1ALJA

Alkaline phosphatase mutant (h412n)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
molecule tags Hydrolase (phosphoric monoester)
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aljA00
1EW8A 3BDGB 1O99A 3UN3A 2IFYA 3LXQA 4GTZA 4LQYA 4UPKA 4CYSA 1KH4A 2XRGA 5IJSA 1SHNA 4B56A 5DLVA 1E1ZP 2W5TA 2XR9A 5DLTA 4UOOA 5LIAA 2IUCA 3WAWA 3MK2A 5KXAA 4KAVA 1URAA 1EI6A 5EGHA 2W8DA 3TX0A 3UO0A 1KHKA 3BDFA 2QZUA 2W8SA 5L0KA 4QAXA 4FDIA 1KHJA 3IGYB 5L0BA 1ALHA 3WAYA 2W5WA 2RH6A 1Y7AA 3T00A 4ZGAA 2X98A 1HQAA 3UN5A 4MHXA 1ALIA 1ZEFA 1K7HA 1SHQA 1ED9A 4UORA 4UPHA 3M8YA 5L0EA 5GRRA 2GA3A 1N2LA 1EJJA 5GOVA 4KJGA 3IGZB 5TJ3A 2GSUA 3NKRA 2D1GA 3ED4A 1B8JA 1AJAA 1KHNA 3NVLA 1ELXA 4GTXA 5IJQA 1ELYA 1AUKA 3M8ZA 1N2KA 3BDHA 3DYCA 4FDJA 5AJ9A 3M7VA 3KD8A 3UNYA 4ZG6A 4CXSA 1AJBA 4LR8A 1ANJA 1KH5A 1KH9A 4N7TA 4NWXA 4NWJA 3WAVA 5LQQA 4LRFA 2ZKTA 3MK1A 3MK0A 3UN2A 3IDDA 4GTYA 2W5RA 2VQRA 4MIVA 2IUCB 3T02A 4LR7A 1Y6VA 4LRBA 4LR2A 4ZG9A 3A52A 1ALKA 5LRNA 1HDHA 4CXUA 3NKMA 3WBHA 3E2DA 1E2SP 3BDGA 3NKPA 4LREA 3NKOA 1ED8A 1ZEBA 4LRCA 3OT9A 1EW2A 4YR1A 2GLQA 1P49A 1O98A 3NKQA 1KHLA 1AJDA 3WAXA 1HJKA 3B5QA 4CXKA 1ANIA 1ALJA 4KM4A 4KAYA 2GSNA 3NKNA 4ZG7A 1URBA 4UOPA 3SZZA 1AJCA 2G9YA 1ELZA 4GTWA 4UPIA 5EGEA 1E3CP 2W5VA 4LRAA 4TN0A 1ZEDA 5C66A 2W5SA 2W5XA 3SZYA 3TWZA 4LR9A 3DPCA 1EW9A 1FSUA 1KH7A 2W5QA 5DLWA 1EQJA 3TG0A 5LRMA 4CYRA 4UPLA 3M8WA 1E33P 2ANHA 5INHA 3CMRA 3Q3QA 5K4PA 2GSOA 4LRDA 4KJDA 5HRTA 4MY4A 3T01A
chains in the Genus database with same CATH superfamily
1EW8A 3BDGB 1O99A 3UN3A 2IFYA 3LXQA 4GTZA 4LQYA 4UPKA 4CYSA 1KH4A 2XRGA 5IJSA 1SHNA 4B56A 5DLVA 1E1ZP 2W5TA 2XR9A 5DLTA 4UOOA 5LIAA 2IUCA 3WAWA 3MK2A 5KXAA 4KAVA 1URAA 1EI6A 5EGHA 2W8DA 3TX0A 3UO0A 1KHKA 3BDFA 2QZUA 2W8SA 5L0KA 4QAXA 4FDIA 1KHJA 3IGYB 5L0BA 1ALHA 3WAYA 2W5WA 2RH6A 1Y7AA 3T00A 4ZGAA 2X98A 1HQAA 3UN5A 4MHXA 1ALIA 1ZEFA 1K7HA 1SHQA 1ED9A 4UORA 4UPHA 3M8YA 5L0EA 5GRRA 2GA3A 1N2LA 1EJJA 5GOVA 4KJGA 3IGZB 5TJ3A 2GSUA 3NKRA 2D1GA 3ED4A 1B8JA 1AJAA 1KHNA 3NVLA 1ELXA 4GTXA 5IJQA 1ELYA 1AUKA 3M8ZA 1N2KA 3BDHA 3DYCA 4FDJA 5AJ9A 3M7VA 3KD8A 3UNYA 4ZG6A 4CXSA 1AJBA 4LR8A 1ANJA 1KH5A 1KH9A 4N7TA 4NWXA 4NWJA 3WAVA 5LQQA 4LRFA 2ZKTA 3MK1A 3MK0A 3UN2A 3IDDA 4GTYA 2W5RA 2VQRA 4MIVA 2IUCB 3T02A 4LR7A 1Y6VA 4LRBA 4LR2A 4ZG9A 3A52A 1ALKA 5LRNA 1HDHA 4CXUA 3NKMA 3WBHA 3E2DA 1E2SP 3BDGA 3NKPA 4LREA 3NKOA 1ED8A 1ZEBA 4LRCA 3OT9A 1EW2A 4YR1A 2GLQA 1P49A 1O98A 3NKQA 1KHLA 1AJDA 3WAXA 1HJKA 3B5QA 4CXKA 1ANIA 1ALJA 4KM4A 4KAYA 2GSNA 3NKNA 4ZG7A 1URBA 4UOPA 3SZZA 1AJCA 2G9YA 1ELZA 4GTWA 4UPIA 5EGEA 1E3CP 2W5VA 4LRAA 4TN0A 1ZEDA 5C66A 2W5SA 2W5XA 3SZYA 3TWZA 4LR9A 3DPCA 1EW9A 1FSUA 1KH7A 2W5QA 5DLWA 1EQJA 3TG0A 5LRMA 4CYRA 4UPLA 3M8WA 1E33P 2ANHA 5INHA 3CMRA 3Q3QA 5K4PA 2GSOA 4LRDA 4KJDA 5HRTA 4MY4A 3T01A
chains in the Genus database with same CATH topology
1EW8A 3BDGB 1O99A 3UN3A 2IFYA 3LXQA 4GTZA 4LQYA 4UPKA 4CYSA 1KH4A 2XRGA 5IJSA 1SHNA 4B56A 5DLVA 1E1ZP 2W5TA 2XR9A 5DLTA 4UOOA 5LIAA 2IUCA 3WAWA 3MK2A 5KXAA 4KAVA 1URAA 1EI6A 5EGHA 2W8DA 3TX0A 3UO0A 1KHKA 3BDFA 2QZUA 2W8SA 5L0KA 4QAXA 4FDIA 1KHJA 3IGYB 5L0BA 1ALHA 3WAYA 2W5WA 2RH6A 1Y7AA 3T00A 4ZGAA 2X98A 1HQAA 3UN5A 4MHXA 1ALIA 1ZEFA 1K7HA 1SHQA 1ED9A 4UORA 4UPHA 3M8YA 5L0EA 5GRRA 2GA3A 1N2LA 1EJJA 5GOVA 4KJGA 3IGZB 5TJ3A 2GSUA 3NKRA 2D1GA 3ED4A 1B8JA 1AJAA 1KHNA 3NVLA 1ELXA 4GTXA 5IJQA 1ELYA 1AUKA 3M8ZA 1N2KA 3BDHA 3DYCA 4FDJA 5AJ9A 3M7VA 3KD8A 3UNYA 4ZG6A 4CXSA 1AJBA 4LR8A 1ANJA 1KH5A 1KH9A 4N7TA 4NWXA 4NWJA 3WAVA 5LQQA 4LRFA 2ZKTA 3MK1A 3MK0A 3UN2A 3IDDA 4GTYA 2W5RA 2VQRA 4MIVA 2IUCB 3T02A 4LR7A 1Y6VA 4LRBA 4LR2A 4ZG9A 3A52A 1ALKA 5LRNA 1HDHA 4CXUA 3NKMA 3WBHA 3E2DA 1E2SP 3BDGA 3NKPA 4LREA 3NKOA 1ED8A 1ZEBA 4LRCA 3OT9A 1EW2A 4YR1A 2GLQA 1P49A 1O98A 3NKQA 1KHLA 1AJDA 3WAXA 1HJKA 3B5QA 4CXKA 1ANIA 1ALJA 4KM4A 4KAYA 2GSNA 3NKNA 4ZG7A 1URBA 4UOPA 3SZZA 1AJCA 2G9YA 1ELZA 4GTWA 4UPIA 5EGEA 1E3CP 2W5VA 4LRAA 4TN0A 1ZEDA 5C66A 2W5SA 2W5XA 3SZYA 3TWZA 4LR9A 3DPCA 1EW9A 1FSUA 1KH7A 2W5QA 5DLWA 1EQJA 3TG0A 5LRMA 4CYRA 4UPLA 3M8WA 1E33P 2ANHA 5INHA 3CMRA 3Q3QA 5K4PA 2GSOA 4LRDA 4KJDA 5HRTA 4MY4A 3T01A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EW8 A;  3BDG B;  1O99 A;  3UN3 A;  2IFY A;  3LXQ A;  4GTZ A;  4LQY A;  4UPK A;  4CYS A;  1KH4 A;  2XRG A;  5IJS A;  1SHN A;  4B56 A;  5DLV A;  1E1Z P;  2W5T A;  2XR9 A;  5DLT A;  4UOO A;  5LIA A;  2IUC A;  3WAW A;  3MK2 A;  5KXA A;  4KAV A;  1URA A;  1EI6 A;  5EGH A;  2W8D A;  3TX0 A;  3UO0 A;  1KHK A;  3BDF A;  2QZU A;  2W8S A;  5L0K A;  4QAX A;  4FDI A;  1KHJ A;  3IGY B;  5L0B A;  1ALH A;  3WAY A;  2W5W A;  2RH6 A;  1Y7A A;  3T00 A;  4ZGA A;  2X98 A;  1HQA A;  3UN5 A;  4MHX A;  1ALI A;  1ZEF A;  1K7H A;  1SHQ A;  1ED9 A;  4UOR A;  4UPH A;  3M8Y A;  5L0E A;  5GRR A;  2GA3 A;  1N2L A;  1EJJ A;  5GOV A;  4KJG A;  3IGZ B;  5TJ3 A;  2GSU A;  3NKR A;  2D1G A;  3ED4 A;  1B8J A;  1AJA A;  1KHN A;  3NVL A;  1ELX A;  4GTX A;  5IJQ A;  1ELY A;  1AUK A;  3M8Z A;  1N2K A;  3BDH A;  3DYC A;  4FDJ A;  5AJ9 A;  3M7V A;  3KD8 A;  3UNY A;  4ZG6 A;  4CXS A;  1AJB A;  4LR8 A;  1ANJ A;  1KH5 A;  1KH9 A;  4N7T A;  4NWX A;  4NWJ A;  3WAV A;  5LQQ A;  4LRF A;  2ZKT A;  3MK1 A;  3MK0 A;  3UN2 A;  3IDD A;  4GTY A;  2W5R A;  2VQR A;  4MIV A;  2IUC B;  3T02 A;  4LR7 A;  1Y6V A;  4LRB A;  4LR2 A;  4ZG9 A;  3A52 A;  1ALK A;  5LRN A;  1HDH A;  4CXU A;  3NKM A;  3WBH A;  3E2D A;  1E2S P;  3BDG A;  3NKP A;  4LRE A;  3NKO A;  1ED8 A;  1ZEB A;  4LRC A;  3OT9 A;  1EW2 A;  4YR1 A;  2GLQ A;  1P49 A;  1O98 A;  3NKQ A;  1KHL A;  1AJD A;  3WAX A;  1HJK A;  3B5Q A;  4CXK A;  1ANI A;  1ALJ A;  4KM4 A;  4KAY A;  2GSN A;  3NKN A;  4ZG7 A;  1URB A;  4UOP A;  3SZZ A;  1AJC A;  2G9Y A;  1ELZ A;  4GTW A;  4UPI A;  5EGE A;  1E3C P;  2W5V A;  4LRA A;  4TN0 A;  1ZED A;  5C66 A;  2W5S A;  2W5X A;  3SZY A;  3TWZ A;  4LR9 A;  3DPC A;  1EW9 A;  1FSU A;  1KH7 A;  2W5Q A;  5DLW A;  1EQJ A;  3TG0 A;  5LRM A;  4CYR A;  4UPL A;  3M8W A;  1E33 P;  2ANH A;  5INH A;  3CMR A;  3Q3Q A;  5K4P A;  2GSO A;  4LRD A;  4KJD A;  5HRT A;  4MY4 A;  3T01 A; 
#chains in the Genus database with same CATH topology
 1EW8 A;  3BDG B;  1O99 A;  3UN3 A;  2IFY A;  3LXQ A;  4GTZ A;  4LQY A;  4UPK A;  4CYS A;  1KH4 A;  2XRG A;  5IJS A;  1SHN A;  4B56 A;  5DLV A;  1E1Z P;  2W5T A;  2XR9 A;  5DLT A;  4UOO A;  5LIA A;  2IUC A;  3WAW A;  3MK2 A;  5KXA A;  4KAV A;  1URA A;  1EI6 A;  5EGH A;  2W8D A;  3TX0 A;  3UO0 A;  1KHK A;  3BDF A;  2QZU A;  2W8S A;  5L0K A;  4QAX A;  4FDI A;  1KHJ A;  3IGY B;  5L0B A;  1ALH A;  3WAY A;  2W5W A;  2RH6 A;  1Y7A A;  3T00 A;  4ZGA A;  2X98 A;  1HQA A;  3UN5 A;  4MHX A;  1ALI A;  1ZEF A;  1K7H A;  1SHQ A;  1ED9 A;  4UOR A;  4UPH A;  3M8Y A;  5L0E A;  5GRR A;  2GA3 A;  1N2L A;  1EJJ A;  5GOV A;  4KJG A;  3IGZ B;  5TJ3 A;  2GSU A;  3NKR A;  2D1G A;  3ED4 A;  1B8J A;  1AJA A;  1KHN A;  3NVL A;  1ELX A;  4GTX A;  5IJQ A;  1ELY A;  1AUK A;  3M8Z A;  1N2K A;  3BDH A;  3DYC A;  4FDJ A;  5AJ9 A;  3M7V A;  3KD8 A;  3UNY A;  4ZG6 A;  4CXS A;  1AJB A;  4LR8 A;  1ANJ A;  1KH5 A;  1KH9 A;  4N7T A;  4NWX A;  4NWJ A;  3WAV A;  5LQQ A;  4LRF A;  2ZKT A;  3MK1 A;  3MK0 A;  3UN2 A;  3IDD A;  4GTY A;  2W5R A;  2VQR A;  4MIV A;  2IUC B;  3T02 A;  4LR7 A;  1Y6V A;  4LRB A;  4LR2 A;  4ZG9 A;  3A52 A;  1ALK A;  5LRN A;  1HDH A;  4CXU A;  3NKM A;  3WBH A;  3E2D A;  1E2S P;  3BDG A;  3NKP A;  4LRE A;  3NKO A;  1ED8 A;  1ZEB A;  4LRC A;  3OT9 A;  1EW2 A;  4YR1 A;  2GLQ A;  1P49 A;  1O98 A;  3NKQ A;  1KHL A;  1AJD A;  3WAX A;  1HJK A;  3B5Q A;  4CXK A;  1ANI A;  1ALJ A;  4KM4 A;  4KAY A;  2GSN A;  3NKN A;  4ZG7 A;  1URB A;  4UOP A;  3SZZ A;  1AJC A;  2G9Y A;  1ELZ A;  4GTW A;  4UPI A;  5EGE A;  1E3C P;  2W5V A;  4LRA A;  4TN0 A;  1ZED A;  5C66 A;  2W5S A;  2W5X A;  3SZY A;  3TWZ A;  4LR9 A;  3DPC A;  1EW9 A;  1FSU A;  1KH7 A;  2W5Q A;  5DLW A;  1EQJ A;  3TG0 A;  5LRM A;  4CYR A;  4UPL A;  3M8W A;  1E33 P;  2ANH A;  5INH A;  3CMR A;  3Q3Q A;  5K4P A;  2GSO A;  4LRD A;  4KJD A;  5HRT A;  4MY4 A;  3T01 A; 
#chains in the Genus database with same CATH homology
 1EW8 A;  3BDG B;  1O99 A;  3UN3 A;  2IFY A;  3LXQ A;  4GTZ A;  4LQY A;  4UPK A;  4CYS A;  1KH4 A;  2XRG A;  5IJS A;  1SHN A;  4B56 A;  5DLV A;  1E1Z P;  2W5T A;  2XR9 A;  5DLT A;  4UOO A;  5LIA A;  2IUC A;  3WAW A;  3MK2 A;  5KXA A;  4KAV A;  1URA A;  1EI6 A;  5EGH A;  2W8D A;  3TX0 A;  3UO0 A;  1KHK A;  3BDF A;  2QZU A;  2W8S A;  5L0K A;  4QAX A;  4FDI A;  1KHJ A;  3IGY B;  5L0B A;  1ALH A;  3WAY A;  2W5W A;  2RH6 A;  1Y7A A;  3T00 A;  4ZGA A;  2X98 A;  1HQA A;  3UN5 A;  4MHX A;  1ALI A;  1ZEF A;  1K7H A;  1SHQ A;  1ED9 A;  4UOR A;  4UPH A;  3M8Y A;  5L0E A;  5GRR A;  2GA3 A;  1N2L A;  1EJJ A;  5GOV A;  4KJG A;  3IGZ B;  5TJ3 A;  2GSU A;  3NKR A;  2D1G A;  3ED4 A;  1B8J A;  1AJA A;  1KHN A;  3NVL A;  1ELX A;  4GTX A;  5IJQ A;  1ELY A;  1AUK A;  3M8Z A;  1N2K A;  3BDH A;  3DYC A;  4FDJ A;  5AJ9 A;  3M7V A;  3KD8 A;  3UNY A;  4ZG6 A;  4CXS A;  1AJB A;  4LR8 A;  1ANJ A;  1KH5 A;  1KH9 A;  4N7T A;  4NWX A;  4NWJ A;  3WAV A;  5LQQ A;  4LRF A;  2ZKT A;  3MK1 A;  3MK0 A;  3UN2 A;  3IDD A;  4GTY A;  2W5R A;  2VQR A;  4MIV A;  2IUC B;  3T02 A;  4LR7 A;  1Y6V A;  4LRB A;  4LR2 A;  4ZG9 A;  3A52 A;  1ALK A;  5LRN A;  1HDH A;  4CXU A;  3NKM A;  3WBH A;  3E2D A;  1E2S P;  3BDG A;  3NKP A;  4LRE A;  3NKO A;  1ED8 A;  1ZEB A;  4LRC A;  3OT9 A;  1EW2 A;  4YR1 A;  2GLQ A;  1P49 A;  1O98 A;  3NKQ A;  1KHL A;  1AJD A;  3WAX A;  1HJK A;  3B5Q A;  4CXK A;  1ANI A;  1ALJ A;  4KM4 A;  4KAY A;  2GSN A;  3NKN A;  4ZG7 A;  1URB A;  4UOP A;  3SZZ A;  1AJC A;  2G9Y A;  1ELZ A;  4GTW A;  4UPI A;  5EGE A;  1E3C P;  2W5V A;  4LRA A;  4TN0 A;  1ZED A;  5C66 A;  2W5S A;  2W5X A;  3SZY A;  3TWZ A;  4LR9 A;  3DPC A;  1EW9 A;  1FSU A;  1KH7 A;  2W5Q A;  5DLW A;  1EQJ A;  3TG0 A;  5LRM A;  4CYR A;  4UPL A;  3M8W A;  1E33 P;  2ANH A;  5INH A;  3CMR A;  3Q3Q A;  5K4P A;  2GSO A;  4LRD A;  4KJD A;  5HRT A;  4MY4 A;  3T01 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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