1ED9A

Structure of e. coli alkaline phosphatase without the inorganic phosphate at 1.75a resolution
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
source organism Escherichia coli
publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
molecule keywords ALKALINE PHOSPHATASE
total genus 167
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed9A00
1KH4A 4ZG9A 5LQQA 1SHNA 4FDJA 4UPIA 1SHQA 5IJQA 4CYRA 4LQYA 4CXKA 2QZUA 4QAXA 2W8SA 1ALHA 1N2LA 1HJKA 2W8DA 1EW9A 1ED8A 1URAA 3BDGB 1EI6A 1B8JA 1E33P 4UOOA 4MHXA 4CXSA 3TG0A 3B5QA 3M8ZA 1KH5A 2GLQA 2XRGA 1AJBA 1ZEDA 1E2SP 5IJSA 3SZYA 3WAYA 2GSUA 3E2DA 1HQAA 4LRDA 3T02A 1K7HA 2GSNA 3UN3A 4LRCA 5GOVA 2IFYA 4MIVA 1ELYA 3IGYB 5DLWA 3T01A 4KJGA 5GRRA 2RH6A 3UNYA 3M8WA 3OT9A 4FDIA 2G9YA 2XR9A 5L0BA 4UOPA 4B56A 1Y7AA 5EGHA 4TN0A 2W5TA 2W5XA 3M8YA 3NKQA 4KJDA 1E1ZP 4N7TA 4LRFA 4LR2A 1AUKA 4ZG6A 1EW2A 1AJCA 1KH9A 3DPCA 3WAVA 4CXUA 1ANIA 1KHKA 3TX0A 2IUCB 4LR8A 3BDFA 3BDHA 5DLTA 5KXAA 4CYSA 4LRBA 2ANHA 3IDDA 3SZZA 1FSUA 2W5QA 1ELXA 1N2KA 3NVLA 4UPHA 4UPLA 1ALIA 3T00A 4KM4A 1AJAA 2W5RA 5L0EA 5HRTA 4GTZA 3ED4A 3NKNA 5AJ9A 5INHA 4KAYA 1ALKA 3MK0A 1AJDA 4UORA 1KHLA 2GSOA 4ZGAA 5EGEA 1O99A 4GTXA 1EQJA 2W5WA 1O98A 1KH7A 2VQRA 2W5VA 3BDGA 3A52A 4LREA 3NKRA 4NWXA 3WAWA 4LR9A 3WBHA 1Y6VA 4ZG7A 4MY4A 3UO0A 4LR7A 1P49A 4UPKA 3CMRA 5K4PA 1HDHA 5TJ3A 1KHNA 3DYCA 1EJJA 1ANJA 4LRAA 2X98A 5L0KA 3Q3QA 3NKMA 1ZEFA 3MK2A 3IGZB 3MK1A 1ED9A 4GTYA 1KHJA 1EW8A 1ALJA 3WAXA 2D1GA 5LRMA 3M7VA 3UN5A 5LRNA 5LIAA 4GTWA 3UN2A 3KD8A 1ELZA 3LXQA 1E3CP 1URBA 3TWZA 3NKOA 2IUCA 1ZEBA 5DLVA 2GA3A 4NWJA 2W5SA 3NKPA 2ZKTA 5C66A 4YR1A 4KAVA
chains in the Genus database with same CATH superfamily
1KH4A 4ZG9A 5LQQA 1SHNA 4FDJA 4UPIA 1SHQA 5IJQA 4CYRA 4LQYA 4CXKA 2QZUA 4QAXA 2W8SA 1ALHA 1N2LA 1HJKA 2W8DA 1EW9A 1ED8A 1URAA 3BDGB 1EI6A 1B8JA 1E33P 4UOOA 4MHXA 4CXSA 3TG0A 3B5QA 3M8ZA 1KH5A 2GLQA 2XRGA 1AJBA 1ZEDA 1E2SP 5IJSA 3SZYA 3WAYA 2GSUA 3E2DA 1HQAA 4LRDA 3T02A 1K7HA 2GSNA 3UN3A 4LRCA 5GOVA 2IFYA 4MIVA 1ELYA 3IGYB 5DLWA 3T01A 4KJGA 5GRRA 2RH6A 3UNYA 3M8WA 3OT9A 4FDIA 2G9YA 2XR9A 5L0BA 4UOPA 4B56A 1Y7AA 5EGHA 4TN0A 2W5TA 2W5XA 3M8YA 3NKQA 4KJDA 1E1ZP 4N7TA 4LRFA 4LR2A 1AUKA 4ZG6A 1EW2A 1AJCA 1KH9A 3DPCA 3WAVA 4CXUA 1ANIA 1KHKA 3TX0A 2IUCB 4LR8A 3BDFA 3BDHA 5DLTA 5KXAA 4CYSA 4LRBA 2ANHA 3IDDA 3SZZA 1FSUA 2W5QA 1ELXA 1N2KA 3NVLA 4UPHA 4UPLA 1ALIA 3T00A 4KM4A 1AJAA 2W5RA 5L0EA 5HRTA 4GTZA 3ED4A 3NKNA 5AJ9A 5INHA 4KAYA 1ALKA 3MK0A 1AJDA 4UORA 1KHLA 2GSOA 4ZGAA 5EGEA 1O99A 4GTXA 1EQJA 2W5WA 1O98A 1KH7A 2VQRA 2W5VA 3BDGA 3A52A 4LREA 3NKRA 4NWXA 3WAWA 4LR9A 3WBHA 1Y6VA 4ZG7A 4MY4A 3UO0A 4LR7A 1P49A 4UPKA 3CMRA 5K4PA 1HDHA 5TJ3A 1KHNA 3DYCA 1EJJA 1ANJA 4LRAA 2X98A 5L0KA 3Q3QA 3NKMA 1ZEFA 3MK2A 3IGZB 3MK1A 1ED9A 4GTYA 1KHJA 1EW8A 1ALJA 3WAXA 2D1GA 5LRMA 3M7VA 3UN5A 5LRNA 5LIAA 4GTWA 3UN2A 3KD8A 1ELZA 3LXQA 1E3CP 1URBA 3TWZA 3NKOA 2IUCA 1ZEBA 5DLVA 2GA3A 4NWJA 2W5SA 3NKPA 2ZKTA 5C66A 4YR1A 4KAVA
chains in the Genus database with same CATH topology
1KH4A 4ZG9A 5LQQA 1SHNA 4FDJA 4UPIA 1SHQA 5IJQA 4CYRA 4LQYA 4CXKA 2QZUA 4QAXA 2W8SA 1ALHA 1N2LA 1HJKA 2W8DA 1EW9A 1ED8A 1URAA 3BDGB 1EI6A 1B8JA 1E33P 4UOOA 4MHXA 4CXSA 3TG0A 3B5QA 3M8ZA 1KH5A 2GLQA 2XRGA 1AJBA 1ZEDA 1E2SP 5IJSA 3SZYA 3WAYA 2GSUA 3E2DA 1HQAA 4LRDA 3T02A 1K7HA 2GSNA 3UN3A 4LRCA 5GOVA 2IFYA 4MIVA 1ELYA 3IGYB 5DLWA 3T01A 4KJGA 5GRRA 2RH6A 3UNYA 3M8WA 3OT9A 4FDIA 2G9YA 2XR9A 5L0BA 4UOPA 4B56A 1Y7AA 5EGHA 4TN0A 2W5TA 2W5XA 3M8YA 3NKQA 4KJDA 1E1ZP 4N7TA 4LRFA 4LR2A 1AUKA 4ZG6A 1EW2A 1AJCA 1KH9A 3DPCA 3WAVA 4CXUA 1ANIA 1KHKA 3TX0A 2IUCB 4LR8A 3BDFA 3BDHA 5DLTA 5KXAA 4CYSA 4LRBA 2ANHA 3IDDA 3SZZA 1FSUA 2W5QA 1ELXA 1N2KA 3NVLA 4UPHA 4UPLA 1ALIA 3T00A 4KM4A 1AJAA 2W5RA 5L0EA 5HRTA 4GTZA 3ED4A 3NKNA 5AJ9A 5INHA 4KAYA 1ALKA 3MK0A 1AJDA 4UORA 1KHLA 2GSOA 4ZGAA 5EGEA 1O99A 4GTXA 1EQJA 2W5WA 1O98A 1KH7A 2VQRA 2W5VA 3BDGA 3A52A 4LREA 3NKRA 4NWXA 3WAWA 4LR9A 3WBHA 1Y6VA 4ZG7A 4MY4A 3UO0A 4LR7A 1P49A 4UPKA 3CMRA 5K4PA 1HDHA 5TJ3A 1KHNA 3DYCA 1EJJA 1ANJA 4LRAA 2X98A 5L0KA 3Q3QA 3NKMA 1ZEFA 3MK2A 3IGZB 3MK1A 1ED9A 4GTYA 1KHJA 1EW8A 1ALJA 3WAXA 2D1GA 5LRMA 3M7VA 3UN5A 5LRNA 5LIAA 4GTWA 3UN2A 3KD8A 1ELZA 3LXQA 1E3CP 1URBA 3TWZA 3NKOA 2IUCA 1ZEBA 5DLVA 2GA3A 4NWJA 2W5SA 3NKPA 2ZKTA 5C66A 4YR1A 4KAVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KH4 A;  4ZG9 A;  5LQQ A;  1SHN A;  4FDJ A;  4UPI A;  1SHQ A;  5IJQ A;  4CYR A;  4LQY A;  4CXK A;  2QZU A;  4QAX A;  2W8S A;  1ALH A;  1N2L A;  1HJK A;  2W8D A;  1EW9 A;  1ED8 A;  1URA A;  3BDG B;  1EI6 A;  1B8J A;  1E33 P;  4UOO A;  4MHX A;  4CXS A;  3TG0 A;  3B5Q A;  3M8Z A;  1KH5 A;  2GLQ A;  2XRG A;  1AJB A;  1ZED A;  1E2S P;  5IJS A;  3SZY A;  3WAY A;  2GSU A;  3E2D A;  1HQA A;  4LRD A;  3T02 A;  1K7H A;  2GSN A;  3UN3 A;  4LRC A;  5GOV A;  2IFY A;  4MIV A;  1ELY A;  3IGY B;  5DLW A;  3T01 A;  4KJG A;  5GRR A;  2RH6 A;  3UNY A;  3M8W A;  3OT9 A;  4FDI A;  2G9Y A;  2XR9 A;  5L0B A;  4UOP A;  4B56 A;  1Y7A A;  5EGH A;  4TN0 A;  2W5T A;  2W5X A;  3M8Y A;  3NKQ A;  4KJD A;  1E1Z P;  4N7T A;  4LRF A;  4LR2 A;  1AUK A;  4ZG6 A;  1EW2 A;  1AJC A;  1KH9 A;  3DPC A;  3WAV A;  4CXU A;  1ANI A;  1KHK A;  3TX0 A;  2IUC B;  4LR8 A;  3BDF A;  3BDH A;  5DLT A;  5KXA A;  4CYS A;  4LRB A;  2ANH A;  3IDD A;  3SZZ A;  1FSU A;  2W5Q A;  1ELX A;  1N2K A;  3NVL A;  4UPH A;  4UPL A;  1ALI A;  3T00 A;  4KM4 A;  1AJA A;  2W5R A;  5L0E A;  5HRT A;  4GTZ A;  3ED4 A;  3NKN A;  5AJ9 A;  5INH A;  4KAY A;  1ALK A;  3MK0 A;  1AJD A;  4UOR A;  1KHL A;  2GSO A;  4ZGA A;  5EGE A;  1O99 A;  4GTX A;  1EQJ A;  2W5W A;  1O98 A;  1KH7 A;  2VQR A;  2W5V A;  3BDG A;  3A52 A;  4LRE A;  3NKR A;  4NWX A;  3WAW A;  4LR9 A;  3WBH A;  1Y6V A;  4ZG7 A;  4MY4 A;  3UO0 A;  4LR7 A;  1P49 A;  4UPK A;  3CMR A;  5K4P A;  1HDH A;  5TJ3 A;  1KHN A;  3DYC A;  1EJJ A;  1ANJ A;  4LRA A;  2X98 A;  5L0K A;  3Q3Q A;  3NKM A;  1ZEF A;  3MK2 A;  3IGZ B;  3MK1 A;  1ED9 A;  4GTY A;  1KHJ A;  1EW8 A;  1ALJ A;  3WAX A;  2D1G A;  5LRM A;  3M7V A;  3UN5 A;  5LRN A;  5LIA A;  4GTW A;  3UN2 A;  3KD8 A;  1ELZ A;  3LXQ A;  1E3C P;  1URB A;  3TWZ A;  3NKO A;  2IUC A;  1ZEB A;  5DLV A;  2GA3 A;  4NWJ A;  2W5S A;  3NKP A;  2ZKT A;  5C66 A;  4YR1 A;  4KAV A; 
#chains in the Genus database with same CATH topology
 1KH4 A;  4ZG9 A;  5LQQ A;  1SHN A;  4FDJ A;  4UPI A;  1SHQ A;  5IJQ A;  4CYR A;  4LQY A;  4CXK A;  2QZU A;  4QAX A;  2W8S A;  1ALH A;  1N2L A;  1HJK A;  2W8D A;  1EW9 A;  1ED8 A;  1URA A;  3BDG B;  1EI6 A;  1B8J A;  1E33 P;  4UOO A;  4MHX A;  4CXS A;  3TG0 A;  3B5Q A;  3M8Z A;  1KH5 A;  2GLQ A;  2XRG A;  1AJB A;  1ZED A;  1E2S P;  5IJS A;  3SZY A;  3WAY A;  2GSU A;  3E2D A;  1HQA A;  4LRD A;  3T02 A;  1K7H A;  2GSN A;  3UN3 A;  4LRC A;  5GOV A;  2IFY A;  4MIV A;  1ELY A;  3IGY B;  5DLW A;  3T01 A;  4KJG A;  5GRR A;  2RH6 A;  3UNY A;  3M8W A;  3OT9 A;  4FDI A;  2G9Y A;  2XR9 A;  5L0B A;  4UOP A;  4B56 A;  1Y7A A;  5EGH A;  4TN0 A;  2W5T A;  2W5X A;  3M8Y A;  3NKQ A;  4KJD A;  1E1Z P;  4N7T A;  4LRF A;  4LR2 A;  1AUK A;  4ZG6 A;  1EW2 A;  1AJC A;  1KH9 A;  3DPC A;  3WAV A;  4CXU A;  1ANI A;  1KHK A;  3TX0 A;  2IUC B;  4LR8 A;  3BDF A;  3BDH A;  5DLT A;  5KXA A;  4CYS A;  4LRB A;  2ANH A;  3IDD A;  3SZZ A;  1FSU A;  2W5Q A;  1ELX A;  1N2K A;  3NVL A;  4UPH A;  4UPL A;  1ALI A;  3T00 A;  4KM4 A;  1AJA A;  2W5R A;  5L0E A;  5HRT A;  4GTZ A;  3ED4 A;  3NKN A;  5AJ9 A;  5INH A;  4KAY A;  1ALK A;  3MK0 A;  1AJD A;  4UOR A;  1KHL A;  2GSO A;  4ZGA A;  5EGE A;  1O99 A;  4GTX A;  1EQJ A;  2W5W A;  1O98 A;  1KH7 A;  2VQR A;  2W5V A;  3BDG A;  3A52 A;  4LRE A;  3NKR A;  4NWX A;  3WAW A;  4LR9 A;  3WBH A;  1Y6V A;  4ZG7 A;  4MY4 A;  3UO0 A;  4LR7 A;  1P49 A;  4UPK A;  3CMR A;  5K4P A;  1HDH A;  5TJ3 A;  1KHN A;  3DYC A;  1EJJ A;  1ANJ A;  4LRA A;  2X98 A;  5L0K A;  3Q3Q A;  3NKM A;  1ZEF A;  3MK2 A;  3IGZ B;  3MK1 A;  1ED9 A;  4GTY A;  1KHJ A;  1EW8 A;  1ALJ A;  3WAX A;  2D1G A;  5LRM A;  3M7V A;  3UN5 A;  5LRN A;  5LIA A;  4GTW A;  3UN2 A;  3KD8 A;  1ELZ A;  3LXQ A;  1E3C P;  1URB A;  3TWZ A;  3NKO A;  2IUC A;  1ZEB A;  5DLV A;  2GA3 A;  4NWJ A;  2W5S A;  3NKP A;  2ZKT A;  5C66 A;  4YR1 A;  4KAV A; 
#chains in the Genus database with same CATH homology
 1KH4 A;  4ZG9 A;  5LQQ A;  1SHN A;  4FDJ A;  4UPI A;  1SHQ A;  5IJQ A;  4CYR A;  4LQY A;  4CXK A;  2QZU A;  4QAX A;  2W8S A;  1ALH A;  1N2L A;  1HJK A;  2W8D A;  1EW9 A;  1ED8 A;  1URA A;  3BDG B;  1EI6 A;  1B8J A;  1E33 P;  4UOO A;  4MHX A;  4CXS A;  3TG0 A;  3B5Q A;  3M8Z A;  1KH5 A;  2GLQ A;  2XRG A;  1AJB A;  1ZED A;  1E2S P;  5IJS A;  3SZY A;  3WAY A;  2GSU A;  3E2D A;  1HQA A;  4LRD A;  3T02 A;  1K7H A;  2GSN A;  3UN3 A;  4LRC A;  5GOV A;  2IFY A;  4MIV A;  1ELY A;  3IGY B;  5DLW A;  3T01 A;  4KJG A;  5GRR A;  2RH6 A;  3UNY A;  3M8W A;  3OT9 A;  4FDI A;  2G9Y A;  2XR9 A;  5L0B A;  4UOP A;  4B56 A;  1Y7A A;  5EGH A;  4TN0 A;  2W5T A;  2W5X A;  3M8Y A;  3NKQ A;  4KJD A;  1E1Z P;  4N7T A;  4LRF A;  4LR2 A;  1AUK A;  4ZG6 A;  1EW2 A;  1AJC A;  1KH9 A;  3DPC A;  3WAV A;  4CXU A;  1ANI A;  1KHK A;  3TX0 A;  2IUC B;  4LR8 A;  3BDF A;  3BDH A;  5DLT A;  5KXA A;  4CYS A;  4LRB A;  2ANH A;  3IDD A;  3SZZ A;  1FSU A;  2W5Q A;  1ELX A;  1N2K A;  3NVL A;  4UPH A;  4UPL A;  1ALI A;  3T00 A;  4KM4 A;  1AJA A;  2W5R A;  5L0E A;  5HRT A;  4GTZ A;  3ED4 A;  3NKN A;  5AJ9 A;  5INH A;  4KAY A;  1ALK A;  3MK0 A;  1AJD A;  4UOR A;  1KHL A;  2GSO A;  4ZGA A;  5EGE A;  1O99 A;  4GTX A;  1EQJ A;  2W5W A;  1O98 A;  1KH7 A;  2VQR A;  2W5V A;  3BDG A;  3A52 A;  4LRE A;  3NKR A;  4NWX A;  3WAW A;  4LR9 A;  3WBH A;  1Y6V A;  4ZG7 A;  4MY4 A;  3UO0 A;  4LR7 A;  1P49 A;  4UPK A;  3CMR A;  5K4P A;  1HDH A;  5TJ3 A;  1KHN A;  3DYC A;  1EJJ A;  1ANJ A;  4LRA A;  2X98 A;  5L0K A;  3Q3Q A;  3NKM A;  1ZEF A;  3MK2 A;  3IGZ B;  3MK1 A;  1ED9 A;  4GTY A;  1KHJ A;  1EW8 A;  1ALJ A;  3WAX A;  2D1G A;  5LRM A;  3M7V A;  3UN5 A;  5LRN A;  5LIA A;  4GTW A;  3UN2 A;  3KD8 A;  1ELZ A;  3LXQ A;  1E3C P;  1URB A;  3TWZ A;  3NKO A;  2IUC A;  1ZEB A;  5DLV A;  2GA3 A;  4NWJ A;  2W5S A;  3NKP A;  2ZKT A;  5C66 A;  4YR1 A;  4KAV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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