1EW2A

Crystal structure of a human phosphatase
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule keywords PHOSPHATASE
molecule tags Hydrolase
total genus 172
structure length 479
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
4QAXA 4KJDA 1E2SP 3NKMA 4KM4A 4UPHA 3M8WA 2W5RA 3SZZA 4ZG7A 3TX0A 4UOOA 3BDFA 1K7HA 4LR2A 1EW9A 3IGZB 5EGEA 4LQYA 2QZUA 4LRFA 5GOVA 2GSUA 3OT9A 2RH6A 1ALJA 1ED8A 4UPIA 3UNYA 3NKPA 3UN2A 3T02A 4MY4A 5LIAA 1EI6A 2W5SA 3NKOA 1Y6VA 4CXSA 2GSNA 4FDIA 1KH4A 3BDGB 4LR7A 2GLQA 2G9YA 3NKQA 5DLTA 3WAVA 2IUCB 1B8JA 3ED4A 2D1GA 4GTXA 4LRDA 1EW8A 3M8YA 4CXUA 5GRRA 5HRTA 2GSOA 2XR9A 4N7TA 3DYCA 4B56A 3WBHA 5EGHA 3DPCA 5KXAA 5K4PA 3UO0A 3LXQA 4NWJA 3WAXA 2W8SA 4GTYA 1KHJA 3MK2A 5LQQA 4LR9A 3IDDA 3UN3A 1HJKA 3IGYB 1ALKA 2VQRA 1AJDA 2X98A 1AJBA 1P49A 4GTWA 5IJQA 1ANIA 1SHNA 5L0EA 1EQJA 1KHNA 3MK1A 1E3CP 1KH5A 1ED9A 3CMRA 2GA3A 5IJSA 1E1ZP 1O99A 4CYSA 1Y7AA 3NVLA 2W5XA 5TJ3A 4KAVA 4LRAA 5DLVA 3BDGA 2IUCA 1ELYA 2ZKTA 3M7VA 1ELZA 3SZYA 3TWZA 4ZG9A 5C66A 5LRNA 3WAYA 1AJCA 4LREA 3Q3QA 1HDHA 3A52A 4MHXA 4MIVA 4UORA 1ALIA 3T00A 3WAWA 3E2DA 3M8ZA 5L0KA 4UOPA 2W5QA 3NKRA 4NWXA 4TN0A 1KH7A 1EW2A 4LRCA 4LR8A 1ZEFA 4CYRA 1URAA 4ZG6A 1ANJA 2W8DA 3TG0A 3MK0A 3B5QA 4UPLA 4ZGAA 2IFYA 5LRMA 1KHLA 1EJJA 1SHQA 1KHKA 4CXKA 1URBA 3UN5A 2XRGA 1AUKA 1HQAA 1ZEBA 1KH9A 3KD8A 5DLWA 4KJGA 2ANHA 1AJAA 1N2LA 3BDHA 1E33P 1ELXA 1N2KA 1ZEDA 4FDJA 4GTZA 3NKNA 1FSUA 2W5WA 2W5TA 3T01A 5AJ9A 1ALHA 2W5VA 5INHA 4YR1A 1O98A 4LRBA 4UPKA 5L0BA 4KAYA
chains in the Genus database with same CATH superfamily
4QAXA 4KJDA 1E2SP 3NKMA 4KM4A 4UPHA 3M8WA 2W5RA 3SZZA 4ZG7A 3TX0A 4UOOA 3BDFA 1K7HA 4LR2A 1EW9A 3IGZB 5EGEA 4LQYA 2QZUA 4LRFA 5GOVA 2GSUA 3OT9A 2RH6A 1ALJA 1ED8A 4UPIA 3UNYA 3NKPA 3UN2A 3T02A 4MY4A 5LIAA 1EI6A 2W5SA 3NKOA 1Y6VA 4CXSA 2GSNA 4FDIA 1KH4A 3BDGB 4LR7A 2GLQA 2G9YA 3NKQA 5DLTA 3WAVA 2IUCB 1B8JA 3ED4A 2D1GA 4GTXA 4LRDA 1EW8A 3M8YA 4CXUA 5GRRA 5HRTA 2GSOA 2XR9A 4N7TA 3DYCA 4B56A 3WBHA 5EGHA 3DPCA 5KXAA 5K4PA 3UO0A 3LXQA 4NWJA 3WAXA 2W8SA 4GTYA 1KHJA 3MK2A 5LQQA 4LR9A 3IDDA 3UN3A 1HJKA 3IGYB 1ALKA 2VQRA 1AJDA 2X98A 1AJBA 1P49A 4GTWA 5IJQA 1ANIA 1SHNA 5L0EA 1EQJA 1KHNA 3MK1A 1E3CP 1KH5A 1ED9A 3CMRA 2GA3A 5IJSA 1E1ZP 1O99A 4CYSA 1Y7AA 3NVLA 2W5XA 5TJ3A 4KAVA 4LRAA 5DLVA 3BDGA 2IUCA 1ELYA 2ZKTA 3M7VA 1ELZA 3SZYA 3TWZA 4ZG9A 5C66A 5LRNA 3WAYA 1AJCA 4LREA 3Q3QA 1HDHA 3A52A 4MHXA 4MIVA 4UORA 1ALIA 3T00A 3WAWA 3E2DA 3M8ZA 5L0KA 4UOPA 2W5QA 3NKRA 4NWXA 4TN0A 1KH7A 1EW2A 4LRCA 4LR8A 1ZEFA 4CYRA 1URAA 4ZG6A 1ANJA 2W8DA 3TG0A 3MK0A 3B5QA 4UPLA 4ZGAA 2IFYA 5LRMA 1KHLA 1EJJA 1SHQA 1KHKA 4CXKA 1URBA 3UN5A 2XRGA 1AUKA 1HQAA 1ZEBA 1KH9A 3KD8A 5DLWA 4KJGA 2ANHA 1AJAA 1N2LA 3BDHA 1E33P 1ELXA 1N2KA 1ZEDA 4FDJA 4GTZA 3NKNA 1FSUA 2W5WA 2W5TA 3T01A 5AJ9A 1ALHA 2W5VA 5INHA 4YR1A 1O98A 4LRBA 4UPKA 5L0BA 4KAYA
chains in the Genus database with same CATH topology
4QAXA 4KJDA 1E2SP 3NKMA 4KM4A 4UPHA 3M8WA 2W5RA 3SZZA 4ZG7A 3TX0A 4UOOA 3BDFA 1K7HA 4LR2A 1EW9A 3IGZB 5EGEA 4LQYA 2QZUA 4LRFA 5GOVA 2GSUA 3OT9A 2RH6A 1ALJA 1ED8A 4UPIA 3UNYA 3NKPA 3UN2A 3T02A 4MY4A 5LIAA 1EI6A 2W5SA 3NKOA 1Y6VA 4CXSA 2GSNA 4FDIA 1KH4A 3BDGB 4LR7A 2GLQA 2G9YA 3NKQA 5DLTA 3WAVA 2IUCB 1B8JA 3ED4A 2D1GA 4GTXA 4LRDA 1EW8A 3M8YA 4CXUA 5GRRA 5HRTA 2GSOA 2XR9A 4N7TA 3DYCA 4B56A 3WBHA 5EGHA 3DPCA 5KXAA 5K4PA 3UO0A 3LXQA 4NWJA 3WAXA 2W8SA 4GTYA 1KHJA 3MK2A 5LQQA 4LR9A 3IDDA 3UN3A 1HJKA 3IGYB 1ALKA 2VQRA 1AJDA 2X98A 1AJBA 1P49A 4GTWA 5IJQA 1ANIA 1SHNA 5L0EA 1EQJA 1KHNA 3MK1A 1E3CP 1KH5A 1ED9A 3CMRA 2GA3A 5IJSA 1E1ZP 1O99A 4CYSA 1Y7AA 3NVLA 2W5XA 5TJ3A 4KAVA 4LRAA 5DLVA 3BDGA 2IUCA 1ELYA 2ZKTA 3M7VA 1ELZA 3SZYA 3TWZA 4ZG9A 5C66A 5LRNA 3WAYA 1AJCA 4LREA 3Q3QA 1HDHA 3A52A 4MHXA 4MIVA 4UORA 1ALIA 3T00A 3WAWA 3E2DA 3M8ZA 5L0KA 4UOPA 2W5QA 3NKRA 4NWXA 4TN0A 1KH7A 1EW2A 4LRCA 4LR8A 1ZEFA 4CYRA 1URAA 4ZG6A 1ANJA 2W8DA 3TG0A 3MK0A 3B5QA 4UPLA 4ZGAA 2IFYA 5LRMA 1KHLA 1EJJA 1SHQA 1KHKA 4CXKA 1URBA 3UN5A 2XRGA 1AUKA 1HQAA 1ZEBA 1KH9A 3KD8A 5DLWA 4KJGA 2ANHA 1AJAA 1N2LA 3BDHA 1E33P 1ELXA 1N2KA 1ZEDA 4FDJA 4GTZA 3NKNA 1FSUA 2W5WA 2W5TA 3T01A 5AJ9A 1ALHA 2W5VA 5INHA 4YR1A 1O98A 4LRBA 4UPKA 5L0BA 4KAYA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4QAX A;  4KJD A;  1E2S P;  3NKM A;  4KM4 A;  4UPH A;  3M8W A;  2W5R A;  3SZZ A;  4ZG7 A;  3TX0 A;  4UOO A;  3BDF A;  1K7H A;  4LR2 A;  1EW9 A;  3IGZ B;  5EGE A;  4LQY A;  2QZU A;  4LRF A;  5GOV A;  2GSU A;  3OT9 A;  2RH6 A;  1ALJ A;  1ED8 A;  4UPI A;  3UNY A;  3NKP A;  3UN2 A;  3T02 A;  4MY4 A;  5LIA A;  1EI6 A;  2W5S A;  3NKO A;  1Y6V A;  4CXS A;  2GSN A;  4FDI A;  1KH4 A;  3BDG B;  4LR7 A;  2GLQ A;  2G9Y A;  3NKQ A;  5DLT A;  3WAV A;  2IUC B;  1B8J A;  3ED4 A;  2D1G A;  4GTX A;  4LRD A;  1EW8 A;  3M8Y A;  4CXU A;  5GRR A;  5HRT A;  2GSO A;  2XR9 A;  4N7T A;  3DYC A;  4B56 A;  3WBH A;  5EGH A;  3DPC A;  5KXA A;  5K4P A;  3UO0 A;  3LXQ A;  4NWJ A;  3WAX A;  2W8S A;  4GTY A;  1KHJ A;  3MK2 A;  5LQQ A;  4LR9 A;  3IDD A;  3UN3 A;  1HJK A;  3IGY B;  1ALK A;  2VQR A;  1AJD A;  2X98 A;  1AJB A;  1P49 A;  4GTW A;  5IJQ A;  1ANI A;  1SHN A;  5L0E A;  1EQJ A;  1KHN A;  3MK1 A;  1E3C P;  1KH5 A;  1ED9 A;  3CMR A;  2GA3 A;  5IJS A;  1E1Z P;  1O99 A;  4CYS A;  1Y7A A;  3NVL A;  2W5X A;  5TJ3 A;  4KAV A;  4LRA A;  5DLV A;  3BDG A;  2IUC A;  1ELY A;  2ZKT A;  3M7V A;  1ELZ A;  3SZY A;  3TWZ A;  4ZG9 A;  5C66 A;  5LRN A;  3WAY A;  1AJC A;  4LRE A;  3Q3Q A;  1HDH A;  3A52 A;  4MHX A;  4MIV A;  4UOR A;  1ALI A;  3T00 A;  3WAW A;  3E2D A;  3M8Z A;  5L0K A;  4UOP A;  2W5Q A;  3NKR A;  4NWX A;  4TN0 A;  1KH7 A;  1EW2 A;  4LRC A;  4LR8 A;  1ZEF A;  4CYR A;  1URA A;  4ZG6 A;  1ANJ A;  2W8D A;  3TG0 A;  3MK0 A;  3B5Q A;  4UPL A;  4ZGA A;  2IFY A;  5LRM A;  1KHL A;  1EJJ A;  1SHQ A;  1KHK A;  4CXK A;  1URB A;  3UN5 A;  2XRG A;  1AUK A;  1HQA A;  1ZEB A;  1KH9 A;  3KD8 A;  5DLW A;  4KJG A;  2ANH A;  1AJA A;  1N2L A;  3BDH A;  1E33 P;  1ELX A;  1N2K A;  1ZED A;  4FDJ A;  4GTZ A;  3NKN A;  1FSU A;  2W5W A;  2W5T A;  3T01 A;  5AJ9 A;  1ALH A;  2W5V A;  5INH A;  4YR1 A;  1O98 A;  4LRB A;  4UPK A;  5L0B A;  4KAY A; 
#chains in the Genus database with same CATH topology
 4QAX A;  4KJD A;  1E2S P;  3NKM A;  4KM4 A;  4UPH A;  3M8W A;  2W5R A;  3SZZ A;  4ZG7 A;  3TX0 A;  4UOO A;  3BDF A;  1K7H A;  4LR2 A;  1EW9 A;  3IGZ B;  5EGE A;  4LQY A;  2QZU A;  4LRF A;  5GOV A;  2GSU A;  3OT9 A;  2RH6 A;  1ALJ A;  1ED8 A;  4UPI A;  3UNY A;  3NKP A;  3UN2 A;  3T02 A;  4MY4 A;  5LIA A;  1EI6 A;  2W5S A;  3NKO A;  1Y6V A;  4CXS A;  2GSN A;  4FDI A;  1KH4 A;  3BDG B;  4LR7 A;  2GLQ A;  2G9Y A;  3NKQ A;  5DLT A;  3WAV A;  2IUC B;  1B8J A;  3ED4 A;  2D1G A;  4GTX A;  4LRD A;  1EW8 A;  3M8Y A;  4CXU A;  5GRR A;  5HRT A;  2GSO A;  2XR9 A;  4N7T A;  3DYC A;  4B56 A;  3WBH A;  5EGH A;  3DPC A;  5KXA A;  5K4P A;  3UO0 A;  3LXQ A;  4NWJ A;  3WAX A;  2W8S A;  4GTY A;  1KHJ A;  3MK2 A;  5LQQ A;  4LR9 A;  3IDD A;  3UN3 A;  1HJK A;  3IGY B;  1ALK A;  2VQR A;  1AJD A;  2X98 A;  1AJB A;  1P49 A;  4GTW A;  5IJQ A;  1ANI A;  1SHN A;  5L0E A;  1EQJ A;  1KHN A;  3MK1 A;  1E3C P;  1KH5 A;  1ED9 A;  3CMR A;  2GA3 A;  5IJS A;  1E1Z P;  1O99 A;  4CYS A;  1Y7A A;  3NVL A;  2W5X A;  5TJ3 A;  4KAV A;  4LRA A;  5DLV A;  3BDG A;  2IUC A;  1ELY A;  2ZKT A;  3M7V A;  1ELZ A;  3SZY A;  3TWZ A;  4ZG9 A;  5C66 A;  5LRN A;  3WAY A;  1AJC A;  4LRE A;  3Q3Q A;  1HDH A;  3A52 A;  4MHX A;  4MIV A;  4UOR A;  1ALI A;  3T00 A;  3WAW A;  3E2D A;  3M8Z A;  5L0K A;  4UOP A;  2W5Q A;  3NKR A;  4NWX A;  4TN0 A;  1KH7 A;  1EW2 A;  4LRC A;  4LR8 A;  1ZEF A;  4CYR A;  1URA A;  4ZG6 A;  1ANJ A;  2W8D A;  3TG0 A;  3MK0 A;  3B5Q A;  4UPL A;  4ZGA A;  2IFY A;  5LRM A;  1KHL A;  1EJJ A;  1SHQ A;  1KHK A;  4CXK A;  1URB A;  3UN5 A;  2XRG A;  1AUK A;  1HQA A;  1ZEB A;  1KH9 A;  3KD8 A;  5DLW A;  4KJG A;  2ANH A;  1AJA A;  1N2L A;  3BDH A;  1E33 P;  1ELX A;  1N2K A;  1ZED A;  4FDJ A;  4GTZ A;  3NKN A;  1FSU A;  2W5W A;  2W5T A;  3T01 A;  5AJ9 A;  1ALH A;  2W5V A;  5INH A;  4YR1 A;  1O98 A;  4LRB A;  4UPK A;  5L0B A;  4KAY A; 
#chains in the Genus database with same CATH homology
 4QAX A;  4KJD A;  1E2S P;  3NKM A;  4KM4 A;  4UPH A;  3M8W A;  2W5R A;  3SZZ A;  4ZG7 A;  3TX0 A;  4UOO A;  3BDF A;  1K7H A;  4LR2 A;  1EW9 A;  3IGZ B;  5EGE A;  4LQY A;  2QZU A;  4LRF A;  5GOV A;  2GSU A;  3OT9 A;  2RH6 A;  1ALJ A;  1ED8 A;  4UPI A;  3UNY A;  3NKP A;  3UN2 A;  3T02 A;  4MY4 A;  5LIA A;  1EI6 A;  2W5S A;  3NKO A;  1Y6V A;  4CXS A;  2GSN A;  4FDI A;  1KH4 A;  3BDG B;  4LR7 A;  2GLQ A;  2G9Y A;  3NKQ A;  5DLT A;  3WAV A;  2IUC B;  1B8J A;  3ED4 A;  2D1G A;  4GTX A;  4LRD A;  1EW8 A;  3M8Y A;  4CXU A;  5GRR A;  5HRT A;  2GSO A;  2XR9 A;  4N7T A;  3DYC A;  4B56 A;  3WBH A;  5EGH A;  3DPC A;  5KXA A;  5K4P A;  3UO0 A;  3LXQ A;  4NWJ A;  3WAX A;  2W8S A;  4GTY A;  1KHJ A;  3MK2 A;  5LQQ A;  4LR9 A;  3IDD A;  3UN3 A;  1HJK A;  3IGY B;  1ALK A;  2VQR A;  1AJD A;  2X98 A;  1AJB A;  1P49 A;  4GTW A;  5IJQ A;  1ANI A;  1SHN A;  5L0E A;  1EQJ A;  1KHN A;  3MK1 A;  1E3C P;  1KH5 A;  1ED9 A;  3CMR A;  2GA3 A;  5IJS A;  1E1Z P;  1O99 A;  4CYS A;  1Y7A A;  3NVL A;  2W5X A;  5TJ3 A;  4KAV A;  4LRA A;  5DLV A;  3BDG A;  2IUC A;  1ELY A;  2ZKT A;  3M7V A;  1ELZ A;  3SZY A;  3TWZ A;  4ZG9 A;  5C66 A;  5LRN A;  3WAY A;  1AJC A;  4LRE A;  3Q3Q A;  1HDH A;  3A52 A;  4MHX A;  4MIV A;  4UOR A;  1ALI A;  3T00 A;  3WAW A;  3E2D A;  3M8Z A;  5L0K A;  4UOP A;  2W5Q A;  3NKR A;  4NWX A;  4TN0 A;  1KH7 A;  1EW2 A;  4LRC A;  4LR8 A;  1ZEF A;  4CYR A;  1URA A;  4ZG6 A;  1ANJ A;  2W8D A;  3TG0 A;  3MK0 A;  3B5Q A;  4UPL A;  4ZGA A;  2IFY A;  5LRM A;  1KHL A;  1EJJ A;  1SHQ A;  1KHK A;  4CXK A;  1URB A;  3UN5 A;  2XRG A;  1AUK A;  1HQA A;  1ZEB A;  1KH9 A;  3KD8 A;  5DLW A;  4KJG A;  2ANH A;  1AJA A;  1N2L A;  3BDH A;  1E33 P;  1ELX A;  1N2K A;  1ZED A;  4FDJ A;  4GTZ A;  3NKN A;  1FSU A;  2W5W A;  2W5T A;  3T01 A;  5AJ9 A;  1ALH A;  2W5V A;  5INH A;  4YR1 A;  1O98 A;  4LRB A;  4UPK A;  5L0B A;  4KAY A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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