1ED8A

Structure of e. coli alkaline phosphatase inhibited by the inorganic phosphate at 1.75a resolution
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 166
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed8A00
5IJSA 1K7HA 1KHLA 2W8DA 1ANIA 5AJ9A 2W5RA 3T01A 4UPIA 3M7VA 2W8SA 5DLVA 4GTWA 3BDGA 4GTZA 4LR2A 3Q3QA 5LQQA 1ALKA 5HRTA 1N2KA 4LQYA 4LRBA 1O98A 1ELYA 1ALHA 2D1GA 1O99A 4UOPA 1SHQA 3MK2A 3LXQA 5C66A 2GSUA 4MHXA 5EGEA 3BDHA 3T00A 1AJCA 1AJDA 4ZG9A 3NVLA 3MK1A 1ZEFA 2X98A 4ZG7A 3IGYB 5EGHA 5LRNA 4QAXA 1ED9A 3UN5A 5L0EA 1HDHA 1E1ZP 1KHJA 4UPKA 1E33P 3BDFA 1FSUA 2VQRA 4TN0A 2GA3A 1URAA 1ZEBA 4GTYA 4FDIA 1Y7AA 4B56A 1ZEDA 3WAVA 1ELXA 2IFYA 2ZKTA 5GOVA 5K4PA 3M8ZA 2W5TA 3T02A 3MK0A 3SZYA 2GSNA 4CXUA 3UNYA 4UORA 5LIAA 4LRFA 3TG0A 1ED8A 4LR8A 4MY4A 3TX0A 3NKRA 4NWXA 3NKMA 3NKNA 3KD8A 1KH4A 2IUCB 1ALIA 4CXSA 1EI6A 1AUKA 1EW8A 4UPHA 4ZG6A 4CXKA 4KM4A 1HJKA 4YR1A 1ALJA 3UN2A 4UOOA 1EW9A 1KHNA 1E2SP 3BDGB 3DYCA 1P49A 1AJBA 2RH6A 2QZUA 3B5QA 4LRAA 1HQAA 1SHNA 1ELZA 4LR9A 2W5QA 3IDDA 5TJ3A 1Y6VA 3NKOA 5DLWA 5DLTA 1B8JA 4UPLA 4FDJA 4LREA 5IJQA 4GTXA 1EW2A 5LRMA 1KH9A 4N7TA 3M8WA 1AJAA 2W5VA 4KJGA 5INHA 2W5XA 5KXAA 1EJJA 3A52A 1N2LA 3M8YA 3UO0A 3NKQA 4ZGAA 2ANHA 3DPCA 3ED4A 4CYSA 5L0KA 4NWJA 2GLQA 2GSOA 3SZZA 4MIVA 3WBHA 3TWZA 4LRCA 1ANJA 1E3CP 2W5SA 4LR7A 3CMRA 1EQJA 1URBA 3WAXA 2W5WA 2G9YA 3IGZB 3NKPA 4KAYA 4CYRA 3E2DA 4LRDA 1KH5A 3WAYA 1KH7A 3OT9A 2XRGA 4KJDA 4KAVA 1KHKA 3WAWA 5L0BA 5GRRA 2XR9A 2IUCA 3UN3A
chains in the Genus database with same CATH superfamily
5IJSA 1K7HA 1KHLA 2W8DA 1ANIA 5AJ9A 2W5RA 3T01A 4UPIA 3M7VA 2W8SA 5DLVA 4GTWA 3BDGA 4GTZA 4LR2A 3Q3QA 5LQQA 1ALKA 5HRTA 1N2KA 4LQYA 4LRBA 1O98A 1ELYA 1ALHA 2D1GA 1O99A 4UOPA 1SHQA 3MK2A 3LXQA 5C66A 2GSUA 4MHXA 5EGEA 3BDHA 3T00A 1AJCA 1AJDA 4ZG9A 3NVLA 3MK1A 1ZEFA 2X98A 4ZG7A 3IGYB 5EGHA 5LRNA 4QAXA 1ED9A 3UN5A 5L0EA 1HDHA 1E1ZP 1KHJA 4UPKA 1E33P 3BDFA 1FSUA 2VQRA 4TN0A 2GA3A 1URAA 1ZEBA 4GTYA 4FDIA 1Y7AA 4B56A 1ZEDA 3WAVA 1ELXA 2IFYA 2ZKTA 5GOVA 5K4PA 3M8ZA 2W5TA 3T02A 3MK0A 3SZYA 2GSNA 4CXUA 3UNYA 4UORA 5LIAA 4LRFA 3TG0A 1ED8A 4LR8A 4MY4A 3TX0A 3NKRA 4NWXA 3NKMA 3NKNA 3KD8A 1KH4A 2IUCB 1ALIA 4CXSA 1EI6A 1AUKA 1EW8A 4UPHA 4ZG6A 4CXKA 4KM4A 1HJKA 4YR1A 1ALJA 3UN2A 4UOOA 1EW9A 1KHNA 1E2SP 3BDGB 3DYCA 1P49A 1AJBA 2RH6A 2QZUA 3B5QA 4LRAA 1HQAA 1SHNA 1ELZA 4LR9A 2W5QA 3IDDA 5TJ3A 1Y6VA 3NKOA 5DLWA 5DLTA 1B8JA 4UPLA 4FDJA 4LREA 5IJQA 4GTXA 1EW2A 5LRMA 1KH9A 4N7TA 3M8WA 1AJAA 2W5VA 4KJGA 5INHA 2W5XA 5KXAA 1EJJA 3A52A 1N2LA 3M8YA 3UO0A 3NKQA 4ZGAA 2ANHA 3DPCA 3ED4A 4CYSA 5L0KA 4NWJA 2GLQA 2GSOA 3SZZA 4MIVA 3WBHA 3TWZA 4LRCA 1ANJA 1E3CP 2W5SA 4LR7A 3CMRA 1EQJA 1URBA 3WAXA 2W5WA 2G9YA 3IGZB 3NKPA 4KAYA 4CYRA 3E2DA 4LRDA 1KH5A 3WAYA 1KH7A 3OT9A 2XRGA 4KJDA 4KAVA 1KHKA 3WAWA 5L0BA 5GRRA 2XR9A 2IUCA 3UN3A
chains in the Genus database with same CATH topology
5IJSA 1K7HA 1KHLA 2W8DA 1ANIA 5AJ9A 2W5RA 3T01A 4UPIA 3M7VA 2W8SA 5DLVA 4GTWA 3BDGA 4GTZA 4LR2A 3Q3QA 5LQQA 1ALKA 5HRTA 1N2KA 4LQYA 4LRBA 1O98A 1ELYA 1ALHA 2D1GA 1O99A 4UOPA 1SHQA 3MK2A 3LXQA 5C66A 2GSUA 4MHXA 5EGEA 3BDHA 3T00A 1AJCA 1AJDA 4ZG9A 3NVLA 3MK1A 1ZEFA 2X98A 4ZG7A 3IGYB 5EGHA 5LRNA 4QAXA 1ED9A 3UN5A 5L0EA 1HDHA 1E1ZP 1KHJA 4UPKA 1E33P 3BDFA 1FSUA 2VQRA 4TN0A 2GA3A 1URAA 1ZEBA 4GTYA 4FDIA 1Y7AA 4B56A 1ZEDA 3WAVA 1ELXA 2IFYA 2ZKTA 5GOVA 5K4PA 3M8ZA 2W5TA 3T02A 3MK0A 3SZYA 2GSNA 4CXUA 3UNYA 4UORA 5LIAA 4LRFA 3TG0A 1ED8A 4LR8A 4MY4A 3TX0A 3NKRA 4NWXA 3NKMA 3NKNA 3KD8A 1KH4A 2IUCB 1ALIA 4CXSA 1EI6A 1AUKA 1EW8A 4UPHA 4ZG6A 4CXKA 4KM4A 1HJKA 4YR1A 1ALJA 3UN2A 4UOOA 1EW9A 1KHNA 1E2SP 3BDGB 3DYCA 1P49A 1AJBA 2RH6A 2QZUA 3B5QA 4LRAA 1HQAA 1SHNA 1ELZA 4LR9A 2W5QA 3IDDA 5TJ3A 1Y6VA 3NKOA 5DLWA 5DLTA 1B8JA 4UPLA 4FDJA 4LREA 5IJQA 4GTXA 1EW2A 5LRMA 1KH9A 4N7TA 3M8WA 1AJAA 2W5VA 4KJGA 5INHA 2W5XA 5KXAA 1EJJA 3A52A 1N2LA 3M8YA 3UO0A 3NKQA 4ZGAA 2ANHA 3DPCA 3ED4A 4CYSA 5L0KA 4NWJA 2GLQA 2GSOA 3SZZA 4MIVA 3WBHA 3TWZA 4LRCA 1ANJA 1E3CP 2W5SA 4LR7A 3CMRA 1EQJA 1URBA 3WAXA 2W5WA 2G9YA 3IGZB 3NKPA 4KAYA 4CYRA 3E2DA 4LRDA 1KH5A 3WAYA 1KH7A 3OT9A 2XRGA 4KJDA 4KAVA 1KHKA 3WAWA 5L0BA 5GRRA 2XR9A 2IUCA 3UN3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IJS A;  1K7H A;  1KHL A;  2W8D A;  1ANI A;  5AJ9 A;  2W5R A;  3T01 A;  4UPI A;  3M7V A;  2W8S A;  5DLV A;  4GTW A;  3BDG A;  4GTZ A;  4LR2 A;  3Q3Q A;  5LQQ A;  1ALK A;  5HRT A;  1N2K A;  4LQY A;  4LRB A;  1O98 A;  1ELY A;  1ALH A;  2D1G A;  1O99 A;  4UOP A;  1SHQ A;  3MK2 A;  3LXQ A;  5C66 A;  2GSU A;  4MHX A;  5EGE A;  3BDH A;  3T00 A;  1AJC A;  1AJD A;  4ZG9 A;  3NVL A;  3MK1 A;  1ZEF A;  2X98 A;  4ZG7 A;  3IGY B;  5EGH A;  5LRN A;  4QAX A;  1ED9 A;  3UN5 A;  5L0E A;  1HDH A;  1E1Z P;  1KHJ A;  4UPK A;  1E33 P;  3BDF A;  1FSU A;  2VQR A;  4TN0 A;  2GA3 A;  1URA A;  1ZEB A;  4GTY A;  4FDI A;  1Y7A A;  4B56 A;  1ZED A;  3WAV A;  1ELX A;  2IFY A;  2ZKT A;  5GOV A;  5K4P A;  3M8Z A;  2W5T A;  3T02 A;  3MK0 A;  3SZY A;  2GSN A;  4CXU A;  3UNY A;  4UOR A;  5LIA A;  4LRF A;  3TG0 A;  1ED8 A;  4LR8 A;  4MY4 A;  3TX0 A;  3NKR A;  4NWX A;  3NKM A;  3NKN A;  3KD8 A;  1KH4 A;  2IUC B;  1ALI A;  4CXS A;  1EI6 A;  1AUK A;  1EW8 A;  4UPH A;  4ZG6 A;  4CXK A;  4KM4 A;  1HJK A;  4YR1 A;  1ALJ A;  3UN2 A;  4UOO A;  1EW9 A;  1KHN A;  1E2S P;  3BDG B;  3DYC A;  1P49 A;  1AJB A;  2RH6 A;  2QZU A;  3B5Q A;  4LRA A;  1HQA A;  1SHN A;  1ELZ A;  4LR9 A;  2W5Q A;  3IDD A;  5TJ3 A;  1Y6V A;  3NKO A;  5DLW A;  5DLT A;  1B8J A;  4UPL A;  4FDJ A;  4LRE A;  5IJQ A;  4GTX A;  1EW2 A;  5LRM A;  1KH9 A;  4N7T A;  3M8W A;  1AJA A;  2W5V A;  4KJG A;  5INH A;  2W5X A;  5KXA A;  1EJJ A;  3A52 A;  1N2L A;  3M8Y A;  3UO0 A;  3NKQ A;  4ZGA A;  2ANH A;  3DPC A;  3ED4 A;  4CYS A;  5L0K A;  4NWJ A;  2GLQ A;  2GSO A;  3SZZ A;  4MIV A;  3WBH A;  3TWZ A;  4LRC A;  1ANJ A;  1E3C P;  2W5S A;  4LR7 A;  3CMR A;  1EQJ A;  1URB A;  3WAX A;  2W5W A;  2G9Y A;  3IGZ B;  3NKP A;  4KAY A;  4CYR A;  3E2D A;  4LRD A;  1KH5 A;  3WAY A;  1KH7 A;  3OT9 A;  2XRG A;  4KJD A;  4KAV A;  1KHK A;  3WAW A;  5L0B A;  5GRR A;  2XR9 A;  2IUC A;  3UN3 A; 
#chains in the Genus database with same CATH topology
 5IJS A;  1K7H A;  1KHL A;  2W8D A;  1ANI A;  5AJ9 A;  2W5R A;  3T01 A;  4UPI A;  3M7V A;  2W8S A;  5DLV A;  4GTW A;  3BDG A;  4GTZ A;  4LR2 A;  3Q3Q A;  5LQQ A;  1ALK A;  5HRT A;  1N2K A;  4LQY A;  4LRB A;  1O98 A;  1ELY A;  1ALH A;  2D1G A;  1O99 A;  4UOP A;  1SHQ A;  3MK2 A;  3LXQ A;  5C66 A;  2GSU A;  4MHX A;  5EGE A;  3BDH A;  3T00 A;  1AJC A;  1AJD A;  4ZG9 A;  3NVL A;  3MK1 A;  1ZEF A;  2X98 A;  4ZG7 A;  3IGY B;  5EGH A;  5LRN A;  4QAX A;  1ED9 A;  3UN5 A;  5L0E A;  1HDH A;  1E1Z P;  1KHJ A;  4UPK A;  1E33 P;  3BDF A;  1FSU A;  2VQR A;  4TN0 A;  2GA3 A;  1URA A;  1ZEB A;  4GTY A;  4FDI A;  1Y7A A;  4B56 A;  1ZED A;  3WAV A;  1ELX A;  2IFY A;  2ZKT A;  5GOV A;  5K4P A;  3M8Z A;  2W5T A;  3T02 A;  3MK0 A;  3SZY A;  2GSN A;  4CXU A;  3UNY A;  4UOR A;  5LIA A;  4LRF A;  3TG0 A;  1ED8 A;  4LR8 A;  4MY4 A;  3TX0 A;  3NKR A;  4NWX A;  3NKM A;  3NKN A;  3KD8 A;  1KH4 A;  2IUC B;  1ALI A;  4CXS A;  1EI6 A;  1AUK A;  1EW8 A;  4UPH A;  4ZG6 A;  4CXK A;  4KM4 A;  1HJK A;  4YR1 A;  1ALJ A;  3UN2 A;  4UOO A;  1EW9 A;  1KHN A;  1E2S P;  3BDG B;  3DYC A;  1P49 A;  1AJB A;  2RH6 A;  2QZU A;  3B5Q A;  4LRA A;  1HQA A;  1SHN A;  1ELZ A;  4LR9 A;  2W5Q A;  3IDD A;  5TJ3 A;  1Y6V A;  3NKO A;  5DLW A;  5DLT A;  1B8J A;  4UPL A;  4FDJ A;  4LRE A;  5IJQ A;  4GTX A;  1EW2 A;  5LRM A;  1KH9 A;  4N7T A;  3M8W A;  1AJA A;  2W5V A;  4KJG A;  5INH A;  2W5X A;  5KXA A;  1EJJ A;  3A52 A;  1N2L A;  3M8Y A;  3UO0 A;  3NKQ A;  4ZGA A;  2ANH A;  3DPC A;  3ED4 A;  4CYS A;  5L0K A;  4NWJ A;  2GLQ A;  2GSO A;  3SZZ A;  4MIV A;  3WBH A;  3TWZ A;  4LRC A;  1ANJ A;  1E3C P;  2W5S A;  4LR7 A;  3CMR A;  1EQJ A;  1URB A;  3WAX A;  2W5W A;  2G9Y A;  3IGZ B;  3NKP A;  4KAY A;  4CYR A;  3E2D A;  4LRD A;  1KH5 A;  3WAY A;  1KH7 A;  3OT9 A;  2XRG A;  4KJD A;  4KAV A;  1KHK A;  3WAW A;  5L0B A;  5GRR A;  2XR9 A;  2IUC A;  3UN3 A; 
#chains in the Genus database with same CATH homology
 5IJS A;  1K7H A;  1KHL A;  2W8D A;  1ANI A;  5AJ9 A;  2W5R A;  3T01 A;  4UPI A;  3M7V A;  2W8S A;  5DLV A;  4GTW A;  3BDG A;  4GTZ A;  4LR2 A;  3Q3Q A;  5LQQ A;  1ALK A;  5HRT A;  1N2K A;  4LQY A;  4LRB A;  1O98 A;  1ELY A;  1ALH A;  2D1G A;  1O99 A;  4UOP A;  1SHQ A;  3MK2 A;  3LXQ A;  5C66 A;  2GSU A;  4MHX A;  5EGE A;  3BDH A;  3T00 A;  1AJC A;  1AJD A;  4ZG9 A;  3NVL A;  3MK1 A;  1ZEF A;  2X98 A;  4ZG7 A;  3IGY B;  5EGH A;  5LRN A;  4QAX A;  1ED9 A;  3UN5 A;  5L0E A;  1HDH A;  1E1Z P;  1KHJ A;  4UPK A;  1E33 P;  3BDF A;  1FSU A;  2VQR A;  4TN0 A;  2GA3 A;  1URA A;  1ZEB A;  4GTY A;  4FDI A;  1Y7A A;  4B56 A;  1ZED A;  3WAV A;  1ELX A;  2IFY A;  2ZKT A;  5GOV A;  5K4P A;  3M8Z A;  2W5T A;  3T02 A;  3MK0 A;  3SZY A;  2GSN A;  4CXU A;  3UNY A;  4UOR A;  5LIA A;  4LRF A;  3TG0 A;  1ED8 A;  4LR8 A;  4MY4 A;  3TX0 A;  3NKR A;  4NWX A;  3NKM A;  3NKN A;  3KD8 A;  1KH4 A;  2IUC B;  1ALI A;  4CXS A;  1EI6 A;  1AUK A;  1EW8 A;  4UPH A;  4ZG6 A;  4CXK A;  4KM4 A;  1HJK A;  4YR1 A;  1ALJ A;  3UN2 A;  4UOO A;  1EW9 A;  1KHN A;  1E2S P;  3BDG B;  3DYC A;  1P49 A;  1AJB A;  2RH6 A;  2QZU A;  3B5Q A;  4LRA A;  1HQA A;  1SHN A;  1ELZ A;  4LR9 A;  2W5Q A;  3IDD A;  5TJ3 A;  1Y6V A;  3NKO A;  5DLW A;  5DLT A;  1B8J A;  4UPL A;  4FDJ A;  4LRE A;  5IJQ A;  4GTX A;  1EW2 A;  5LRM A;  1KH9 A;  4N7T A;  3M8W A;  1AJA A;  2W5V A;  4KJG A;  5INH A;  2W5X A;  5KXA A;  1EJJ A;  3A52 A;  1N2L A;  3M8Y A;  3UO0 A;  3NKQ A;  4ZGA A;  2ANH A;  3DPC A;  3ED4 A;  4CYS A;  5L0K A;  4NWJ A;  2GLQ A;  2GSO A;  3SZZ A;  4MIV A;  3WBH A;  3TWZ A;  4LRC A;  1ANJ A;  1E3C P;  2W5S A;  4LR7 A;  3CMR A;  1EQJ A;  1URB A;  3WAX A;  2W5W A;  2G9Y A;  3IGZ B;  3NKP A;  4KAY A;  4CYR A;  3E2D A;  4LRD A;  1KH5 A;  3WAY A;  1KH7 A;  3OT9 A;  2XRG A;  4KJD A;  4KAV A;  1KHK A;  3WAW A;  5L0B A;  5GRR A;  2XR9 A;  2IUC A;  3UN3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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