1ED9A

Structure of e. coli alkaline phosphatase without the inorganic phosphate at 1.75a resolution
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 167
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed9A00
5LIAA 1KHJA 3M7VA 3TX0A 3SZYA 3UN3A 1ALIA 1ELYA 4CXKA 4FDJA 5K4PA 4CXUA 4YR1A 4GTZA 4NWJA 2W5VA 2XRGA 3UN5A 1AJBA 3WBHA 5L0EA 3OT9A 3T01A 1HQAA 5GRRA 3IGYB 1N2LA 4GTYA 4KJDA 1AJCA 1SHNA 4UOPA 4ZG6A 1ZEFA 1E1ZP 5EGHA 4MIVA 1KH9A 3DPCA 1P49A 3M8ZA 4CYSA 2GSUA 4LRBA 3KD8A 5INHA 2GSNA 1ANJA 2W8DA 3B5QA 3ED4A 3IGZB 3MK2A 3MK0A 1SHQA 3NKQA 4QAXA 1EJJA 2GLQA 2ANHA 1EW9A 2ZKTA 1ALHA 1KHKA 2X98A 1ZEDA 2RH6A 3BDGA 4LR7A 1FSUA 1EW2A 4KAYA 4GTWA 4LR8A 3WAXA 1EQJA 4UORA 3BDFA 4ZGAA 5L0BA 1ELZA 5IJQA 1ANIA 4UPLA 1AJAA 2W5WA 1ZEBA 2D1GA 3WAYA 3Q3QA 4MHXA 5DLWA 1KH7A 4LQYA 4LR9A 3E2DA 4LR2A 2QZUA 3NKMA 1ALJA 4MY4A 4KAVA 1O98A 1EI6A 4CYRA 3NKPA 1URBA 2W5QA 5TJ3A 3T00A 2G9YA 1EW8A 3BDGB 3A52A 5LRMA 3CMRA 2W8SA 3WAWA 4GTXA 1Y7AA 1K7HA 3NKNA 1KHNA 4UPHA 2IFYA 5LRNA 5DLTA 3IDDA 4UOOA 3TG0A 1AUKA 3SZZA 4N7TA 4LRDA 4UPIA 4LRAA 4UPKA 2IUCA 5KXAA 3NKRA 1O99A 3BDHA 3UN2A 1ED8A 2W5XA 3LXQA 4TN0A 2W5TA 3NVLA 4KM4A 1URAA 4LRCA 3TWZA 1B8JA 1Y6VA 1E2SP 2W5RA 5L0KA 3WAVA 5IJSA 1E3CP 1KHLA 2GA3A 3T02A 5HRTA 2XR9A 1KH5A 4LREA 3M8YA 4KJGA 1ELXA 4ZG9A 3UNYA 1HDHA 5LQQA 1KH4A 1AJDA 1N2KA 4B56A 5C66A 2IUCB 1ALKA 4NWXA 5EGEA 5DLVA 1HJKA 3NKOA 2VQRA 2GSOA 5GOVA 3DYCA 4FDIA 4ZG7A 1E33P 3M8WA 4CXSA 4LRFA 1ED9A 3UO0A 3MK1A 2W5SA 5AJ9A
chains in the Genus database with same CATH superfamily
5LIAA 1KHJA 3M7VA 3TX0A 3SZYA 3UN3A 1ALIA 1ELYA 4CXKA 4FDJA 5K4PA 4CXUA 4YR1A 4GTZA 4NWJA 2W5VA 2XRGA 3UN5A 1AJBA 3WBHA 5L0EA 3OT9A 3T01A 1HQAA 5GRRA 3IGYB 1N2LA 4GTYA 4KJDA 1AJCA 1SHNA 4UOPA 4ZG6A 1ZEFA 1E1ZP 5EGHA 4MIVA 1KH9A 3DPCA 1P49A 3M8ZA 4CYSA 2GSUA 4LRBA 3KD8A 5INHA 2GSNA 1ANJA 2W8DA 3B5QA 3ED4A 3IGZB 3MK2A 3MK0A 1SHQA 3NKQA 4QAXA 1EJJA 2GLQA 2ANHA 1EW9A 2ZKTA 1ALHA 1KHKA 2X98A 1ZEDA 2RH6A 3BDGA 4LR7A 1FSUA 1EW2A 4KAYA 4GTWA 4LR8A 3WAXA 1EQJA 4UORA 3BDFA 4ZGAA 5L0BA 1ELZA 5IJQA 1ANIA 4UPLA 1AJAA 2W5WA 1ZEBA 2D1GA 3WAYA 3Q3QA 4MHXA 5DLWA 1KH7A 4LQYA 4LR9A 3E2DA 4LR2A 2QZUA 3NKMA 1ALJA 4MY4A 4KAVA 1O98A 1EI6A 4CYRA 3NKPA 1URBA 2W5QA 5TJ3A 3T00A 2G9YA 1EW8A 3BDGB 3A52A 5LRMA 3CMRA 2W8SA 3WAWA 4GTXA 1Y7AA 1K7HA 3NKNA 1KHNA 4UPHA 2IFYA 5LRNA 5DLTA 3IDDA 4UOOA 3TG0A 1AUKA 3SZZA 4N7TA 4LRDA 4UPIA 4LRAA 4UPKA 2IUCA 5KXAA 3NKRA 1O99A 3BDHA 3UN2A 1ED8A 2W5XA 3LXQA 4TN0A 2W5TA 3NVLA 4KM4A 1URAA 4LRCA 3TWZA 1B8JA 1Y6VA 1E2SP 2W5RA 5L0KA 3WAVA 5IJSA 1E3CP 1KHLA 2GA3A 3T02A 5HRTA 2XR9A 1KH5A 4LREA 3M8YA 4KJGA 1ELXA 4ZG9A 3UNYA 1HDHA 5LQQA 1KH4A 1AJDA 1N2KA 4B56A 5C66A 2IUCB 1ALKA 4NWXA 5EGEA 5DLVA 1HJKA 3NKOA 2VQRA 2GSOA 5GOVA 3DYCA 4FDIA 4ZG7A 1E33P 3M8WA 4CXSA 4LRFA 1ED9A 3UO0A 3MK1A 2W5SA 5AJ9A
chains in the Genus database with same CATH topology
5LIAA 1KHJA 3M7VA 3TX0A 3SZYA 3UN3A 1ALIA 1ELYA 4CXKA 4FDJA 5K4PA 4CXUA 4YR1A 4GTZA 4NWJA 2W5VA 2XRGA 3UN5A 1AJBA 3WBHA 5L0EA 3OT9A 3T01A 1HQAA 5GRRA 3IGYB 1N2LA 4GTYA 4KJDA 1AJCA 1SHNA 4UOPA 4ZG6A 1ZEFA 1E1ZP 5EGHA 4MIVA 1KH9A 3DPCA 1P49A 3M8ZA 4CYSA 2GSUA 4LRBA 3KD8A 5INHA 2GSNA 1ANJA 2W8DA 3B5QA 3ED4A 3IGZB 3MK2A 3MK0A 1SHQA 3NKQA 4QAXA 1EJJA 2GLQA 2ANHA 1EW9A 2ZKTA 1ALHA 1KHKA 2X98A 1ZEDA 2RH6A 3BDGA 4LR7A 1FSUA 1EW2A 4KAYA 4GTWA 4LR8A 3WAXA 1EQJA 4UORA 3BDFA 4ZGAA 5L0BA 1ELZA 5IJQA 1ANIA 4UPLA 1AJAA 2W5WA 1ZEBA 2D1GA 3WAYA 3Q3QA 4MHXA 5DLWA 1KH7A 4LQYA 4LR9A 3E2DA 4LR2A 2QZUA 3NKMA 1ALJA 4MY4A 4KAVA 1O98A 1EI6A 4CYRA 3NKPA 1URBA 2W5QA 5TJ3A 3T00A 2G9YA 1EW8A 3BDGB 3A52A 5LRMA 3CMRA 2W8SA 3WAWA 4GTXA 1Y7AA 1K7HA 3NKNA 1KHNA 4UPHA 2IFYA 5LRNA 5DLTA 3IDDA 4UOOA 3TG0A 1AUKA 3SZZA 4N7TA 4LRDA 4UPIA 4LRAA 4UPKA 2IUCA 5KXAA 3NKRA 1O99A 3BDHA 3UN2A 1ED8A 2W5XA 3LXQA 4TN0A 2W5TA 3NVLA 4KM4A 1URAA 4LRCA 3TWZA 1B8JA 1Y6VA 1E2SP 2W5RA 5L0KA 3WAVA 5IJSA 1E3CP 1KHLA 2GA3A 3T02A 5HRTA 2XR9A 1KH5A 4LREA 3M8YA 4KJGA 1ELXA 4ZG9A 3UNYA 1HDHA 5LQQA 1KH4A 1AJDA 1N2KA 4B56A 5C66A 2IUCB 1ALKA 4NWXA 5EGEA 5DLVA 1HJKA 3NKOA 2VQRA 2GSOA 5GOVA 3DYCA 4FDIA 4ZG7A 1E33P 3M8WA 4CXSA 4LRFA 1ED9A 3UO0A 3MK1A 2W5SA 5AJ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LIA A;  1KHJ A;  3M7V A;  3TX0 A;  3SZY A;  3UN3 A;  1ALI A;  1ELY A;  4CXK A;  4FDJ A;  5K4P A;  4CXU A;  4YR1 A;  4GTZ A;  4NWJ A;  2W5V A;  2XRG A;  3UN5 A;  1AJB A;  3WBH A;  5L0E A;  3OT9 A;  3T01 A;  1HQA A;  5GRR A;  3IGY B;  1N2L A;  4GTY A;  4KJD A;  1AJC A;  1SHN A;  4UOP A;  4ZG6 A;  1ZEF A;  1E1Z P;  5EGH A;  4MIV A;  1KH9 A;  3DPC A;  1P49 A;  3M8Z A;  4CYS A;  2GSU A;  4LRB A;  3KD8 A;  5INH A;  2GSN A;  1ANJ A;  2W8D A;  3B5Q A;  3ED4 A;  3IGZ B;  3MK2 A;  3MK0 A;  1SHQ A;  3NKQ A;  4QAX A;  1EJJ A;  2GLQ A;  2ANH A;  1EW9 A;  2ZKT A;  1ALH A;  1KHK A;  2X98 A;  1ZED A;  2RH6 A;  3BDG A;  4LR7 A;  1FSU A;  1EW2 A;  4KAY A;  4GTW A;  4LR8 A;  3WAX A;  1EQJ A;  4UOR A;  3BDF A;  4ZGA A;  5L0B A;  1ELZ A;  5IJQ A;  1ANI A;  4UPL A;  1AJA A;  2W5W A;  1ZEB A;  2D1G A;  3WAY A;  3Q3Q A;  4MHX A;  5DLW A;  1KH7 A;  4LQY A;  4LR9 A;  3E2D A;  4LR2 A;  2QZU A;  3NKM A;  1ALJ A;  4MY4 A;  4KAV A;  1O98 A;  1EI6 A;  4CYR A;  3NKP A;  1URB A;  2W5Q A;  5TJ3 A;  3T00 A;  2G9Y A;  1EW8 A;  3BDG B;  3A52 A;  5LRM A;  3CMR A;  2W8S A;  3WAW A;  4GTX A;  1Y7A A;  1K7H A;  3NKN A;  1KHN A;  4UPH A;  2IFY A;  5LRN A;  5DLT A;  3IDD A;  4UOO A;  3TG0 A;  1AUK A;  3SZZ A;  4N7T A;  4LRD A;  4UPI A;  4LRA A;  4UPK A;  2IUC A;  5KXA A;  3NKR A;  1O99 A;  3BDH A;  3UN2 A;  1ED8 A;  2W5X A;  3LXQ A;  4TN0 A;  2W5T A;  3NVL A;  4KM4 A;  1URA A;  4LRC A;  3TWZ A;  1B8J A;  1Y6V A;  1E2S P;  2W5R A;  5L0K A;  3WAV A;  5IJS A;  1E3C P;  1KHL A;  2GA3 A;  3T02 A;  5HRT A;  2XR9 A;  1KH5 A;  4LRE A;  3M8Y A;  4KJG A;  1ELX A;  4ZG9 A;  3UNY A;  1HDH A;  5LQQ A;  1KH4 A;  1AJD A;  1N2K A;  4B56 A;  5C66 A;  2IUC B;  1ALK A;  4NWX A;  5EGE A;  5DLV A;  1HJK A;  3NKO A;  2VQR A;  2GSO A;  5GOV A;  3DYC A;  4FDI A;  4ZG7 A;  1E33 P;  3M8W A;  4CXS A;  4LRF A;  1ED9 A;  3UO0 A;  3MK1 A;  2W5S A;  5AJ9 A; 
#chains in the Genus database with same CATH topology
 5LIA A;  1KHJ A;  3M7V A;  3TX0 A;  3SZY A;  3UN3 A;  1ALI A;  1ELY A;  4CXK A;  4FDJ A;  5K4P A;  4CXU A;  4YR1 A;  4GTZ A;  4NWJ A;  2W5V A;  2XRG A;  3UN5 A;  1AJB A;  3WBH A;  5L0E A;  3OT9 A;  3T01 A;  1HQA A;  5GRR A;  3IGY B;  1N2L A;  4GTY A;  4KJD A;  1AJC A;  1SHN A;  4UOP A;  4ZG6 A;  1ZEF A;  1E1Z P;  5EGH A;  4MIV A;  1KH9 A;  3DPC A;  1P49 A;  3M8Z A;  4CYS A;  2GSU A;  4LRB A;  3KD8 A;  5INH A;  2GSN A;  1ANJ A;  2W8D A;  3B5Q A;  3ED4 A;  3IGZ B;  3MK2 A;  3MK0 A;  1SHQ A;  3NKQ A;  4QAX A;  1EJJ A;  2GLQ A;  2ANH A;  1EW9 A;  2ZKT A;  1ALH A;  1KHK A;  2X98 A;  1ZED A;  2RH6 A;  3BDG A;  4LR7 A;  1FSU A;  1EW2 A;  4KAY A;  4GTW A;  4LR8 A;  3WAX A;  1EQJ A;  4UOR A;  3BDF A;  4ZGA A;  5L0B A;  1ELZ A;  5IJQ A;  1ANI A;  4UPL A;  1AJA A;  2W5W A;  1ZEB A;  2D1G A;  3WAY A;  3Q3Q A;  4MHX A;  5DLW A;  1KH7 A;  4LQY A;  4LR9 A;  3E2D A;  4LR2 A;  2QZU A;  3NKM A;  1ALJ A;  4MY4 A;  4KAV A;  1O98 A;  1EI6 A;  4CYR A;  3NKP A;  1URB A;  2W5Q A;  5TJ3 A;  3T00 A;  2G9Y A;  1EW8 A;  3BDG B;  3A52 A;  5LRM A;  3CMR A;  2W8S A;  3WAW A;  4GTX A;  1Y7A A;  1K7H A;  3NKN A;  1KHN A;  4UPH A;  2IFY A;  5LRN A;  5DLT A;  3IDD A;  4UOO A;  3TG0 A;  1AUK A;  3SZZ A;  4N7T A;  4LRD A;  4UPI A;  4LRA A;  4UPK A;  2IUC A;  5KXA A;  3NKR A;  1O99 A;  3BDH A;  3UN2 A;  1ED8 A;  2W5X A;  3LXQ A;  4TN0 A;  2W5T A;  3NVL A;  4KM4 A;  1URA A;  4LRC A;  3TWZ A;  1B8J A;  1Y6V A;  1E2S P;  2W5R A;  5L0K A;  3WAV A;  5IJS A;  1E3C P;  1KHL A;  2GA3 A;  3T02 A;  5HRT A;  2XR9 A;  1KH5 A;  4LRE A;  3M8Y A;  4KJG A;  1ELX A;  4ZG9 A;  3UNY A;  1HDH A;  5LQQ A;  1KH4 A;  1AJD A;  1N2K A;  4B56 A;  5C66 A;  2IUC B;  1ALK A;  4NWX A;  5EGE A;  5DLV A;  1HJK A;  3NKO A;  2VQR A;  2GSO A;  5GOV A;  3DYC A;  4FDI A;  4ZG7 A;  1E33 P;  3M8W A;  4CXS A;  4LRF A;  1ED9 A;  3UO0 A;  3MK1 A;  2W5S A;  5AJ9 A; 
#chains in the Genus database with same CATH homology
 5LIA A;  1KHJ A;  3M7V A;  3TX0 A;  3SZY A;  3UN3 A;  1ALI A;  1ELY A;  4CXK A;  4FDJ A;  5K4P A;  4CXU A;  4YR1 A;  4GTZ A;  4NWJ A;  2W5V A;  2XRG A;  3UN5 A;  1AJB A;  3WBH A;  5L0E A;  3OT9 A;  3T01 A;  1HQA A;  5GRR A;  3IGY B;  1N2L A;  4GTY A;  4KJD A;  1AJC A;  1SHN A;  4UOP A;  4ZG6 A;  1ZEF A;  1E1Z P;  5EGH A;  4MIV A;  1KH9 A;  3DPC A;  1P49 A;  3M8Z A;  4CYS A;  2GSU A;  4LRB A;  3KD8 A;  5INH A;  2GSN A;  1ANJ A;  2W8D A;  3B5Q A;  3ED4 A;  3IGZ B;  3MK2 A;  3MK0 A;  1SHQ A;  3NKQ A;  4QAX A;  1EJJ A;  2GLQ A;  2ANH A;  1EW9 A;  2ZKT A;  1ALH A;  1KHK A;  2X98 A;  1ZED A;  2RH6 A;  3BDG A;  4LR7 A;  1FSU A;  1EW2 A;  4KAY A;  4GTW A;  4LR8 A;  3WAX A;  1EQJ A;  4UOR A;  3BDF A;  4ZGA A;  5L0B A;  1ELZ A;  5IJQ A;  1ANI A;  4UPL A;  1AJA A;  2W5W A;  1ZEB A;  2D1G A;  3WAY A;  3Q3Q A;  4MHX A;  5DLW A;  1KH7 A;  4LQY A;  4LR9 A;  3E2D A;  4LR2 A;  2QZU A;  3NKM A;  1ALJ A;  4MY4 A;  4KAV A;  1O98 A;  1EI6 A;  4CYR A;  3NKP A;  1URB A;  2W5Q A;  5TJ3 A;  3T00 A;  2G9Y A;  1EW8 A;  3BDG B;  3A52 A;  5LRM A;  3CMR A;  2W8S A;  3WAW A;  4GTX A;  1Y7A A;  1K7H A;  3NKN A;  1KHN A;  4UPH A;  2IFY A;  5LRN A;  5DLT A;  3IDD A;  4UOO A;  3TG0 A;  1AUK A;  3SZZ A;  4N7T A;  4LRD A;  4UPI A;  4LRA A;  4UPK A;  2IUC A;  5KXA A;  3NKR A;  1O99 A;  3BDH A;  3UN2 A;  1ED8 A;  2W5X A;  3LXQ A;  4TN0 A;  2W5T A;  3NVL A;  4KM4 A;  1URA A;  4LRC A;  3TWZ A;  1B8J A;  1Y6V A;  1E2S P;  2W5R A;  5L0K A;  3WAV A;  5IJS A;  1E3C P;  1KHL A;  2GA3 A;  3T02 A;  5HRT A;  2XR9 A;  1KH5 A;  4LRE A;  3M8Y A;  4KJG A;  1ELX A;  4ZG9 A;  3UNY A;  1HDH A;  5LQQ A;  1KH4 A;  1AJD A;  1N2K A;  4B56 A;  5C66 A;  2IUC B;  1ALK A;  4NWX A;  5EGE A;  5DLV A;  1HJK A;  3NKO A;  2VQR A;  2GSO A;  5GOV A;  3DYC A;  4FDI A;  4ZG7 A;  1E33 P;  3M8W A;  4CXS A;  4LRF A;  1ED9 A;  3UO0 A;  3MK1 A;  2W5S A;  5AJ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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