1EW2A

Crystal structure of a human phosphatase
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords PHOSPHATASE
total genus 172
structure length 479
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
2W5WA 1ANJA 4NWJA 3NKPA 1ALIA 1ED9A 3WBHA 4LRFA 1Y7AA 1N2KA 4LR8A 1O98A 3IGYB 1AJBA 1K7HA 4LQYA 5EGHA 3T02A 1Y6VA 2GSUA 1HQAA 4MY4A 1ELXA 3MK2A 3KD8A 1KHKA 4FDJA 1ED8A 4KM4A 1E33P 5DLTA 2G9YA 4LRBA 5K4PA 2W5SA 1KHLA 3MK0A 4ZG9A 1SHQA 5IJSA 4LRAA 5L0KA 1EW8A 1ALJA 2ANHA 5AJ9A 5DLWA 5EGEA 5C66A 1AJCA 2RH6A 3WAVA 1SHNA 4CXSA 1AJDA 1ZEDA 3WAWA 1URBA 5L0EA 4NWXA 2D1GA 4GTZA 1EQJA 3MK1A 4UPHA 1P49A 4UOOA 2IUCA 3E2DA 1ALHA 3DPCA 4KAVA 4UORA 4ZG7A 3T01A 1B8JA 3NVLA 4LR2A 3OT9A 1AJAA 1E2SP 1EI6A 3WAYA 1ANIA 1N2LA 1O99A 4B56A 2IUCB 4LRDA 1ZEFA 1HDHA 5LIAA 1ZEBA 4GTYA 3TG0A 3IGZB 4KJGA 4KAYA 2W5RA 4ZG6A 3UNYA 5INHA 3UO0A 1ELZA 3SZYA 2XRGA 1ELYA 5LRNA 5KXAA 2VQRA 2X98A 5DLVA 4LR9A 4GTWA 3IDDA 5LQQA 2W8DA 3NKQA 4CYSA 2GA3A 4CXKA 4GTXA 5HRTA 3NKOA 4UOPA 4CYRA 2W5TA 3UN2A 3WAXA 1EW9A 2GSOA 2ZKTA 4LREA 1KHNA 3NKNA 4MHXA 3TX0A 3BDGA 1URAA 4QAXA 1FSUA 3BDHA 1E3CP 3TWZA 1ALKA 3SZZA 3NKMA 4FDIA 5GOVA 4UPLA 3BDGB 1E1ZP 4LR7A 4YR1A 1KH9A 3CMRA 3M8YA 2W5XA 4TN0A 1EJJA 5IJQA 4MIVA 3UN3A 2GLQA 3M7VA 2GSNA 5LRMA 5GRRA 3B5QA 4KJDA 3M8WA 1HJKA 4CXUA 3BDFA 1AUKA 2W5VA 2QZUA 2IFYA 3DYCA 3T00A 1KHJA 3UN5A 3Q3QA 3A52A 4N7TA 1KH4A 4UPKA 2W5QA 2XR9A 3LXQA 3NKRA 1KH7A 4ZGAA 1KH5A 3ED4A 2W8SA 4UPIA 1EW2A 4LRCA 5L0BA 5TJ3A 3M8ZA
chains in the Genus database with same CATH superfamily
2W5WA 1ANJA 4NWJA 3NKPA 1ALIA 1ED9A 3WBHA 4LRFA 1Y7AA 1N2KA 4LR8A 1O98A 3IGYB 1AJBA 1K7HA 4LQYA 5EGHA 3T02A 1Y6VA 2GSUA 1HQAA 4MY4A 1ELXA 3MK2A 3KD8A 1KHKA 4FDJA 1ED8A 4KM4A 1E33P 5DLTA 2G9YA 4LRBA 5K4PA 2W5SA 1KHLA 3MK0A 4ZG9A 1SHQA 5IJSA 4LRAA 5L0KA 1EW8A 1ALJA 2ANHA 5AJ9A 5DLWA 5EGEA 5C66A 1AJCA 2RH6A 3WAVA 1SHNA 4CXSA 1AJDA 1ZEDA 3WAWA 1URBA 5L0EA 4NWXA 2D1GA 4GTZA 1EQJA 3MK1A 4UPHA 1P49A 4UOOA 2IUCA 3E2DA 1ALHA 3DPCA 4KAVA 4UORA 4ZG7A 3T01A 1B8JA 3NVLA 4LR2A 3OT9A 1AJAA 1E2SP 1EI6A 3WAYA 1ANIA 1N2LA 1O99A 4B56A 2IUCB 4LRDA 1ZEFA 1HDHA 5LIAA 1ZEBA 4GTYA 3TG0A 3IGZB 4KJGA 4KAYA 2W5RA 4ZG6A 3UNYA 5INHA 3UO0A 1ELZA 3SZYA 2XRGA 1ELYA 5LRNA 5KXAA 2VQRA 2X98A 5DLVA 4LR9A 4GTWA 3IDDA 5LQQA 2W8DA 3NKQA 4CYSA 2GA3A 4CXKA 4GTXA 5HRTA 3NKOA 4UOPA 4CYRA 2W5TA 3UN2A 3WAXA 1EW9A 2GSOA 2ZKTA 4LREA 1KHNA 3NKNA 4MHXA 3TX0A 3BDGA 1URAA 4QAXA 1FSUA 3BDHA 1E3CP 3TWZA 1ALKA 3SZZA 3NKMA 4FDIA 5GOVA 4UPLA 3BDGB 1E1ZP 4LR7A 4YR1A 1KH9A 3CMRA 3M8YA 2W5XA 4TN0A 1EJJA 5IJQA 4MIVA 3UN3A 2GLQA 3M7VA 2GSNA 5LRMA 5GRRA 3B5QA 4KJDA 3M8WA 1HJKA 4CXUA 3BDFA 1AUKA 2W5VA 2QZUA 2IFYA 3DYCA 3T00A 1KHJA 3UN5A 3Q3QA 3A52A 4N7TA 1KH4A 4UPKA 2W5QA 2XR9A 3LXQA 3NKRA 1KH7A 4ZGAA 1KH5A 3ED4A 2W8SA 4UPIA 1EW2A 4LRCA 5L0BA 5TJ3A 3M8ZA
chains in the Genus database with same CATH topology
2W5WA 1ANJA 4NWJA 3NKPA 1ALIA 1ED9A 3WBHA 4LRFA 1Y7AA 1N2KA 4LR8A 1O98A 3IGYB 1AJBA 1K7HA 4LQYA 5EGHA 3T02A 1Y6VA 2GSUA 1HQAA 4MY4A 1ELXA 3MK2A 3KD8A 1KHKA 4FDJA 1ED8A 4KM4A 1E33P 5DLTA 2G9YA 4LRBA 5K4PA 2W5SA 1KHLA 3MK0A 4ZG9A 1SHQA 5IJSA 4LRAA 5L0KA 1EW8A 1ALJA 2ANHA 5AJ9A 5DLWA 5EGEA 5C66A 1AJCA 2RH6A 3WAVA 1SHNA 4CXSA 1AJDA 1ZEDA 3WAWA 1URBA 5L0EA 4NWXA 2D1GA 4GTZA 1EQJA 3MK1A 4UPHA 1P49A 4UOOA 2IUCA 3E2DA 1ALHA 3DPCA 4KAVA 4UORA 4ZG7A 3T01A 1B8JA 3NVLA 4LR2A 3OT9A 1AJAA 1E2SP 1EI6A 3WAYA 1ANIA 1N2LA 1O99A 4B56A 2IUCB 4LRDA 1ZEFA 1HDHA 5LIAA 1ZEBA 4GTYA 3TG0A 3IGZB 4KJGA 4KAYA 2W5RA 4ZG6A 3UNYA 5INHA 3UO0A 1ELZA 3SZYA 2XRGA 1ELYA 5LRNA 5KXAA 2VQRA 2X98A 5DLVA 4LR9A 4GTWA 3IDDA 5LQQA 2W8DA 3NKQA 4CYSA 2GA3A 4CXKA 4GTXA 5HRTA 3NKOA 4UOPA 4CYRA 2W5TA 3UN2A 3WAXA 1EW9A 2GSOA 2ZKTA 4LREA 1KHNA 3NKNA 4MHXA 3TX0A 3BDGA 1URAA 4QAXA 1FSUA 3BDHA 1E3CP 3TWZA 1ALKA 3SZZA 3NKMA 4FDIA 5GOVA 4UPLA 3BDGB 1E1ZP 4LR7A 4YR1A 1KH9A 3CMRA 3M8YA 2W5XA 4TN0A 1EJJA 5IJQA 4MIVA 3UN3A 2GLQA 3M7VA 2GSNA 5LRMA 5GRRA 3B5QA 4KJDA 3M8WA 1HJKA 4CXUA 3BDFA 1AUKA 2W5VA 2QZUA 2IFYA 3DYCA 3T00A 1KHJA 3UN5A 3Q3QA 3A52A 4N7TA 1KH4A 4UPKA 2W5QA 2XR9A 3LXQA 3NKRA 1KH7A 4ZGAA 1KH5A 3ED4A 2W8SA 4UPIA 1EW2A 4LRCA 5L0BA 5TJ3A 3M8ZA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2W5W A;  1ANJ A;  4NWJ A;  3NKP A;  1ALI A;  1ED9 A;  3WBH A;  4LRF A;  1Y7A A;  1N2K A;  4LR8 A;  1O98 A;  3IGY B;  1AJB A;  1K7H A;  4LQY A;  5EGH A;  3T02 A;  1Y6V A;  2GSU A;  1HQA A;  4MY4 A;  1ELX A;  3MK2 A;  3KD8 A;  1KHK A;  4FDJ A;  1ED8 A;  4KM4 A;  1E33 P;  5DLT A;  2G9Y A;  4LRB A;  5K4P A;  2W5S A;  1KHL A;  3MK0 A;  4ZG9 A;  1SHQ A;  5IJS A;  4LRA A;  5L0K A;  1EW8 A;  1ALJ A;  2ANH A;  5AJ9 A;  5DLW A;  5EGE A;  5C66 A;  1AJC A;  2RH6 A;  3WAV A;  1SHN A;  4CXS A;  1AJD A;  1ZED A;  3WAW A;  1URB A;  5L0E A;  4NWX A;  2D1G A;  4GTZ A;  1EQJ A;  3MK1 A;  4UPH A;  1P49 A;  4UOO A;  2IUC A;  3E2D A;  1ALH A;  3DPC A;  4KAV A;  4UOR A;  4ZG7 A;  3T01 A;  1B8J A;  3NVL A;  4LR2 A;  3OT9 A;  1AJA A;  1E2S P;  1EI6 A;  3WAY A;  1ANI A;  1N2L A;  1O99 A;  4B56 A;  2IUC B;  4LRD A;  1ZEF A;  1HDH A;  5LIA A;  1ZEB A;  4GTY A;  3TG0 A;  3IGZ B;  4KJG A;  4KAY A;  2W5R A;  4ZG6 A;  3UNY A;  5INH A;  3UO0 A;  1ELZ A;  3SZY A;  2XRG A;  1ELY A;  5LRN A;  5KXA A;  2VQR A;  2X98 A;  5DLV A;  4LR9 A;  4GTW A;  3IDD A;  5LQQ A;  2W8D A;  3NKQ A;  4CYS A;  2GA3 A;  4CXK A;  4GTX A;  5HRT A;  3NKO A;  4UOP A;  4CYR A;  2W5T A;  3UN2 A;  3WAX A;  1EW9 A;  2GSO A;  2ZKT A;  4LRE A;  1KHN A;  3NKN A;  4MHX A;  3TX0 A;  3BDG A;  1URA A;  4QAX A;  1FSU A;  3BDH A;  1E3C P;  3TWZ A;  1ALK A;  3SZZ A;  3NKM A;  4FDI A;  5GOV A;  4UPL A;  3BDG B;  1E1Z P;  4LR7 A;  4YR1 A;  1KH9 A;  3CMR A;  3M8Y A;  2W5X A;  4TN0 A;  1EJJ A;  5IJQ A;  4MIV A;  3UN3 A;  2GLQ A;  3M7V A;  2GSN A;  5LRM A;  5GRR A;  3B5Q A;  4KJD A;  3M8W A;  1HJK A;  4CXU A;  3BDF A;  1AUK A;  2W5V A;  2QZU A;  2IFY A;  3DYC A;  3T00 A;  1KHJ A;  3UN5 A;  3Q3Q A;  3A52 A;  4N7T A;  1KH4 A;  4UPK A;  2W5Q A;  2XR9 A;  3LXQ A;  3NKR A;  1KH7 A;  4ZGA A;  1KH5 A;  3ED4 A;  2W8S A;  4UPI A;  1EW2 A;  4LRC A;  5L0B A;  5TJ3 A;  3M8Z A; 
#chains in the Genus database with same CATH topology
 2W5W A;  1ANJ A;  4NWJ A;  3NKP A;  1ALI A;  1ED9 A;  3WBH A;  4LRF A;  1Y7A A;  1N2K A;  4LR8 A;  1O98 A;  3IGY B;  1AJB A;  1K7H A;  4LQY A;  5EGH A;  3T02 A;  1Y6V A;  2GSU A;  1HQA A;  4MY4 A;  1ELX A;  3MK2 A;  3KD8 A;  1KHK A;  4FDJ A;  1ED8 A;  4KM4 A;  1E33 P;  5DLT A;  2G9Y A;  4LRB A;  5K4P A;  2W5S A;  1KHL A;  3MK0 A;  4ZG9 A;  1SHQ A;  5IJS A;  4LRA A;  5L0K A;  1EW8 A;  1ALJ A;  2ANH A;  5AJ9 A;  5DLW A;  5EGE A;  5C66 A;  1AJC A;  2RH6 A;  3WAV A;  1SHN A;  4CXS A;  1AJD A;  1ZED A;  3WAW A;  1URB A;  5L0E A;  4NWX A;  2D1G A;  4GTZ A;  1EQJ A;  3MK1 A;  4UPH A;  1P49 A;  4UOO A;  2IUC A;  3E2D A;  1ALH A;  3DPC A;  4KAV A;  4UOR A;  4ZG7 A;  3T01 A;  1B8J A;  3NVL A;  4LR2 A;  3OT9 A;  1AJA A;  1E2S P;  1EI6 A;  3WAY A;  1ANI A;  1N2L A;  1O99 A;  4B56 A;  2IUC B;  4LRD A;  1ZEF A;  1HDH A;  5LIA A;  1ZEB A;  4GTY A;  3TG0 A;  3IGZ B;  4KJG A;  4KAY A;  2W5R A;  4ZG6 A;  3UNY A;  5INH A;  3UO0 A;  1ELZ A;  3SZY A;  2XRG A;  1ELY A;  5LRN A;  5KXA A;  2VQR A;  2X98 A;  5DLV A;  4LR9 A;  4GTW A;  3IDD A;  5LQQ A;  2W8D A;  3NKQ A;  4CYS A;  2GA3 A;  4CXK A;  4GTX A;  5HRT A;  3NKO A;  4UOP A;  4CYR A;  2W5T A;  3UN2 A;  3WAX A;  1EW9 A;  2GSO A;  2ZKT A;  4LRE A;  1KHN A;  3NKN A;  4MHX A;  3TX0 A;  3BDG A;  1URA A;  4QAX A;  1FSU A;  3BDH A;  1E3C P;  3TWZ A;  1ALK A;  3SZZ A;  3NKM A;  4FDI A;  5GOV A;  4UPL A;  3BDG B;  1E1Z P;  4LR7 A;  4YR1 A;  1KH9 A;  3CMR A;  3M8Y A;  2W5X A;  4TN0 A;  1EJJ A;  5IJQ A;  4MIV A;  3UN3 A;  2GLQ A;  3M7V A;  2GSN A;  5LRM A;  5GRR A;  3B5Q A;  4KJD A;  3M8W A;  1HJK A;  4CXU A;  3BDF A;  1AUK A;  2W5V A;  2QZU A;  2IFY A;  3DYC A;  3T00 A;  1KHJ A;  3UN5 A;  3Q3Q A;  3A52 A;  4N7T A;  1KH4 A;  4UPK A;  2W5Q A;  2XR9 A;  3LXQ A;  3NKR A;  1KH7 A;  4ZGA A;  1KH5 A;  3ED4 A;  2W8S A;  4UPI A;  1EW2 A;  4LRC A;  5L0B A;  5TJ3 A;  3M8Z A; 
#chains in the Genus database with same CATH homology
 2W5W A;  1ANJ A;  4NWJ A;  3NKP A;  1ALI A;  1ED9 A;  3WBH A;  4LRF A;  1Y7A A;  1N2K A;  4LR8 A;  1O98 A;  3IGY B;  1AJB A;  1K7H A;  4LQY A;  5EGH A;  3T02 A;  1Y6V A;  2GSU A;  1HQA A;  4MY4 A;  1ELX A;  3MK2 A;  3KD8 A;  1KHK A;  4FDJ A;  1ED8 A;  4KM4 A;  1E33 P;  5DLT A;  2G9Y A;  4LRB A;  5K4P A;  2W5S A;  1KHL A;  3MK0 A;  4ZG9 A;  1SHQ A;  5IJS A;  4LRA A;  5L0K A;  1EW8 A;  1ALJ A;  2ANH A;  5AJ9 A;  5DLW A;  5EGE A;  5C66 A;  1AJC A;  2RH6 A;  3WAV A;  1SHN A;  4CXS A;  1AJD A;  1ZED A;  3WAW A;  1URB A;  5L0E A;  4NWX A;  2D1G A;  4GTZ A;  1EQJ A;  3MK1 A;  4UPH A;  1P49 A;  4UOO A;  2IUC A;  3E2D A;  1ALH A;  3DPC A;  4KAV A;  4UOR A;  4ZG7 A;  3T01 A;  1B8J A;  3NVL A;  4LR2 A;  3OT9 A;  1AJA A;  1E2S P;  1EI6 A;  3WAY A;  1ANI A;  1N2L A;  1O99 A;  4B56 A;  2IUC B;  4LRD A;  1ZEF A;  1HDH A;  5LIA A;  1ZEB A;  4GTY A;  3TG0 A;  3IGZ B;  4KJG A;  4KAY A;  2W5R A;  4ZG6 A;  3UNY A;  5INH A;  3UO0 A;  1ELZ A;  3SZY A;  2XRG A;  1ELY A;  5LRN A;  5KXA A;  2VQR A;  2X98 A;  5DLV A;  4LR9 A;  4GTW A;  3IDD A;  5LQQ A;  2W8D A;  3NKQ A;  4CYS A;  2GA3 A;  4CXK A;  4GTX A;  5HRT A;  3NKO A;  4UOP A;  4CYR A;  2W5T A;  3UN2 A;  3WAX A;  1EW9 A;  2GSO A;  2ZKT A;  4LRE A;  1KHN A;  3NKN A;  4MHX A;  3TX0 A;  3BDG A;  1URA A;  4QAX A;  1FSU A;  3BDH A;  1E3C P;  3TWZ A;  1ALK A;  3SZZ A;  3NKM A;  4FDI A;  5GOV A;  4UPL A;  3BDG B;  1E1Z P;  4LR7 A;  4YR1 A;  1KH9 A;  3CMR A;  3M8Y A;  2W5X A;  4TN0 A;  1EJJ A;  5IJQ A;  4MIV A;  3UN3 A;  2GLQ A;  3M7V A;  2GSN A;  5LRM A;  5GRR A;  3B5Q A;  4KJD A;  3M8W A;  1HJK A;  4CXU A;  3BDF A;  1AUK A;  2W5V A;  2QZU A;  2IFY A;  3DYC A;  3T00 A;  1KHJ A;  3UN5 A;  3Q3Q A;  3A52 A;  4N7T A;  1KH4 A;  4UPK A;  2W5Q A;  2XR9 A;  3LXQ A;  3NKR A;  1KH7 A;  4ZGA A;  1KH5 A;  3ED4 A;  2W8S A;  4UPI A;  1EW2 A;  4LRC A;  5L0B A;  5TJ3 A;  3M8Z A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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