1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
molecule keywords ALKALINE PHOSPHATASE
molecule tags Hydrolase
source organism Escherichia coli
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
4LR9A 5EGHA 3NKNA 3UN5A 1KH7A 2IUCA 2GSNA 1URAA 3WAVA 4LREA 5AJ9A 5C66A 3MK0A 4CYRA 4CYSA 5DLWA 1AJBA 1ALKA 3DPCA 3TG0A 4LR2A 2IUCB 3SZZA 2W5XA 3CMRA 1EJJA 1Y6VA 2W5RA 4LRBA 4UOOA 3E2DA 3UNYA 3M8YA 1EQJA 1EI6A 3WAWA 3IDDA 1KHLA 1KHNA 2QZUA 2W5SA 3NKOA 1E2SP 4UPKA 3WAYA 4NWJA 4UPLA 3MK1A 3ED4A 4ZGAA 3TX0A 5L0EA 1P49A 2W5QA 1O99A 1ALHA 3BDFA 5EGEA 3M7VA 4KAYA 4LR8A 4MY4A 5IJQA 4FDIA 1AJAA 4MIVA 1K7HA 2ANHA 4GTZA 4UPIA 2XRGA 2W5WA 2GSOA 1ANJA 5TJ3A 4B56A 5GRRA 1ALJA 1KHKA 1E3CP 4LR7A 3M8WA 3NKPA 5DLVA 5GOVA 4LRCA 4KJGA 2GSUA 1ZEDA 2GA3A 3WBHA 4KM4A 4ZG6A 1EW2A 4GTYA 1AJDA 4KAVA 1HDHA 4MHXA 2G9YA 5HRTA 3IGZB 1ELZA 4N7TA 4TN0A 1SHNA 5L0KA 5INHA 3T00A 1ED8A 2GLQA 3Q3QA 3B5QA 2W8DA 3M8ZA 4LRFA 4NWXA 5LQQA 3A52A 3BDHA 2IFYA 3IGYB 5LIAA 1HJKA 1KH5A 1ZEBA 3SZYA 4GTXA 3UN2A 3MK2A 1O98A 4ZG9A 2VQRA 3NKRA 4CXSA 4LQYA 3WAXA 1KHJA 1URBA 2W5TA 4LRDA 1N2LA 4YR1A 3NKQA 4KJDA 4UPHA 5LRMA 4QAXA 3TWZA 3DYCA 1B8JA 1ZEFA 5LRNA 3BDGA 5IJSA 5L0BA 3OT9A 1ELXA 4UORA 1E1ZP 4LRAA 1N2KA 2X98A 1FSUA 2XR9A 3LXQA 3NVLA 4CXUA 4GTWA 3T02A 3UN3A 3KD8A 1KH9A 1ED9A 1HQAA 2W8SA 3BDGB 1KH4A 1EW9A 3UO0A 3NKMA 4UOPA 1AUKA 1ANIA 1ELYA 4CXKA 1Y7AA 1AJCA 5K4PA 2D1GA 5DLTA 3T01A 1EW8A 1SHQA 4ZG7A 5KXAA 1ALIA 1E33P 4FDJA 2ZKTA 2W5VA 2RH6A
chains in the Genus database with same CATH superfamily
4LR9A 5EGHA 3NKNA 3UN5A 1KH7A 2IUCA 2GSNA 1URAA 3WAVA 4LREA 5AJ9A 5C66A 3MK0A 4CYRA 4CYSA 5DLWA 1AJBA 1ALKA 3DPCA 3TG0A 4LR2A 2IUCB 3SZZA 2W5XA 3CMRA 1EJJA 1Y6VA 2W5RA 4LRBA 4UOOA 3E2DA 3UNYA 3M8YA 1EQJA 1EI6A 3WAWA 3IDDA 1KHLA 1KHNA 2QZUA 2W5SA 3NKOA 1E2SP 4UPKA 3WAYA 4NWJA 4UPLA 3MK1A 3ED4A 4ZGAA 3TX0A 5L0EA 1P49A 2W5QA 1O99A 1ALHA 3BDFA 5EGEA 3M7VA 4KAYA 4LR8A 4MY4A 5IJQA 4FDIA 1AJAA 4MIVA 1K7HA 2ANHA 4GTZA 4UPIA 2XRGA 2W5WA 2GSOA 1ANJA 5TJ3A 4B56A 5GRRA 1ALJA 1KHKA 1E3CP 4LR7A 3M8WA 3NKPA 5DLVA 5GOVA 4LRCA 4KJGA 2GSUA 1ZEDA 2GA3A 3WBHA 4KM4A 4ZG6A 1EW2A 4GTYA 1AJDA 4KAVA 1HDHA 4MHXA 2G9YA 5HRTA 3IGZB 1ELZA 4N7TA 4TN0A 1SHNA 5L0KA 5INHA 3T00A 1ED8A 2GLQA 3Q3QA 3B5QA 2W8DA 3M8ZA 4LRFA 4NWXA 5LQQA 3A52A 3BDHA 2IFYA 3IGYB 5LIAA 1HJKA 1KH5A 1ZEBA 3SZYA 4GTXA 3UN2A 3MK2A 1O98A 4ZG9A 2VQRA 3NKRA 4CXSA 4LQYA 3WAXA 1KHJA 1URBA 2W5TA 4LRDA 1N2LA 4YR1A 3NKQA 4KJDA 4UPHA 5LRMA 4QAXA 3TWZA 3DYCA 1B8JA 1ZEFA 5LRNA 3BDGA 5IJSA 5L0BA 3OT9A 1ELXA 4UORA 1E1ZP 4LRAA 1N2KA 2X98A 1FSUA 2XR9A 3LXQA 3NVLA 4CXUA 4GTWA 3T02A 3UN3A 3KD8A 1KH9A 1ED9A 1HQAA 2W8SA 3BDGB 1KH4A 1EW9A 3UO0A 3NKMA 4UOPA 1AUKA 1ANIA 1ELYA 4CXKA 1Y7AA 1AJCA 5K4PA 2D1GA 5DLTA 3T01A 1EW8A 1SHQA 4ZG7A 5KXAA 1ALIA 1E33P 4FDJA 2ZKTA 2W5VA 2RH6A
chains in the Genus database with same CATH topology
4LR9A 5EGHA 3NKNA 3UN5A 1KH7A 2IUCA 2GSNA 1URAA 3WAVA 4LREA 5AJ9A 5C66A 3MK0A 4CYRA 4CYSA 5DLWA 1AJBA 1ALKA 3DPCA 3TG0A 4LR2A 2IUCB 3SZZA 2W5XA 3CMRA 1EJJA 1Y6VA 2W5RA 4LRBA 4UOOA 3E2DA 3UNYA 3M8YA 1EQJA 1EI6A 3WAWA 3IDDA 1KHLA 1KHNA 2QZUA 2W5SA 3NKOA 1E2SP 4UPKA 3WAYA 4NWJA 4UPLA 3MK1A 3ED4A 4ZGAA 3TX0A 5L0EA 1P49A 2W5QA 1O99A 1ALHA 3BDFA 5EGEA 3M7VA 4KAYA 4LR8A 4MY4A 5IJQA 4FDIA 1AJAA 4MIVA 1K7HA 2ANHA 4GTZA 4UPIA 2XRGA 2W5WA 2GSOA 1ANJA 5TJ3A 4B56A 5GRRA 1ALJA 1KHKA 1E3CP 4LR7A 3M8WA 3NKPA 5DLVA 5GOVA 4LRCA 4KJGA 2GSUA 1ZEDA 2GA3A 3WBHA 4KM4A 4ZG6A 1EW2A 4GTYA 1AJDA 4KAVA 1HDHA 4MHXA 2G9YA 5HRTA 3IGZB 1ELZA 4N7TA 4TN0A 1SHNA 5L0KA 5INHA 3T00A 1ED8A 2GLQA 3Q3QA 3B5QA 2W8DA 3M8ZA 4LRFA 4NWXA 5LQQA 3A52A 3BDHA 2IFYA 3IGYB 5LIAA 1HJKA 1KH5A 1ZEBA 3SZYA 4GTXA 3UN2A 3MK2A 1O98A 4ZG9A 2VQRA 3NKRA 4CXSA 4LQYA 3WAXA 1KHJA 1URBA 2W5TA 4LRDA 1N2LA 4YR1A 3NKQA 4KJDA 4UPHA 5LRMA 4QAXA 3TWZA 3DYCA 1B8JA 1ZEFA 5LRNA 3BDGA 5IJSA 5L0BA 3OT9A 1ELXA 4UORA 1E1ZP 4LRAA 1N2KA 2X98A 1FSUA 2XR9A 3LXQA 3NVLA 4CXUA 4GTWA 3T02A 3UN3A 3KD8A 1KH9A 1ED9A 1HQAA 2W8SA 3BDGB 1KH4A 1EW9A 3UO0A 3NKMA 4UOPA 1AUKA 1ANIA 1ELYA 4CXKA 1Y7AA 1AJCA 5K4PA 2D1GA 5DLTA 3T01A 1EW8A 1SHQA 4ZG7A 5KXAA 1ALIA 1E33P 4FDJA 2ZKTA 2W5VA 2RH6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR9 A;  5EGH A;  3NKN A;  3UN5 A;  1KH7 A;  2IUC A;  2GSN A;  1URA A;  3WAV A;  4LRE A;  5AJ9 A;  5C66 A;  3MK0 A;  4CYR A;  4CYS A;  5DLW A;  1AJB A;  1ALK A;  3DPC A;  3TG0 A;  4LR2 A;  2IUC B;  3SZZ A;  2W5X A;  3CMR A;  1EJJ A;  1Y6V A;  2W5R A;  4LRB A;  4UOO A;  3E2D A;  3UNY A;  3M8Y A;  1EQJ A;  1EI6 A;  3WAW A;  3IDD A;  1KHL A;  1KHN A;  2QZU A;  2W5S A;  3NKO A;  1E2S P;  4UPK A;  3WAY A;  4NWJ A;  4UPL A;  3MK1 A;  3ED4 A;  4ZGA A;  3TX0 A;  5L0E A;  1P49 A;  2W5Q A;  1O99 A;  1ALH A;  3BDF A;  5EGE A;  3M7V A;  4KAY A;  4LR8 A;  4MY4 A;  5IJQ A;  4FDI A;  1AJA A;  4MIV A;  1K7H A;  2ANH A;  4GTZ A;  4UPI A;  2XRG A;  2W5W A;  2GSO A;  1ANJ A;  5TJ3 A;  4B56 A;  5GRR A;  1ALJ A;  1KHK A;  1E3C P;  4LR7 A;  3M8W A;  3NKP A;  5DLV A;  5GOV A;  4LRC A;  4KJG A;  2GSU A;  1ZED A;  2GA3 A;  3WBH A;  4KM4 A;  4ZG6 A;  1EW2 A;  4GTY A;  1AJD A;  4KAV A;  1HDH A;  4MHX A;  2G9Y A;  5HRT A;  3IGZ B;  1ELZ A;  4N7T A;  4TN0 A;  1SHN A;  5L0K A;  5INH A;  3T00 A;  1ED8 A;  2GLQ A;  3Q3Q A;  3B5Q A;  2W8D A;  3M8Z A;  4LRF A;  4NWX A;  5LQQ A;  3A52 A;  3BDH A;  2IFY A;  3IGY B;  5LIA A;  1HJK A;  1KH5 A;  1ZEB A;  3SZY A;  4GTX A;  3UN2 A;  3MK2 A;  1O98 A;  4ZG9 A;  2VQR A;  3NKR A;  4CXS A;  4LQY A;  3WAX A;  1KHJ A;  1URB A;  2W5T A;  4LRD A;  1N2L A;  4YR1 A;  3NKQ A;  4KJD A;  4UPH A;  5LRM A;  4QAX A;  3TWZ A;  3DYC A;  1B8J A;  1ZEF A;  5LRN A;  3BDG A;  5IJS A;  5L0B A;  3OT9 A;  1ELX A;  4UOR A;  1E1Z P;  4LRA A;  1N2K A;  2X98 A;  1FSU A;  2XR9 A;  3LXQ A;  3NVL A;  4CXU A;  4GTW A;  3T02 A;  3UN3 A;  3KD8 A;  1KH9 A;  1ED9 A;  1HQA A;  2W8S A;  3BDG B;  1KH4 A;  1EW9 A;  3UO0 A;  3NKM A;  4UOP A;  1AUK A;  1ANI A;  1ELY A;  4CXK A;  1Y7A A;  1AJC A;  5K4P A;  2D1G A;  5DLT A;  3T01 A;  1EW8 A;  1SHQ A;  4ZG7 A;  5KXA A;  1ALI A;  1E33 P;  4FDJ A;  2ZKT A;  2W5V A;  2RH6 A; 
#chains in the Genus database with same CATH topology
 4LR9 A;  5EGH A;  3NKN A;  3UN5 A;  1KH7 A;  2IUC A;  2GSN A;  1URA A;  3WAV A;  4LRE A;  5AJ9 A;  5C66 A;  3MK0 A;  4CYR A;  4CYS A;  5DLW A;  1AJB A;  1ALK A;  3DPC A;  3TG0 A;  4LR2 A;  2IUC B;  3SZZ A;  2W5X A;  3CMR A;  1EJJ A;  1Y6V A;  2W5R A;  4LRB A;  4UOO A;  3E2D A;  3UNY A;  3M8Y A;  1EQJ A;  1EI6 A;  3WAW A;  3IDD A;  1KHL A;  1KHN A;  2QZU A;  2W5S A;  3NKO A;  1E2S P;  4UPK A;  3WAY A;  4NWJ A;  4UPL A;  3MK1 A;  3ED4 A;  4ZGA A;  3TX0 A;  5L0E A;  1P49 A;  2W5Q A;  1O99 A;  1ALH A;  3BDF A;  5EGE A;  3M7V A;  4KAY A;  4LR8 A;  4MY4 A;  5IJQ A;  4FDI A;  1AJA A;  4MIV A;  1K7H A;  2ANH A;  4GTZ A;  4UPI A;  2XRG A;  2W5W A;  2GSO A;  1ANJ A;  5TJ3 A;  4B56 A;  5GRR A;  1ALJ A;  1KHK A;  1E3C P;  4LR7 A;  3M8W A;  3NKP A;  5DLV A;  5GOV A;  4LRC A;  4KJG A;  2GSU A;  1ZED A;  2GA3 A;  3WBH A;  4KM4 A;  4ZG6 A;  1EW2 A;  4GTY A;  1AJD A;  4KAV A;  1HDH A;  4MHX A;  2G9Y A;  5HRT A;  3IGZ B;  1ELZ A;  4N7T A;  4TN0 A;  1SHN A;  5L0K A;  5INH A;  3T00 A;  1ED8 A;  2GLQ A;  3Q3Q A;  3B5Q A;  2W8D A;  3M8Z A;  4LRF A;  4NWX A;  5LQQ A;  3A52 A;  3BDH A;  2IFY A;  3IGY B;  5LIA A;  1HJK A;  1KH5 A;  1ZEB A;  3SZY A;  4GTX A;  3UN2 A;  3MK2 A;  1O98 A;  4ZG9 A;  2VQR A;  3NKR A;  4CXS A;  4LQY A;  3WAX A;  1KHJ A;  1URB A;  2W5T A;  4LRD A;  1N2L A;  4YR1 A;  3NKQ A;  4KJD A;  4UPH A;  5LRM A;  4QAX A;  3TWZ A;  3DYC A;  1B8J A;  1ZEF A;  5LRN A;  3BDG A;  5IJS A;  5L0B A;  3OT9 A;  1ELX A;  4UOR A;  1E1Z P;  4LRA A;  1N2K A;  2X98 A;  1FSU A;  2XR9 A;  3LXQ A;  3NVL A;  4CXU A;  4GTW A;  3T02 A;  3UN3 A;  3KD8 A;  1KH9 A;  1ED9 A;  1HQA A;  2W8S A;  3BDG B;  1KH4 A;  1EW9 A;  3UO0 A;  3NKM A;  4UOP A;  1AUK A;  1ANI A;  1ELY A;  4CXK A;  1Y7A A;  1AJC A;  5K4P A;  2D1G A;  5DLT A;  3T01 A;  1EW8 A;  1SHQ A;  4ZG7 A;  5KXA A;  1ALI A;  1E33 P;  4FDJ A;  2ZKT A;  2W5V A;  2RH6 A; 
#chains in the Genus database with same CATH homology
 4LR9 A;  5EGH A;  3NKN A;  3UN5 A;  1KH7 A;  2IUC A;  2GSN A;  1URA A;  3WAV A;  4LRE A;  5AJ9 A;  5C66 A;  3MK0 A;  4CYR A;  4CYS A;  5DLW A;  1AJB A;  1ALK A;  3DPC A;  3TG0 A;  4LR2 A;  2IUC B;  3SZZ A;  2W5X A;  3CMR A;  1EJJ A;  1Y6V A;  2W5R A;  4LRB A;  4UOO A;  3E2D A;  3UNY A;  3M8Y A;  1EQJ A;  1EI6 A;  3WAW A;  3IDD A;  1KHL A;  1KHN A;  2QZU A;  2W5S A;  3NKO A;  1E2S P;  4UPK A;  3WAY A;  4NWJ A;  4UPL A;  3MK1 A;  3ED4 A;  4ZGA A;  3TX0 A;  5L0E A;  1P49 A;  2W5Q A;  1O99 A;  1ALH A;  3BDF A;  5EGE A;  3M7V A;  4KAY A;  4LR8 A;  4MY4 A;  5IJQ A;  4FDI A;  1AJA A;  4MIV A;  1K7H A;  2ANH A;  4GTZ A;  4UPI A;  2XRG A;  2W5W A;  2GSO A;  1ANJ A;  5TJ3 A;  4B56 A;  5GRR A;  1ALJ A;  1KHK A;  1E3C P;  4LR7 A;  3M8W A;  3NKP A;  5DLV A;  5GOV A;  4LRC A;  4KJG A;  2GSU A;  1ZED A;  2GA3 A;  3WBH A;  4KM4 A;  4ZG6 A;  1EW2 A;  4GTY A;  1AJD A;  4KAV A;  1HDH A;  4MHX A;  2G9Y A;  5HRT A;  3IGZ B;  1ELZ A;  4N7T A;  4TN0 A;  1SHN A;  5L0K A;  5INH A;  3T00 A;  1ED8 A;  2GLQ A;  3Q3Q A;  3B5Q A;  2W8D A;  3M8Z A;  4LRF A;  4NWX A;  5LQQ A;  3A52 A;  3BDH A;  2IFY A;  3IGY B;  5LIA A;  1HJK A;  1KH5 A;  1ZEB A;  3SZY A;  4GTX A;  3UN2 A;  3MK2 A;  1O98 A;  4ZG9 A;  2VQR A;  3NKR A;  4CXS A;  4LQY A;  3WAX A;  1KHJ A;  1URB A;  2W5T A;  4LRD A;  1N2L A;  4YR1 A;  3NKQ A;  4KJD A;  4UPH A;  5LRM A;  4QAX A;  3TWZ A;  3DYC A;  1B8J A;  1ZEF A;  5LRN A;  3BDG A;  5IJS A;  5L0B A;  3OT9 A;  1ELX A;  4UOR A;  1E1Z P;  4LRA A;  1N2K A;  2X98 A;  1FSU A;  2XR9 A;  3LXQ A;  3NVL A;  4CXU A;  4GTW A;  3T02 A;  3UN3 A;  3KD8 A;  1KH9 A;  1ED9 A;  1HQA A;  2W8S A;  3BDG B;  1KH4 A;  1EW9 A;  3UO0 A;  3NKM A;  4UOP A;  1AUK A;  1ANI A;  1ELY A;  4CXK A;  1Y7A A;  1AJC A;  5K4P A;  2D1G A;  5DLT A;  3T01 A;  1EW8 A;  1SHQ A;  4ZG7 A;  5KXA A;  1ALI A;  1E33 P;  4FDJ A;  2ZKT A;  2W5V A;  2RH6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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