1AJCA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
449
structure length
446
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Non specific mono-esterase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 160
structure length 446
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajcA00
2W5WA 4FDJA 4FDIA 4CXSA 3NVLA 3WAYA 1ANIA 4UOPA 4LRDA 4CXUA 5C66A 4UORA 3Q3QA 2IUCA 5LRNA 1ED8A 3TG0A 3CMRA 3T02A 1Y6VA 1EQJA 1N2LA 1SHNA 3NKNA 1KH5A 4YR1A 3WAWA 5L0EA 3MK2A 1ALKA 2GSNA 1K7HA 4LR8A 4GTZA 1ANJA 1ELXA 1ELYA 4NWXA 4KJGA 2W5SA 2QZUA 2XR9A 2W5RA 2IFYA 1ALJA 3IDDA 3DYCA 1AUKA 1EW9A 4LR9A 1AJDA 3KD8A 2GLQA 4LRFA 1FSUA 2G9YA 3LXQA 2VQRA 1E1ZP 3WAXA 1EJJA 1HJKA 2W5VA 3NKOA 1URAA 5DLTA 3BDGA 5EGEA 4ZG7A 4ZGAA 1KHJA 3BDHA 1KH9A 5LIAA 3NKMA 5IJSA 3B5QA 3TWZA 1O99A 1KH7A 4UPIA 3A52A 2XRGA 1Y7AA 1P49A 5K4PA 3ED4A 1SHQA 5AJ9A 4UPKA 3NKRA 4LR2A 5LRMA 4KJDA 3OT9A 2D1GA 3BDFA 3WBHA 2GSOA 5EGHA 4GTWA 1AJCA 3SZZA 2IUCB 5INHA 4UOOA 3WAVA 1HDHA 3IGZB 5GOVA 3M8YA 3NKPA 3T01A 1ALIA 4GTYA 2W5XA 3M7VA 3NKQA 1KHKA 3T00A 1ZEFA 4UPLA 4MIVA 4LRBA 4LR7A 3UN5A 1EW2A 4MY4A 5DLVA 4KAYA 5LQQA 3M8ZA 1ELZA 1KH4A 4GTXA 4B56A 4LRCA 4LQYA 3MK0A 1HQAA 4LREA 2ZKTA 2RH6A 1B8JA 4ZG9A 5L0BA 2X98A 3UN3A 4NWJA 1N2KA 4MHXA 4CYRA 5KXAA 1E33P 5L0KA 4CXKA 1EW8A 4QAXA 1KHNA 4KAVA 3SZYA 3DPCA 5DLWA 1URBA 2GSUA 4ZG6A 1EI6A 3TX0A 1KHLA 1O98A 3BDGB 4LRAA 3E2DA 4N7TA 2ANHA 3IGYB 3UNYA 3MK1A 5HRTA 4UPHA 2W5TA 1AJBA 2W5QA 5IJQA 1E3CP 1ZEBA 4CYSA 1E2SP 5TJ3A 2W8SA 4KM4A 3M8WA 1AJAA 5GRRA 1ZEDA 2W8DA 3UO0A 3UN2A 1ALHA 2GA3A 4TN0A 1ED9A
chains in the Genus database with same CATH superfamily
2W5WA 4FDJA 4FDIA 4CXSA 3NVLA 3WAYA 1ANIA 4UOPA 4LRDA 4CXUA 5C66A 4UORA 3Q3QA 2IUCA 5LRNA 1ED8A 3TG0A 3CMRA 3T02A 1Y6VA 1EQJA 1N2LA 1SHNA 3NKNA 1KH5A 4YR1A 3WAWA 5L0EA 3MK2A 1ALKA 2GSNA 1K7HA 4LR8A 4GTZA 1ANJA 1ELXA 1ELYA 4NWXA 4KJGA 2W5SA 2QZUA 2XR9A 2W5RA 2IFYA 1ALJA 3IDDA 3DYCA 1AUKA 1EW9A 4LR9A 1AJDA 3KD8A 2GLQA 4LRFA 1FSUA 2G9YA 3LXQA 2VQRA 1E1ZP 3WAXA 1EJJA 1HJKA 2W5VA 3NKOA 1URAA 5DLTA 3BDGA 5EGEA 4ZG7A 4ZGAA 1KHJA 3BDHA 1KH9A 5LIAA 3NKMA 5IJSA 3B5QA 3TWZA 1O99A 1KH7A 4UPIA 3A52A 2XRGA 1Y7AA 1P49A 5K4PA 3ED4A 1SHQA 5AJ9A 4UPKA 3NKRA 4LR2A 5LRMA 4KJDA 3OT9A 2D1GA 3BDFA 3WBHA 2GSOA 5EGHA 4GTWA 1AJCA 3SZZA 2IUCB 5INHA 4UOOA 3WAVA 1HDHA 3IGZB 5GOVA 3M8YA 3NKPA 3T01A 1ALIA 4GTYA 2W5XA 3M7VA 3NKQA 1KHKA 3T00A 1ZEFA 4UPLA 4MIVA 4LRBA 4LR7A 3UN5A 1EW2A 4MY4A 5DLVA 4KAYA 5LQQA 3M8ZA 1ELZA 1KH4A 4GTXA 4B56A 4LRCA 4LQYA 3MK0A 1HQAA 4LREA 2ZKTA 2RH6A 1B8JA 4ZG9A 5L0BA 2X98A 3UN3A 4NWJA 1N2KA 4MHXA 4CYRA 5KXAA 1E33P 5L0KA 4CXKA 1EW8A 4QAXA 1KHNA 4KAVA 3SZYA 3DPCA 5DLWA 1URBA 2GSUA 4ZG6A 1EI6A 3TX0A 1KHLA 1O98A 3BDGB 4LRAA 3E2DA 4N7TA 2ANHA 3IGYB 3UNYA 3MK1A 5HRTA 4UPHA 2W5TA 1AJBA 2W5QA 5IJQA 1E3CP 1ZEBA 4CYSA 1E2SP 5TJ3A 2W8SA 4KM4A 3M8WA 1AJAA 5GRRA 1ZEDA 2W8DA 3UO0A 3UN2A 1ALHA 2GA3A 4TN0A 1ED9A
chains in the Genus database with same CATH topology
2W5WA 4FDJA 4FDIA 4CXSA 3NVLA 3WAYA 1ANIA 4UOPA 4LRDA 4CXUA 5C66A 4UORA 3Q3QA 2IUCA 5LRNA 1ED8A 3TG0A 3CMRA 3T02A 1Y6VA 1EQJA 1N2LA 1SHNA 3NKNA 1KH5A 4YR1A 3WAWA 5L0EA 3MK2A 1ALKA 2GSNA 1K7HA 4LR8A 4GTZA 1ANJA 1ELXA 1ELYA 4NWXA 4KJGA 2W5SA 2QZUA 2XR9A 2W5RA 2IFYA 1ALJA 3IDDA 3DYCA 1AUKA 1EW9A 4LR9A 1AJDA 3KD8A 2GLQA 4LRFA 1FSUA 2G9YA 3LXQA 2VQRA 1E1ZP 3WAXA 1EJJA 1HJKA 2W5VA 3NKOA 1URAA 5DLTA 3BDGA 5EGEA 4ZG7A 4ZGAA 1KHJA 3BDHA 1KH9A 5LIAA 3NKMA 5IJSA 3B5QA 3TWZA 1O99A 1KH7A 4UPIA 3A52A 2XRGA 1Y7AA 1P49A 5K4PA 3ED4A 1SHQA 5AJ9A 4UPKA 3NKRA 4LR2A 5LRMA 4KJDA 3OT9A 2D1GA 3BDFA 3WBHA 2GSOA 5EGHA 4GTWA 1AJCA 3SZZA 2IUCB 5INHA 4UOOA 3WAVA 1HDHA 3IGZB 5GOVA 3M8YA 3NKPA 3T01A 1ALIA 4GTYA 2W5XA 3M7VA 3NKQA 1KHKA 3T00A 1ZEFA 4UPLA 4MIVA 4LRBA 4LR7A 3UN5A 1EW2A 4MY4A 5DLVA 4KAYA 5LQQA 3M8ZA 1ELZA 1KH4A 4GTXA 4B56A 4LRCA 4LQYA 3MK0A 1HQAA 4LREA 2ZKTA 2RH6A 1B8JA 4ZG9A 5L0BA 2X98A 3UN3A 4NWJA 1N2KA 4MHXA 4CYRA 5KXAA 1E33P 5L0KA 4CXKA 1EW8A 4QAXA 1KHNA 4KAVA 3SZYA 3DPCA 5DLWA 1URBA 2GSUA 4ZG6A 1EI6A 3TX0A 1KHLA 1O98A 3BDGB 4LRAA 3E2DA 4N7TA 2ANHA 3IGYB 3UNYA 3MK1A 5HRTA 4UPHA 2W5TA 1AJBA 2W5QA 5IJQA 1E3CP 1ZEBA 4CYSA 1E2SP 5TJ3A 2W8SA 4KM4A 3M8WA 1AJAA 5GRRA 1ZEDA 2W8DA 3UO0A 3UN2A 1ALHA 2GA3A 4TN0A 1ED9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W5W A;  4FDJ A;  4FDI A;  4CXS A;  3NVL A;  3WAY A;  1ANI A;  4UOP A;  4LRD A;  4CXU A;  5C66 A;  4UOR A;  3Q3Q A;  2IUC A;  5LRN A;  1ED8 A;  3TG0 A;  3CMR A;  3T02 A;  1Y6V A;  1EQJ A;  1N2L A;  1SHN A;  3NKN A;  1KH5 A;  4YR1 A;  3WAW A;  5L0E A;  3MK2 A;  1ALK A;  2GSN A;  1K7H A;  4LR8 A;  4GTZ A;  1ANJ A;  1ELX A;  1ELY A;  4NWX A;  4KJG A;  2W5S A;  2QZU A;  2XR9 A;  2W5R A;  2IFY A;  1ALJ A;  3IDD A;  3DYC A;  1AUK A;  1EW9 A;  4LR9 A;  1AJD A;  3KD8 A;  2GLQ A;  4LRF A;  1FSU A;  2G9Y A;  3LXQ A;  2VQR A;  1E1Z P;  3WAX A;  1EJJ A;  1HJK A;  2W5V A;  3NKO A;  1URA A;  5DLT A;  3BDG A;  5EGE A;  4ZG7 A;  4ZGA A;  1KHJ A;  3BDH A;  1KH9 A;  5LIA A;  3NKM A;  5IJS A;  3B5Q A;  3TWZ A;  1O99 A;  1KH7 A;  4UPI A;  3A52 A;  2XRG A;  1Y7A A;  1P49 A;  5K4P A;  3ED4 A;  1SHQ A;  5AJ9 A;  4UPK A;  3NKR A;  4LR2 A;  5LRM A;  4KJD A;  3OT9 A;  2D1G A;  3BDF A;  3WBH A;  2GSO A;  5EGH A;  4GTW A;  1AJC A;  3SZZ A;  2IUC B;  5INH A;  4UOO A;  3WAV A;  1HDH A;  3IGZ B;  5GOV A;  3M8Y A;  3NKP A;  3T01 A;  1ALI A;  4GTY A;  2W5X A;  3M7V A;  3NKQ A;  1KHK A;  3T00 A;  1ZEF A;  4UPL A;  4MIV A;  4LRB A;  4LR7 A;  3UN5 A;  1EW2 A;  4MY4 A;  5DLV A;  4KAY A;  5LQQ A;  3M8Z A;  1ELZ A;  1KH4 A;  4GTX A;  4B56 A;  4LRC A;  4LQY A;  3MK0 A;  1HQA A;  4LRE A;  2ZKT A;  2RH6 A;  1B8J A;  4ZG9 A;  5L0B A;  2X98 A;  3UN3 A;  4NWJ A;  1N2K A;  4MHX A;  4CYR A;  5KXA A;  1E33 P;  5L0K A;  4CXK A;  1EW8 A;  4QAX A;  1KHN A;  4KAV A;  3SZY A;  3DPC A;  5DLW A;  1URB A;  2GSU A;  4ZG6 A;  1EI6 A;  3TX0 A;  1KHL A;  1O98 A;  3BDG B;  4LRA A;  3E2D A;  4N7T A;  2ANH A;  3IGY B;  3UNY A;  3MK1 A;  5HRT A;  4UPH A;  2W5T A;  1AJB A;  2W5Q A;  5IJQ A;  1E3C P;  1ZEB A;  4CYS A;  1E2S P;  5TJ3 A;  2W8S A;  4KM4 A;  3M8W A;  1AJA A;  5GRR A;  1ZED A;  2W8D A;  3UO0 A;  3UN2 A;  1ALH A;  2GA3 A;  4TN0 A;  1ED9 A; 
#chains in the Genus database with same CATH topology
 2W5W A;  4FDJ A;  4FDI A;  4CXS A;  3NVL A;  3WAY A;  1ANI A;  4UOP A;  4LRD A;  4CXU A;  5C66 A;  4UOR A;  3Q3Q A;  2IUC A;  5LRN A;  1ED8 A;  3TG0 A;  3CMR A;  3T02 A;  1Y6V A;  1EQJ A;  1N2L A;  1SHN A;  3NKN A;  1KH5 A;  4YR1 A;  3WAW A;  5L0E A;  3MK2 A;  1ALK A;  2GSN A;  1K7H A;  4LR8 A;  4GTZ A;  1ANJ A;  1ELX A;  1ELY A;  4NWX A;  4KJG A;  2W5S A;  2QZU A;  2XR9 A;  2W5R A;  2IFY A;  1ALJ A;  3IDD A;  3DYC A;  1AUK A;  1EW9 A;  4LR9 A;  1AJD A;  3KD8 A;  2GLQ A;  4LRF A;  1FSU A;  2G9Y A;  3LXQ A;  2VQR A;  1E1Z P;  3WAX A;  1EJJ A;  1HJK A;  2W5V A;  3NKO A;  1URA A;  5DLT A;  3BDG A;  5EGE A;  4ZG7 A;  4ZGA A;  1KHJ A;  3BDH A;  1KH9 A;  5LIA A;  3NKM A;  5IJS A;  3B5Q A;  3TWZ A;  1O99 A;  1KH7 A;  4UPI A;  3A52 A;  2XRG A;  1Y7A A;  1P49 A;  5K4P A;  3ED4 A;  1SHQ A;  5AJ9 A;  4UPK A;  3NKR A;  4LR2 A;  5LRM A;  4KJD A;  3OT9 A;  2D1G A;  3BDF A;  3WBH A;  2GSO A;  5EGH A;  4GTW A;  1AJC A;  3SZZ A;  2IUC B;  5INH A;  4UOO A;  3WAV A;  1HDH A;  3IGZ B;  5GOV A;  3M8Y A;  3NKP A;  3T01 A;  1ALI A;  4GTY A;  2W5X A;  3M7V A;  3NKQ A;  1KHK A;  3T00 A;  1ZEF A;  4UPL A;  4MIV A;  4LRB A;  4LR7 A;  3UN5 A;  1EW2 A;  4MY4 A;  5DLV A;  4KAY A;  5LQQ A;  3M8Z A;  1ELZ A;  1KH4 A;  4GTX A;  4B56 A;  4LRC A;  4LQY A;  3MK0 A;  1HQA A;  4LRE A;  2ZKT A;  2RH6 A;  1B8J A;  4ZG9 A;  5L0B A;  2X98 A;  3UN3 A;  4NWJ A;  1N2K A;  4MHX A;  4CYR A;  5KXA A;  1E33 P;  5L0K A;  4CXK A;  1EW8 A;  4QAX A;  1KHN A;  4KAV A;  3SZY A;  3DPC A;  5DLW A;  1URB A;  2GSU A;  4ZG6 A;  1EI6 A;  3TX0 A;  1KHL A;  1O98 A;  3BDG B;  4LRA A;  3E2D A;  4N7T A;  2ANH A;  3IGY B;  3UNY A;  3MK1 A;  5HRT A;  4UPH A;  2W5T A;  1AJB A;  2W5Q A;  5IJQ A;  1E3C P;  1ZEB A;  4CYS A;  1E2S P;  5TJ3 A;  2W8S A;  4KM4 A;  3M8W A;  1AJA A;  5GRR A;  1ZED A;  2W8D A;  3UO0 A;  3UN2 A;  1ALH A;  2GA3 A;  4TN0 A;  1ED9 A; 
#chains in the Genus database with same CATH homology
 2W5W A;  4FDJ A;  4FDI A;  4CXS A;  3NVL A;  3WAY A;  1ANI A;  4UOP A;  4LRD A;  4CXU A;  5C66 A;  4UOR A;  3Q3Q A;  2IUC A;  5LRN A;  1ED8 A;  3TG0 A;  3CMR A;  3T02 A;  1Y6V A;  1EQJ A;  1N2L A;  1SHN A;  3NKN A;  1KH5 A;  4YR1 A;  3WAW A;  5L0E A;  3MK2 A;  1ALK A;  2GSN A;  1K7H A;  4LR8 A;  4GTZ A;  1ANJ A;  1ELX A;  1ELY A;  4NWX A;  4KJG A;  2W5S A;  2QZU A;  2XR9 A;  2W5R A;  2IFY A;  1ALJ A;  3IDD A;  3DYC A;  1AUK A;  1EW9 A;  4LR9 A;  1AJD A;  3KD8 A;  2GLQ A;  4LRF A;  1FSU A;  2G9Y A;  3LXQ A;  2VQR A;  1E1Z P;  3WAX A;  1EJJ A;  1HJK A;  2W5V A;  3NKO A;  1URA A;  5DLT A;  3BDG A;  5EGE A;  4ZG7 A;  4ZGA A;  1KHJ A;  3BDH A;  1KH9 A;  5LIA A;  3NKM A;  5IJS A;  3B5Q A;  3TWZ A;  1O99 A;  1KH7 A;  4UPI A;  3A52 A;  2XRG A;  1Y7A A;  1P49 A;  5K4P A;  3ED4 A;  1SHQ A;  5AJ9 A;  4UPK A;  3NKR A;  4LR2 A;  5LRM A;  4KJD A;  3OT9 A;  2D1G A;  3BDF A;  3WBH A;  2GSO A;  5EGH A;  4GTW A;  1AJC A;  3SZZ A;  2IUC B;  5INH A;  4UOO A;  3WAV A;  1HDH A;  3IGZ B;  5GOV A;  3M8Y A;  3NKP A;  3T01 A;  1ALI A;  4GTY A;  2W5X A;  3M7V A;  3NKQ A;  1KHK A;  3T00 A;  1ZEF A;  4UPL A;  4MIV A;  4LRB A;  4LR7 A;  3UN5 A;  1EW2 A;  4MY4 A;  5DLV A;  4KAY A;  5LQQ A;  3M8Z A;  1ELZ A;  1KH4 A;  4GTX A;  4B56 A;  4LRC A;  4LQY A;  3MK0 A;  1HQA A;  4LRE A;  2ZKT A;  2RH6 A;  1B8J A;  4ZG9 A;  5L0B A;  2X98 A;  3UN3 A;  4NWJ A;  1N2K A;  4MHX A;  4CYR A;  5KXA A;  1E33 P;  5L0K A;  4CXK A;  1EW8 A;  4QAX A;  1KHN A;  4KAV A;  3SZY A;  3DPC A;  5DLW A;  1URB A;  2GSU A;  4ZG6 A;  1EI6 A;  3TX0 A;  1KHL A;  1O98 A;  3BDG B;  4LRA A;  3E2D A;  4N7T A;  2ANH A;  3IGY B;  3UNY A;  3MK1 A;  5HRT A;  4UPH A;  2W5T A;  1AJB A;  2W5Q A;  5IJQ A;  1E3C P;  1ZEB A;  4CYS A;  1E2S P;  5TJ3 A;  2W8S A;  4KM4 A;  3M8W A;  1AJA A;  5GRR A;  1ZED A;  2W8D A;  3UO0 A;  3UN2 A;  1ALH A;  2GA3 A;  4TN0 A;  1ED9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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