1AJCA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
449
structure length
446
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Non specific mono-esterase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 160
structure length 446
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajcA00
1ELYA 4GTZA 1E2SP 3SZYA 3T02A 4LRBA 3NKOA 5LRMA 3WAXA 2W5RA 4UPHA 4CXSA 5LIAA 1AJAA 3IDDA 1B8JA 1SHQA 2GSNA 3M7VA 4ZG9A 2IFYA 2XRGA 5EGEA 4LRCA 1EI6A 5L0EA 3CMRA 3M8ZA 1P49A 1ED8A 4QAXA 4UOOA 3KD8A 1KHNA 1O98A 1URBA 5HRTA 2GA3A 1ALIA 1KH4A 2W5XA 3DYCA 1KHLA 5L0BA 1E33P 3DPCA 1HQAA 4LR2A 1KH7A 3NKPA 3NKNA 5LQQA 3BDHA 4UOPA 4MIVA 2IUCB 4KM4A 1Y7AA 4UPIA 1ZEFA 3WBHA 3UO0A 5IJQA 2X98A 2W8SA 3M8WA 4CXUA 4CYSA 3TWZA 5L0KA 4LRAA 5TJ3A 1ANJA 3NKQA 4FDIA 4LRFA 1HDHA 3E2DA 3IGYB 3NKRA 3UN3A 2GSOA 4CYRA 2RH6A 1E1ZP 1ELXA 1EJJA 1HJKA 3Q3QA 1FSUA 5INHA 1N2LA 4YR1A 2IUCA 1ZEBA 3WAVA 4NWXA 1ED9A 2QZUA 1ZEDA 5GRRA 5DLVA 4GTWA 1AUKA 2ANHA 4KJDA 3BDFA 4KJGA 2D1GA 4NWJA 4UPKA 4UORA 2W8DA 3LXQA 1EQJA 5KXAA 2VQRA 1Y6VA 5GOVA 1AJDA 3ED4A 3WAYA 3SZZA 1O99A 3NVLA 3TX0A 4LRDA 4KAVA 3M8YA 3B5QA 4ZGAA 5K4PA 1ALKA 4KAYA 4UPLA 5IJSA 3MK0A 1K7HA 4FDJA 1KHJA 5EGHA 1AJCA 2ZKTA 4MY4A 3UN5A 3A52A 2W5VA 2XR9A 1KH9A 4ZG7A 5LRNA 2W5QA 3NKMA 4GTXA 5C66A 3OT9A 2W5WA 3BDGB 4GTYA 4CXKA 1N2KA 4LR7A 3MK2A 3UNYA 5AJ9A 1URAA 1EW9A 4MHXA 4N7TA 4ZG6A 1E3CP 1AJBA 3UN2A 3IGZB 5DLTA 1ALJA 1EW8A 1ELZA 4B56A 4LQYA 1SHNA 1KH5A 2GLQA 2W5TA 1KHKA 5DLWA 3MK1A 2W5SA 4LREA 3WAWA 3BDGA 1ANIA 3T00A 3TG0A 4LR8A 3T01A 1ALHA 2G9YA 4TN0A 1EW2A 2GSUA 4LR9A
chains in the Genus database with same CATH superfamily
1ELYA 4GTZA 1E2SP 3SZYA 3T02A 4LRBA 3NKOA 5LRMA 3WAXA 2W5RA 4UPHA 4CXSA 5LIAA 1AJAA 3IDDA 1B8JA 1SHQA 2GSNA 3M7VA 4ZG9A 2IFYA 2XRGA 5EGEA 4LRCA 1EI6A 5L0EA 3CMRA 3M8ZA 1P49A 1ED8A 4QAXA 4UOOA 3KD8A 1KHNA 1O98A 1URBA 5HRTA 2GA3A 1ALIA 1KH4A 2W5XA 3DYCA 1KHLA 5L0BA 1E33P 3DPCA 1HQAA 4LR2A 1KH7A 3NKPA 3NKNA 5LQQA 3BDHA 4UOPA 4MIVA 2IUCB 4KM4A 1Y7AA 4UPIA 1ZEFA 3WBHA 3UO0A 5IJQA 2X98A 2W8SA 3M8WA 4CXUA 4CYSA 3TWZA 5L0KA 4LRAA 5TJ3A 1ANJA 3NKQA 4FDIA 4LRFA 1HDHA 3E2DA 3IGYB 3NKRA 3UN3A 2GSOA 4CYRA 2RH6A 1E1ZP 1ELXA 1EJJA 1HJKA 3Q3QA 1FSUA 5INHA 1N2LA 4YR1A 2IUCA 1ZEBA 3WAVA 4NWXA 1ED9A 2QZUA 1ZEDA 5GRRA 5DLVA 4GTWA 1AUKA 2ANHA 4KJDA 3BDFA 4KJGA 2D1GA 4NWJA 4UPKA 4UORA 2W8DA 3LXQA 1EQJA 5KXAA 2VQRA 1Y6VA 5GOVA 1AJDA 3ED4A 3WAYA 3SZZA 1O99A 3NVLA 3TX0A 4LRDA 4KAVA 3M8YA 3B5QA 4ZGAA 5K4PA 1ALKA 4KAYA 4UPLA 5IJSA 3MK0A 1K7HA 4FDJA 1KHJA 5EGHA 1AJCA 2ZKTA 4MY4A 3UN5A 3A52A 2W5VA 2XR9A 1KH9A 4ZG7A 5LRNA 2W5QA 3NKMA 4GTXA 5C66A 3OT9A 2W5WA 3BDGB 4GTYA 4CXKA 1N2KA 4LR7A 3MK2A 3UNYA 5AJ9A 1URAA 1EW9A 4MHXA 4N7TA 4ZG6A 1E3CP 1AJBA 3UN2A 3IGZB 5DLTA 1ALJA 1EW8A 1ELZA 4B56A 4LQYA 1SHNA 1KH5A 2GLQA 2W5TA 1KHKA 5DLWA 3MK1A 2W5SA 4LREA 3WAWA 3BDGA 1ANIA 3T00A 3TG0A 4LR8A 3T01A 1ALHA 2G9YA 4TN0A 1EW2A 2GSUA 4LR9A
chains in the Genus database with same CATH topology
1ELYA 4GTZA 1E2SP 3SZYA 3T02A 4LRBA 3NKOA 5LRMA 3WAXA 2W5RA 4UPHA 4CXSA 5LIAA 1AJAA 3IDDA 1B8JA 1SHQA 2GSNA 3M7VA 4ZG9A 2IFYA 2XRGA 5EGEA 4LRCA 1EI6A 5L0EA 3CMRA 3M8ZA 1P49A 1ED8A 4QAXA 4UOOA 3KD8A 1KHNA 1O98A 1URBA 5HRTA 2GA3A 1ALIA 1KH4A 2W5XA 3DYCA 1KHLA 5L0BA 1E33P 3DPCA 1HQAA 4LR2A 1KH7A 3NKPA 3NKNA 5LQQA 3BDHA 4UOPA 4MIVA 2IUCB 4KM4A 1Y7AA 4UPIA 1ZEFA 3WBHA 3UO0A 5IJQA 2X98A 2W8SA 3M8WA 4CXUA 4CYSA 3TWZA 5L0KA 4LRAA 5TJ3A 1ANJA 3NKQA 4FDIA 4LRFA 1HDHA 3E2DA 3IGYB 3NKRA 3UN3A 2GSOA 4CYRA 2RH6A 1E1ZP 1ELXA 1EJJA 1HJKA 3Q3QA 1FSUA 5INHA 1N2LA 4YR1A 2IUCA 1ZEBA 3WAVA 4NWXA 1ED9A 2QZUA 1ZEDA 5GRRA 5DLVA 4GTWA 1AUKA 2ANHA 4KJDA 3BDFA 4KJGA 2D1GA 4NWJA 4UPKA 4UORA 2W8DA 3LXQA 1EQJA 5KXAA 2VQRA 1Y6VA 5GOVA 1AJDA 3ED4A 3WAYA 3SZZA 1O99A 3NVLA 3TX0A 4LRDA 4KAVA 3M8YA 3B5QA 4ZGAA 5K4PA 1ALKA 4KAYA 4UPLA 5IJSA 3MK0A 1K7HA 4FDJA 1KHJA 5EGHA 1AJCA 2ZKTA 4MY4A 3UN5A 3A52A 2W5VA 2XR9A 1KH9A 4ZG7A 5LRNA 2W5QA 3NKMA 4GTXA 5C66A 3OT9A 2W5WA 3BDGB 4GTYA 4CXKA 1N2KA 4LR7A 3MK2A 3UNYA 5AJ9A 1URAA 1EW9A 4MHXA 4N7TA 4ZG6A 1E3CP 1AJBA 3UN2A 3IGZB 5DLTA 1ALJA 1EW8A 1ELZA 4B56A 4LQYA 1SHNA 1KH5A 2GLQA 2W5TA 1KHKA 5DLWA 3MK1A 2W5SA 4LREA 3WAWA 3BDGA 1ANIA 3T00A 3TG0A 4LR8A 3T01A 1ALHA 2G9YA 4TN0A 1EW2A 2GSUA 4LR9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ELY A;  4GTZ A;  1E2S P;  3SZY A;  3T02 A;  4LRB A;  3NKO A;  5LRM A;  3WAX A;  2W5R A;  4UPH A;  4CXS A;  5LIA A;  1AJA A;  3IDD A;  1B8J A;  1SHQ A;  2GSN A;  3M7V A;  4ZG9 A;  2IFY A;  2XRG A;  5EGE A;  4LRC A;  1EI6 A;  5L0E A;  3CMR A;  3M8Z A;  1P49 A;  1ED8 A;  4QAX A;  4UOO A;  3KD8 A;  1KHN A;  1O98 A;  1URB A;  5HRT A;  2GA3 A;  1ALI A;  1KH4 A;  2W5X A;  3DYC A;  1KHL A;  5L0B A;  1E33 P;  3DPC A;  1HQA A;  4LR2 A;  1KH7 A;  3NKP A;  3NKN A;  5LQQ A;  3BDH A;  4UOP A;  4MIV A;  2IUC B;  4KM4 A;  1Y7A A;  4UPI A;  1ZEF A;  3WBH A;  3UO0 A;  5IJQ A;  2X98 A;  2W8S A;  3M8W A;  4CXU A;  4CYS A;  3TWZ A;  5L0K A;  4LRA A;  5TJ3 A;  1ANJ A;  3NKQ A;  4FDI A;  4LRF A;  1HDH A;  3E2D A;  3IGY B;  3NKR A;  3UN3 A;  2GSO A;  4CYR A;  2RH6 A;  1E1Z P;  1ELX A;  1EJJ A;  1HJK A;  3Q3Q A;  1FSU A;  5INH A;  1N2L A;  4YR1 A;  2IUC A;  1ZEB A;  3WAV A;  4NWX A;  1ED9 A;  2QZU A;  1ZED A;  5GRR A;  5DLV A;  4GTW A;  1AUK A;  2ANH A;  4KJD A;  3BDF A;  4KJG A;  2D1G A;  4NWJ A;  4UPK A;  4UOR A;  2W8D A;  3LXQ A;  1EQJ A;  5KXA A;  2VQR A;  1Y6V A;  5GOV A;  1AJD A;  3ED4 A;  3WAY A;  3SZZ A;  1O99 A;  3NVL A;  3TX0 A;  4LRD A;  4KAV A;  3M8Y A;  3B5Q A;  4ZGA A;  5K4P A;  1ALK A;  4KAY A;  4UPL A;  5IJS A;  3MK0 A;  1K7H A;  4FDJ A;  1KHJ A;  5EGH A;  1AJC A;  2ZKT A;  4MY4 A;  3UN5 A;  3A52 A;  2W5V A;  2XR9 A;  1KH9 A;  4ZG7 A;  5LRN A;  2W5Q A;  3NKM A;  4GTX A;  5C66 A;  3OT9 A;  2W5W A;  3BDG B;  4GTY A;  4CXK A;  1N2K A;  4LR7 A;  3MK2 A;  3UNY A;  5AJ9 A;  1URA A;  1EW9 A;  4MHX A;  4N7T A;  4ZG6 A;  1E3C P;  1AJB A;  3UN2 A;  3IGZ B;  5DLT A;  1ALJ A;  1EW8 A;  1ELZ A;  4B56 A;  4LQY A;  1SHN A;  1KH5 A;  2GLQ A;  2W5T A;  1KHK A;  5DLW A;  3MK1 A;  2W5S A;  4LRE A;  3WAW A;  3BDG A;  1ANI A;  3T00 A;  3TG0 A;  4LR8 A;  3T01 A;  1ALH A;  2G9Y A;  4TN0 A;  1EW2 A;  2GSU A;  4LR9 A; 
#chains in the Genus database with same CATH topology
 1ELY A;  4GTZ A;  1E2S P;  3SZY A;  3T02 A;  4LRB A;  3NKO A;  5LRM A;  3WAX A;  2W5R A;  4UPH A;  4CXS A;  5LIA A;  1AJA A;  3IDD A;  1B8J A;  1SHQ A;  2GSN A;  3M7V A;  4ZG9 A;  2IFY A;  2XRG A;  5EGE A;  4LRC A;  1EI6 A;  5L0E A;  3CMR A;  3M8Z A;  1P49 A;  1ED8 A;  4QAX A;  4UOO A;  3KD8 A;  1KHN A;  1O98 A;  1URB A;  5HRT A;  2GA3 A;  1ALI A;  1KH4 A;  2W5X A;  3DYC A;  1KHL A;  5L0B A;  1E33 P;  3DPC A;  1HQA A;  4LR2 A;  1KH7 A;  3NKP A;  3NKN A;  5LQQ A;  3BDH A;  4UOP A;  4MIV A;  2IUC B;  4KM4 A;  1Y7A A;  4UPI A;  1ZEF A;  3WBH A;  3UO0 A;  5IJQ A;  2X98 A;  2W8S A;  3M8W A;  4CXU A;  4CYS A;  3TWZ A;  5L0K A;  4LRA A;  5TJ3 A;  1ANJ A;  3NKQ A;  4FDI A;  4LRF A;  1HDH A;  3E2D A;  3IGY B;  3NKR A;  3UN3 A;  2GSO A;  4CYR A;  2RH6 A;  1E1Z P;  1ELX A;  1EJJ A;  1HJK A;  3Q3Q A;  1FSU A;  5INH A;  1N2L A;  4YR1 A;  2IUC A;  1ZEB A;  3WAV A;  4NWX A;  1ED9 A;  2QZU A;  1ZED A;  5GRR A;  5DLV A;  4GTW A;  1AUK A;  2ANH A;  4KJD A;  3BDF A;  4KJG A;  2D1G A;  4NWJ A;  4UPK A;  4UOR A;  2W8D A;  3LXQ A;  1EQJ A;  5KXA A;  2VQR A;  1Y6V A;  5GOV A;  1AJD A;  3ED4 A;  3WAY A;  3SZZ A;  1O99 A;  3NVL A;  3TX0 A;  4LRD A;  4KAV A;  3M8Y A;  3B5Q A;  4ZGA A;  5K4P A;  1ALK A;  4KAY A;  4UPL A;  5IJS A;  3MK0 A;  1K7H A;  4FDJ A;  1KHJ A;  5EGH A;  1AJC A;  2ZKT A;  4MY4 A;  3UN5 A;  3A52 A;  2W5V A;  2XR9 A;  1KH9 A;  4ZG7 A;  5LRN A;  2W5Q A;  3NKM A;  4GTX A;  5C66 A;  3OT9 A;  2W5W A;  3BDG B;  4GTY A;  4CXK A;  1N2K A;  4LR7 A;  3MK2 A;  3UNY A;  5AJ9 A;  1URA A;  1EW9 A;  4MHX A;  4N7T A;  4ZG6 A;  1E3C P;  1AJB A;  3UN2 A;  3IGZ B;  5DLT A;  1ALJ A;  1EW8 A;  1ELZ A;  4B56 A;  4LQY A;  1SHN A;  1KH5 A;  2GLQ A;  2W5T A;  1KHK A;  5DLW A;  3MK1 A;  2W5S A;  4LRE A;  3WAW A;  3BDG A;  1ANI A;  3T00 A;  3TG0 A;  4LR8 A;  3T01 A;  1ALH A;  2G9Y A;  4TN0 A;  1EW2 A;  2GSU A;  4LR9 A; 
#chains in the Genus database with same CATH homology
 1ELY A;  4GTZ A;  1E2S P;  3SZY A;  3T02 A;  4LRB A;  3NKO A;  5LRM A;  3WAX A;  2W5R A;  4UPH A;  4CXS A;  5LIA A;  1AJA A;  3IDD A;  1B8J A;  1SHQ A;  2GSN A;  3M7V A;  4ZG9 A;  2IFY A;  2XRG A;  5EGE A;  4LRC A;  1EI6 A;  5L0E A;  3CMR A;  3M8Z A;  1P49 A;  1ED8 A;  4QAX A;  4UOO A;  3KD8 A;  1KHN A;  1O98 A;  1URB A;  5HRT A;  2GA3 A;  1ALI A;  1KH4 A;  2W5X A;  3DYC A;  1KHL A;  5L0B A;  1E33 P;  3DPC A;  1HQA A;  4LR2 A;  1KH7 A;  3NKP A;  3NKN A;  5LQQ A;  3BDH A;  4UOP A;  4MIV A;  2IUC B;  4KM4 A;  1Y7A A;  4UPI A;  1ZEF A;  3WBH A;  3UO0 A;  5IJQ A;  2X98 A;  2W8S A;  3M8W A;  4CXU A;  4CYS A;  3TWZ A;  5L0K A;  4LRA A;  5TJ3 A;  1ANJ A;  3NKQ A;  4FDI A;  4LRF A;  1HDH A;  3E2D A;  3IGY B;  3NKR A;  3UN3 A;  2GSO A;  4CYR A;  2RH6 A;  1E1Z P;  1ELX A;  1EJJ A;  1HJK A;  3Q3Q A;  1FSU A;  5INH A;  1N2L A;  4YR1 A;  2IUC A;  1ZEB A;  3WAV A;  4NWX A;  1ED9 A;  2QZU A;  1ZED A;  5GRR A;  5DLV A;  4GTW A;  1AUK A;  2ANH A;  4KJD A;  3BDF A;  4KJG A;  2D1G A;  4NWJ A;  4UPK A;  4UOR A;  2W8D A;  3LXQ A;  1EQJ A;  5KXA A;  2VQR A;  1Y6V A;  5GOV A;  1AJD A;  3ED4 A;  3WAY A;  3SZZ A;  1O99 A;  3NVL A;  3TX0 A;  4LRD A;  4KAV A;  3M8Y A;  3B5Q A;  4ZGA A;  5K4P A;  1ALK A;  4KAY A;  4UPL A;  5IJS A;  3MK0 A;  1K7H A;  4FDJ A;  1KHJ A;  5EGH A;  1AJC A;  2ZKT A;  4MY4 A;  3UN5 A;  3A52 A;  2W5V A;  2XR9 A;  1KH9 A;  4ZG7 A;  5LRN A;  2W5Q A;  3NKM A;  4GTX A;  5C66 A;  3OT9 A;  2W5W A;  3BDG B;  4GTY A;  4CXK A;  1N2K A;  4LR7 A;  3MK2 A;  3UNY A;  5AJ9 A;  1URA A;  1EW9 A;  4MHX A;  4N7T A;  4ZG6 A;  1E3C P;  1AJB A;  3UN2 A;  3IGZ B;  5DLT A;  1ALJ A;  1EW8 A;  1ELZ A;  4B56 A;  4LQY A;  1SHN A;  1KH5 A;  2GLQ A;  2W5T A;  1KHK A;  5DLW A;  3MK1 A;  2W5S A;  4LRE A;  3WAW A;  3BDG A;  1ANI A;  3T00 A;  3TG0 A;  4LR8 A;  3T01 A;  1ALH A;  2G9Y A;  4TN0 A;  1EW2 A;  2GSU A;  4LR9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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