3MK1A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 180
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
180
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
total genus 180
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk1A00
3IDDA 3MK1A 4LREA 3KD8A 3NKMA 3BDHA 3E2DA 3MK0A 5L0KA 3MK2A 3WAYA 4LRDA 1ED9A 1O98A 5TJ3A 2GSNA 1ANIA 5DLWA 3SZYA 1EJJA 3Q3QA 3UO0A 2GLQA 2ANHA 3WAWA 4ZGAA 4CYRA 1E3CP 1ALJA 3BDFA 1ALKA 1KH9A 5LIAA 4FDIA 4LRFA 3NKOA 2QZUA 1FSUA 2W8DA 4LR8A 3T01A 3M8WA 1EQJA 4CXKA 5L0BA 3CMRA 1ALHA 4NWJA 4N7TA 5LQQA 3OT9A 4LRBA 3TG0A 1B8JA 1E33P 2W5RA 2ZKTA 3BDGB 3IGYB 4NWXA 2IFYA 1AJBA 4MIVA 2W5QA 1EI6A 2XR9A 4LRAA 4KJDA 5AJ9A 3NKQA 1Y6VA 1HJKA 1KHNA 1KH7A 1O99A 4GTYA 2GSOA 5IJSA 4MHXA 2X98A 3UNYA 2GSUA 4FDJA 3TX0A 1EW8A 4B56A 3UN5A 1AJAA 4LRCA 2W5XA 4UPIA 1AJDA 1SHNA 1URAA 1Y7AA 2XRGA 5INHA 3M7VA 1URBA 4KJGA 3BDGA 1HDHA 1KHJA 4KAYA 1K7HA 5K4PA 4QAXA 5L0EA 2IUCA 1ED8A 1N2KA 5GRRA 1KH4A 4ZG9A 5KXAA 2VQRA 2W5SA 1ALIA 4GTWA 2D1GA 3NKPA 1KH5A 4UOOA 1EW9A 1ANJA 1ZEDA 1AUKA 3ED4A 4LR7A 4CYSA 3IGZB 4LR9A 5HRTA 5EGHA 5C66A 2GA3A 4MY4A 3LXQA 3A52A 3NKNA 2W5VA 1HQAA 3WBHA 3TWZA 3T02A 5DLTA 3DYCA 5IJQA 3UN3A 1ELYA 3DPCA 2W5WA 3SZZA 4UORA 4UPHA 1EW2A 5LRMA 2IUCB 5LRNA 3NKRA 1AJCA 4KM4A 4LQYA 3UN2A 4LR2A 1ELZA 1KHLA 4KAVA 1E1ZP 3NVLA 3B5QA 1ELXA 4UPKA 5EGEA 1N2LA 1ZEBA 4GTXA 5DLVA 3T00A 4TN0A 2G9YA 3M8ZA 1ZEFA 2W8SA 3M8YA 5GOVA 4UPLA 1E2SP 4UOPA 1P49A 3WAVA 4GTZA 1SHQA 4ZG7A 1KHKA 2W5TA 4CXUA 2RH6A 4YR1A 4CXSA 4ZG6A 3WAXA
chains in the Genus database with same CATH superfamily
3IDDA 3MK1A 4LREA 3KD8A 3NKMA 3BDHA 3E2DA 3MK0A 5L0KA 3MK2A 3WAYA 4LRDA 1ED9A 1O98A 5TJ3A 2GSNA 1ANIA 5DLWA 3SZYA 1EJJA 3Q3QA 3UO0A 2GLQA 2ANHA 3WAWA 4ZGAA 4CYRA 1E3CP 1ALJA 3BDFA 1ALKA 1KH9A 5LIAA 4FDIA 4LRFA 3NKOA 2QZUA 1FSUA 2W8DA 4LR8A 3T01A 3M8WA 1EQJA 4CXKA 5L0BA 3CMRA 1ALHA 4NWJA 4N7TA 5LQQA 3OT9A 4LRBA 3TG0A 1B8JA 1E33P 2W5RA 2ZKTA 3BDGB 3IGYB 4NWXA 2IFYA 1AJBA 4MIVA 2W5QA 1EI6A 2XR9A 4LRAA 4KJDA 5AJ9A 3NKQA 1Y6VA 1HJKA 1KHNA 1KH7A 1O99A 4GTYA 2GSOA 5IJSA 4MHXA 2X98A 3UNYA 2GSUA 4FDJA 3TX0A 1EW8A 4B56A 3UN5A 1AJAA 4LRCA 2W5XA 4UPIA 1AJDA 1SHNA 1URAA 1Y7AA 2XRGA 5INHA 3M7VA 1URBA 4KJGA 3BDGA 1HDHA 1KHJA 4KAYA 1K7HA 5K4PA 4QAXA 5L0EA 2IUCA 1ED8A 1N2KA 5GRRA 1KH4A 4ZG9A 5KXAA 2VQRA 2W5SA 1ALIA 4GTWA 2D1GA 3NKPA 1KH5A 4UOOA 1EW9A 1ANJA 1ZEDA 1AUKA 3ED4A 4LR7A 4CYSA 3IGZB 4LR9A 5HRTA 5EGHA 5C66A 2GA3A 4MY4A 3LXQA 3A52A 3NKNA 2W5VA 1HQAA 3WBHA 3TWZA 3T02A 5DLTA 3DYCA 5IJQA 3UN3A 1ELYA 3DPCA 2W5WA 3SZZA 4UORA 4UPHA 1EW2A 5LRMA 2IUCB 5LRNA 3NKRA 1AJCA 4KM4A 4LQYA 3UN2A 4LR2A 1ELZA 1KHLA 4KAVA 1E1ZP 3NVLA 3B5QA 1ELXA 4UPKA 5EGEA 1N2LA 1ZEBA 4GTXA 5DLVA 3T00A 4TN0A 2G9YA 3M8ZA 1ZEFA 2W8SA 3M8YA 5GOVA 4UPLA 1E2SP 4UOPA 1P49A 3WAVA 4GTZA 1SHQA 4ZG7A 1KHKA 2W5TA 4CXUA 2RH6A 4YR1A 4CXSA 4ZG6A 3WAXA
chains in the Genus database with same CATH topology
3IDDA 3MK1A 4LREA 3KD8A 3NKMA 3BDHA 3E2DA 3MK0A 5L0KA 3MK2A 3WAYA 4LRDA 1ED9A 1O98A 5TJ3A 2GSNA 1ANIA 5DLWA 3SZYA 1EJJA 3Q3QA 3UO0A 2GLQA 2ANHA 3WAWA 4ZGAA 4CYRA 1E3CP 1ALJA 3BDFA 1ALKA 1KH9A 5LIAA 4FDIA 4LRFA 3NKOA 2QZUA 1FSUA 2W8DA 4LR8A 3T01A 3M8WA 1EQJA 4CXKA 5L0BA 3CMRA 1ALHA 4NWJA 4N7TA 5LQQA 3OT9A 4LRBA 3TG0A 1B8JA 1E33P 2W5RA 2ZKTA 3BDGB 3IGYB 4NWXA 2IFYA 1AJBA 4MIVA 2W5QA 1EI6A 2XR9A 4LRAA 4KJDA 5AJ9A 3NKQA 1Y6VA 1HJKA 1KHNA 1KH7A 1O99A 4GTYA 2GSOA 5IJSA 4MHXA 2X98A 3UNYA 2GSUA 4FDJA 3TX0A 1EW8A 4B56A 3UN5A 1AJAA 4LRCA 2W5XA 4UPIA 1AJDA 1SHNA 1URAA 1Y7AA 2XRGA 5INHA 3M7VA 1URBA 4KJGA 3BDGA 1HDHA 1KHJA 4KAYA 1K7HA 5K4PA 4QAXA 5L0EA 2IUCA 1ED8A 1N2KA 5GRRA 1KH4A 4ZG9A 5KXAA 2VQRA 2W5SA 1ALIA 4GTWA 2D1GA 3NKPA 1KH5A 4UOOA 1EW9A 1ANJA 1ZEDA 1AUKA 3ED4A 4LR7A 4CYSA 3IGZB 4LR9A 5HRTA 5EGHA 5C66A 2GA3A 4MY4A 3LXQA 3A52A 3NKNA 2W5VA 1HQAA 3WBHA 3TWZA 3T02A 5DLTA 3DYCA 5IJQA 3UN3A 1ELYA 3DPCA 2W5WA 3SZZA 4UORA 4UPHA 1EW2A 5LRMA 2IUCB 5LRNA 3NKRA 1AJCA 4KM4A 4LQYA 3UN2A 4LR2A 1ELZA 1KHLA 4KAVA 1E1ZP 3NVLA 3B5QA 1ELXA 4UPKA 5EGEA 1N2LA 1ZEBA 4GTXA 5DLVA 3T00A 4TN0A 2G9YA 3M8ZA 1ZEFA 2W8SA 3M8YA 5GOVA 4UPLA 1E2SP 4UOPA 1P49A 3WAVA 4GTZA 1SHQA 4ZG7A 1KHKA 2W5TA 4CXUA 2RH6A 4YR1A 4CXSA 4ZG6A 3WAXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IDD A;  3MK1 A;  4LRE A;  3KD8 A;  3NKM A;  3BDH A;  3E2D A;  3MK0 A;  5L0K A;  3MK2 A;  3WAY A;  4LRD A;  1ED9 A;  1O98 A;  5TJ3 A;  2GSN A;  1ANI A;  5DLW A;  3SZY A;  1EJJ A;  3Q3Q A;  3UO0 A;  2GLQ A;  2ANH A;  3WAW A;  4ZGA A;  4CYR A;  1E3C P;  1ALJ A;  3BDF A;  1ALK A;  1KH9 A;  5LIA A;  4FDI A;  4LRF A;  3NKO A;  2QZU A;  1FSU A;  2W8D A;  4LR8 A;  3T01 A;  3M8W A;  1EQJ A;  4CXK A;  5L0B A;  3CMR A;  1ALH A;  4NWJ A;  4N7T A;  5LQQ A;  3OT9 A;  4LRB A;  3TG0 A;  1B8J A;  1E33 P;  2W5R A;  2ZKT A;  3BDG B;  3IGY B;  4NWX A;  2IFY A;  1AJB A;  4MIV A;  2W5Q A;  1EI6 A;  2XR9 A;  4LRA A;  4KJD A;  5AJ9 A;  3NKQ A;  1Y6V A;  1HJK A;  1KHN A;  1KH7 A;  1O99 A;  4GTY A;  2GSO A;  5IJS A;  4MHX A;  2X98 A;  3UNY A;  2GSU A;  4FDJ A;  3TX0 A;  1EW8 A;  4B56 A;  3UN5 A;  1AJA A;  4LRC A;  2W5X A;  4UPI A;  1AJD A;  1SHN A;  1URA A;  1Y7A A;  2XRG A;  5INH A;  3M7V A;  1URB A;  4KJG A;  3BDG A;  1HDH A;  1KHJ A;  4KAY A;  1K7H A;  5K4P A;  4QAX A;  5L0E A;  2IUC A;  1ED8 A;  1N2K A;  5GRR A;  1KH4 A;  4ZG9 A;  5KXA A;  2VQR A;  2W5S A;  1ALI A;  4GTW A;  2D1G A;  3NKP A;  1KH5 A;  4UOO A;  1EW9 A;  1ANJ A;  1ZED A;  1AUK A;  3ED4 A;  4LR7 A;  4CYS A;  3IGZ B;  4LR9 A;  5HRT A;  5EGH A;  5C66 A;  2GA3 A;  4MY4 A;  3LXQ A;  3A52 A;  3NKN A;  2W5V A;  1HQA A;  3WBH A;  3TWZ A;  3T02 A;  5DLT A;  3DYC A;  5IJQ A;  3UN3 A;  1ELY A;  3DPC A;  2W5W A;  3SZZ A;  4UOR A;  4UPH A;  1EW2 A;  5LRM A;  2IUC B;  5LRN A;  3NKR A;  1AJC A;  4KM4 A;  4LQY A;  3UN2 A;  4LR2 A;  1ELZ A;  1KHL A;  4KAV A;  1E1Z P;  3NVL A;  3B5Q A;  1ELX A;  4UPK A;  5EGE A;  1N2L A;  1ZEB A;  4GTX A;  5DLV A;  3T00 A;  4TN0 A;  2G9Y A;  3M8Z A;  1ZEF A;  2W8S A;  3M8Y A;  5GOV A;  4UPL A;  1E2S P;  4UOP A;  1P49 A;  3WAV A;  4GTZ A;  1SHQ A;  4ZG7 A;  1KHK A;  2W5T A;  4CXU A;  2RH6 A;  4YR1 A;  4CXS A;  4ZG6 A;  3WAX A; 
#chains in the Genus database with same CATH topology
 3IDD A;  3MK1 A;  4LRE A;  3KD8 A;  3NKM A;  3BDH A;  3E2D A;  3MK0 A;  5L0K A;  3MK2 A;  3WAY A;  4LRD A;  1ED9 A;  1O98 A;  5TJ3 A;  2GSN A;  1ANI A;  5DLW A;  3SZY A;  1EJJ A;  3Q3Q A;  3UO0 A;  2GLQ A;  2ANH A;  3WAW A;  4ZGA A;  4CYR A;  1E3C P;  1ALJ A;  3BDF A;  1ALK A;  1KH9 A;  5LIA A;  4FDI A;  4LRF A;  3NKO A;  2QZU A;  1FSU A;  2W8D A;  4LR8 A;  3T01 A;  3M8W A;  1EQJ A;  4CXK A;  5L0B A;  3CMR A;  1ALH A;  4NWJ A;  4N7T A;  5LQQ A;  3OT9 A;  4LRB A;  3TG0 A;  1B8J A;  1E33 P;  2W5R A;  2ZKT A;  3BDG B;  3IGY B;  4NWX A;  2IFY A;  1AJB A;  4MIV A;  2W5Q A;  1EI6 A;  2XR9 A;  4LRA A;  4KJD A;  5AJ9 A;  3NKQ A;  1Y6V A;  1HJK A;  1KHN A;  1KH7 A;  1O99 A;  4GTY A;  2GSO A;  5IJS A;  4MHX A;  2X98 A;  3UNY A;  2GSU A;  4FDJ A;  3TX0 A;  1EW8 A;  4B56 A;  3UN5 A;  1AJA A;  4LRC A;  2W5X A;  4UPI A;  1AJD A;  1SHN A;  1URA A;  1Y7A A;  2XRG A;  5INH A;  3M7V A;  1URB A;  4KJG A;  3BDG A;  1HDH A;  1KHJ A;  4KAY A;  1K7H A;  5K4P A;  4QAX A;  5L0E A;  2IUC A;  1ED8 A;  1N2K A;  5GRR A;  1KH4 A;  4ZG9 A;  5KXA A;  2VQR A;  2W5S A;  1ALI A;  4GTW A;  2D1G A;  3NKP A;  1KH5 A;  4UOO A;  1EW9 A;  1ANJ A;  1ZED A;  1AUK A;  3ED4 A;  4LR7 A;  4CYS A;  3IGZ B;  4LR9 A;  5HRT A;  5EGH A;  5C66 A;  2GA3 A;  4MY4 A;  3LXQ A;  3A52 A;  3NKN A;  2W5V A;  1HQA A;  3WBH A;  3TWZ A;  3T02 A;  5DLT A;  3DYC A;  5IJQ A;  3UN3 A;  1ELY A;  3DPC A;  2W5W A;  3SZZ A;  4UOR A;  4UPH A;  1EW2 A;  5LRM A;  2IUC B;  5LRN A;  3NKR A;  1AJC A;  4KM4 A;  4LQY A;  3UN2 A;  4LR2 A;  1ELZ A;  1KHL A;  4KAV A;  1E1Z P;  3NVL A;  3B5Q A;  1ELX A;  4UPK A;  5EGE A;  1N2L A;  1ZEB A;  4GTX A;  5DLV A;  3T00 A;  4TN0 A;  2G9Y A;  3M8Z A;  1ZEF A;  2W8S A;  3M8Y A;  5GOV A;  4UPL A;  1E2S P;  4UOP A;  1P49 A;  3WAV A;  4GTZ A;  1SHQ A;  4ZG7 A;  1KHK A;  2W5T A;  4CXU A;  2RH6 A;  4YR1 A;  4CXS A;  4ZG6 A;  3WAX A; 
#chains in the Genus database with same CATH homology
 3IDD A;  3MK1 A;  4LRE A;  3KD8 A;  3NKM A;  3BDH A;  3E2D A;  3MK0 A;  5L0K A;  3MK2 A;  3WAY A;  4LRD A;  1ED9 A;  1O98 A;  5TJ3 A;  2GSN A;  1ANI A;  5DLW A;  3SZY A;  1EJJ A;  3Q3Q A;  3UO0 A;  2GLQ A;  2ANH A;  3WAW A;  4ZGA A;  4CYR A;  1E3C P;  1ALJ A;  3BDF A;  1ALK A;  1KH9 A;  5LIA A;  4FDI A;  4LRF A;  3NKO A;  2QZU A;  1FSU A;  2W8D A;  4LR8 A;  3T01 A;  3M8W A;  1EQJ A;  4CXK A;  5L0B A;  3CMR A;  1ALH A;  4NWJ A;  4N7T A;  5LQQ A;  3OT9 A;  4LRB A;  3TG0 A;  1B8J A;  1E33 P;  2W5R A;  2ZKT A;  3BDG B;  3IGY B;  4NWX A;  2IFY A;  1AJB A;  4MIV A;  2W5Q A;  1EI6 A;  2XR9 A;  4LRA A;  4KJD A;  5AJ9 A;  3NKQ A;  1Y6V A;  1HJK A;  1KHN A;  1KH7 A;  1O99 A;  4GTY A;  2GSO A;  5IJS A;  4MHX A;  2X98 A;  3UNY A;  2GSU A;  4FDJ A;  3TX0 A;  1EW8 A;  4B56 A;  3UN5 A;  1AJA A;  4LRC A;  2W5X A;  4UPI A;  1AJD A;  1SHN A;  1URA A;  1Y7A A;  2XRG A;  5INH A;  3M7V A;  1URB A;  4KJG A;  3BDG A;  1HDH A;  1KHJ A;  4KAY A;  1K7H A;  5K4P A;  4QAX A;  5L0E A;  2IUC A;  1ED8 A;  1N2K A;  5GRR A;  1KH4 A;  4ZG9 A;  5KXA A;  2VQR A;  2W5S A;  1ALI A;  4GTW A;  2D1G A;  3NKP A;  1KH5 A;  4UOO A;  1EW9 A;  1ANJ A;  1ZED A;  1AUK A;  3ED4 A;  4LR7 A;  4CYS A;  3IGZ B;  4LR9 A;  5HRT A;  5EGH A;  5C66 A;  2GA3 A;  4MY4 A;  3LXQ A;  3A52 A;  3NKN A;  2W5V A;  1HQA A;  3WBH A;  3TWZ A;  3T02 A;  5DLT A;  3DYC A;  5IJQ A;  3UN3 A;  1ELY A;  3DPC A;  2W5W A;  3SZZ A;  4UOR A;  4UPH A;  1EW2 A;  5LRM A;  2IUC B;  5LRN A;  3NKR A;  1AJC A;  4KM4 A;  4LQY A;  3UN2 A;  4LR2 A;  1ELZ A;  1KHL A;  4KAV A;  1E1Z P;  3NVL A;  3B5Q A;  1ELX A;  4UPK A;  5EGE A;  1N2L A;  1ZEB A;  4GTX A;  5DLV A;  3T00 A;  4TN0 A;  2G9Y A;  3M8Z A;  1ZEF A;  2W8S A;  3M8Y A;  5GOV A;  4UPL A;  1E2S P;  4UOP A;  1P49 A;  3WAV A;  4GTZ A;  1SHQ A;  4ZG7 A;  1KHK A;  2W5T A;  4CXU A;  2RH6 A;  4YR1 A;  4CXS A;  4ZG6 A;  3WAX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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