1B8JA

Alkaline phosphatase complexed with vanadate
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A model of the transition state in the alkaline phosphatase reaction.
pubmed doi rcsb
molecule tags Alkaline phosphatase
source organism Escherichia coli
molecule keywords PROTEIN (ALKALINE PHOSPHATASE)
total genus 163
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1999-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1b8jA00
1KH4A 4KJDA 1ALKA 1ALJA 1SHQA 3WAYA 2ZKTA 1O99A 3M7VA 2IUCB 1KHLA 3NKOA 1P49A 4NWXA 3BDHA 4CYRA 3UO0A 1ALIA 4MY4A 3MK1A 3TX0A 1KHKA 4UPIA 4LR7A 3MK0A 4MIVA 4KJGA 1N2KA 5LIAA 5IJQA 4UOOA 5GRRA 4LR9A 1HQAA 1ELXA 4LR2A 2X98A 1AJCA 1B8JA 3UNYA 5DLVA 3M8ZA 3BDGB 5EGEA 5IJSA 1AJAA 3LXQA 2W5WA 3ED4A 3MK2A 2G9YA 4TN0A 1KHJA 2W5QA 2W5SA 1E33P 4CYSA 4UPLA 5L0EA 4ZG6A 1KH5A 1FSUA 4LRFA 3DYCA 3SZYA 5LQQA 1ED8A 3M8WA 4CXUA 5K4PA 3WAWA 1EW8A 1ZEFA 1ANJA 3IGZB 4CXKA 2W5TA 4LQYA 3NKPA 3TG0A 2D1GA 4MHXA 4UOPA 1SHNA 3UN3A 1ELYA 3UN2A 1ZEDA 3T00A 5L0KA 4YR1A 3NKMA 2GSUA 5AJ9A 4LRDA 4QAXA 2GSOA 3UN5A 1HDHA 1KHNA 4KAVA 1KH7A 5LRMA 4FDJA 4KAYA 1EJJA 4NWJA 1ZEBA 4UPKA 5DLWA 5L0BA 2IFYA 1URAA 4LRBA 4UPHA 3NKNA 1URBA 2W8DA 2W8SA 3BDGA 4N7TA 1AJDA 1Y6VA 3SZZA 4KM4A 4B56A 2W5XA 5INHA 1ANIA 1EW2A 5HRTA 3E2DA 2GLQA 2IUCA 3WBHA 1KH9A 3TWZA 3NKQA 2GSNA 1EW9A 3A52A 3IDDA 1K7HA 3KD8A 4CXSA 4LRAA 4ZG7A 1HJKA 1Y7AA 1E3CP 4GTZA 1EQJA 1O98A 3WAXA 3DPCA 1E2SP 3T02A 2XR9A 3BDFA 2QZUA 3B5QA 1EI6A 3Q3QA 1N2LA 2W5RA 2ANHA 3NKRA 4LREA 4ZGAA 2RH6A 2GA3A 2XRGA 3OT9A 3T01A 4GTXA 1AJBA 1AUKA 1ELZA 3M8YA 3NVLA 5GOVA 4LR8A 5DLTA 3IGYB 1ALHA 3WAVA 5EGHA 5TJ3A 5C66A 5KXAA 5LRNA 3CMRA 4UORA 2VQRA 1E1ZP 4ZG9A 4FDIA 4GTYA 4GTWA 4LRCA 2W5VA 1ED9A
chains in the Genus database with same CATH superfamily
1KH4A 4KJDA 1ALKA 1ALJA 1SHQA 3WAYA 2ZKTA 1O99A 3M7VA 2IUCB 1KHLA 3NKOA 1P49A 4NWXA 3BDHA 4CYRA 3UO0A 1ALIA 4MY4A 3MK1A 3TX0A 1KHKA 4UPIA 4LR7A 3MK0A 4MIVA 4KJGA 1N2KA 5LIAA 5IJQA 4UOOA 5GRRA 4LR9A 1HQAA 1ELXA 4LR2A 2X98A 1AJCA 1B8JA 3UNYA 5DLVA 3M8ZA 3BDGB 5EGEA 5IJSA 1AJAA 3LXQA 2W5WA 3ED4A 3MK2A 2G9YA 4TN0A 1KHJA 2W5QA 2W5SA 1E33P 4CYSA 4UPLA 5L0EA 4ZG6A 1KH5A 1FSUA 4LRFA 3DYCA 3SZYA 5LQQA 1ED8A 3M8WA 4CXUA 5K4PA 3WAWA 1EW8A 1ZEFA 1ANJA 3IGZB 4CXKA 2W5TA 4LQYA 3NKPA 3TG0A 2D1GA 4MHXA 4UOPA 1SHNA 3UN3A 1ELYA 3UN2A 1ZEDA 3T00A 5L0KA 4YR1A 3NKMA 2GSUA 5AJ9A 4LRDA 4QAXA 2GSOA 3UN5A 1HDHA 1KHNA 4KAVA 1KH7A 5LRMA 4FDJA 4KAYA 1EJJA 4NWJA 1ZEBA 4UPKA 5DLWA 5L0BA 2IFYA 1URAA 4LRBA 4UPHA 3NKNA 1URBA 2W8DA 2W8SA 3BDGA 4N7TA 1AJDA 1Y6VA 3SZZA 4KM4A 4B56A 2W5XA 5INHA 1ANIA 1EW2A 5HRTA 3E2DA 2GLQA 2IUCA 3WBHA 1KH9A 3TWZA 3NKQA 2GSNA 1EW9A 3A52A 3IDDA 1K7HA 3KD8A 4CXSA 4LRAA 4ZG7A 1HJKA 1Y7AA 1E3CP 4GTZA 1EQJA 1O98A 3WAXA 3DPCA 1E2SP 3T02A 2XR9A 3BDFA 2QZUA 3B5QA 1EI6A 3Q3QA 1N2LA 2W5RA 2ANHA 3NKRA 4LREA 4ZGAA 2RH6A 2GA3A 2XRGA 3OT9A 3T01A 4GTXA 1AJBA 1AUKA 1ELZA 3M8YA 3NVLA 5GOVA 4LR8A 5DLTA 3IGYB 1ALHA 3WAVA 5EGHA 5TJ3A 5C66A 5KXAA 5LRNA 3CMRA 4UORA 2VQRA 1E1ZP 4ZG9A 4FDIA 4GTYA 4GTWA 4LRCA 2W5VA 1ED9A
chains in the Genus database with same CATH topology
1KH4A 4KJDA 1ALKA 1ALJA 1SHQA 3WAYA 2ZKTA 1O99A 3M7VA 2IUCB 1KHLA 3NKOA 1P49A 4NWXA 3BDHA 4CYRA 3UO0A 1ALIA 4MY4A 3MK1A 3TX0A 1KHKA 4UPIA 4LR7A 3MK0A 4MIVA 4KJGA 1N2KA 5LIAA 5IJQA 4UOOA 5GRRA 4LR9A 1HQAA 1ELXA 4LR2A 2X98A 1AJCA 1B8JA 3UNYA 5DLVA 3M8ZA 3BDGB 5EGEA 5IJSA 1AJAA 3LXQA 2W5WA 3ED4A 3MK2A 2G9YA 4TN0A 1KHJA 2W5QA 2W5SA 1E33P 4CYSA 4UPLA 5L0EA 4ZG6A 1KH5A 1FSUA 4LRFA 3DYCA 3SZYA 5LQQA 1ED8A 3M8WA 4CXUA 5K4PA 3WAWA 1EW8A 1ZEFA 1ANJA 3IGZB 4CXKA 2W5TA 4LQYA 3NKPA 3TG0A 2D1GA 4MHXA 4UOPA 1SHNA 3UN3A 1ELYA 3UN2A 1ZEDA 3T00A 5L0KA 4YR1A 3NKMA 2GSUA 5AJ9A 4LRDA 4QAXA 2GSOA 3UN5A 1HDHA 1KHNA 4KAVA 1KH7A 5LRMA 4FDJA 4KAYA 1EJJA 4NWJA 1ZEBA 4UPKA 5DLWA 5L0BA 2IFYA 1URAA 4LRBA 4UPHA 3NKNA 1URBA 2W8DA 2W8SA 3BDGA 4N7TA 1AJDA 1Y6VA 3SZZA 4KM4A 4B56A 2W5XA 5INHA 1ANIA 1EW2A 5HRTA 3E2DA 2GLQA 2IUCA 3WBHA 1KH9A 3TWZA 3NKQA 2GSNA 1EW9A 3A52A 3IDDA 1K7HA 3KD8A 4CXSA 4LRAA 4ZG7A 1HJKA 1Y7AA 1E3CP 4GTZA 1EQJA 1O98A 3WAXA 3DPCA 1E2SP 3T02A 2XR9A 3BDFA 2QZUA 3B5QA 1EI6A 3Q3QA 1N2LA 2W5RA 2ANHA 3NKRA 4LREA 4ZGAA 2RH6A 2GA3A 2XRGA 3OT9A 3T01A 4GTXA 1AJBA 1AUKA 1ELZA 3M8YA 3NVLA 5GOVA 4LR8A 5DLTA 3IGYB 1ALHA 3WAVA 5EGHA 5TJ3A 5C66A 5KXAA 5LRNA 3CMRA 4UORA 2VQRA 1E1ZP 4ZG9A 4FDIA 4GTYA 4GTWA 4LRCA 2W5VA 1ED9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KH4 A;  4KJD A;  1ALK A;  1ALJ A;  1SHQ A;  3WAY A;  2ZKT A;  1O99 A;  3M7V A;  2IUC B;  1KHL A;  3NKO A;  1P49 A;  4NWX A;  3BDH A;  4CYR A;  3UO0 A;  1ALI A;  4MY4 A;  3MK1 A;  3TX0 A;  1KHK A;  4UPI A;  4LR7 A;  3MK0 A;  4MIV A;  4KJG A;  1N2K A;  5LIA A;  5IJQ A;  4UOO A;  5GRR A;  4LR9 A;  1HQA A;  1ELX A;  4LR2 A;  2X98 A;  1AJC A;  1B8J A;  3UNY A;  5DLV A;  3M8Z A;  3BDG B;  5EGE A;  5IJS A;  1AJA A;  3LXQ A;  2W5W A;  3ED4 A;  3MK2 A;  2G9Y A;  4TN0 A;  1KHJ A;  2W5Q A;  2W5S A;  1E33 P;  4CYS A;  4UPL A;  5L0E A;  4ZG6 A;  1KH5 A;  1FSU A;  4LRF A;  3DYC A;  3SZY A;  5LQQ A;  1ED8 A;  3M8W A;  4CXU A;  5K4P A;  3WAW A;  1EW8 A;  1ZEF A;  1ANJ A;  3IGZ B;  4CXK A;  2W5T A;  4LQY A;  3NKP A;  3TG0 A;  2D1G A;  4MHX A;  4UOP A;  1SHN A;  3UN3 A;  1ELY A;  3UN2 A;  1ZED A;  3T00 A;  5L0K A;  4YR1 A;  3NKM A;  2GSU A;  5AJ9 A;  4LRD A;  4QAX A;  2GSO A;  3UN5 A;  1HDH A;  1KHN A;  4KAV A;  1KH7 A;  5LRM A;  4FDJ A;  4KAY A;  1EJJ A;  4NWJ A;  1ZEB A;  4UPK A;  5DLW A;  5L0B A;  2IFY A;  1URA A;  4LRB A;  4UPH A;  3NKN A;  1URB A;  2W8D A;  2W8S A;  3BDG A;  4N7T A;  1AJD A;  1Y6V A;  3SZZ A;  4KM4 A;  4B56 A;  2W5X A;  5INH A;  1ANI A;  1EW2 A;  5HRT A;  3E2D A;  2GLQ A;  2IUC A;  3WBH A;  1KH9 A;  3TWZ A;  3NKQ A;  2GSN A;  1EW9 A;  3A52 A;  3IDD A;  1K7H A;  3KD8 A;  4CXS A;  4LRA A;  4ZG7 A;  1HJK A;  1Y7A A;  1E3C P;  4GTZ A;  1EQJ A;  1O98 A;  3WAX A;  3DPC A;  1E2S P;  3T02 A;  2XR9 A;  3BDF A;  2QZU A;  3B5Q A;  1EI6 A;  3Q3Q A;  1N2L A;  2W5R A;  2ANH A;  3NKR A;  4LRE A;  4ZGA A;  2RH6 A;  2GA3 A;  2XRG A;  3OT9 A;  3T01 A;  4GTX A;  1AJB A;  1AUK A;  1ELZ A;  3M8Y A;  3NVL A;  5GOV A;  4LR8 A;  5DLT A;  3IGY B;  1ALH A;  3WAV A;  5EGH A;  5TJ3 A;  5C66 A;  5KXA A;  5LRN A;  3CMR A;  4UOR A;  2VQR A;  1E1Z P;  4ZG9 A;  4FDI A;  4GTY A;  4GTW A;  4LRC A;  2W5V A;  1ED9 A; 
#chains in the Genus database with same CATH topology
 1KH4 A;  4KJD A;  1ALK A;  1ALJ A;  1SHQ A;  3WAY A;  2ZKT A;  1O99 A;  3M7V A;  2IUC B;  1KHL A;  3NKO A;  1P49 A;  4NWX A;  3BDH A;  4CYR A;  3UO0 A;  1ALI A;  4MY4 A;  3MK1 A;  3TX0 A;  1KHK A;  4UPI A;  4LR7 A;  3MK0 A;  4MIV A;  4KJG A;  1N2K A;  5LIA A;  5IJQ A;  4UOO A;  5GRR A;  4LR9 A;  1HQA A;  1ELX A;  4LR2 A;  2X98 A;  1AJC A;  1B8J A;  3UNY A;  5DLV A;  3M8Z A;  3BDG B;  5EGE A;  5IJS A;  1AJA A;  3LXQ A;  2W5W A;  3ED4 A;  3MK2 A;  2G9Y A;  4TN0 A;  1KHJ A;  2W5Q A;  2W5S A;  1E33 P;  4CYS A;  4UPL A;  5L0E A;  4ZG6 A;  1KH5 A;  1FSU A;  4LRF A;  3DYC A;  3SZY A;  5LQQ A;  1ED8 A;  3M8W A;  4CXU A;  5K4P A;  3WAW A;  1EW8 A;  1ZEF A;  1ANJ A;  3IGZ B;  4CXK A;  2W5T A;  4LQY A;  3NKP A;  3TG0 A;  2D1G A;  4MHX A;  4UOP A;  1SHN A;  3UN3 A;  1ELY A;  3UN2 A;  1ZED A;  3T00 A;  5L0K A;  4YR1 A;  3NKM A;  2GSU A;  5AJ9 A;  4LRD A;  4QAX A;  2GSO A;  3UN5 A;  1HDH A;  1KHN A;  4KAV A;  1KH7 A;  5LRM A;  4FDJ A;  4KAY A;  1EJJ A;  4NWJ A;  1ZEB A;  4UPK A;  5DLW A;  5L0B A;  2IFY A;  1URA A;  4LRB A;  4UPH A;  3NKN A;  1URB A;  2W8D A;  2W8S A;  3BDG A;  4N7T A;  1AJD A;  1Y6V A;  3SZZ A;  4KM4 A;  4B56 A;  2W5X A;  5INH A;  1ANI A;  1EW2 A;  5HRT A;  3E2D A;  2GLQ A;  2IUC A;  3WBH A;  1KH9 A;  3TWZ A;  3NKQ A;  2GSN A;  1EW9 A;  3A52 A;  3IDD A;  1K7H A;  3KD8 A;  4CXS A;  4LRA A;  4ZG7 A;  1HJK A;  1Y7A A;  1E3C P;  4GTZ A;  1EQJ A;  1O98 A;  3WAX A;  3DPC A;  1E2S P;  3T02 A;  2XR9 A;  3BDF A;  2QZU A;  3B5Q A;  1EI6 A;  3Q3Q A;  1N2L A;  2W5R A;  2ANH A;  3NKR A;  4LRE A;  4ZGA A;  2RH6 A;  2GA3 A;  2XRG A;  3OT9 A;  3T01 A;  4GTX A;  1AJB A;  1AUK A;  1ELZ A;  3M8Y A;  3NVL A;  5GOV A;  4LR8 A;  5DLT A;  3IGY B;  1ALH A;  3WAV A;  5EGH A;  5TJ3 A;  5C66 A;  5KXA A;  5LRN A;  3CMR A;  4UOR A;  2VQR A;  1E1Z P;  4ZG9 A;  4FDI A;  4GTY A;  4GTW A;  4LRC A;  2W5V A;  1ED9 A; 
#chains in the Genus database with same CATH homology
 1KH4 A;  4KJD A;  1ALK A;  1ALJ A;  1SHQ A;  3WAY A;  2ZKT A;  1O99 A;  3M7V A;  2IUC B;  1KHL A;  3NKO A;  1P49 A;  4NWX A;  3BDH A;  4CYR A;  3UO0 A;  1ALI A;  4MY4 A;  3MK1 A;  3TX0 A;  1KHK A;  4UPI A;  4LR7 A;  3MK0 A;  4MIV A;  4KJG A;  1N2K A;  5LIA A;  5IJQ A;  4UOO A;  5GRR A;  4LR9 A;  1HQA A;  1ELX A;  4LR2 A;  2X98 A;  1AJC A;  1B8J A;  3UNY A;  5DLV A;  3M8Z A;  3BDG B;  5EGE A;  5IJS A;  1AJA A;  3LXQ A;  2W5W A;  3ED4 A;  3MK2 A;  2G9Y A;  4TN0 A;  1KHJ A;  2W5Q A;  2W5S A;  1E33 P;  4CYS A;  4UPL A;  5L0E A;  4ZG6 A;  1KH5 A;  1FSU A;  4LRF A;  3DYC A;  3SZY A;  5LQQ A;  1ED8 A;  3M8W A;  4CXU A;  5K4P A;  3WAW A;  1EW8 A;  1ZEF A;  1ANJ A;  3IGZ B;  4CXK A;  2W5T A;  4LQY A;  3NKP A;  3TG0 A;  2D1G A;  4MHX A;  4UOP A;  1SHN A;  3UN3 A;  1ELY A;  3UN2 A;  1ZED A;  3T00 A;  5L0K A;  4YR1 A;  3NKM A;  2GSU A;  5AJ9 A;  4LRD A;  4QAX A;  2GSO A;  3UN5 A;  1HDH A;  1KHN A;  4KAV A;  1KH7 A;  5LRM A;  4FDJ A;  4KAY A;  1EJJ A;  4NWJ A;  1ZEB A;  4UPK A;  5DLW A;  5L0B A;  2IFY A;  1URA A;  4LRB A;  4UPH A;  3NKN A;  1URB A;  2W8D A;  2W8S A;  3BDG A;  4N7T A;  1AJD A;  1Y6V A;  3SZZ A;  4KM4 A;  4B56 A;  2W5X A;  5INH A;  1ANI A;  1EW2 A;  5HRT A;  3E2D A;  2GLQ A;  2IUC A;  3WBH A;  1KH9 A;  3TWZ A;  3NKQ A;  2GSN A;  1EW9 A;  3A52 A;  3IDD A;  1K7H A;  3KD8 A;  4CXS A;  4LRA A;  4ZG7 A;  1HJK A;  1Y7A A;  1E3C P;  4GTZ A;  1EQJ A;  1O98 A;  3WAX A;  3DPC A;  1E2S P;  3T02 A;  2XR9 A;  3BDF A;  2QZU A;  3B5Q A;  1EI6 A;  3Q3Q A;  1N2L A;  2W5R A;  2ANH A;  3NKR A;  4LRE A;  4ZGA A;  2RH6 A;  2GA3 A;  2XRG A;  3OT9 A;  3T01 A;  4GTX A;  1AJB A;  1AUK A;  1ELZ A;  3M8Y A;  3NVL A;  5GOV A;  4LR8 A;  5DLT A;  3IGY B;  1ALH A;  3WAV A;  5EGH A;  5TJ3 A;  5C66 A;  5KXA A;  5LRN A;  3CMR A;  4UOR A;  2VQR A;  1E1Z P;  4ZG9 A;  4FDI A;  4GTY A;  4GTW A;  4LRC A;  2W5V A;  1ED9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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