1EW8 | Genus

Total Genus 155

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	155
Knots found	KnotProt 2.0: S +3₁
sequence length	449
structure length	449
Chain Sequence	TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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Viewer cachePut cache://localLOAD_/file/5cfb17ec56e559ced255c1fe/pdb.gz

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The Resolver thinks Pdb

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Time for openFile(/file/5cfb17ec56e559ced255c1fe/pdb.gz): 1824 ms

reading 449 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

449 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 42 ms

Adding embedded #jmolscript: select ({0:448});backbone only;select *;

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

publication title	Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes. pubmed rcsb
molecule keywords	ALKALINE PHOSPHATASE
molecule tags	Hydrolase
source organism	Escherichia coli
total genus	155
structure length	449
sequence length	449
chains with identical sequence	B
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2000-04-24

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1ew8A00

3LXQA 1URBA 3NKRA 3BDGA 3E2DA 3M8ZA 4LRCA 3T02A 1SHQA 4CYRA 3OT9A 2QZUA 1KHJA 1ZEFA 1SHNA 4LRBA 2GSNA 1ALKA 1KHLA 1ALIA 4LR7A 1KH4A 5LQQA 3UN3A 4GTZA 1N2KA 1P49A 4KM4A 5IJQA 5GRRA 4UPIA 1EQJA 2XR9A 3KD8A 3NKNA 4UPHA 1EW8A 4LR9A 4MY4A 5K4PA 3TWZA 1EI6A 5TJ3A 4CYSA 4LRAA 1ED8A 5L0KA 3NKQA 2ANHA 3UNYA 2ZKTA 3M8WA 4KAYA 3IDDA 1KHNA 5AJ9A 4GTWA 4GTXA 1ED9A 1AJDA 2GSUA 1AJBA 3UN2A 3MK2A 1ALJA 4KJGA 5DLWA 4NWJA 1EW9A 5DLTA 4CXUA 1ZEBA 2D1GA 2G9YA 5C66A 5INHA 3NKOA 2IUCA 4NWXA 2W5QA 1ALHA 3BDGB 3WAWA 5L0BA 5HRTA 4LRDA 2W5VA 4UOOA 1ANJA 1ELYA 2W5SA 4UPLA 5LIAA 2W5XA 4ZG7A 4FDIA 4YR1A 2IUCB 2GSOA 1EW2A 1AUKA 4LQYA 3WAXA 4CXSA 3WAYA 4LREA 3UN5A 4N7TA 1KH5A 5DLVA 2X98A 4UORA 2W5WA 1Y6VA 2W5RA 1ANIA 3CMRA 5EGHA 1KH7A 1EJJA 1Y7AA 2W8SA 3MK0A 3TG0A 4QAXA 4LRFA 5KXAA 3MK1A 3IGYB 3WBHA 4ZG6A 1E3CP 4KJDA 2VQRA 4GTYA 5LRMA 3Q3QA 3UO0A 1URAA 1B8JA 4UOPA 1HDHA 1ELZA 4UPKA 3BDHA 1KH9A 1E2SP 4KAVA 3A52A 3BDFA 3NVLA 2GA3A 4MHXA 4FDJA 1ZEDA 2GLQA 4LR2A 1E1ZP 1FSUA 1AJCA 3SZYA 2RH6A 4CXKA 4MIVA 1ELXA 1HQAA 3DYCA 2W5TA 3WAVA 3T01A 4LR8A 5L0EA 3T00A 3M7VA 1HJKA 3NKMA 4TN0A 3IGZB 3SZZA 4ZGAA 1AJAA 3ED4A 3B5QA 1O98A 1O99A 2IFYA 3NKPA 5IJSA 5LRNA 5GOVA 2XRGA 4B56A 3DPCA 3TX0A 4ZG9A 1KHKA 1N2LA 3M8YA 1E33P 2W8DA 5EGEA 1K7HA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3LXQ A;  1URB A;  3NKR A;  3BDG A;  3E2D A;  3M8Z A;  4LRC A;  3T02 A;  1SHQ A;  4CYR A;  3OT9 A;  2QZU A;  1KHJ A;  1ZEF A;  1SHN A;  4LRB A;  2GSN A;  1ALK A;  1KHL A;  1ALI A;  4LR7 A;  1KH4 A;  5LQQ A;  3UN3 A;  4GTZ A;  1N2K A;  1P49 A;  4KM4 A;  5IJQ A;  5GRR A;  4UPI A;  1EQJ A;  2XR9 A;  3KD8 A;  3NKN A;  4UPH A;  1EW8 A;  4LR9 A;  4MY4 A;  5K4P A;  3TWZ A;  1EI6 A;  5TJ3 A;  4CYS A;  4LRA A;  1ED8 A;  5L0K A;  3NKQ A;  2ANH A;  3UNY A;  2ZKT A;  3M8W A;  4KAY A;  3IDD A;  1KHN A;  5AJ9 A;  4GTW A;  4GTX A;  1ED9 A;  1AJD A;  2GSU A;  1AJB A;  3UN2 A;  3MK2 A;  1ALJ A;  4KJG A;  5DLW A;  4NWJ A;  1EW9 A;  5DLT A;  4CXU A;  1ZEB A;  2D1G A;  2G9Y A;  5C66 A;  5INH A;  3NKO A;  2IUC A;  4NWX A;  2W5Q A;  1ALH A;  3BDG B;  3WAW A;  5L0B A;  5HRT A;  4LRD A;  2W5V A;  4UOO A;  1ANJ A;  1ELY A;  2W5S A;  4UPL A;  5LIA A;  2W5X A;  4ZG7 A;  4FDI A;  4YR1 A;  2IUC B;  2GSO A;  1EW2 A;  1AUK A;  4LQY A;  3WAX A;  4CXS A;  3WAY A;  4LRE A;  3UN5 A;  4N7T A;  1KH5 A;  5DLV A;  2X98 A;  4UOR A;  2W5W A;  1Y6V A;  2W5R A;  1ANI A;  3CMR A;  5EGH A;  1KH7 A;  1EJJ A;  1Y7A A;  2W8S A;  3MK0 A;  3TG0 A;  4QAX A;  4LRF A;  5KXA A;  3MK1 A;  3IGY B;  3WBH A;  4ZG6 A;  1E3C P;  4KJD A;  2VQR A;  4GTY A;  5LRM A;  3Q3Q A;  3UO0 A;  1URA A;  1B8J A;  4UOP A;  1HDH A;  1ELZ A;  4UPK A;  3BDH A;  1KH9 A;  1E2S P;  4KAV A;  3A52 A;  3BDF A;  3NVL A;  2GA3 A;  4MHX A;  4FDJ A;  1ZED A;  2GLQ A;  4LR2 A;  1E1Z P;  1FSU A;  1AJC A;  3SZY A;  2RH6 A;  4CXK A;  4MIV A;  1ELX A;  1HQA A;  3DYC A;  2W5T A;  3WAV A;  3T01 A;  4LR8 A;  5L0E A;  3T00 A;  3M7V A;  1HJK A;  3NKM A;  4TN0 A;  3IGZ B;  3SZZ A;  4ZGA A;  1AJA A;  3ED4 A;  3B5Q A;  1O98 A;  1O99 A;  2IFY A;  3NKP A;  5IJS A;  5LRN A;  5GOV A;  2XRG A;  4B56 A;  3DPC A;  3TX0 A;  4ZG9 A;  1KHK A;  1N2L A;  3M8Y A;  1E33 P;  2W8D A;  5EGE A;  1K7H A; 
#chains in the Genus database with same CATH topology
 3LXQ A;  1URB A;  3NKR A;  3BDG A;  3E2D A;  3M8Z A;  4LRC A;  3T02 A;  1SHQ A;  4CYR A;  3OT9 A;  2QZU A;  1KHJ A;  1ZEF A;  1SHN A;  4LRB A;  2GSN A;  1ALK A;  1KHL A;  1ALI A;  4LR7 A;  1KH4 A;  5LQQ A;  3UN3 A;  4GTZ A;  1N2K A;  1P49 A;  4KM4 A;  5IJQ A;  5GRR A;  4UPI A;  1EQJ A;  2XR9 A;  3KD8 A;  3NKN A;  4UPH A;  1EW8 A;  4LR9 A;  4MY4 A;  5K4P A;  3TWZ A;  1EI6 A;  5TJ3 A;  4CYS A;  4LRA A;  1ED8 A;  5L0K A;  3NKQ A;  2ANH A;  3UNY A;  2ZKT A;  3M8W A;  4KAY A;  3IDD A;  1KHN A;  5AJ9 A;  4GTW A;  4GTX A;  1ED9 A;  1AJD A;  2GSU A;  1AJB A;  3UN2 A;  3MK2 A;  1ALJ A;  4KJG A;  5DLW A;  4NWJ A;  1EW9 A;  5DLT A;  4CXU A;  1ZEB A;  2D1G A;  2G9Y A;  5C66 A;  5INH A;  3NKO A;  2IUC A;  4NWX A;  2W5Q A;  1ALH A;  3BDG B;  3WAW A;  5L0B A;  5HRT A;  4LRD A;  2W5V A;  4UOO A;  1ANJ A;  1ELY A;  2W5S A;  4UPL A;  5LIA A;  2W5X A;  4ZG7 A;  4FDI A;  4YR1 A;  2IUC B;  2GSO A;  1EW2 A;  1AUK A;  4LQY A;  3WAX A;  4CXS A;  3WAY A;  4LRE A;  3UN5 A;  4N7T A;  1KH5 A;  5DLV A;  2X98 A;  4UOR A;  2W5W A;  1Y6V A;  2W5R A;  1ANI A;  3CMR A;  5EGH A;  1KH7 A;  1EJJ A;  1Y7A A;  2W8S A;  3MK0 A;  3TG0 A;  4QAX A;  4LRF A;  5KXA A;  3MK1 A;  3IGY B;  3WBH A;  4ZG6 A;  1E3C P;  4KJD A;  2VQR A;  4GTY A;  5LRM A;  3Q3Q A;  3UO0 A;  1URA A;  1B8J A;  4UOP A;  1HDH A;  1ELZ A;  4UPK A;  3BDH A;  1KH9 A;  1E2S P;  4KAV A;  3A52 A;  3BDF A;  3NVL A;  2GA3 A;  4MHX A;  4FDJ A;  1ZED A;  2GLQ A;  4LR2 A;  1E1Z P;  1FSU A;  1AJC A;  3SZY A;  2RH6 A;  4CXK A;  4MIV A;  1ELX A;  1HQA A;  3DYC A;  2W5T A;  3WAV A;  3T01 A;  4LR8 A;  5L0E A;  3T00 A;  3M7V A;  1HJK A;  3NKM A;  4TN0 A;  3IGZ B;  3SZZ A;  4ZGA A;  1AJA A;  3ED4 A;  3B5Q A;  1O98 A;  1O99 A;  2IFY A;  3NKP A;  5IJS A;  5LRN A;  5GOV A;  2XRG A;  4B56 A;  3DPC A;  3TX0 A;  4ZG9 A;  1KHK A;  1N2L A;  3M8Y A;  1E33 P;  2W8D A;  5EGE A;  1K7H A; 
#chains in the Genus database with same CATH homology
 3LXQ A;  1URB A;  3NKR A;  3BDG A;  3E2D A;  3M8Z A;  4LRC A;  3T02 A;  1SHQ A;  4CYR A;  3OT9 A;  2QZU A;  1KHJ A;  1ZEF A;  1SHN A;  4LRB A;  2GSN A;  1ALK A;  1KHL A;  1ALI A;  4LR7 A;  1KH4 A;  5LQQ A;  3UN3 A;  4GTZ A;  1N2K A;  1P49 A;  4KM4 A;  5IJQ A;  5GRR A;  4UPI A;  1EQJ A;  2XR9 A;  3KD8 A;  3NKN A;  4UPH A;  1EW8 A;  4LR9 A;  4MY4 A;  5K4P A;  3TWZ A;  1EI6 A;  5TJ3 A;  4CYS A;  4LRA A;  1ED8 A;  5L0K A;  3NKQ A;  2ANH A;  3UNY A;  2ZKT A;  3M8W A;  4KAY A;  3IDD A;  1KHN A;  5AJ9 A;  4GTW A;  4GTX A;  1ED9 A;  1AJD A;  2GSU A;  1AJB A;  3UN2 A;  3MK2 A;  1ALJ A;  4KJG A;  5DLW A;  4NWJ A;  1EW9 A;  5DLT A;  4CXU A;  1ZEB A;  2D1G A;  2G9Y A;  5C66 A;  5INH A;  3NKO A;  2IUC A;  4NWX A;  2W5Q A;  1ALH A;  3BDG B;  3WAW A;  5L0B A;  5HRT A;  4LRD A;  2W5V A;  4UOO A;  1ANJ A;  1ELY A;  2W5S A;  4UPL A;  5LIA A;  2W5X A;  4ZG7 A;  4FDI A;  4YR1 A;  2IUC B;  2GSO A;  1EW2 A;  1AUK A;  4LQY A;  3WAX A;  4CXS A;  3WAY A;  4LRE A;  3UN5 A;  4N7T A;  1KH5 A;  5DLV A;  2X98 A;  4UOR A;  2W5W A;  1Y6V A;  2W5R A;  1ANI A;  3CMR A;  5EGH A;  1KH7 A;  1EJJ A;  1Y7A A;  2W8S A;  3MK0 A;  3TG0 A;  4QAX A;  4LRF A;  5KXA A;  3MK1 A;  3IGY B;  3WBH A;  4ZG6 A;  1E3C P;  4KJD A;  2VQR A;  4GTY A;  5LRM A;  3Q3Q A;  3UO0 A;  1URA A;  1B8J A;  4UOP A;  1HDH A;  1ELZ A;  4UPK A;  3BDH A;  1KH9 A;  1E2S P;  4KAV A;  3A52 A;  3BDF A;  3NVL A;  2GA3 A;  4MHX A;  4FDJ A;  1ZED A;  2GLQ A;  4LR2 A;  1E1Z P;  1FSU A;  1AJC A;  3SZY A;  2RH6 A;  4CXK A;  4MIV A;  1ELX A;  1HQA A;  3DYC A;  2W5T A;  3WAV A;  3T01 A;  4LR8 A;  5L0E A;  3T00 A;  3M7V A;  1HJK A;  3NKM A;  4TN0 A;  3IGZ B;  3SZZ A;  4ZGA A;  1AJA A;  3ED4 A;  3B5Q A;  1O98 A;  1O99 A;  2IFY A;  3NKP A;  5IJS A;  5LRN A;  5GOV A;  2XRG A;  4B56 A;  3DPC A;  3TX0 A;  4ZG9 A;  1KHK A;  1N2L A;  3M8Y A;  1E33 P;  2W8D A;  5EGE A;  1K7H A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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1EW8A

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations