1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
3BDGB 1HDHA 5LIAA 3IGYB 3CMRA 3UN2A 3TWZA 2XRGA 4LQYA 1HQAA 4LRCA 3T01A 5L0BA 1AJDA 5DLVA 3UN3A 4KJDA 1URBA 4ZGAA 2IFYA 2X98A 3DPCA 4LREA 2IUCA 1KHKA 1N2KA 1AJCA 4CYSA 1EQJA 3UO0A 1EI6A 1O99A 1ZEBA 3WAXA 4MHXA 3BDGA 4CXSA 3M8WA 3BDHA 1O98A 5INHA 1SHNA 4LRFA 4LRAA 1ZEDA 2QZUA 3MK2A 5AJ9A 2W5SA 4LR2A 2ZKTA 5IJQA 3ED4A 3MK1A 3M7VA 4GTZA 1ELZA 4TN0A 5DLTA 3IDDA 1ED8A 1AJAA 3T00A 1E1ZP 1ALKA 1AJBA 1EW9A 4ZG7A 4GTWA 5TJ3A 3UN5A 3B5QA 2GSOA 2W5TA 5LRMA 4UPKA 1EW2A 4ZG6A 4LR9A 2GA3A 2W5QA 3IGZB 4NWXA 3WAYA 4YR1A 4QAXA 4N7TA 1KHJA 4UPLA 3NKPA 3E2DA 4CYRA 2G9YA 1Y6VA 5EGEA 4CXUA 2RH6A 5L0EA 2XR9A 3OT9A 3A52A 1KH4A 2W5RA 4LRDA 4CXKA 1AUKA 5DLWA 1E2SP 1E3CP 3WAWA 3DYCA 4MIVA 1ALJA 1ANJA 3Q3QA 5L0KA 1ZEFA 4GTXA 3SZYA 1K7HA 1ED9A 3TX0A 4KJGA 5IJSA 4KAYA 3BDFA 4LRBA 4ZG9A 1FSUA 3NKNA 1KH9A 4NWJA 1SHQA 1HJKA 2W5XA 3M8ZA 4FDIA 4UOOA 5GOVA 5GRRA 5LQQA 1EJJA 1KHNA 4UOPA 3T02A 1KH7A 2VQRA 3NKOA 1ELYA 4LR8A 3NVLA 2GLQA 1ELXA 5K4PA 4KM4A 4UORA 1N2LA 2W5VA 4GTYA 4MY4A 2GSUA 3UNYA 2W8SA 3WBHA 5HRTA 1ANIA 3WAVA 3MK0A 5LRNA 3TG0A 5C66A 2GSNA 2W8DA 2ANHA 1KHLA 1P49A 4LR7A 4B56A 4KAVA 3SZZA 1URAA 1ALHA 3KD8A 4FDJA 3NKQA 3NKMA 5KXAA 3M8YA 5EGHA 4UPIA 2D1GA 3LXQA 3NKRA 2W5WA 1KH5A 1E33P 2IUCB 1EW8A 1ALIA 1Y7AA 4UPHA 1B8JA
chains in the Genus database with same CATH superfamily
3BDGB 1HDHA 5LIAA 3IGYB 3CMRA 3UN2A 3TWZA 2XRGA 4LQYA 1HQAA 4LRCA 3T01A 5L0BA 1AJDA 5DLVA 3UN3A 4KJDA 1URBA 4ZGAA 2IFYA 2X98A 3DPCA 4LREA 2IUCA 1KHKA 1N2KA 1AJCA 4CYSA 1EQJA 3UO0A 1EI6A 1O99A 1ZEBA 3WAXA 4MHXA 3BDGA 4CXSA 3M8WA 3BDHA 1O98A 5INHA 1SHNA 4LRFA 4LRAA 1ZEDA 2QZUA 3MK2A 5AJ9A 2W5SA 4LR2A 2ZKTA 5IJQA 3ED4A 3MK1A 3M7VA 4GTZA 1ELZA 4TN0A 5DLTA 3IDDA 1ED8A 1AJAA 3T00A 1E1ZP 1ALKA 1AJBA 1EW9A 4ZG7A 4GTWA 5TJ3A 3UN5A 3B5QA 2GSOA 2W5TA 5LRMA 4UPKA 1EW2A 4ZG6A 4LR9A 2GA3A 2W5QA 3IGZB 4NWXA 3WAYA 4YR1A 4QAXA 4N7TA 1KHJA 4UPLA 3NKPA 3E2DA 4CYRA 2G9YA 1Y6VA 5EGEA 4CXUA 2RH6A 5L0EA 2XR9A 3OT9A 3A52A 1KH4A 2W5RA 4LRDA 4CXKA 1AUKA 5DLWA 1E2SP 1E3CP 3WAWA 3DYCA 4MIVA 1ALJA 1ANJA 3Q3QA 5L0KA 1ZEFA 4GTXA 3SZYA 1K7HA 1ED9A 3TX0A 4KJGA 5IJSA 4KAYA 3BDFA 4LRBA 4ZG9A 1FSUA 3NKNA 1KH9A 4NWJA 1SHQA 1HJKA 2W5XA 3M8ZA 4FDIA 4UOOA 5GOVA 5GRRA 5LQQA 1EJJA 1KHNA 4UOPA 3T02A 1KH7A 2VQRA 3NKOA 1ELYA 4LR8A 3NVLA 2GLQA 1ELXA 5K4PA 4KM4A 4UORA 1N2LA 2W5VA 4GTYA 4MY4A 2GSUA 3UNYA 2W8SA 3WBHA 5HRTA 1ANIA 3WAVA 3MK0A 5LRNA 3TG0A 5C66A 2GSNA 2W8DA 2ANHA 1KHLA 1P49A 4LR7A 4B56A 4KAVA 3SZZA 1URAA 1ALHA 3KD8A 4FDJA 3NKQA 3NKMA 5KXAA 3M8YA 5EGHA 4UPIA 2D1GA 3LXQA 3NKRA 2W5WA 1KH5A 1E33P 2IUCB 1EW8A 1ALIA 1Y7AA 4UPHA 1B8JA
chains in the Genus database with same CATH topology
3BDGB 1HDHA 5LIAA 3IGYB 3CMRA 3UN2A 3TWZA 2XRGA 4LQYA 1HQAA 4LRCA 3T01A 5L0BA 1AJDA 5DLVA 3UN3A 4KJDA 1URBA 4ZGAA 2IFYA 2X98A 3DPCA 4LREA 2IUCA 1KHKA 1N2KA 1AJCA 4CYSA 1EQJA 3UO0A 1EI6A 1O99A 1ZEBA 3WAXA 4MHXA 3BDGA 4CXSA 3M8WA 3BDHA 1O98A 5INHA 1SHNA 4LRFA 4LRAA 1ZEDA 2QZUA 3MK2A 5AJ9A 2W5SA 4LR2A 2ZKTA 5IJQA 3ED4A 3MK1A 3M7VA 4GTZA 1ELZA 4TN0A 5DLTA 3IDDA 1ED8A 1AJAA 3T00A 1E1ZP 1ALKA 1AJBA 1EW9A 4ZG7A 4GTWA 5TJ3A 3UN5A 3B5QA 2GSOA 2W5TA 5LRMA 4UPKA 1EW2A 4ZG6A 4LR9A 2GA3A 2W5QA 3IGZB 4NWXA 3WAYA 4YR1A 4QAXA 4N7TA 1KHJA 4UPLA 3NKPA 3E2DA 4CYRA 2G9YA 1Y6VA 5EGEA 4CXUA 2RH6A 5L0EA 2XR9A 3OT9A 3A52A 1KH4A 2W5RA 4LRDA 4CXKA 1AUKA 5DLWA 1E2SP 1E3CP 3WAWA 3DYCA 4MIVA 1ALJA 1ANJA 3Q3QA 5L0KA 1ZEFA 4GTXA 3SZYA 1K7HA 1ED9A 3TX0A 4KJGA 5IJSA 4KAYA 3BDFA 4LRBA 4ZG9A 1FSUA 3NKNA 1KH9A 4NWJA 1SHQA 1HJKA 2W5XA 3M8ZA 4FDIA 4UOOA 5GOVA 5GRRA 5LQQA 1EJJA 1KHNA 4UOPA 3T02A 1KH7A 2VQRA 3NKOA 1ELYA 4LR8A 3NVLA 2GLQA 1ELXA 5K4PA 4KM4A 4UORA 1N2LA 2W5VA 4GTYA 4MY4A 2GSUA 3UNYA 2W8SA 3WBHA 5HRTA 1ANIA 3WAVA 3MK0A 5LRNA 3TG0A 5C66A 2GSNA 2W8DA 2ANHA 1KHLA 1P49A 4LR7A 4B56A 4KAVA 3SZZA 1URAA 1ALHA 3KD8A 4FDJA 3NKQA 3NKMA 5KXAA 3M8YA 5EGHA 4UPIA 2D1GA 3LXQA 3NKRA 2W5WA 1KH5A 1E33P 2IUCB 1EW8A 1ALIA 1Y7AA 4UPHA 1B8JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDG B;  1HDH A;  5LIA A;  3IGY B;  3CMR A;  3UN2 A;  3TWZ A;  2XRG A;  4LQY A;  1HQA A;  4LRC A;  3T01 A;  5L0B A;  1AJD A;  5DLV A;  3UN3 A;  4KJD A;  1URB A;  4ZGA A;  2IFY A;  2X98 A;  3DPC A;  4LRE A;  2IUC A;  1KHK A;  1N2K A;  1AJC A;  4CYS A;  1EQJ A;  3UO0 A;  1EI6 A;  1O99 A;  1ZEB A;  3WAX A;  4MHX A;  3BDG A;  4CXS A;  3M8W A;  3BDH A;  1O98 A;  5INH A;  1SHN A;  4LRF A;  4LRA A;  1ZED A;  2QZU A;  3MK2 A;  5AJ9 A;  2W5S A;  4LR2 A;  2ZKT A;  5IJQ A;  3ED4 A;  3MK1 A;  3M7V A;  4GTZ A;  1ELZ A;  4TN0 A;  5DLT A;  3IDD A;  1ED8 A;  1AJA A;  3T00 A;  1E1Z P;  1ALK A;  1AJB A;  1EW9 A;  4ZG7 A;  4GTW A;  5TJ3 A;  3UN5 A;  3B5Q A;  2GSO A;  2W5T A;  5LRM A;  4UPK A;  1EW2 A;  4ZG6 A;  4LR9 A;  2GA3 A;  2W5Q A;  3IGZ B;  4NWX A;  3WAY A;  4YR1 A;  4QAX A;  4N7T A;  1KHJ A;  4UPL A;  3NKP A;  3E2D A;  4CYR A;  2G9Y A;  1Y6V A;  5EGE A;  4CXU A;  2RH6 A;  5L0E A;  2XR9 A;  3OT9 A;  3A52 A;  1KH4 A;  2W5R A;  4LRD A;  4CXK A;  1AUK A;  5DLW A;  1E2S P;  1E3C P;  3WAW A;  3DYC A;  4MIV A;  1ALJ A;  1ANJ A;  3Q3Q A;  5L0K A;  1ZEF A;  4GTX A;  3SZY A;  1K7H A;  1ED9 A;  3TX0 A;  4KJG A;  5IJS A;  4KAY A;  3BDF A;  4LRB A;  4ZG9 A;  1FSU A;  3NKN A;  1KH9 A;  4NWJ A;  1SHQ A;  1HJK A;  2W5X A;  3M8Z A;  4FDI A;  4UOO A;  5GOV A;  5GRR A;  5LQQ A;  1EJJ A;  1KHN A;  4UOP A;  3T02 A;  1KH7 A;  2VQR A;  3NKO A;  1ELY A;  4LR8 A;  3NVL A;  2GLQ A;  1ELX A;  5K4P A;  4KM4 A;  4UOR A;  1N2L A;  2W5V A;  4GTY A;  4MY4 A;  2GSU A;  3UNY A;  2W8S A;  3WBH A;  5HRT A;  1ANI A;  3WAV A;  3MK0 A;  5LRN A;  3TG0 A;  5C66 A;  2GSN A;  2W8D A;  2ANH A;  1KHL A;  1P49 A;  4LR7 A;  4B56 A;  4KAV A;  3SZZ A;  1URA A;  1ALH A;  3KD8 A;  4FDJ A;  3NKQ A;  3NKM A;  5KXA A;  3M8Y A;  5EGH A;  4UPI A;  2D1G A;  3LXQ A;  3NKR A;  2W5W A;  1KH5 A;  1E33 P;  2IUC B;  1EW8 A;  1ALI A;  1Y7A A;  4UPH A;  1B8J A; 
#chains in the Genus database with same CATH topology
 3BDG B;  1HDH A;  5LIA A;  3IGY B;  3CMR A;  3UN2 A;  3TWZ A;  2XRG A;  4LQY A;  1HQA A;  4LRC A;  3T01 A;  5L0B A;  1AJD A;  5DLV A;  3UN3 A;  4KJD A;  1URB A;  4ZGA A;  2IFY A;  2X98 A;  3DPC A;  4LRE A;  2IUC A;  1KHK A;  1N2K A;  1AJC A;  4CYS A;  1EQJ A;  3UO0 A;  1EI6 A;  1O99 A;  1ZEB A;  3WAX A;  4MHX A;  3BDG A;  4CXS A;  3M8W A;  3BDH A;  1O98 A;  5INH A;  1SHN A;  4LRF A;  4LRA A;  1ZED A;  2QZU A;  3MK2 A;  5AJ9 A;  2W5S A;  4LR2 A;  2ZKT A;  5IJQ A;  3ED4 A;  3MK1 A;  3M7V A;  4GTZ A;  1ELZ A;  4TN0 A;  5DLT A;  3IDD A;  1ED8 A;  1AJA A;  3T00 A;  1E1Z P;  1ALK A;  1AJB A;  1EW9 A;  4ZG7 A;  4GTW A;  5TJ3 A;  3UN5 A;  3B5Q A;  2GSO A;  2W5T A;  5LRM A;  4UPK A;  1EW2 A;  4ZG6 A;  4LR9 A;  2GA3 A;  2W5Q A;  3IGZ B;  4NWX A;  3WAY A;  4YR1 A;  4QAX A;  4N7T A;  1KHJ A;  4UPL A;  3NKP A;  3E2D A;  4CYR A;  2G9Y A;  1Y6V A;  5EGE A;  4CXU A;  2RH6 A;  5L0E A;  2XR9 A;  3OT9 A;  3A52 A;  1KH4 A;  2W5R A;  4LRD A;  4CXK A;  1AUK A;  5DLW A;  1E2S P;  1E3C P;  3WAW A;  3DYC A;  4MIV A;  1ALJ A;  1ANJ A;  3Q3Q A;  5L0K A;  1ZEF A;  4GTX A;  3SZY A;  1K7H A;  1ED9 A;  3TX0 A;  4KJG A;  5IJS A;  4KAY A;  3BDF A;  4LRB A;  4ZG9 A;  1FSU A;  3NKN A;  1KH9 A;  4NWJ A;  1SHQ A;  1HJK A;  2W5X A;  3M8Z A;  4FDI A;  4UOO A;  5GOV A;  5GRR A;  5LQQ A;  1EJJ A;  1KHN A;  4UOP A;  3T02 A;  1KH7 A;  2VQR A;  3NKO A;  1ELY A;  4LR8 A;  3NVL A;  2GLQ A;  1ELX A;  5K4P A;  4KM4 A;  4UOR A;  1N2L A;  2W5V A;  4GTY A;  4MY4 A;  2GSU A;  3UNY A;  2W8S A;  3WBH A;  5HRT A;  1ANI A;  3WAV A;  3MK0 A;  5LRN A;  3TG0 A;  5C66 A;  2GSN A;  2W8D A;  2ANH A;  1KHL A;  1P49 A;  4LR7 A;  4B56 A;  4KAV A;  3SZZ A;  1URA A;  1ALH A;  3KD8 A;  4FDJ A;  3NKQ A;  3NKM A;  5KXA A;  3M8Y A;  5EGH A;  4UPI A;  2D1G A;  3LXQ A;  3NKR A;  2W5W A;  1KH5 A;  1E33 P;  2IUC B;  1EW8 A;  1ALI A;  1Y7A A;  4UPH A;  1B8J A; 
#chains in the Genus database with same CATH homology
 3BDG B;  1HDH A;  5LIA A;  3IGY B;  3CMR A;  3UN2 A;  3TWZ A;  2XRG A;  4LQY A;  1HQA A;  4LRC A;  3T01 A;  5L0B A;  1AJD A;  5DLV A;  3UN3 A;  4KJD A;  1URB A;  4ZGA A;  2IFY A;  2X98 A;  3DPC A;  4LRE A;  2IUC A;  1KHK A;  1N2K A;  1AJC A;  4CYS A;  1EQJ A;  3UO0 A;  1EI6 A;  1O99 A;  1ZEB A;  3WAX A;  4MHX A;  3BDG A;  4CXS A;  3M8W A;  3BDH A;  1O98 A;  5INH A;  1SHN A;  4LRF A;  4LRA A;  1ZED A;  2QZU A;  3MK2 A;  5AJ9 A;  2W5S A;  4LR2 A;  2ZKT A;  5IJQ A;  3ED4 A;  3MK1 A;  3M7V A;  4GTZ A;  1ELZ A;  4TN0 A;  5DLT A;  3IDD A;  1ED8 A;  1AJA A;  3T00 A;  1E1Z P;  1ALK A;  1AJB A;  1EW9 A;  4ZG7 A;  4GTW A;  5TJ3 A;  3UN5 A;  3B5Q A;  2GSO A;  2W5T A;  5LRM A;  4UPK A;  1EW2 A;  4ZG6 A;  4LR9 A;  2GA3 A;  2W5Q A;  3IGZ B;  4NWX A;  3WAY A;  4YR1 A;  4QAX A;  4N7T A;  1KHJ A;  4UPL A;  3NKP A;  3E2D A;  4CYR A;  2G9Y A;  1Y6V A;  5EGE A;  4CXU A;  2RH6 A;  5L0E A;  2XR9 A;  3OT9 A;  3A52 A;  1KH4 A;  2W5R A;  4LRD A;  4CXK A;  1AUK A;  5DLW A;  1E2S P;  1E3C P;  3WAW A;  3DYC A;  4MIV A;  1ALJ A;  1ANJ A;  3Q3Q A;  5L0K A;  1ZEF A;  4GTX A;  3SZY A;  1K7H A;  1ED9 A;  3TX0 A;  4KJG A;  5IJS A;  4KAY A;  3BDF A;  4LRB A;  4ZG9 A;  1FSU A;  3NKN A;  1KH9 A;  4NWJ A;  1SHQ A;  1HJK A;  2W5X A;  3M8Z A;  4FDI A;  4UOO A;  5GOV A;  5GRR A;  5LQQ A;  1EJJ A;  1KHN A;  4UOP A;  3T02 A;  1KH7 A;  2VQR A;  3NKO A;  1ELY A;  4LR8 A;  3NVL A;  2GLQ A;  1ELX A;  5K4P A;  4KM4 A;  4UOR A;  1N2L A;  2W5V A;  4GTY A;  4MY4 A;  2GSU A;  3UNY A;  2W8S A;  3WBH A;  5HRT A;  1ANI A;  3WAV A;  3MK0 A;  5LRN A;  3TG0 A;  5C66 A;  2GSN A;  2W8D A;  2ANH A;  1KHL A;  1P49 A;  4LR7 A;  4B56 A;  4KAV A;  3SZZ A;  1URA A;  1ALH A;  3KD8 A;  4FDJ A;  3NKQ A;  3NKM A;  5KXA A;  3M8Y A;  5EGH A;  4UPI A;  2D1G A;  3LXQ A;  3NKR A;  2W5W A;  1KH5 A;  1E33 P;  2IUC B;  1EW8 A;  1ALI A;  1Y7A A;  4UPH A;  1B8J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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