1ANJ | Genus

Total Genus 160

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	160
Knots found	KnotProt 2.0: S +3₁
sequence length	446
structure length	446
Chain Sequence	MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDHQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

publication title	Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases. pubmed doi rcsb
molecule keywords	ALKALINE PHOSPHATASE
molecule tags	Alkaline phosphatase
source organism	Escherichia coli
total genus	160
structure length	446
sequence length	446
chains with identical sequence	B
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	1995-09-06

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1anjA00

1ELYA 1KH9A 3OT9A 4LRCA 3DYCA 4LR7A 2RH6A 3T02A 3UNYA 1URAA 5LRMA 2W5XA 2XR9A 1E3CP 3TG0A 3MK2A 4UPLA 1EJJA 1KHNA 2IUCA 4KM4A 4CYSA 4ZG6A 2X98A 2VQRA 4GTWA 4LR8A 3SZZA 4LR9A 2W5QA 1EW8A 3M8ZA 3E2DA 1Y6VA 3UN2A 3UN5A 4MHXA 1ANIA 4GTYA 4GTZA 1AUKA 3TWZA 4GTXA 1FSUA 1E2SP 1HJKA 1KH7A 3WAYA 1N2KA 1AJDA 3BDGA 2GSOA 5DLTA 4ZG9A 4LRBA 4FDJA 3WAWA 3IGYB 5L0BA 4LRDA 1ALIA 4LRFA 2ZKTA 5GRRA 3LXQA 1KH4A 1ED8A 3ED4A 4FDIA 3WAXA 1ANJA 3MK0A 2D1GA 1ALJA 2GSNA 3KD8A 5TJ3A 1EI6A 1ALHA 5L0KA 5LQQA 3B5QA 2IFYA 3NKPA 3NKRA 2W5TA 1KH5A 3WBHA 1SHNA 2IUCB 4NWXA 3SZYA 2GSUA 3TX0A 3M8WA 4CYRA 5IJQA 5EGEA 4CXUA 5HRTA 2XRGA 3M8YA 4KJDA 1EW2A 2ANHA 1B8JA 5LIAA 1K7HA 5K4PA 5L0EA 3T01A 2W8SA 2W5RA 3MK1A 4QAXA 4CXKA 1URBA 3A52A 3UO0A 1ED9A 1EQJA 3NVLA 4MIVA 4MY4A 1ZEFA 1KHLA 1ELZA 2QZUA 4LR2A 3IGZB 2W5SA 4KAVA 1EW9A 3WAVA 3T00A 1HQAA 2W8DA 4ZG7A 3BDGB 2W5VA 2W5WA 3M7VA 4KJGA 1KHJA 4UPKA 3NKNA 4LRAA 5GOVA 5AJ9A 3BDHA 3BDFA 1E33P 1SHQA 3DPCA 3NKMA 2G9YA 2GLQA 3Q3QA 4TN0A 5C66A 5LRNA 3CMRA 4UORA 1HDHA 3NKOA 5DLVA 4NWJA 4LREA 1O99A 5INHA 1ZEDA 4UOOA 1N2LA 1P49A 1ALKA 1KHKA 1E1ZP 3NKQA 4UOPA 5KXAA 4YR1A 4UPIA 1AJBA 5DLWA 4ZGAA 1O98A 1AJCA 5EGHA 2GA3A 5IJSA 3UN3A 4B56A 3IDDA 1ELXA 4KAYA 1ZEBA 1AJAA 4LQYA 4CXSA 4N7TA 4UPHA 1Y7AA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1ELY A;  1KH9 A;  3OT9 A;  4LRC A;  3DYC A;  4LR7 A;  2RH6 A;  3T02 A;  3UNY A;  1URA A;  5LRM A;  2W5X A;  2XR9 A;  1E3C P;  3TG0 A;  3MK2 A;  4UPL A;  1EJJ A;  1KHN A;  2IUC A;  4KM4 A;  4CYS A;  4ZG6 A;  2X98 A;  2VQR A;  4GTW A;  4LR8 A;  3SZZ A;  4LR9 A;  2W5Q A;  1EW8 A;  3M8Z A;  3E2D A;  1Y6V A;  3UN2 A;  3UN5 A;  4MHX A;  1ANI A;  4GTY A;  4GTZ A;  1AUK A;  3TWZ A;  4GTX A;  1FSU A;  1E2S P;  1HJK A;  1KH7 A;  3WAY A;  1N2K A;  1AJD A;  3BDG A;  2GSO A;  5DLT A;  4ZG9 A;  4LRB A;  4FDJ A;  3WAW A;  3IGY B;  5L0B A;  4LRD A;  1ALI A;  4LRF A;  2ZKT A;  5GRR A;  3LXQ A;  1KH4 A;  1ED8 A;  3ED4 A;  4FDI A;  3WAX A;  1ANJ A;  3MK0 A;  2D1G A;  1ALJ A;  2GSN A;  3KD8 A;  5TJ3 A;  1EI6 A;  1ALH A;  5L0K A;  5LQQ A;  3B5Q A;  2IFY A;  3NKP A;  3NKR A;  2W5T A;  1KH5 A;  3WBH A;  1SHN A;  2IUC B;  4NWX A;  3SZY A;  2GSU A;  3TX0 A;  3M8W A;  4CYR A;  5IJQ A;  5EGE A;  4CXU A;  5HRT A;  2XRG A;  3M8Y A;  4KJD A;  1EW2 A;  2ANH A;  1B8J A;  5LIA A;  1K7H A;  5K4P A;  5L0E A;  3T01 A;  2W8S A;  2W5R A;  3MK1 A;  4QAX A;  4CXK A;  1URB A;  3A52 A;  3UO0 A;  1ED9 A;  1EQJ A;  3NVL A;  4MIV A;  4MY4 A;  1ZEF A;  1KHL A;  1ELZ A;  2QZU A;  4LR2 A;  3IGZ B;  2W5S A;  4KAV A;  1EW9 A;  3WAV A;  3T00 A;  1HQA A;  2W8D A;  4ZG7 A;  3BDG B;  2W5V A;  2W5W A;  3M7V A;  4KJG A;  1KHJ A;  4UPK A;  3NKN A;  4LRA A;  5GOV A;  5AJ9 A;  3BDH A;  3BDF A;  1E33 P;  1SHQ A;  3DPC A;  3NKM A;  2G9Y A;  2GLQ A;  3Q3Q A;  4TN0 A;  5C66 A;  5LRN A;  3CMR A;  4UOR A;  1HDH A;  3NKO A;  5DLV A;  4NWJ A;  4LRE A;  1O99 A;  5INH A;  1ZED A;  4UOO A;  1N2L A;  1P49 A;  1ALK A;  1KHK A;  1E1Z P;  3NKQ A;  4UOP A;  5KXA A;  4YR1 A;  4UPI A;  1AJB A;  5DLW A;  4ZGA A;  1O98 A;  1AJC A;  5EGH A;  2GA3 A;  5IJS A;  3UN3 A;  4B56 A;  3IDD A;  1ELX A;  4KAY A;  1ZEB A;  1AJA A;  4LQY A;  4CXS A;  4N7T A;  4UPH A;  1Y7A A; 
#chains in the Genus database with same CATH topology
 1ELY A;  1KH9 A;  3OT9 A;  4LRC A;  3DYC A;  4LR7 A;  2RH6 A;  3T02 A;  3UNY A;  1URA A;  5LRM A;  2W5X A;  2XR9 A;  1E3C P;  3TG0 A;  3MK2 A;  4UPL A;  1EJJ A;  1KHN A;  2IUC A;  4KM4 A;  4CYS A;  4ZG6 A;  2X98 A;  2VQR A;  4GTW A;  4LR8 A;  3SZZ A;  4LR9 A;  2W5Q A;  1EW8 A;  3M8Z A;  3E2D A;  1Y6V A;  3UN2 A;  3UN5 A;  4MHX A;  1ANI A;  4GTY A;  4GTZ A;  1AUK A;  3TWZ A;  4GTX A;  1FSU A;  1E2S P;  1HJK A;  1KH7 A;  3WAY A;  1N2K A;  1AJD A;  3BDG A;  2GSO A;  5DLT A;  4ZG9 A;  4LRB A;  4FDJ A;  3WAW A;  3IGY B;  5L0B A;  4LRD A;  1ALI A;  4LRF A;  2ZKT A;  5GRR A;  3LXQ A;  1KH4 A;  1ED8 A;  3ED4 A;  4FDI A;  3WAX A;  1ANJ A;  3MK0 A;  2D1G A;  1ALJ A;  2GSN A;  3KD8 A;  5TJ3 A;  1EI6 A;  1ALH A;  5L0K A;  5LQQ A;  3B5Q A;  2IFY A;  3NKP A;  3NKR A;  2W5T A;  1KH5 A;  3WBH A;  1SHN A;  2IUC B;  4NWX A;  3SZY A;  2GSU A;  3TX0 A;  3M8W A;  4CYR A;  5IJQ A;  5EGE A;  4CXU A;  5HRT A;  2XRG A;  3M8Y A;  4KJD A;  1EW2 A;  2ANH A;  1B8J A;  5LIA A;  1K7H A;  5K4P A;  5L0E A;  3T01 A;  2W8S A;  2W5R A;  3MK1 A;  4QAX A;  4CXK A;  1URB A;  3A52 A;  3UO0 A;  1ED9 A;  1EQJ A;  3NVL A;  4MIV A;  4MY4 A;  1ZEF A;  1KHL A;  1ELZ A;  2QZU A;  4LR2 A;  3IGZ B;  2W5S A;  4KAV A;  1EW9 A;  3WAV A;  3T00 A;  1HQA A;  2W8D A;  4ZG7 A;  3BDG B;  2W5V A;  2W5W A;  3M7V A;  4KJG A;  1KHJ A;  4UPK A;  3NKN A;  4LRA A;  5GOV A;  5AJ9 A;  3BDH A;  3BDF A;  1E33 P;  1SHQ A;  3DPC A;  3NKM A;  2G9Y A;  2GLQ A;  3Q3Q A;  4TN0 A;  5C66 A;  5LRN A;  3CMR A;  4UOR A;  1HDH A;  3NKO A;  5DLV A;  4NWJ A;  4LRE A;  1O99 A;  5INH A;  1ZED A;  4UOO A;  1N2L A;  1P49 A;  1ALK A;  1KHK A;  1E1Z P;  3NKQ A;  4UOP A;  5KXA A;  4YR1 A;  4UPI A;  1AJB A;  5DLW A;  4ZGA A;  1O98 A;  1AJC A;  5EGH A;  2GA3 A;  5IJS A;  3UN3 A;  4B56 A;  3IDD A;  1ELX A;  4KAY A;  1ZEB A;  1AJA A;  4LQY A;  4CXS A;  4N7T A;  4UPH A;  1Y7A A; 
#chains in the Genus database with same CATH homology
 1ELY A;  1KH9 A;  3OT9 A;  4LRC A;  3DYC A;  4LR7 A;  2RH6 A;  3T02 A;  3UNY A;  1URA A;  5LRM A;  2W5X A;  2XR9 A;  1E3C P;  3TG0 A;  3MK2 A;  4UPL A;  1EJJ A;  1KHN A;  2IUC A;  4KM4 A;  4CYS A;  4ZG6 A;  2X98 A;  2VQR A;  4GTW A;  4LR8 A;  3SZZ A;  4LR9 A;  2W5Q A;  1EW8 A;  3M8Z A;  3E2D A;  1Y6V A;  3UN2 A;  3UN5 A;  4MHX A;  1ANI A;  4GTY A;  4GTZ A;  1AUK A;  3TWZ A;  4GTX A;  1FSU A;  1E2S P;  1HJK A;  1KH7 A;  3WAY A;  1N2K A;  1AJD A;  3BDG A;  2GSO A;  5DLT A;  4ZG9 A;  4LRB A;  4FDJ A;  3WAW A;  3IGY B;  5L0B A;  4LRD A;  1ALI A;  4LRF A;  2ZKT A;  5GRR A;  3LXQ A;  1KH4 A;  1ED8 A;  3ED4 A;  4FDI A;  3WAX A;  1ANJ A;  3MK0 A;  2D1G A;  1ALJ A;  2GSN A;  3KD8 A;  5TJ3 A;  1EI6 A;  1ALH A;  5L0K A;  5LQQ A;  3B5Q A;  2IFY A;  3NKP A;  3NKR A;  2W5T A;  1KH5 A;  3WBH A;  1SHN A;  2IUC B;  4NWX A;  3SZY A;  2GSU A;  3TX0 A;  3M8W A;  4CYR A;  5IJQ A;  5EGE A;  4CXU A;  5HRT A;  2XRG A;  3M8Y A;  4KJD A;  1EW2 A;  2ANH A;  1B8J A;  5LIA A;  1K7H A;  5K4P A;  5L0E A;  3T01 A;  2W8S A;  2W5R A;  3MK1 A;  4QAX A;  4CXK A;  1URB A;  3A52 A;  3UO0 A;  1ED9 A;  1EQJ A;  3NVL A;  4MIV A;  4MY4 A;  1ZEF A;  1KHL A;  1ELZ A;  2QZU A;  4LR2 A;  3IGZ B;  2W5S A;  4KAV A;  1EW9 A;  3WAV A;  3T00 A;  1HQA A;  2W8D A;  4ZG7 A;  3BDG B;  2W5V A;  2W5W A;  3M7V A;  4KJG A;  1KHJ A;  4UPK A;  3NKN A;  4LRA A;  5GOV A;  5AJ9 A;  3BDH A;  3BDF A;  1E33 P;  1SHQ A;  3DPC A;  3NKM A;  2G9Y A;  2GLQ A;  3Q3Q A;  4TN0 A;  5C66 A;  5LRN A;  3CMR A;  4UOR A;  1HDH A;  3NKO A;  5DLV A;  4NWJ A;  4LRE A;  1O99 A;  5INH A;  1ZED A;  4UOO A;  1N2L A;  1P49 A;  1ALK A;  1KHK A;  1E1Z P;  3NKQ A;  4UOP A;  5KXA A;  4YR1 A;  4UPI A;  1AJB A;  5DLW A;  4ZGA A;  1O98 A;  1AJC A;  5EGH A;  2GA3 A;  5IJS A;  3UN3 A;  4B56 A;  3IDD A;  1ELX A;  4KAY A;  1ZEB A;  1AJA A;  4LQY A;  4CXS A;  4N7T A;  4UPH A;  1Y7A A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1ANJA

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations