1B8JA

Alkaline phosphatase complexed with vanadate
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A model of the transition state in the alkaline phosphatase reaction.
pubmed doi rcsb
molecule tags Alkaline phosphatase
source organism Escherichia coli
molecule keywords PROTEIN (ALKALINE PHOSPHATASE)
total genus 163
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1999-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1b8jA00
5HRTA 4NWJA 1AJAA 3ED4A 1HJKA 3T00A 4LR2A 4UPLA 4LR9A 4ZGAA 1ELZA 4MY4A 3DYCA 4LR7A 1EW8A 2X98A 1ALHA 4GTZA 4YR1A 5L0KA 1ANIA 4KM4A 4UPHA 3IGYB 5DLWA 4ZG6A 4CXKA 3A52A 4UOPA 3BDHA 4KJDA 3BDGA 4KAVA 3BDFA 5K4PA 4LRBA 4NWXA 5C66A 3NKRA 1B8JA 2ZKTA 5IJQA 4UOOA 3DPCA 3MK2A 1O99A 4ZG7A 1E1ZP 1EJJA 4LR8A 3WAWA 4KAYA 3LXQA 1URBA 2W5TA 3IDDA 3NKQA 4MHXA 2W5QA 5DLTA 1ALIA 3MK1A 1ALJA 5KXAA 3NKNA 2GSNA 3WAYA 5TJ3A 3BDGB 1K7HA 4LRAA 3NKPA 2W5WA 5IJSA 1N2LA 1HQAA 1ED8A 4CYSA 4FDIA 2ANHA 1KHKA 1ZEDA 2W5SA 4GTYA 1P49A 1EI6A 3MK0A 3OT9A 1ED9A 3NKOA 3TX0A 3UN2A 5LRNA 1O98A 1KHLA 4TN0A 4B56A 1AJDA 4UPIA 3M8ZA 4LRCA 3E2DA 1EQJA 1EW9A 2IUCA 1N2KA 1KH4A 2QZUA 3TG0A 4N7TA 3NKMA 3M8WA 5EGHA 2W5RA 1ZEFA 1ELXA 1EW2A 5LQQA 3NVLA 3M7VA 5L0BA 2VQRA 4UORA 4ZG9A 2G9YA 1FSUA 4GTWA 2RH6A 1AJBA 2W5VA 4QAXA 3WAVA 4CXUA 3T01A 1HDHA 1URAA 4LQYA 3UO0A 2IUCB 3M8YA 3UN3A 4LREA 1ZEBA 3B5QA 1KH5A 4UPKA 5AJ9A 3UN5A 1KHJA 4GTXA 1SHQA 3WBHA 3SZYA 4CXSA 3SZZA 1E33P 1SHNA 3TWZA 1E3CP 1KH9A 2GLQA 1KH7A 2GA3A 1ANJA 2GSUA 5GRRA 2W8DA 2IFYA 1E2SP 5DLVA 1KHNA 2W5XA 3CMRA 4MIVA 4KJGA 1ALKA 5INHA 2D1GA 1AUKA 1Y6VA 4CYRA 1Y7AA 1ELYA 2W8SA 3UNYA 1AJCA 3IGZB 2GSOA 2XRGA 2XR9A 4FDJA 5EGEA 3WAXA 3T02A 5GOVA 4LRFA 5LRMA 3Q3QA 3KD8A 5L0EA 4LRDA 5LIAA
chains in the Genus database with same CATH superfamily
5HRTA 4NWJA 1AJAA 3ED4A 1HJKA 3T00A 4LR2A 4UPLA 4LR9A 4ZGAA 1ELZA 4MY4A 3DYCA 4LR7A 1EW8A 2X98A 1ALHA 4GTZA 4YR1A 5L0KA 1ANIA 4KM4A 4UPHA 3IGYB 5DLWA 4ZG6A 4CXKA 3A52A 4UOPA 3BDHA 4KJDA 3BDGA 4KAVA 3BDFA 5K4PA 4LRBA 4NWXA 5C66A 3NKRA 1B8JA 2ZKTA 5IJQA 4UOOA 3DPCA 3MK2A 1O99A 4ZG7A 1E1ZP 1EJJA 4LR8A 3WAWA 4KAYA 3LXQA 1URBA 2W5TA 3IDDA 3NKQA 4MHXA 2W5QA 5DLTA 1ALIA 3MK1A 1ALJA 5KXAA 3NKNA 2GSNA 3WAYA 5TJ3A 3BDGB 1K7HA 4LRAA 3NKPA 2W5WA 5IJSA 1N2LA 1HQAA 1ED8A 4CYSA 4FDIA 2ANHA 1KHKA 1ZEDA 2W5SA 4GTYA 1P49A 1EI6A 3MK0A 3OT9A 1ED9A 3NKOA 3TX0A 3UN2A 5LRNA 1O98A 1KHLA 4TN0A 4B56A 1AJDA 4UPIA 3M8ZA 4LRCA 3E2DA 1EQJA 1EW9A 2IUCA 1N2KA 1KH4A 2QZUA 3TG0A 4N7TA 3NKMA 3M8WA 5EGHA 2W5RA 1ZEFA 1ELXA 1EW2A 5LQQA 3NVLA 3M7VA 5L0BA 2VQRA 4UORA 4ZG9A 2G9YA 1FSUA 4GTWA 2RH6A 1AJBA 2W5VA 4QAXA 3WAVA 4CXUA 3T01A 1HDHA 1URAA 4LQYA 3UO0A 2IUCB 3M8YA 3UN3A 4LREA 1ZEBA 3B5QA 1KH5A 4UPKA 5AJ9A 3UN5A 1KHJA 4GTXA 1SHQA 3WBHA 3SZYA 4CXSA 3SZZA 1E33P 1SHNA 3TWZA 1E3CP 1KH9A 2GLQA 1KH7A 2GA3A 1ANJA 2GSUA 5GRRA 2W8DA 2IFYA 1E2SP 5DLVA 1KHNA 2W5XA 3CMRA 4MIVA 4KJGA 1ALKA 5INHA 2D1GA 1AUKA 1Y6VA 4CYRA 1Y7AA 1ELYA 2W8SA 3UNYA 1AJCA 3IGZB 2GSOA 2XRGA 2XR9A 4FDJA 5EGEA 3WAXA 3T02A 5GOVA 4LRFA 5LRMA 3Q3QA 3KD8A 5L0EA 4LRDA 5LIAA
chains in the Genus database with same CATH topology
5HRTA 4NWJA 1AJAA 3ED4A 1HJKA 3T00A 4LR2A 4UPLA 4LR9A 4ZGAA 1ELZA 4MY4A 3DYCA 4LR7A 1EW8A 2X98A 1ALHA 4GTZA 4YR1A 5L0KA 1ANIA 4KM4A 4UPHA 3IGYB 5DLWA 4ZG6A 4CXKA 3A52A 4UOPA 3BDHA 4KJDA 3BDGA 4KAVA 3BDFA 5K4PA 4LRBA 4NWXA 5C66A 3NKRA 1B8JA 2ZKTA 5IJQA 4UOOA 3DPCA 3MK2A 1O99A 4ZG7A 1E1ZP 1EJJA 4LR8A 3WAWA 4KAYA 3LXQA 1URBA 2W5TA 3IDDA 3NKQA 4MHXA 2W5QA 5DLTA 1ALIA 3MK1A 1ALJA 5KXAA 3NKNA 2GSNA 3WAYA 5TJ3A 3BDGB 1K7HA 4LRAA 3NKPA 2W5WA 5IJSA 1N2LA 1HQAA 1ED8A 4CYSA 4FDIA 2ANHA 1KHKA 1ZEDA 2W5SA 4GTYA 1P49A 1EI6A 3MK0A 3OT9A 1ED9A 3NKOA 3TX0A 3UN2A 5LRNA 1O98A 1KHLA 4TN0A 4B56A 1AJDA 4UPIA 3M8ZA 4LRCA 3E2DA 1EQJA 1EW9A 2IUCA 1N2KA 1KH4A 2QZUA 3TG0A 4N7TA 3NKMA 3M8WA 5EGHA 2W5RA 1ZEFA 1ELXA 1EW2A 5LQQA 3NVLA 3M7VA 5L0BA 2VQRA 4UORA 4ZG9A 2G9YA 1FSUA 4GTWA 2RH6A 1AJBA 2W5VA 4QAXA 3WAVA 4CXUA 3T01A 1HDHA 1URAA 4LQYA 3UO0A 2IUCB 3M8YA 3UN3A 4LREA 1ZEBA 3B5QA 1KH5A 4UPKA 5AJ9A 3UN5A 1KHJA 4GTXA 1SHQA 3WBHA 3SZYA 4CXSA 3SZZA 1E33P 1SHNA 3TWZA 1E3CP 1KH9A 2GLQA 1KH7A 2GA3A 1ANJA 2GSUA 5GRRA 2W8DA 2IFYA 1E2SP 5DLVA 1KHNA 2W5XA 3CMRA 4MIVA 4KJGA 1ALKA 5INHA 2D1GA 1AUKA 1Y6VA 4CYRA 1Y7AA 1ELYA 2W8SA 3UNYA 1AJCA 3IGZB 2GSOA 2XRGA 2XR9A 4FDJA 5EGEA 3WAXA 3T02A 5GOVA 4LRFA 5LRMA 3Q3QA 3KD8A 5L0EA 4LRDA 5LIAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HRT A;  4NWJ A;  1AJA A;  3ED4 A;  1HJK A;  3T00 A;  4LR2 A;  4UPL A;  4LR9 A;  4ZGA A;  1ELZ A;  4MY4 A;  3DYC A;  4LR7 A;  1EW8 A;  2X98 A;  1ALH A;  4GTZ A;  4YR1 A;  5L0K A;  1ANI A;  4KM4 A;  4UPH A;  3IGY B;  5DLW A;  4ZG6 A;  4CXK A;  3A52 A;  4UOP A;  3BDH A;  4KJD A;  3BDG A;  4KAV A;  3BDF A;  5K4P A;  4LRB A;  4NWX A;  5C66 A;  3NKR A;  1B8J A;  2ZKT A;  5IJQ A;  4UOO A;  3DPC A;  3MK2 A;  1O99 A;  4ZG7 A;  1E1Z P;  1EJJ A;  4LR8 A;  3WAW A;  4KAY A;  3LXQ A;  1URB A;  2W5T A;  3IDD A;  3NKQ A;  4MHX A;  2W5Q A;  5DLT A;  1ALI A;  3MK1 A;  1ALJ A;  5KXA A;  3NKN A;  2GSN A;  3WAY A;  5TJ3 A;  3BDG B;  1K7H A;  4LRA A;  3NKP A;  2W5W A;  5IJS A;  1N2L A;  1HQA A;  1ED8 A;  4CYS A;  4FDI A;  2ANH A;  1KHK A;  1ZED A;  2W5S A;  4GTY A;  1P49 A;  1EI6 A;  3MK0 A;  3OT9 A;  1ED9 A;  3NKO A;  3TX0 A;  3UN2 A;  5LRN A;  1O98 A;  1KHL A;  4TN0 A;  4B56 A;  1AJD A;  4UPI A;  3M8Z A;  4LRC A;  3E2D A;  1EQJ A;  1EW9 A;  2IUC A;  1N2K A;  1KH4 A;  2QZU A;  3TG0 A;  4N7T A;  3NKM A;  3M8W A;  5EGH A;  2W5R A;  1ZEF A;  1ELX A;  1EW2 A;  5LQQ A;  3NVL A;  3M7V A;  5L0B A;  2VQR A;  4UOR A;  4ZG9 A;  2G9Y A;  1FSU A;  4GTW A;  2RH6 A;  1AJB A;  2W5V A;  4QAX A;  3WAV A;  4CXU A;  3T01 A;  1HDH A;  1URA A;  4LQY A;  3UO0 A;  2IUC B;  3M8Y A;  3UN3 A;  4LRE A;  1ZEB A;  3B5Q A;  1KH5 A;  4UPK A;  5AJ9 A;  3UN5 A;  1KHJ A;  4GTX A;  1SHQ A;  3WBH A;  3SZY A;  4CXS A;  3SZZ A;  1E33 P;  1SHN A;  3TWZ A;  1E3C P;  1KH9 A;  2GLQ A;  1KH7 A;  2GA3 A;  1ANJ A;  2GSU A;  5GRR A;  2W8D A;  2IFY A;  1E2S P;  5DLV A;  1KHN A;  2W5X A;  3CMR A;  4MIV A;  4KJG A;  1ALK A;  5INH A;  2D1G A;  1AUK A;  1Y6V A;  4CYR A;  1Y7A A;  1ELY A;  2W8S A;  3UNY A;  1AJC A;  3IGZ B;  2GSO A;  2XRG A;  2XR9 A;  4FDJ A;  5EGE A;  3WAX A;  3T02 A;  5GOV A;  4LRF A;  5LRM A;  3Q3Q A;  3KD8 A;  5L0E A;  4LRD A;  5LIA A; 
#chains in the Genus database with same CATH topology
 5HRT A;  4NWJ A;  1AJA A;  3ED4 A;  1HJK A;  3T00 A;  4LR2 A;  4UPL A;  4LR9 A;  4ZGA A;  1ELZ A;  4MY4 A;  3DYC A;  4LR7 A;  1EW8 A;  2X98 A;  1ALH A;  4GTZ A;  4YR1 A;  5L0K A;  1ANI A;  4KM4 A;  4UPH A;  3IGY B;  5DLW A;  4ZG6 A;  4CXK A;  3A52 A;  4UOP A;  3BDH A;  4KJD A;  3BDG A;  4KAV A;  3BDF A;  5K4P A;  4LRB A;  4NWX A;  5C66 A;  3NKR A;  1B8J A;  2ZKT A;  5IJQ A;  4UOO A;  3DPC A;  3MK2 A;  1O99 A;  4ZG7 A;  1E1Z P;  1EJJ A;  4LR8 A;  3WAW A;  4KAY A;  3LXQ A;  1URB A;  2W5T A;  3IDD A;  3NKQ A;  4MHX A;  2W5Q A;  5DLT A;  1ALI A;  3MK1 A;  1ALJ A;  5KXA A;  3NKN A;  2GSN A;  3WAY A;  5TJ3 A;  3BDG B;  1K7H A;  4LRA A;  3NKP A;  2W5W A;  5IJS A;  1N2L A;  1HQA A;  1ED8 A;  4CYS A;  4FDI A;  2ANH A;  1KHK A;  1ZED A;  2W5S A;  4GTY A;  1P49 A;  1EI6 A;  3MK0 A;  3OT9 A;  1ED9 A;  3NKO A;  3TX0 A;  3UN2 A;  5LRN A;  1O98 A;  1KHL A;  4TN0 A;  4B56 A;  1AJD A;  4UPI A;  3M8Z A;  4LRC A;  3E2D A;  1EQJ A;  1EW9 A;  2IUC A;  1N2K A;  1KH4 A;  2QZU A;  3TG0 A;  4N7T A;  3NKM A;  3M8W A;  5EGH A;  2W5R A;  1ZEF A;  1ELX A;  1EW2 A;  5LQQ A;  3NVL A;  3M7V A;  5L0B A;  2VQR A;  4UOR A;  4ZG9 A;  2G9Y A;  1FSU A;  4GTW A;  2RH6 A;  1AJB A;  2W5V A;  4QAX A;  3WAV A;  4CXU A;  3T01 A;  1HDH A;  1URA A;  4LQY A;  3UO0 A;  2IUC B;  3M8Y A;  3UN3 A;  4LRE A;  1ZEB A;  3B5Q A;  1KH5 A;  4UPK A;  5AJ9 A;  3UN5 A;  1KHJ A;  4GTX A;  1SHQ A;  3WBH A;  3SZY A;  4CXS A;  3SZZ A;  1E33 P;  1SHN A;  3TWZ A;  1E3C P;  1KH9 A;  2GLQ A;  1KH7 A;  2GA3 A;  1ANJ A;  2GSU A;  5GRR A;  2W8D A;  2IFY A;  1E2S P;  5DLV A;  1KHN A;  2W5X A;  3CMR A;  4MIV A;  4KJG A;  1ALK A;  5INH A;  2D1G A;  1AUK A;  1Y6V A;  4CYR A;  1Y7A A;  1ELY A;  2W8S A;  3UNY A;  1AJC A;  3IGZ B;  2GSO A;  2XRG A;  2XR9 A;  4FDJ A;  5EGE A;  3WAX A;  3T02 A;  5GOV A;  4LRF A;  5LRM A;  3Q3Q A;  3KD8 A;  5L0E A;  4LRD A;  5LIA A; 
#chains in the Genus database with same CATH homology
 5HRT A;  4NWJ A;  1AJA A;  3ED4 A;  1HJK A;  3T00 A;  4LR2 A;  4UPL A;  4LR9 A;  4ZGA A;  1ELZ A;  4MY4 A;  3DYC A;  4LR7 A;  1EW8 A;  2X98 A;  1ALH A;  4GTZ A;  4YR1 A;  5L0K A;  1ANI A;  4KM4 A;  4UPH A;  3IGY B;  5DLW A;  4ZG6 A;  4CXK A;  3A52 A;  4UOP A;  3BDH A;  4KJD A;  3BDG A;  4KAV A;  3BDF A;  5K4P A;  4LRB A;  4NWX A;  5C66 A;  3NKR A;  1B8J A;  2ZKT A;  5IJQ A;  4UOO A;  3DPC A;  3MK2 A;  1O99 A;  4ZG7 A;  1E1Z P;  1EJJ A;  4LR8 A;  3WAW A;  4KAY A;  3LXQ A;  1URB A;  2W5T A;  3IDD A;  3NKQ A;  4MHX A;  2W5Q A;  5DLT A;  1ALI A;  3MK1 A;  1ALJ A;  5KXA A;  3NKN A;  2GSN A;  3WAY A;  5TJ3 A;  3BDG B;  1K7H A;  4LRA A;  3NKP A;  2W5W A;  5IJS A;  1N2L A;  1HQA A;  1ED8 A;  4CYS A;  4FDI A;  2ANH A;  1KHK A;  1ZED A;  2W5S A;  4GTY A;  1P49 A;  1EI6 A;  3MK0 A;  3OT9 A;  1ED9 A;  3NKO A;  3TX0 A;  3UN2 A;  5LRN A;  1O98 A;  1KHL A;  4TN0 A;  4B56 A;  1AJD A;  4UPI A;  3M8Z A;  4LRC A;  3E2D A;  1EQJ A;  1EW9 A;  2IUC A;  1N2K A;  1KH4 A;  2QZU A;  3TG0 A;  4N7T A;  3NKM A;  3M8W A;  5EGH A;  2W5R A;  1ZEF A;  1ELX A;  1EW2 A;  5LQQ A;  3NVL A;  3M7V A;  5L0B A;  2VQR A;  4UOR A;  4ZG9 A;  2G9Y A;  1FSU A;  4GTW A;  2RH6 A;  1AJB A;  2W5V A;  4QAX A;  3WAV A;  4CXU A;  3T01 A;  1HDH A;  1URA A;  4LQY A;  3UO0 A;  2IUC B;  3M8Y A;  3UN3 A;  4LRE A;  1ZEB A;  3B5Q A;  1KH5 A;  4UPK A;  5AJ9 A;  3UN5 A;  1KHJ A;  4GTX A;  1SHQ A;  3WBH A;  3SZY A;  4CXS A;  3SZZ A;  1E33 P;  1SHN A;  3TWZ A;  1E3C P;  1KH9 A;  2GLQ A;  1KH7 A;  2GA3 A;  1ANJ A;  2GSU A;  5GRR A;  2W8D A;  2IFY A;  1E2S P;  5DLV A;  1KHN A;  2W5X A;  3CMR A;  4MIV A;  4KJG A;  1ALK A;  5INH A;  2D1G A;  1AUK A;  1Y6V A;  4CYR A;  1Y7A A;  1ELY A;  2W8S A;  3UNY A;  1AJC A;  3IGZ B;  2GSO A;  2XRG A;  2XR9 A;  4FDJ A;  5EGE A;  3WAX A;  3T02 A;  5GOV A;  4LRF A;  5LRM A;  3Q3Q A;  3KD8 A;  5L0E A;  4LRD A;  5LIA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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