1EW9A

Alkaline phosphatase (e.c. 3.1.3.1) complex with mercaptomethyl phosphonate
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 159
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew9A00
1ELZA 3TX0A 3WAWA 5DLWA 3TG0A 4B56A 2GSOA 1B8JA 5DLVA 1KH4A 5K4PA 4NWJA 1ALKA 1ALHA 1AJBA 3IDDA 4CYSA 1ELYA 2XR9A 3M8YA 1KH9A 2GLQA 4GTWA 4UPKA 4UORA 3TWZA 4UPHA 5L0KA 3NKMA 4UPIA 5DLTA 2GA3A 4KM4A 3M8WA 4KAYA 4CYRA 4NWXA 4ZGAA 2W5XA 4CXSA 1ELXA 1ZEFA 1Y6VA 1KHKA 3UN5A 3MK0A 1EQJA 3UNYA 2QZUA 3WBHA 4CXUA 2W8SA 1E2SP 3CMRA 1ZEBA 3E2DA 2W5SA 5LIAA 1ALJA 1KH5A 3NKOA 3OT9A 4CXKA 5KXAA 5L0BA 1ANIA 3MK1A 4TN0A 1N2KA 3KD8A 3SZZA 2W5RA 1K7HA 3IGYB 3NKPA 4LREA 3BDHA 1O99A 1E1ZP 1URBA 1ALIA 2VQRA 4LRFA 1SHNA 5L0EA 2ANHA 2W5QA 5IJQA 1EJJA 1AJCA 1ANJA 1ED8A 4LR7A 5GOVA 4LR2A 3WAYA 2X98A 3SZYA 1KH7A 4FDJA 3M8ZA 1KHJA 3LXQA 3UO0A 1AJAA 2W5VA 5HRTA 4LQYA 4N7TA 4LR9A 5C66A 1EW8A 2GSUA 5AJ9A 5GRRA 1N2LA 4MIVA 1HQAA 1P49A 2W5WA 3UN3A 4KJDA 4UOPA 3M7VA 4UOOA 5EGEA 1ZEDA 3T01A 1KHNA 3BDFA 3T02A 1Y7AA 2G9YA 3DYCA 3NVLA 5LRMA 2GSNA 3UN2A 3WAVA 2RH6A 2IUCB 3NKNA 4KJGA 2IUCA 1FSUA 5TJ3A 1HJKA 4KAVA 3T00A 4UPLA 5LQQA 1KHLA 4YR1A 1HDHA 1URAA 1SHQA 4QAXA 1E33P 1E3CP 2IFYA 5LRNA 2D1GA 5INHA 5IJSA 4FDIA 3DPCA 4GTYA 4ZG9A 1O98A 3ED4A 4LRDA 1EW2A 3Q3QA 4ZG7A 3NKRA 4MY4A 2W5TA 1AJDA 2ZKTA 4LRCA 4GTXA 3IGZB 1AUKA 1ED9A 5EGHA 1EW9A 2W8DA 3A52A 4ZG6A 2XRGA 1EI6A 3BDGB 4LRAA 4MHXA 3WAXA 3BDGA 4LR8A 4GTZA 3MK2A 3NKQA 3B5QA 4LRBA
chains in the Genus database with same CATH superfamily
1ELZA 3TX0A 3WAWA 5DLWA 3TG0A 4B56A 2GSOA 1B8JA 5DLVA 1KH4A 5K4PA 4NWJA 1ALKA 1ALHA 1AJBA 3IDDA 4CYSA 1ELYA 2XR9A 3M8YA 1KH9A 2GLQA 4GTWA 4UPKA 4UORA 3TWZA 4UPHA 5L0KA 3NKMA 4UPIA 5DLTA 2GA3A 4KM4A 3M8WA 4KAYA 4CYRA 4NWXA 4ZGAA 2W5XA 4CXSA 1ELXA 1ZEFA 1Y6VA 1KHKA 3UN5A 3MK0A 1EQJA 3UNYA 2QZUA 3WBHA 4CXUA 2W8SA 1E2SP 3CMRA 1ZEBA 3E2DA 2W5SA 5LIAA 1ALJA 1KH5A 3NKOA 3OT9A 4CXKA 5KXAA 5L0BA 1ANIA 3MK1A 4TN0A 1N2KA 3KD8A 3SZZA 2W5RA 1K7HA 3IGYB 3NKPA 4LREA 3BDHA 1O99A 1E1ZP 1URBA 1ALIA 2VQRA 4LRFA 1SHNA 5L0EA 2ANHA 2W5QA 5IJQA 1EJJA 1AJCA 1ANJA 1ED8A 4LR7A 5GOVA 4LR2A 3WAYA 2X98A 3SZYA 1KH7A 4FDJA 3M8ZA 1KHJA 3LXQA 3UO0A 1AJAA 2W5VA 5HRTA 4LQYA 4N7TA 4LR9A 5C66A 1EW8A 2GSUA 5AJ9A 5GRRA 1N2LA 4MIVA 1HQAA 1P49A 2W5WA 3UN3A 4KJDA 4UOPA 3M7VA 4UOOA 5EGEA 1ZEDA 3T01A 1KHNA 3BDFA 3T02A 1Y7AA 2G9YA 3DYCA 3NVLA 5LRMA 2GSNA 3UN2A 3WAVA 2RH6A 2IUCB 3NKNA 4KJGA 2IUCA 1FSUA 5TJ3A 1HJKA 4KAVA 3T00A 4UPLA 5LQQA 1KHLA 4YR1A 1HDHA 1URAA 1SHQA 4QAXA 1E33P 1E3CP 2IFYA 5LRNA 2D1GA 5INHA 5IJSA 4FDIA 3DPCA 4GTYA 4ZG9A 1O98A 3ED4A 4LRDA 1EW2A 3Q3QA 4ZG7A 3NKRA 4MY4A 2W5TA 1AJDA 2ZKTA 4LRCA 4GTXA 3IGZB 1AUKA 1ED9A 5EGHA 1EW9A 2W8DA 3A52A 4ZG6A 2XRGA 1EI6A 3BDGB 4LRAA 4MHXA 3WAXA 3BDGA 4LR8A 4GTZA 3MK2A 3NKQA 3B5QA 4LRBA
chains in the Genus database with same CATH topology
1ELZA 3TX0A 3WAWA 5DLWA 3TG0A 4B56A 2GSOA 1B8JA 5DLVA 1KH4A 5K4PA 4NWJA 1ALKA 1ALHA 1AJBA 3IDDA 4CYSA 1ELYA 2XR9A 3M8YA 1KH9A 2GLQA 4GTWA 4UPKA 4UORA 3TWZA 4UPHA 5L0KA 3NKMA 4UPIA 5DLTA 2GA3A 4KM4A 3M8WA 4KAYA 4CYRA 4NWXA 4ZGAA 2W5XA 4CXSA 1ELXA 1ZEFA 1Y6VA 1KHKA 3UN5A 3MK0A 1EQJA 3UNYA 2QZUA 3WBHA 4CXUA 2W8SA 1E2SP 3CMRA 1ZEBA 3E2DA 2W5SA 5LIAA 1ALJA 1KH5A 3NKOA 3OT9A 4CXKA 5KXAA 5L0BA 1ANIA 3MK1A 4TN0A 1N2KA 3KD8A 3SZZA 2W5RA 1K7HA 3IGYB 3NKPA 4LREA 3BDHA 1O99A 1E1ZP 1URBA 1ALIA 2VQRA 4LRFA 1SHNA 5L0EA 2ANHA 2W5QA 5IJQA 1EJJA 1AJCA 1ANJA 1ED8A 4LR7A 5GOVA 4LR2A 3WAYA 2X98A 3SZYA 1KH7A 4FDJA 3M8ZA 1KHJA 3LXQA 3UO0A 1AJAA 2W5VA 5HRTA 4LQYA 4N7TA 4LR9A 5C66A 1EW8A 2GSUA 5AJ9A 5GRRA 1N2LA 4MIVA 1HQAA 1P49A 2W5WA 3UN3A 4KJDA 4UOPA 3M7VA 4UOOA 5EGEA 1ZEDA 3T01A 1KHNA 3BDFA 3T02A 1Y7AA 2G9YA 3DYCA 3NVLA 5LRMA 2GSNA 3UN2A 3WAVA 2RH6A 2IUCB 3NKNA 4KJGA 2IUCA 1FSUA 5TJ3A 1HJKA 4KAVA 3T00A 4UPLA 5LQQA 1KHLA 4YR1A 1HDHA 1URAA 1SHQA 4QAXA 1E33P 1E3CP 2IFYA 5LRNA 2D1GA 5INHA 5IJSA 4FDIA 3DPCA 4GTYA 4ZG9A 1O98A 3ED4A 4LRDA 1EW2A 3Q3QA 4ZG7A 3NKRA 4MY4A 2W5TA 1AJDA 2ZKTA 4LRCA 4GTXA 3IGZB 1AUKA 1ED9A 5EGHA 1EW9A 2W8DA 3A52A 4ZG6A 2XRGA 1EI6A 3BDGB 4LRAA 4MHXA 3WAXA 3BDGA 4LR8A 4GTZA 3MK2A 3NKQA 3B5QA 4LRBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ELZ A;  3TX0 A;  3WAW A;  5DLW A;  3TG0 A;  4B56 A;  2GSO A;  1B8J A;  5DLV A;  1KH4 A;  5K4P A;  4NWJ A;  1ALK A;  1ALH A;  1AJB A;  3IDD A;  4CYS A;  1ELY A;  2XR9 A;  3M8Y A;  1KH9 A;  2GLQ A;  4GTW A;  4UPK A;  4UOR A;  3TWZ A;  4UPH A;  5L0K A;  3NKM A;  4UPI A;  5DLT A;  2GA3 A;  4KM4 A;  3M8W A;  4KAY A;  4CYR A;  4NWX A;  4ZGA A;  2W5X A;  4CXS A;  1ELX A;  1ZEF A;  1Y6V A;  1KHK A;  3UN5 A;  3MK0 A;  1EQJ A;  3UNY A;  2QZU A;  3WBH A;  4CXU A;  2W8S A;  1E2S P;  3CMR A;  1ZEB A;  3E2D A;  2W5S A;  5LIA A;  1ALJ A;  1KH5 A;  3NKO A;  3OT9 A;  4CXK A;  5KXA A;  5L0B A;  1ANI A;  3MK1 A;  4TN0 A;  1N2K A;  3KD8 A;  3SZZ A;  2W5R A;  1K7H A;  3IGY B;  3NKP A;  4LRE A;  3BDH A;  1O99 A;  1E1Z P;  1URB A;  1ALI A;  2VQR A;  4LRF A;  1SHN A;  5L0E A;  2ANH A;  2W5Q A;  5IJQ A;  1EJJ A;  1AJC A;  1ANJ A;  1ED8 A;  4LR7 A;  5GOV A;  4LR2 A;  3WAY A;  2X98 A;  3SZY A;  1KH7 A;  4FDJ A;  3M8Z A;  1KHJ A;  3LXQ A;  3UO0 A;  1AJA A;  2W5V A;  5HRT A;  4LQY A;  4N7T A;  4LR9 A;  5C66 A;  1EW8 A;  2GSU A;  5AJ9 A;  5GRR A;  1N2L A;  4MIV A;  1HQA A;  1P49 A;  2W5W A;  3UN3 A;  4KJD A;  4UOP A;  3M7V A;  4UOO A;  5EGE A;  1ZED A;  3T01 A;  1KHN A;  3BDF A;  3T02 A;  1Y7A A;  2G9Y A;  3DYC A;  3NVL A;  5LRM A;  2GSN A;  3UN2 A;  3WAV A;  2RH6 A;  2IUC B;  3NKN A;  4KJG A;  2IUC A;  1FSU A;  5TJ3 A;  1HJK A;  4KAV A;  3T00 A;  4UPL A;  5LQQ A;  1KHL A;  4YR1 A;  1HDH A;  1URA A;  1SHQ A;  4QAX A;  1E33 P;  1E3C P;  2IFY A;  5LRN A;  2D1G A;  5INH A;  5IJS A;  4FDI A;  3DPC A;  4GTY A;  4ZG9 A;  1O98 A;  3ED4 A;  4LRD A;  1EW2 A;  3Q3Q A;  4ZG7 A;  3NKR A;  4MY4 A;  2W5T A;  1AJD A;  2ZKT A;  4LRC A;  4GTX A;  3IGZ B;  1AUK A;  1ED9 A;  5EGH A;  1EW9 A;  2W8D A;  3A52 A;  4ZG6 A;  2XRG A;  1EI6 A;  3BDG B;  4LRA A;  4MHX A;  3WAX A;  3BDG A;  4LR8 A;  4GTZ A;  3MK2 A;  3NKQ A;  3B5Q A;  4LRB A; 
#chains in the Genus database with same CATH topology
 1ELZ A;  3TX0 A;  3WAW A;  5DLW A;  3TG0 A;  4B56 A;  2GSO A;  1B8J A;  5DLV A;  1KH4 A;  5K4P A;  4NWJ A;  1ALK A;  1ALH A;  1AJB A;  3IDD A;  4CYS A;  1ELY A;  2XR9 A;  3M8Y A;  1KH9 A;  2GLQ A;  4GTW A;  4UPK A;  4UOR A;  3TWZ A;  4UPH A;  5L0K A;  3NKM A;  4UPI A;  5DLT A;  2GA3 A;  4KM4 A;  3M8W A;  4KAY A;  4CYR A;  4NWX A;  4ZGA A;  2W5X A;  4CXS A;  1ELX A;  1ZEF A;  1Y6V A;  1KHK A;  3UN5 A;  3MK0 A;  1EQJ A;  3UNY A;  2QZU A;  3WBH A;  4CXU A;  2W8S A;  1E2S P;  3CMR A;  1ZEB A;  3E2D A;  2W5S A;  5LIA A;  1ALJ A;  1KH5 A;  3NKO A;  3OT9 A;  4CXK A;  5KXA A;  5L0B A;  1ANI A;  3MK1 A;  4TN0 A;  1N2K A;  3KD8 A;  3SZZ A;  2W5R A;  1K7H A;  3IGY B;  3NKP A;  4LRE A;  3BDH A;  1O99 A;  1E1Z P;  1URB A;  1ALI A;  2VQR A;  4LRF A;  1SHN A;  5L0E A;  2ANH A;  2W5Q A;  5IJQ A;  1EJJ A;  1AJC A;  1ANJ A;  1ED8 A;  4LR7 A;  5GOV A;  4LR2 A;  3WAY A;  2X98 A;  3SZY A;  1KH7 A;  4FDJ A;  3M8Z A;  1KHJ A;  3LXQ A;  3UO0 A;  1AJA A;  2W5V A;  5HRT A;  4LQY A;  4N7T A;  4LR9 A;  5C66 A;  1EW8 A;  2GSU A;  5AJ9 A;  5GRR A;  1N2L A;  4MIV A;  1HQA A;  1P49 A;  2W5W A;  3UN3 A;  4KJD A;  4UOP A;  3M7V A;  4UOO A;  5EGE A;  1ZED A;  3T01 A;  1KHN A;  3BDF A;  3T02 A;  1Y7A A;  2G9Y A;  3DYC A;  3NVL A;  5LRM A;  2GSN A;  3UN2 A;  3WAV A;  2RH6 A;  2IUC B;  3NKN A;  4KJG A;  2IUC A;  1FSU A;  5TJ3 A;  1HJK A;  4KAV A;  3T00 A;  4UPL A;  5LQQ A;  1KHL A;  4YR1 A;  1HDH A;  1URA A;  1SHQ A;  4QAX A;  1E33 P;  1E3C P;  2IFY A;  5LRN A;  2D1G A;  5INH A;  5IJS A;  4FDI A;  3DPC A;  4GTY A;  4ZG9 A;  1O98 A;  3ED4 A;  4LRD A;  1EW2 A;  3Q3Q A;  4ZG7 A;  3NKR A;  4MY4 A;  2W5T A;  1AJD A;  2ZKT A;  4LRC A;  4GTX A;  3IGZ B;  1AUK A;  1ED9 A;  5EGH A;  1EW9 A;  2W8D A;  3A52 A;  4ZG6 A;  2XRG A;  1EI6 A;  3BDG B;  4LRA A;  4MHX A;  3WAX A;  3BDG A;  4LR8 A;  4GTZ A;  3MK2 A;  3NKQ A;  3B5Q A;  4LRB A; 
#chains in the Genus database with same CATH homology
 1ELZ A;  3TX0 A;  3WAW A;  5DLW A;  3TG0 A;  4B56 A;  2GSO A;  1B8J A;  5DLV A;  1KH4 A;  5K4P A;  4NWJ A;  1ALK A;  1ALH A;  1AJB A;  3IDD A;  4CYS A;  1ELY A;  2XR9 A;  3M8Y A;  1KH9 A;  2GLQ A;  4GTW A;  4UPK A;  4UOR A;  3TWZ A;  4UPH A;  5L0K A;  3NKM A;  4UPI A;  5DLT A;  2GA3 A;  4KM4 A;  3M8W A;  4KAY A;  4CYR A;  4NWX A;  4ZGA A;  2W5X A;  4CXS A;  1ELX A;  1ZEF A;  1Y6V A;  1KHK A;  3UN5 A;  3MK0 A;  1EQJ A;  3UNY A;  2QZU A;  3WBH A;  4CXU A;  2W8S A;  1E2S P;  3CMR A;  1ZEB A;  3E2D A;  2W5S A;  5LIA A;  1ALJ A;  1KH5 A;  3NKO A;  3OT9 A;  4CXK A;  5KXA A;  5L0B A;  1ANI A;  3MK1 A;  4TN0 A;  1N2K A;  3KD8 A;  3SZZ A;  2W5R A;  1K7H A;  3IGY B;  3NKP A;  4LRE A;  3BDH A;  1O99 A;  1E1Z P;  1URB A;  1ALI A;  2VQR A;  4LRF A;  1SHN A;  5L0E A;  2ANH A;  2W5Q A;  5IJQ A;  1EJJ A;  1AJC A;  1ANJ A;  1ED8 A;  4LR7 A;  5GOV A;  4LR2 A;  3WAY A;  2X98 A;  3SZY A;  1KH7 A;  4FDJ A;  3M8Z A;  1KHJ A;  3LXQ A;  3UO0 A;  1AJA A;  2W5V A;  5HRT A;  4LQY A;  4N7T A;  4LR9 A;  5C66 A;  1EW8 A;  2GSU A;  5AJ9 A;  5GRR A;  1N2L A;  4MIV A;  1HQA A;  1P49 A;  2W5W A;  3UN3 A;  4KJD A;  4UOP A;  3M7V A;  4UOO A;  5EGE A;  1ZED A;  3T01 A;  1KHN A;  3BDF A;  3T02 A;  1Y7A A;  2G9Y A;  3DYC A;  3NVL A;  5LRM A;  2GSN A;  3UN2 A;  3WAV A;  2RH6 A;  2IUC B;  3NKN A;  4KJG A;  2IUC A;  1FSU A;  5TJ3 A;  1HJK A;  4KAV A;  3T00 A;  4UPL A;  5LQQ A;  1KHL A;  4YR1 A;  1HDH A;  1URA A;  1SHQ A;  4QAX A;  1E33 P;  1E3C P;  2IFY A;  5LRN A;  2D1G A;  5INH A;  5IJS A;  4FDI A;  3DPC A;  4GTY A;  4ZG9 A;  1O98 A;  3ED4 A;  4LRD A;  1EW2 A;  3Q3Q A;  4ZG7 A;  3NKR A;  4MY4 A;  2W5T A;  1AJD A;  2ZKT A;  4LRC A;  4GTX A;  3IGZ B;  1AUK A;  1ED9 A;  5EGH A;  1EW9 A;  2W8D A;  3A52 A;  4ZG6 A;  2XRG A;  1EI6 A;  3BDG B;  4LRA A;  4MHX A;  3WAX A;  3BDG A;  4LR8 A;  4GTZ A;  3MK2 A;  3NKQ A;  3B5Q A;  4LRB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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