1GA 4UORA 4CXUA 4LRDA 1E33P 4UPKA 4ZG9A 5LRMA 5HRTA 4CXKA 2W5RA 1O98A 4LREA 3DYCA 3M7VA 4LR8A 3UNYA 2IFYA 5LIAA 4LR9A 4LR2A 2W8SA 3DPCA 3NKMA 3NKNA 5DLVA 4FDJA 1ZEBA 1KH7A 3UN2A 3BDGB 3T00A 4TN0A 1SHQA 2IUCA 5IJQA 5K4PA 3OT9A 5GOVA 1E2SP 2W5WA 4KAVA 3E2DA 1E3CP 4LRAA 3NVLA 1ZEFA 4GTYA 4NWXA 4B56A 1AUKA 2W5XA 3NKRA 4CYRA 3IDDA 3LXQA 4YR1A 5DLTA 5AJ9A 1URBA 5L0KA 5IJSA 4KJGA 5TJ3A 1EW2A 3WAWA 5GRRA 2X98A 4ZGAA 4UOPA 1AJAA 3CMRA 4GTXA 3IGYB 3BDHA 4MHXA 3BDFA 2W5SA 4LRFA 2RH6A 1KHJA 5KXAA 5EGEA 3Q3QA 5LRNA 1ED8A 4N7TA 4KAYA 1URAA 2ZKTA 3TWZA 3NKQA 3IGZB 3M8YA 3MK1A 1ALKA 1KHLA 1SHNA 1ELXA 3M8WA 4LQYA 5L0EA 1KH5A 1K7HA 3BDGA 4GTZA 1HDHA 1ELZA 4LRBA 3WAYA 1N2LA 5L0BA 3M8ZA 3MK0A 3UN5A 4MIVA 1ALHA 3NKPA 5INHA 1EI6A 2XRGA 2W5QA 1ALIA 4UPHA 1Y7AA 4KJDA 1EW9A 4NWJA 3SZYA 1ALJA 1ZEDA 3NKOA 4GTWA 3TG0A 5EGHA 1B8JA 2GA3A 1P49A 1KHKA 4CXSA 1AJBA 1KHNA 2GSOA 1HJKA 2GLQA 4MY4A 4QAXA 3T01A 1HQAA 3UN3A 2VQRA 2GSNA 1O99A 3SZZA 2W5VA 1EW8A 1ED9A 3KD8A 1AJCA 4ZG6A 4ZG7A 4UOOA 2W8DA 1E1ZP 3WAXA 1Y6VA 2ANHA 2G9YA 3B5QA 2XR9A 2W5TA 1KH4A 4LRCA 1EQJA 1FSUA 1AJDA 2GSUA 4UPLA 3WAVA 3A52A 2IUCB 3TX0A 1ANIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LQQ A;  4LR7 A;  4FDI A;  5C66 A;  5DLW A;  3T02 A;  1EJJ A;  1ANJ A;  1KH9 A;  3ED4 A;  4UPI A;  4CYS A;  1ELY A;  3WBH A;  3MK2 A;  1N2K A;  2QZU A;  4KM4 A;  3UO0 A;  2D1G A;  4UOR A;  4CXU A;  4LRD A;  1E33 P;  4UPK A;  4ZG9 A;  5LRM A;  5HRT A;  4CXK A;  2W5R A;  1O98 A;  4LRE A;  3DYC A;  3M7V A;  4LR8 A;  3UNY A;  2IFY A;  5LIA A;  4LR9 A;  4LR2 A;  2W8S A;  3DPC A;  3NKM A;  3NKN A;  5DLV A;  4FDJ A;  1ZEB A;  1KH7 A;  3UN2 A;  3BDG B;  3T00 A;  4TN0 A;  1SHQ A;  2IUC A;  5IJQ A;  5K4P A;  3OT9 A;  5GOV A;  1E2S P;  2W5W A;  4KAV A;  3E2D A;  1E3C P;  4LRA A;  3NVL A;  1ZEF A;  4GTY A;  4NWX A;  4B56 A;  1AUK A;  2W5X A;  3NKR A;  4CYR A;  3IDD A;  3LXQ A;  4YR1 A;  5DLT A;  5AJ9 A;  1URB A;  5L0K A;  5IJS A;  4KJG A;  5TJ3 A;  1EW2 A;  3WAW A;  5GRR A;  2X98 A;  4ZGA A;  4UOP A;  1AJA A;  3CMR A;  4GTX A;  3IGY B;  3BDH A;  4MHX A;  3BDF A;  2W5S A;  4LRF A;  2RH6 A;  1KHJ A;  5KXA A;  5EGE A;  3Q3Q A;  5LRN A;  1ED8 A;  4N7T A;  4KAY A;  1URA A;  2ZKT A;  3TWZ A;  3NKQ A;  3IGZ B;  3M8Y A;  3MK1 A;  1ALK A;  1KHL A;  1SHN A;  1ELX A;  3M8W A;  4LQY A;  5L0E A;  1KH5 A;  1K7H A;  3BDG A;  4GTZ A;  1HDH A;  1ELZ A;  4LRB A;  3WAY A;  1N2L A;  5L0B A;  3M8Z A;  3MK0 A;  3UN5 A;  4MIV A;  1ALH A;  3NKP A;  5INH A;  1EI6 A;  2XRG A;  2W5Q A;  1ALI A;  4UPH A;  1Y7A A;  4KJD A;  1EW9 A;  4NWJ A;  3SZY A;  1ALJ A;  1ZED A;  3NKO A;  4GTW A;  3TG0 A;  5EGH A;  1B8J A;  2GA3 A;  1P49 A;  1KHK A;  4CXS A;  1AJB A;  1KHN A;  2GSO A;  1HJK A;  2GLQ A;  4MY4 A;  4QAX A;  3T01 A;  1HQA A;  3UN3 A;  2VQR A;  2GSN A;  1O99 A;  3SZZ A;  2W5V A;  1EW8 A;  1ED9 A;  3KD8 A;  1AJC A;  4ZG6 A;  4ZG7 A;  4UOO A;  2W8D A;  1E1Z P;  3WAX A;  1Y6V A;  2ANH A;  2G9Y A;  3B5Q A;  2XR9 A;  2W5T A;  1KH4 A;  4LRC A;  1EQJ A;  1FSU A;  1AJD A;  2GSU A;  4UPL A;  3WAV A;  3A52 A;  2IUC B;  3TX0 A;  1ANI A; 
#chains in the Genus database with same CATH topology
 5LQQ A;  4LR7 A;  4FDI A;  5C66 A;  5DLW A;  3T02 A;  1EJJ A;  1ANJ A;  1KH9 A;  3ED4 A;  4UPI A;  4CYS A;  1ELY A;  3WBH A;  3MK2 A;  1N2K A;  2QZU A;  4KM4 A;  3UO0 A;  2D1G A;  4UOR A;  4CXU A;  4LRD A;  1E33 P;  4UPK A;  4ZG9 A;  5LRM A;  5HRT A;  4CXK A;  2W5R A;  1O98 A;  4LRE A;  3DYC A;  3M7V A;  4LR8 A;  3UNY A;  2IFY A;  5LIA A;  4LR9 A;  4LR2 A;  2W8S A;  3DPC A;  3NKM A;  3NKN A;  5DLV A;  4FDJ A;  1ZEB A;  1KH7 A;  3UN2 A;  3BDG B;  3T00 A;  4TN0 A;  1SHQ A;  2IUC A;  5IJQ A;  5K4P A;  3OT9 A;  5GOV A;  1E2S P;  2W5W A;  4KAV A;  3E2D A;  1E3C P;  4LRA A;  3NVL A;  1ZEF A;  4GTY A;  4NWX A;  4B56 A;  1AUK A;  2W5X A;  3NKR A;  4CYR A;  3IDD A;  3LXQ A;  4YR1 A;  5DLT A;  5AJ9 A;  1URB A;  5L0K A;  5IJS A;  4KJG A;  5TJ3 A;  1EW2 A;  3WAW A;  5GRR A;  2X98 A;  4ZGA A;  4UOP A;  1AJA A;  3CMR A;  4GTX A;  3IGY B;  3BDH A;  4MHX A;  3BDF A;  2W5S A;  4LRF A;  2RH6 A;  1KHJ A;  5KXA A;  5EGE A;  3Q3Q A;  5LRN A;  1ED8 A;  4N7T A;  4KAY A;  1URA A;  2ZKT A;  3TWZ A;  3NKQ A;  3IGZ B;  3M8Y A;  3MK1 A;  1ALK A;  1KHL A;  1SHN A;  1ELX A;  3M8W A;  4LQY A;  5L0E A;  1KH5 A;  1K7H A;  3BDG A;  4GTZ A;  1HDH A;  1ELZ A;  4LRB A;  3WAY A;  1N2L A;  5L0B A;  3M8Z A;  3MK0 A;  3UN5 A;  4MIV A;  1ALH A;  3NKP A;  5INH A;  1EI6 A;  2XRG A;  2W5Q A;  1ALI A;  4UPH A;  1Y7A A;  4KJD A;  1EW9 A;  4NWJ A;  3SZY A;  1ALJ A;  1ZED A;  3NKO A;  4GTW A;  3TG0 A;  5EGH A;  1B8J A;  2GA3 A;  1P49 A;  1KHK A;  4CXS A;  1AJB A;  1KHN A;  2GSO A;  1HJK A;  2GLQ A;  4MY4 A;  4QAX A;  3T01 A;  1HQA A;  3UN3 A;  2VQR A;  2GSN A;  1O99 A;  3SZZ A;  2W5V A;  1EW8 A;  1ED9 A;  3KD8 A;  1AJC A;  4ZG6 A;  4ZG7 A;  4UOO A;  2W8D A;  1E1Z P;  3WAX A;  1Y6V A;  2ANH A;  2G9Y A;  3B5Q A;  2XR9 A;  2W5T A;  1KH4 A;  4LRC A;  1EQJ A;  1FSU A;  1AJD A;  2GSU A;  4UPL A;  3WAV A;  3A52 A;  2IUC B;  3TX0 A;  1ANI A; 
#chains in the Genus database with same CATH homology
 5LQQ A;  4LR7 A;  4FDI A;  5C66 A;  5DLW A;  3T02 A;  1EJJ A;  1ANJ A;  1KH9 A;  3ED4 A;  4UPI A;  4CYS A;  1ELY A;  3WBH A;  3MK2 A;  1N2K A;  2QZU A;  4KM4 A;  3UO0 A;  2D1G A;  4UOR A;  4CXU A;  4LRD A;  1E33 P;  4UPK A;  4ZG9 A;  5LRM A;  5HRT A;  4CXK A;  2W5R A;  1O98 A;  4LRE A;  3DYC A;  3M7V A;  4LR8 A;  3UNY A;  2IFY A;  5LIA A;  4LR9 A;  4LR2 A;  2W8S A;  3DPC A;  3NKM A;  3NKN A;  5DLV A;  4FDJ A;  1ZEB A;  1KH7 A;  3UN2 A;  3BDG B;  3T00 A;  4TN0 A;  1SHQ A;  2IUC A;  5IJQ A;  5K4P A;  3OT9 A;  5GOV A;  1E2S P;  2W5W A;  4KAV A;  3E2D A;  1E3C P;  4LRA A;  3NVL A;  1ZEF A;  4GTY A;  4NWX A;  4B56 A;  1AUK A;  2W5X A;  3NKR A;  4CYR A;  3IDD A;  3LXQ A;  4YR1 A;  5DLT A;  5AJ9 A;  1URB A;  5L0K A;  5IJS A;  4KJG A;  5TJ3 A;  1EW2 A;  3WAW A;  5GRR A;  2X98 A;  4ZGA A;  4UOP A;  1AJA A;  3CMR A;  4GTX A;  3IGY B;  3BDH A;  4MHX A;  3BDF A;  2W5S A;  4LRF A;  2RH6 A;  1KHJ A;  5KXA A;  5EGE A;  3Q3Q A;  5LRN A;  1ED8 A;  4N7T A;  4KAY A;  1URA A;  2ZKT A;  3TWZ A;  3NKQ A;  3IGZ B;  3M8Y A;  3MK1 A;  1ALK A;  1KHL A;  1SHN A;  1ELX A;  3M8W A;  4LQY A;  5L0E A;  1KH5 A;  1K7H A;  3BDG A;  4GTZ A;  1HDH A;  1ELZ A;  4LRB A;  3WAY A;  1N2L A;  5L0B A;  3M8Z A;  3MK0 A;  3UN5 A;  4MIV A;  1ALH A;  3NKP A;  5INH A;  1EI6 A;  2XRG A;  2W5Q A;  1ALI A;  4UPH A;  1Y7A A;  4KJD A;  1EW9 A;  4NWJ A;  3SZY A;  1ALJ A;  1ZED A;  3NKO A;  4GTW A;  3TG0 A;  5EGH A;  1B8J A;  2GA3 A;  1P49 A;  1KHK A;  4CXS A;  1AJB A;  1KHN A;  2GSO A;  1HJK A;  2GLQ A;  4MY4 A;  4QAX A;  3T01 A;  1HQA A;  3UN3 A;  2VQR A;  2GSN A;  1O99 A;  3SZZ A;  2W5V A;  1EW8 A;  1ED9 A;  3KD8 A;  1AJC A;  4ZG6 A;  4ZG7 A;  4UOO A;  2W8D A;  1E1Z P;  3WAX A;  1Y6V A;  2ANH A;  2G9Y A;  3B5Q A;  2XR9 A;  2W5T A;  1KH4 A;  4LRC A;  1EQJ A;  1FSU A;  1AJD A;  2GSU A;  4UPL A;  3WAV A;  3A52 A;  2IUC B;  3TX0 A;  1ANI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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