1HJKA

Alkaline phosphatase mutant h331q
Total Genus 152
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDQAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Trapping and visualization of a covalent enzyme-phosphate intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 152
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1997-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hjkA00
1ALHA 1EQJA 2W5SA 3ED4A 4FDIA 1ED9A 5DLTA 5LIAA 1ALKA 4B56A 1KHNA 2GSUA 3MK2A 4GTXA 1HQAA 4ZG6A 4NWXA 4LRBA 5IJQA 3BDGA 3NKRA 1HDHA 1ANIA 2IUCB 1KH7A 1N2KA 1Y6VA 5LRNA 3UN5A 1ZEFA 5AJ9A 3M8YA 1URBA 1EW8A 1E33P 4LQYA 1KHKA 1N2LA 4N7TA 2X98A 3B5QA 3CMRA 3WBHA 2W8DA 2GSNA 4MIVA 1O99A 2W5VA 2W5XA 5INHA 4UPHA 3TX0A 4CXSA 2VQRA 3UO0A 3E2DA 4LR2A 4UOPA 4UOOA 1ZEBA 1E3CP 3BDFA 4KAYA 4UPLA 1AJAA 1EJJA 1P49A 4KJDA 2ANHA 5L0BA 3TWZA 4CYSA 2XR9A 4MHXA 5LRMA 3T02A 1EI6A 3IGYB 1SHQA 4YR1A 4UPIA 5IJSA 3BDGB 1Y7AA 3LXQA 3BDHA 1KHLA 4QAXA 5GOVA 1ALJA 4TN0A 4UORA 4ZGAA 5EGEA 2ZKTA 3IDDA 1FSUA 2XRGA 5DLVA 4GTYA 5L0KA 1EW9A 5C66A 3NKQA 2W8SA 3NKNA 4LRFA 3DYCA 4MY4A 1KH9A 4ZG7A 3DPCA 1KH5A 5KXAA 5LQQA 5K4PA 3UNYA 3NKMA 4LRCA 1SHNA 2G9YA 3Q3QA 4LR9A 2W5WA 2IUCA 4LR7A 3NKOA 3M7VA 2D1GA 3A52A 3T01A 2RH6A 4NWJA 5L0EA 2W5QA 3KD8A 4KJGA 5EGHA 2QZUA 3NVLA 1AUKA 3WAVA 1O98A 1AJBA 1HJKA 3M8WA 1KH4A 1AJCA 3IGZB 4KM4A 2W5TA 1URAA 5GRRA 2IFYA 3SZZA 3MK1A 4GTZA 4LRAA 3UN3A 3T00A 4LREA 3UN2A 5TJ3A 1E2SP 4LRDA 3WAXA 4ZG9A 4GTWA 1KHJA 1ALIA 4FDJA 1ELYA 5HRTA 1ED8A 2GLQA 4KAVA 4LR8A 3TG0A 1AJDA 3OT9A 4UPKA 3MK0A 5DLWA 1K7HA 3NKPA 1B8JA 4CYRA 1ZEDA 1ELXA 2W5RA 3SZYA 2GA3A 3M8ZA 2GSOA 4CXUA 1E1ZP 3WAYA 4CXKA 1EW2A 3WAWA 1ANJA 1ELZA
chains in the Genus database with same CATH superfamily
1ALHA 1EQJA 2W5SA 3ED4A 4FDIA 1ED9A 5DLTA 5LIAA 1ALKA 4B56A 1KHNA 2GSUA 3MK2A 4GTXA 1HQAA 4ZG6A 4NWXA 4LRBA 5IJQA 3BDGA 3NKRA 1HDHA 1ANIA 2IUCB 1KH7A 1N2KA 1Y6VA 5LRNA 3UN5A 1ZEFA 5AJ9A 3M8YA 1URBA 1EW8A 1E33P 4LQYA 1KHKA 1N2LA 4N7TA 2X98A 3B5QA 3CMRA 3WBHA 2W8DA 2GSNA 4MIVA 1O99A 2W5VA 2W5XA 5INHA 4UPHA 3TX0A 4CXSA 2VQRA 3UO0A 3E2DA 4LR2A 4UOPA 4UOOA 1ZEBA 1E3CP 3BDFA 4KAYA 4UPLA 1AJAA 1EJJA 1P49A 4KJDA 2ANHA 5L0BA 3TWZA 4CYSA 2XR9A 4MHXA 5LRMA 3T02A 1EI6A 3IGYB 1SHQA 4YR1A 4UPIA 5IJSA 3BDGB 1Y7AA 3LXQA 3BDHA 1KHLA 4QAXA 5GOVA 1ALJA 4TN0A 4UORA 4ZGAA 5EGEA 2ZKTA 3IDDA 1FSUA 2XRGA 5DLVA 4GTYA 5L0KA 1EW9A 5C66A 3NKQA 2W8SA 3NKNA 4LRFA 3DYCA 4MY4A 1KH9A 4ZG7A 3DPCA 1KH5A 5KXAA 5LQQA 5K4PA 3UNYA 3NKMA 4LRCA 1SHNA 2G9YA 3Q3QA 4LR9A 2W5WA 2IUCA 4LR7A 3NKOA 3M7VA 2D1GA 3A52A 3T01A 2RH6A 4NWJA 5L0EA 2W5QA 3KD8A 4KJGA 5EGHA 2QZUA 3NVLA 1AUKA 3WAVA 1O98A 1AJBA 1HJKA 3M8WA 1KH4A 1AJCA 3IGZB 4KM4A 2W5TA 1URAA 5GRRA 2IFYA 3SZZA 3MK1A 4GTZA 4LRAA 3UN3A 3T00A 4LREA 3UN2A 5TJ3A 1E2SP 4LRDA 3WAXA 4ZG9A 4GTWA 1KHJA 1ALIA 4FDJA 1ELYA 5HRTA 1ED8A 2GLQA 4KAVA 4LR8A 3TG0A 1AJDA 3OT9A 4UPKA 3MK0A 5DLWA 1K7HA 3NKPA 1B8JA 4CYRA 1ZEDA 1ELXA 2W5RA 3SZYA 2GA3A 3M8ZA 2GSOA 4CXUA 1E1ZP 3WAYA 4CXKA 1EW2A 3WAWA 1ANJA 1ELZA
chains in the Genus database with same CATH topology
1ALHA 1EQJA 2W5SA 3ED4A 4FDIA 1ED9A 5DLTA 5LIAA 1ALKA 4B56A 1KHNA 2GSUA 3MK2A 4GTXA 1HQAA 4ZG6A 4NWXA 4LRBA 5IJQA 3BDGA 3NKRA 1HDHA 1ANIA 2IUCB 1KH7A 1N2KA 1Y6VA 5LRNA 3UN5A 1ZEFA 5AJ9A 3M8YA 1URBA 1EW8A 1E33P 4LQYA 1KHKA 1N2LA 4N7TA 2X98A 3B5QA 3CMRA 3WBHA 2W8DA 2GSNA 4MIVA 1O99A 2W5VA 2W5XA 5INHA 4UPHA 3TX0A 4CXSA 2VQRA 3UO0A 3E2DA 4LR2A 4UOPA 4UOOA 1ZEBA 1E3CP 3BDFA 4KAYA 4UPLA 1AJAA 1EJJA 1P49A 4KJDA 2ANHA 5L0BA 3TWZA 4CYSA 2XR9A 4MHXA 5LRMA 3T02A 1EI6A 3IGYB 1SHQA 4YR1A 4UPIA 5IJSA 3BDGB 1Y7AA 3LXQA 3BDHA 1KHLA 4QAXA 5GOVA 1ALJA 4TN0A 4UORA 4ZGAA 5EGEA 2ZKTA 3IDDA 1FSUA 2XRGA 5DLVA 4GTYA 5L0KA 1EW9A 5C66A 3NKQA 2W8SA 3NKNA 4LRFA 3DYCA 4MY4A 1KH9A 4ZG7A 3DPCA 1KH5A 5KXAA 5LQQA 5K4PA 3UNYA 3NKMA 4LRCA 1SHNA 2G9YA 3Q3QA 4LR9A 2W5WA 2IUCA 4LR7A 3NKOA 3M7VA 2D1GA 3A52A 3T01A 2RH6A 4NWJA 5L0EA 2W5QA 3KD8A 4KJGA 5EGHA 2QZUA 3NVLA 1AUKA 3WAVA 1O98A 1AJBA 1HJKA 3M8WA 1KH4A 1AJCA 3IGZB 4KM4A 2W5TA 1URAA 5GRRA 2IFYA 3SZZA 3MK1A 4GTZA 4LRAA 3UN3A 3T00A 4LREA 3UN2A 5TJ3A 1E2SP 4LRDA 3WAXA 4ZG9A 4GTWA 1KHJA 1ALIA 4FDJA 1ELYA 5HRTA 1ED8A 2GLQA 4KAVA 4LR8A 3TG0A 1AJDA 3OT9A 4UPKA 3MK0A 5DLWA 1K7HA 3NKPA 1B8JA 4CYRA 1ZEDA 1ELXA 2W5RA 3SZYA 2GA3A 3M8ZA 2GSOA 4CXUA 1E1ZP 3WAYA 4CXKA 1EW2A 3WAWA 1ANJA 1ELZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ALH A;  1EQJ A;  2W5S A;  3ED4 A;  4FDI A;  1ED9 A;  5DLT A;  5LIA A;  1ALK A;  4B56 A;  1KHN A;  2GSU A;  3MK2 A;  4GTX A;  1HQA A;  4ZG6 A;  4NWX A;  4LRB A;  5IJQ A;  3BDG A;  3NKR A;  1HDH A;  1ANI A;  2IUC B;  1KH7 A;  1N2K A;  1Y6V A;  5LRN A;  3UN5 A;  1ZEF A;  5AJ9 A;  3M8Y A;  1URB A;  1EW8 A;  1E33 P;  4LQY A;  1KHK A;  1N2L A;  4N7T A;  2X98 A;  3B5Q A;  3CMR A;  3WBH A;  2W8D A;  2GSN A;  4MIV A;  1O99 A;  2W5V A;  2W5X A;  5INH A;  4UPH A;  3TX0 A;  4CXS A;  2VQR A;  3UO0 A;  3E2D A;  4LR2 A;  4UOP A;  4UOO A;  1ZEB A;  1E3C P;  3BDF A;  4KAY A;  4UPL A;  1AJA A;  1EJJ A;  1P49 A;  4KJD A;  2ANH A;  5L0B A;  3TWZ A;  4CYS A;  2XR9 A;  4MHX A;  5LRM A;  3T02 A;  1EI6 A;  3IGY B;  1SHQ A;  4YR1 A;  4UPI A;  5IJS A;  3BDG B;  1Y7A A;  3LXQ A;  3BDH A;  1KHL A;  4QAX A;  5GOV A;  1ALJ A;  4TN0 A;  4UOR A;  4ZGA A;  5EGE A;  2ZKT A;  3IDD A;  1FSU A;  2XRG A;  5DLV A;  4GTY A;  5L0K A;  1EW9 A;  5C66 A;  3NKQ A;  2W8S A;  3NKN A;  4LRF A;  3DYC A;  4MY4 A;  1KH9 A;  4ZG7 A;  3DPC A;  1KH5 A;  5KXA A;  5LQQ A;  5K4P A;  3UNY A;  3NKM A;  4LRC A;  1SHN A;  2G9Y A;  3Q3Q A;  4LR9 A;  2W5W A;  2IUC A;  4LR7 A;  3NKO A;  3M7V A;  2D1G A;  3A52 A;  3T01 A;  2RH6 A;  4NWJ A;  5L0E A;  2W5Q A;  3KD8 A;  4KJG A;  5EGH A;  2QZU A;  3NVL A;  1AUK A;  3WAV A;  1O98 A;  1AJB A;  1HJK A;  3M8W A;  1KH4 A;  1AJC A;  3IGZ B;  4KM4 A;  2W5T A;  1URA A;  5GRR A;  2IFY A;  3SZZ A;  3MK1 A;  4GTZ A;  4LRA A;  3UN3 A;  3T00 A;  4LRE A;  3UN2 A;  5TJ3 A;  1E2S P;  4LRD A;  3WAX A;  4ZG9 A;  4GTW A;  1KHJ A;  1ALI A;  4FDJ A;  1ELY A;  5HRT A;  1ED8 A;  2GLQ A;  4KAV A;  4LR8 A;  3TG0 A;  1AJD A;  3OT9 A;  4UPK A;  3MK0 A;  5DLW A;  1K7H A;  3NKP A;  1B8J A;  4CYR A;  1ZED A;  1ELX A;  2W5R A;  3SZY A;  2GA3 A;  3M8Z A;  2GSO A;  4CXU A;  1E1Z P;  3WAY A;  4CXK A;  1EW2 A;  3WAW A;  1ANJ A;  1ELZ A; 
#chains in the Genus database with same CATH topology
 1ALH A;  1EQJ A;  2W5S A;  3ED4 A;  4FDI A;  1ED9 A;  5DLT A;  5LIA A;  1ALK A;  4B56 A;  1KHN A;  2GSU A;  3MK2 A;  4GTX A;  1HQA A;  4ZG6 A;  4NWX A;  4LRB A;  5IJQ A;  3BDG A;  3NKR A;  1HDH A;  1ANI A;  2IUC B;  1KH7 A;  1N2K A;  1Y6V A;  5LRN A;  3UN5 A;  1ZEF A;  5AJ9 A;  3M8Y A;  1URB A;  1EW8 A;  1E33 P;  4LQY A;  1KHK A;  1N2L A;  4N7T A;  2X98 A;  3B5Q A;  3CMR A;  3WBH A;  2W8D A;  2GSN A;  4MIV A;  1O99 A;  2W5V A;  2W5X A;  5INH A;  4UPH A;  3TX0 A;  4CXS A;  2VQR A;  3UO0 A;  3E2D A;  4LR2 A;  4UOP A;  4UOO A;  1ZEB A;  1E3C P;  3BDF A;  4KAY A;  4UPL A;  1AJA A;  1EJJ A;  1P49 A;  4KJD A;  2ANH A;  5L0B A;  3TWZ A;  4CYS A;  2XR9 A;  4MHX A;  5LRM A;  3T02 A;  1EI6 A;  3IGY B;  1SHQ A;  4YR1 A;  4UPI A;  5IJS A;  3BDG B;  1Y7A A;  3LXQ A;  3BDH A;  1KHL A;  4QAX A;  5GOV A;  1ALJ A;  4TN0 A;  4UOR A;  4ZGA A;  5EGE A;  2ZKT A;  3IDD A;  1FSU A;  2XRG A;  5DLV A;  4GTY A;  5L0K A;  1EW9 A;  5C66 A;  3NKQ A;  2W8S A;  3NKN A;  4LRF A;  3DYC A;  4MY4 A;  1KH9 A;  4ZG7 A;  3DPC A;  1KH5 A;  5KXA A;  5LQQ A;  5K4P A;  3UNY A;  3NKM A;  4LRC A;  1SHN A;  2G9Y A;  3Q3Q A;  4LR9 A;  2W5W A;  2IUC A;  4LR7 A;  3NKO A;  3M7V A;  2D1G A;  3A52 A;  3T01 A;  2RH6 A;  4NWJ A;  5L0E A;  2W5Q A;  3KD8 A;  4KJG A;  5EGH A;  2QZU A;  3NVL A;  1AUK A;  3WAV A;  1O98 A;  1AJB A;  1HJK A;  3M8W A;  1KH4 A;  1AJC A;  3IGZ B;  4KM4 A;  2W5T A;  1URA A;  5GRR A;  2IFY A;  3SZZ A;  3MK1 A;  4GTZ A;  4LRA A;  3UN3 A;  3T00 A;  4LRE A;  3UN2 A;  5TJ3 A;  1E2S P;  4LRD A;  3WAX A;  4ZG9 A;  4GTW A;  1KHJ A;  1ALI A;  4FDJ A;  1ELY A;  5HRT A;  1ED8 A;  2GLQ A;  4KAV A;  4LR8 A;  3TG0 A;  1AJD A;  3OT9 A;  4UPK A;  3MK0 A;  5DLW A;  1K7H A;  3NKP A;  1B8J A;  4CYR A;  1ZED A;  1ELX A;  2W5R A;  3SZY A;  2GA3 A;  3M8Z A;  2GSO A;  4CXU A;  1E1Z P;  3WAY A;  4CXK A;  1EW2 A;  3WAW A;  1ANJ A;  1ELZ A; 
#chains in the Genus database with same CATH homology
 1ALH A;  1EQJ A;  2W5S A;  3ED4 A;  4FDI A;  1ED9 A;  5DLT A;  5LIA A;  1ALK A;  4B56 A;  1KHN A;  2GSU A;  3MK2 A;  4GTX A;  1HQA A;  4ZG6 A;  4NWX A;  4LRB A;  5IJQ A;  3BDG A;  3NKR A;  1HDH A;  1ANI A;  2IUC B;  1KH7 A;  1N2K A;  1Y6V A;  5LRN A;  3UN5 A;  1ZEF A;  5AJ9 A;  3M8Y A;  1URB A;  1EW8 A;  1E33 P;  4LQY A;  1KHK A;  1N2L A;  4N7T A;  2X98 A;  3B5Q A;  3CMR A;  3WBH A;  2W8D A;  2GSN A;  4MIV A;  1O99 A;  2W5V A;  2W5X A;  5INH A;  4UPH A;  3TX0 A;  4CXS A;  2VQR A;  3UO0 A;  3E2D A;  4LR2 A;  4UOP A;  4UOO A;  1ZEB A;  1E3C P;  3BDF A;  4KAY A;  4UPL A;  1AJA A;  1EJJ A;  1P49 A;  4KJD A;  2ANH A;  5L0B A;  3TWZ A;  4CYS A;  2XR9 A;  4MHX A;  5LRM A;  3T02 A;  1EI6 A;  3IGY B;  1SHQ A;  4YR1 A;  4UPI A;  5IJS A;  3BDG B;  1Y7A A;  3LXQ A;  3BDH A;  1KHL A;  4QAX A;  5GOV A;  1ALJ A;  4TN0 A;  4UOR A;  4ZGA A;  5EGE A;  2ZKT A;  3IDD A;  1FSU A;  2XRG A;  5DLV A;  4GTY A;  5L0K A;  1EW9 A;  5C66 A;  3NKQ A;  2W8S A;  3NKN A;  4LRF A;  3DYC A;  4MY4 A;  1KH9 A;  4ZG7 A;  3DPC A;  1KH5 A;  5KXA A;  5LQQ A;  5K4P A;  3UNY A;  3NKM A;  4LRC A;  1SHN A;  2G9Y A;  3Q3Q A;  4LR9 A;  2W5W A;  2IUC A;  4LR7 A;  3NKO A;  3M7V A;  2D1G A;  3A52 A;  3T01 A;  2RH6 A;  4NWJ A;  5L0E A;  2W5Q A;  3KD8 A;  4KJG A;  5EGH A;  2QZU A;  3NVL A;  1AUK A;  3WAV A;  1O98 A;  1AJB A;  1HJK A;  3M8W A;  1KH4 A;  1AJC A;  3IGZ B;  4KM4 A;  2W5T A;  1URA A;  5GRR A;  2IFY A;  3SZZ A;  3MK1 A;  4GTZ A;  4LRA A;  3UN3 A;  3T00 A;  4LRE A;  3UN2 A;  5TJ3 A;  1E2S P;  4LRD A;  3WAX A;  4ZG9 A;  4GTW A;  1KHJ A;  1ALI A;  4FDJ A;  1ELY A;  5HRT A;  1ED8 A;  2GLQ A;  4KAV A;  4LR8 A;  3TG0 A;  1AJD A;  3OT9 A;  4UPK A;  3MK0 A;  5DLW A;  1K7H A;  3NKP A;  1B8J A;  4CYR A;  1ZED A;  1ELX A;  2W5R A;  3SZY A;  2GA3 A;  3M8Z A;  2GSO A;  4CXU A;  1E1Z P;  3WAY A;  4CXK A;  1EW2 A;  3WAW A;  1ANJ A;  1ELZ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...