1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
2GSUA 2IFYA 5LIAA 1E2SP 3BDGB 1KHJA 1ANIA 4ZG6A 3T00A 2XR9A 1E3CP 1URAA 2QZUA 4GTXA 5EGHA 4NWJA 3NKQA 4LRBA 3UNYA 4KAYA 4MY4A 3UO0A 2W8DA 1URBA 5IJQA 4LR7A 4LRDA 5L0KA 2W5TA 3T02A 3NKRA 1Y6VA 2IUCA 1ALIA 3M8WA 4LRAA 5K4PA 1E1ZP 1ALHA 4LREA 3WAVA 1ZEBA 1EI6A 2GLQA 3IGZB 4YR1A 5LRNA 2IUCB 1KHNA 4LR2A 4ZG9A 5EGEA 3LXQA 3DPCA 3MK2A 2RH6A 4GTYA 2ANHA 1EJJA 1ED9A 1P49A 4GTZA 3UN5A 3SZZA 3WAWA 1KHKA 1ZEDA 1ALJA 4UOPA 4ZGAA 1SHQA 3OT9A 2W5WA 1HQAA 1EQJA 3CMRA 4MIVA 5TJ3A 3DYCA 1K7HA 4N7TA 4B56A 3SZYA 5GRRA 4TN0A 1KH5A 3NKNA 1ELXA 4LQYA 1EW9A 2W8SA 5C66A 3MK0A 1E33P 3TX0A 1AJAA 3WBHA 1HDHA 4QAXA 5AJ9A 3M8ZA 5DLWA 4LRFA 1FSUA 5DLVA 1O99A 1EW8A 4UPKA 1N2LA 1ANJA 3NKMA 2W5QA 4GTWA 3UN3A 2W5RA 2X98A 4LR8A 1Y7AA 1KH4A 4CYRA 3ED4A 4KAVA 3WAYA 1SHNA 1ED8A 1HJKA 2W5SA 3NKPA 4KJGA 5HRTA 3TG0A 1ELZA 3E2DA 1AUKA 4CXKA 1EW2A 4KM4A 3M8YA 2D1GA 3BDHA 1ZEFA 4MHXA 3NKOA 2W5XA 1KH7A 4ZG7A 3NVLA 4UPIA 5GOVA 3MK1A 5LQQA 4CXSA 1O98A 4NWXA 4UORA 4FDJA 4FDIA 5IJSA 1KH9A 3KD8A 2W5VA 3WAXA 3BDFA 5KXAA 3TWZA 3IGYB 5L0BA 4UOOA 4CXUA 2ZKTA 1KHLA 1B8JA 5LRMA 4KJDA 1ELYA 2VQRA 3T01A 3Q3QA 4CYSA 2GSOA 2GA3A 1AJBA 3IDDA 3A52A 2GSNA 1N2KA 2XRGA 4UPHA 5L0EA 4UPLA 3BDGA 3B5QA 2G9YA 4LR9A 3UN2A 1AJDA 3M7VA 1ALKA 5INHA 4LRCA 1AJCA 5DLTA
chains in the Genus database with same CATH superfamily
2GSUA 2IFYA 5LIAA 1E2SP 3BDGB 1KHJA 1ANIA 4ZG6A 3T00A 2XR9A 1E3CP 1URAA 2QZUA 4GTXA 5EGHA 4NWJA 3NKQA 4LRBA 3UNYA 4KAYA 4MY4A 3UO0A 2W8DA 1URBA 5IJQA 4LR7A 4LRDA 5L0KA 2W5TA 3T02A 3NKRA 1Y6VA 2IUCA 1ALIA 3M8WA 4LRAA 5K4PA 1E1ZP 1ALHA 4LREA 3WAVA 1ZEBA 1EI6A 2GLQA 3IGZB 4YR1A 5LRNA 2IUCB 1KHNA 4LR2A 4ZG9A 5EGEA 3LXQA 3DPCA 3MK2A 2RH6A 4GTYA 2ANHA 1EJJA 1ED9A 1P49A 4GTZA 3UN5A 3SZZA 3WAWA 1KHKA 1ZEDA 1ALJA 4UOPA 4ZGAA 1SHQA 3OT9A 2W5WA 1HQAA 1EQJA 3CMRA 4MIVA 5TJ3A 3DYCA 1K7HA 4N7TA 4B56A 3SZYA 5GRRA 4TN0A 1KH5A 3NKNA 1ELXA 4LQYA 1EW9A 2W8SA 5C66A 3MK0A 1E33P 3TX0A 1AJAA 3WBHA 1HDHA 4QAXA 5AJ9A 3M8ZA 5DLWA 4LRFA 1FSUA 5DLVA 1O99A 1EW8A 4UPKA 1N2LA 1ANJA 3NKMA 2W5QA 4GTWA 3UN3A 2W5RA 2X98A 4LR8A 1Y7AA 1KH4A 4CYRA 3ED4A 4KAVA 3WAYA 1SHNA 1ED8A 1HJKA 2W5SA 3NKPA 4KJGA 5HRTA 3TG0A 1ELZA 3E2DA 1AUKA 4CXKA 1EW2A 4KM4A 3M8YA 2D1GA 3BDHA 1ZEFA 4MHXA 3NKOA 2W5XA 1KH7A 4ZG7A 3NVLA 4UPIA 5GOVA 3MK1A 5LQQA 4CXSA 1O98A 4NWXA 4UORA 4FDJA 4FDIA 5IJSA 1KH9A 3KD8A 2W5VA 3WAXA 3BDFA 5KXAA 3TWZA 3IGYB 5L0BA 4UOOA 4CXUA 2ZKTA 1KHLA 1B8JA 5LRMA 4KJDA 1ELYA 2VQRA 3T01A 3Q3QA 4CYSA 2GSOA 2GA3A 1AJBA 3IDDA 3A52A 2GSNA 1N2KA 2XRGA 4UPHA 5L0EA 4UPLA 3BDGA 3B5QA 2G9YA 4LR9A 3UN2A 1AJDA 3M7VA 1ALKA 5INHA 4LRCA 1AJCA 5DLTA
chains in the Genus database with same CATH topology
2GSUA 2IFYA 5LIAA 1E2SP 3BDGB 1KHJA 1ANIA 4ZG6A 3T00A 2XR9A 1E3CP 1URAA 2QZUA 4GTXA 5EGHA 4NWJA 3NKQA 4LRBA 3UNYA 4KAYA 4MY4A 3UO0A 2W8DA 1URBA 5IJQA 4LR7A 4LRDA 5L0KA 2W5TA 3T02A 3NKRA 1Y6VA 2IUCA 1ALIA 3M8WA 4LRAA 5K4PA 1E1ZP 1ALHA 4LREA 3WAVA 1ZEBA 1EI6A 2GLQA 3IGZB 4YR1A 5LRNA 2IUCB 1KHNA 4LR2A 4ZG9A 5EGEA 3LXQA 3DPCA 3MK2A 2RH6A 4GTYA 2ANHA 1EJJA 1ED9A 1P49A 4GTZA 3UN5A 3SZZA 3WAWA 1KHKA 1ZEDA 1ALJA 4UOPA 4ZGAA 1SHQA 3OT9A 2W5WA 1HQAA 1EQJA 3CMRA 4MIVA 5TJ3A 3DYCA 1K7HA 4N7TA 4B56A 3SZYA 5GRRA 4TN0A 1KH5A 3NKNA 1ELXA 4LQYA 1EW9A 2W8SA 5C66A 3MK0A 1E33P 3TX0A 1AJAA 3WBHA 1HDHA 4QAXA 5AJ9A 3M8ZA 5DLWA 4LRFA 1FSUA 5DLVA 1O99A 1EW8A 4UPKA 1N2LA 1ANJA 3NKMA 2W5QA 4GTWA 3UN3A 2W5RA 2X98A 4LR8A 1Y7AA 1KH4A 4CYRA 3ED4A 4KAVA 3WAYA 1SHNA 1ED8A 1HJKA 2W5SA 3NKPA 4KJGA 5HRTA 3TG0A 1ELZA 3E2DA 1AUKA 4CXKA 1EW2A 4KM4A 3M8YA 2D1GA 3BDHA 1ZEFA 4MHXA 3NKOA 2W5XA 1KH7A 4ZG7A 3NVLA 4UPIA 5GOVA 3MK1A 5LQQA 4CXSA 1O98A 4NWXA 4UORA 4FDJA 4FDIA 5IJSA 1KH9A 3KD8A 2W5VA 3WAXA 3BDFA 5KXAA 3TWZA 3IGYB 5L0BA 4UOOA 4CXUA 2ZKTA 1KHLA 1B8JA 5LRMA 4KJDA 1ELYA 2VQRA 3T01A 3Q3QA 4CYSA 2GSOA 2GA3A 1AJBA 3IDDA 3A52A 2GSNA 1N2KA 2XRGA 4UPHA 5L0EA 4UPLA 3BDGA 3B5QA 2G9YA 4LR9A 3UN2A 1AJDA 3M7VA 1ALKA 5INHA 4LRCA 1AJCA 5DLTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GSU A;  2IFY A;  5LIA A;  1E2S P;  3BDG B;  1KHJ A;  1ANI A;  4ZG6 A;  3T00 A;  2XR9 A;  1E3C P;  1URA A;  2QZU A;  4GTX A;  5EGH A;  4NWJ A;  3NKQ A;  4LRB A;  3UNY A;  4KAY A;  4MY4 A;  3UO0 A;  2W8D A;  1URB A;  5IJQ A;  4LR7 A;  4LRD A;  5L0K A;  2W5T A;  3T02 A;  3NKR A;  1Y6V A;  2IUC A;  1ALI A;  3M8W A;  4LRA A;  5K4P A;  1E1Z P;  1ALH A;  4LRE A;  3WAV A;  1ZEB A;  1EI6 A;  2GLQ A;  3IGZ B;  4YR1 A;  5LRN A;  2IUC B;  1KHN A;  4LR2 A;  4ZG9 A;  5EGE A;  3LXQ A;  3DPC A;  3MK2 A;  2RH6 A;  4GTY A;  2ANH A;  1EJJ A;  1ED9 A;  1P49 A;  4GTZ A;  3UN5 A;  3SZZ A;  3WAW A;  1KHK A;  1ZED A;  1ALJ A;  4UOP A;  4ZGA A;  1SHQ A;  3OT9 A;  2W5W A;  1HQA A;  1EQJ A;  3CMR A;  4MIV A;  5TJ3 A;  3DYC A;  1K7H A;  4N7T A;  4B56 A;  3SZY A;  5GRR A;  4TN0 A;  1KH5 A;  3NKN A;  1ELX A;  4LQY A;  1EW9 A;  2W8S A;  5C66 A;  3MK0 A;  1E33 P;  3TX0 A;  1AJA A;  3WBH A;  1HDH A;  4QAX A;  5AJ9 A;  3M8Z A;  5DLW A;  4LRF A;  1FSU A;  5DLV A;  1O99 A;  1EW8 A;  4UPK A;  1N2L A;  1ANJ A;  3NKM A;  2W5Q A;  4GTW A;  3UN3 A;  2W5R A;  2X98 A;  4LR8 A;  1Y7A A;  1KH4 A;  4CYR A;  3ED4 A;  4KAV A;  3WAY A;  1SHN A;  1ED8 A;  1HJK A;  2W5S A;  3NKP A;  4KJG A;  5HRT A;  3TG0 A;  1ELZ A;  3E2D A;  1AUK A;  4CXK A;  1EW2 A;  4KM4 A;  3M8Y A;  2D1G A;  3BDH A;  1ZEF A;  4MHX A;  3NKO A;  2W5X A;  1KH7 A;  4ZG7 A;  3NVL A;  4UPI A;  5GOV A;  3MK1 A;  5LQQ A;  4CXS A;  1O98 A;  4NWX A;  4UOR A;  4FDJ A;  4FDI A;  5IJS A;  1KH9 A;  3KD8 A;  2W5V A;  3WAX A;  3BDF A;  5KXA A;  3TWZ A;  3IGY B;  5L0B A;  4UOO A;  4CXU A;  2ZKT A;  1KHL A;  1B8J A;  5LRM A;  4KJD A;  1ELY A;  2VQR A;  3T01 A;  3Q3Q A;  4CYS A;  2GSO A;  2GA3 A;  1AJB A;  3IDD A;  3A52 A;  2GSN A;  1N2K A;  2XRG A;  4UPH A;  5L0E A;  4UPL A;  3BDG A;  3B5Q A;  2G9Y A;  4LR9 A;  3UN2 A;  1AJD A;  3M7V A;  1ALK A;  5INH A;  4LRC A;  1AJC A;  5DLT A; 
#chains in the Genus database with same CATH topology
 2GSU A;  2IFY A;  5LIA A;  1E2S P;  3BDG B;  1KHJ A;  1ANI A;  4ZG6 A;  3T00 A;  2XR9 A;  1E3C P;  1URA A;  2QZU A;  4GTX A;  5EGH A;  4NWJ A;  3NKQ A;  4LRB A;  3UNY A;  4KAY A;  4MY4 A;  3UO0 A;  2W8D A;  1URB A;  5IJQ A;  4LR7 A;  4LRD A;  5L0K A;  2W5T A;  3T02 A;  3NKR A;  1Y6V A;  2IUC A;  1ALI A;  3M8W A;  4LRA A;  5K4P A;  1E1Z P;  1ALH A;  4LRE A;  3WAV A;  1ZEB A;  1EI6 A;  2GLQ A;  3IGZ B;  4YR1 A;  5LRN A;  2IUC B;  1KHN A;  4LR2 A;  4ZG9 A;  5EGE A;  3LXQ A;  3DPC A;  3MK2 A;  2RH6 A;  4GTY A;  2ANH A;  1EJJ A;  1ED9 A;  1P49 A;  4GTZ A;  3UN5 A;  3SZZ A;  3WAW A;  1KHK A;  1ZED A;  1ALJ A;  4UOP A;  4ZGA A;  1SHQ A;  3OT9 A;  2W5W A;  1HQA A;  1EQJ A;  3CMR A;  4MIV A;  5TJ3 A;  3DYC A;  1K7H A;  4N7T A;  4B56 A;  3SZY A;  5GRR A;  4TN0 A;  1KH5 A;  3NKN A;  1ELX A;  4LQY A;  1EW9 A;  2W8S A;  5C66 A;  3MK0 A;  1E33 P;  3TX0 A;  1AJA A;  3WBH A;  1HDH A;  4QAX A;  5AJ9 A;  3M8Z A;  5DLW A;  4LRF A;  1FSU A;  5DLV A;  1O99 A;  1EW8 A;  4UPK A;  1N2L A;  1ANJ A;  3NKM A;  2W5Q A;  4GTW A;  3UN3 A;  2W5R A;  2X98 A;  4LR8 A;  1Y7A A;  1KH4 A;  4CYR A;  3ED4 A;  4KAV A;  3WAY A;  1SHN A;  1ED8 A;  1HJK A;  2W5S A;  3NKP A;  4KJG A;  5HRT A;  3TG0 A;  1ELZ A;  3E2D A;  1AUK A;  4CXK A;  1EW2 A;  4KM4 A;  3M8Y A;  2D1G A;  3BDH A;  1ZEF A;  4MHX A;  3NKO A;  2W5X A;  1KH7 A;  4ZG7 A;  3NVL A;  4UPI A;  5GOV A;  3MK1 A;  5LQQ A;  4CXS A;  1O98 A;  4NWX A;  4UOR A;  4FDJ A;  4FDI A;  5IJS A;  1KH9 A;  3KD8 A;  2W5V A;  3WAX A;  3BDF A;  5KXA A;  3TWZ A;  3IGY B;  5L0B A;  4UOO A;  4CXU A;  2ZKT A;  1KHL A;  1B8J A;  5LRM A;  4KJD A;  1ELY A;  2VQR A;  3T01 A;  3Q3Q A;  4CYS A;  2GSO A;  2GA3 A;  1AJB A;  3IDD A;  3A52 A;  2GSN A;  1N2K A;  2XRG A;  4UPH A;  5L0E A;  4UPL A;  3BDG A;  3B5Q A;  2G9Y A;  4LR9 A;  3UN2 A;  1AJD A;  3M7V A;  1ALK A;  5INH A;  4LRC A;  1AJC A;  5DLT A; 
#chains in the Genus database with same CATH homology
 2GSU A;  2IFY A;  5LIA A;  1E2S P;  3BDG B;  1KHJ A;  1ANI A;  4ZG6 A;  3T00 A;  2XR9 A;  1E3C P;  1URA A;  2QZU A;  4GTX A;  5EGH A;  4NWJ A;  3NKQ A;  4LRB A;  3UNY A;  4KAY A;  4MY4 A;  3UO0 A;  2W8D A;  1URB A;  5IJQ A;  4LR7 A;  4LRD A;  5L0K A;  2W5T A;  3T02 A;  3NKR A;  1Y6V A;  2IUC A;  1ALI A;  3M8W A;  4LRA A;  5K4P A;  1E1Z P;  1ALH A;  4LRE A;  3WAV A;  1ZEB A;  1EI6 A;  2GLQ A;  3IGZ B;  4YR1 A;  5LRN A;  2IUC B;  1KHN A;  4LR2 A;  4ZG9 A;  5EGE A;  3LXQ A;  3DPC A;  3MK2 A;  2RH6 A;  4GTY A;  2ANH A;  1EJJ A;  1ED9 A;  1P49 A;  4GTZ A;  3UN5 A;  3SZZ A;  3WAW A;  1KHK A;  1ZED A;  1ALJ A;  4UOP A;  4ZGA A;  1SHQ A;  3OT9 A;  2W5W A;  1HQA A;  1EQJ A;  3CMR A;  4MIV A;  5TJ3 A;  3DYC A;  1K7H A;  4N7T A;  4B56 A;  3SZY A;  5GRR A;  4TN0 A;  1KH5 A;  3NKN A;  1ELX A;  4LQY A;  1EW9 A;  2W8S A;  5C66 A;  3MK0 A;  1E33 P;  3TX0 A;  1AJA A;  3WBH A;  1HDH A;  4QAX A;  5AJ9 A;  3M8Z A;  5DLW A;  4LRF A;  1FSU A;  5DLV A;  1O99 A;  1EW8 A;  4UPK A;  1N2L A;  1ANJ A;  3NKM A;  2W5Q A;  4GTW A;  3UN3 A;  2W5R A;  2X98 A;  4LR8 A;  1Y7A A;  1KH4 A;  4CYR A;  3ED4 A;  4KAV A;  3WAY A;  1SHN A;  1ED8 A;  1HJK A;  2W5S A;  3NKP A;  4KJG A;  5HRT A;  3TG0 A;  1ELZ A;  3E2D A;  1AUK A;  4CXK A;  1EW2 A;  4KM4 A;  3M8Y A;  2D1G A;  3BDH A;  1ZEF A;  4MHX A;  3NKO A;  2W5X A;  1KH7 A;  4ZG7 A;  3NVL A;  4UPI A;  5GOV A;  3MK1 A;  5LQQ A;  4CXS A;  1O98 A;  4NWX A;  4UOR A;  4FDJ A;  4FDI A;  5IJS A;  1KH9 A;  3KD8 A;  2W5V A;  3WAX A;  3BDF A;  5KXA A;  3TWZ A;  3IGY B;  5L0B A;  4UOO A;  4CXU A;  2ZKT A;  1KHL A;  1B8J A;  5LRM A;  4KJD A;  1ELY A;  2VQR A;  3T01 A;  3Q3Q A;  4CYS A;  2GSO A;  2GA3 A;  1AJB A;  3IDD A;  3A52 A;  2GSN A;  1N2K A;  2XRG A;  4UPH A;  5L0E A;  4UPL A;  3BDG A;  3B5Q A;  2G9Y A;  4LR9 A;  3UN2 A;  1AJD A;  3M7V A;  1ALK A;  5INH A;  4LRC A;  1AJC A;  5DLT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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